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2024

Journal Article

Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein

McMillan, Christopher L. D., Wijesundara, Danushka K., Choo, Jovin J. Y., Amarilla, Alberto A., Modhiran, Naphak, Fernando, Germain J. P., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R. and Muller, David A. (2024). Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein. Journal of General Virology, 105 (1) 001947, 1-6. doi: 10.1099/jgv.0.001947

Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein

2023

Journal Article

Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine

Wijesundara, Danushka K., Yeow, Arthur, McMillan, Christopher L. D., Choo, Jovin J. Y., Todorovic, Aleksandra, Mekonnen, Zelalem A., Masavuli, Makutiro G., Young, Paul R., Gowans, Eric J., Grubor-Bauk, Branka and Muller, David A. (2023). Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine. Molecular Therapy Nucleic Acids, 34 102056, 102056. doi: 10.1016/j.omtn.2023.102056

Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine

2023

Journal Article

Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial

Chappell, Keith J., Mordant, Francesca L., Amarilla, Alberto A., Modhiran, Naphak, Liang, Benjamin, Li, Zheyi, Wijesundara, Danushka K., Lackenby, Julia A., Griffin, Paul, Bennet, Jillian K., Hensen, Luca, Zhang, Wuji, Nguyen, Thi H.O., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Kedzierska, Katherine, Ranasinghe, Charani, Subbarao, Kanta, Watterson, Daniel, Young, Paul R. and Munro, Trent P. (2023). Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial. eBioMedicine, 97 104842, 104842. doi: 10.1016/j.ebiom.2023.104842

Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial

2023

Journal Article

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

2022

Journal Article

LUNG group 2 innate lymphoid cells as a new adjuvant target to enhance intranasal vaccine efficacy against influenza

Williams, Clare M., Roy, Sreeja, Sun, Wei, Furuya, Andrea M., Wijesundara, Danushka K. and Furuya, Yoichi (2022). LUNG group 2 innate lymphoid cells as a new adjuvant target to enhance intranasal vaccine efficacy against influenza. Clinical and Translational Immunology, 11 (3) e1381. doi: 10.1002/cti2.1381

LUNG group 2 innate lymphoid cells as a new adjuvant target to enhance intranasal vaccine efficacy against influenza

2021

Journal Article

Fear of influenza resurgence amid covid-19 pandemic: need for effective flu vaccine still exists

Wijesundara, Danushka K., Williams, Clare, Sun, Wei, Furuya, Andrea Marias and Furuya, Yoichi (2021). Fear of influenza resurgence amid covid-19 pandemic: need for effective flu vaccine still exists. Vaccines, 9 (10) 1198, 1198. doi: 10.3390/VACCINES9101198

Fear of influenza resurgence amid covid-19 pandemic: need for effective flu vaccine still exists

2021

Journal Article

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial

Chappell, Keith J., Mordant, Francesca L., Li, Zheyi, Wijesundara, Danushka K., Ellenberg, Paula, Lackenby, Julia A., Cheung, Stacey T. M., Modhiran, Naphak, Avumegah, Michael S., Henderson, Christina L., Hoger, Kym, Griffin, Paul, Bennet, Jillian, Hensen, Luca, Zhang, Wuji, Nguyen, Thi H. O., Marrero-Hernandez, Sara, Selva, Kevin J., Chung, Amy W., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Nicholson, Suellen, Corby, Stavroula, Holgate, Thomas, Wines, Bruce D., Hogarth, P Mark, Kedzierska, Katherine ... Munro, Trent P. (2021). Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial. The Lancet Infectious Diseases, 21 (10), 1383-1394. doi: 10.1016/S1473-3099(21)00200-0

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial

2021

Journal Article

Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Watterson, Daniel, Wijesundara, Danushka K., Modhiran, Naphak, Mordant, Francesca L., Li, Zheyi, Avumegah, Michael S., McMillan, Christopher L. D., Lackenby, Julia, Guilfoyle, Kate, van Amerongen, Geert, Stittelaar, Koert, Cheung, Stacey T. M., Bibby, Summa, Daleris, Mallory, Hoger, Kym, Gillard, Marianne, Radunz, Eve, Jones, Martina L., Hughes, Karen, Hughes, Ben, Goh, Justin, Edwards, David, Scoble, Judith, Pearce, Lesley, Kowalczyk, Lukasz, Phan, Tram, La, Mylinh, Lu, Louis, Pham, Tam ... Chappell, Keith J. (2021). Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2. Clinical & Translational Immunology, 10 (4) e1269, e1269. doi: 10.1002/cti2.1269

Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

2021

Journal Article

Adjuvant selection for influenza and RSV prefusion subunit vaccines

Isaacs, Ariel, Li, Zheyi, Cheung, Stacey T. M., Wijesundara, Danushka K., McMillan, Christopher L. D., Modhiran, Naphak, Young, Paul R., Ranasinghe, Charani, Watterson, Daniel and Chappell, Keith J. (2021). Adjuvant selection for influenza and RSV prefusion subunit vaccines. Vaccines, 9 (2) 71, 1-14. doi: 10.3390/vaccines9020071

Adjuvant selection for influenza and RSV prefusion subunit vaccines

2020

Journal Article

Impact of pre-existing immunity to influenza on live-attenuated influenza vaccine (Laiv) immunogenicity

Roy, Sreeja, Williams, Clare M., Wijesundara, Danushka K. and Furuya, Yoichi (2020). Impact of pre-existing immunity to influenza on live-attenuated influenza vaccine (Laiv) immunogenicity. Vaccines, 8 (4) 683, 1-13. doi: 10.3390/vaccines8040683

Impact of pre-existing immunity to influenza on live-attenuated influenza vaccine (Laiv) immunogenicity

2020

Journal Article

Rapid response subunit vaccine design in the absence of structural information

Wijesundara, Danushka K., Avumegah, Michael S., Lackenby, Julia, Modhiran, Naphak, Isaacs, Ariel, Young, Paul R., Watterson, Daniel and Chappell, Keith J. (2020). Rapid response subunit vaccine design in the absence of structural information. Frontiers in Immunology, 11 592370, 592370. doi: 10.3389/fimmu.2020.592370

Rapid response subunit vaccine design in the absence of structural information

2020

Journal Article

Immunological memory in imiquimod-induced murine model of psoriasiform dermatitis

Fenix, Kevin, Wijesundara, Danushka K., Cowin, Allison J., Grubor-Bauk, Branka and Kopecki, Zlatko (2020). Immunological memory in imiquimod-induced murine model of psoriasiform dermatitis. International Journal of Molecular Sciences, 21 (19) 7228, 1-13. doi: 10.3390/ijms21197228

Immunological memory in imiquimod-induced murine model of psoriasiform dermatitis

2020

Journal Article

Impact of pre-existing immunity on live attenuated influenza vaccine-induced cross-protective immunity

Roy, Sreeja, Williams, Clare M., Pardo, Julian, Wijesundara, Danushka K. and Furuya, Yoichi (2020). Impact of pre-existing immunity on live attenuated influenza vaccine-induced cross-protective immunity. Vaccines, 8 (3) 459, 1-6. doi: 10.3390/vaccines8030459

Impact of pre-existing immunity on live attenuated influenza vaccine-induced cross-protective immunity

2020

Journal Article

Safety profile of a multi-antigenic DNA vaccine against hepatitis C virus

Gummow, Jason, Masavuli, Makutiro G., Mekonnen, Zelalem A., Li, Yanrui, Wijesundara, Danushka K., Shrestha, Ashish C., Voskoboinik, Ilia, Gowans, Eric J. and Grubor-Bauk, Branka (2020). Safety profile of a multi-antigenic DNA vaccine against hepatitis C virus. Vaccines, 8 (1) 53, 1-15. doi: 10.3390/vaccines8010053

Safety profile of a multi-antigenic DNA vaccine against hepatitis C virus