Professor Fiona Simpson
Professor

Fiona Simpson

Email: 
Phone: 
+61 7 344 36930

Background

PLEASE NOTE THAT ANY AUTHORSHIP ALTERATIONS LISTING ME AS SIMPSON-FRASER BELOW ARE INCORRECT. ALL PUBLICATIONS ARE FIONA SIMPSON. MY PROFESSIONAL NAME IS FIONA SIMPSON.

https://www.abc.net.au/radionational/programs/ockhamsrazor/the-tricky-business-of-cancer-research/9498246

Our laboratory is involved in cross-discipline research studying endocytosis, cancer, pharmacology and immunology to improve therapies used in cancer treatment.

Availability

Professor Fiona Simpson is:
Available for supervision
Media expert

Fields of research

Biological Sciences Clinical sciences Genetics

Qualifications

  • Doctor of Philosophy, University of Cambridge
  • Bachelor (Honours) of Biochemistry, University of Edinburgh

Research interests

  • Changing the timing of anti-tumour therapy

    We are interested in slowing down or speeding up the delivery of drugs into tumour cells to maximise their anti-tumour activity and improve outcomes for cancer patients while reducing side-effects.

Search Professor Fiona Simpson’s works on UQ eSpace

84 works between 1993 and 2024
All (84) Journal Article (65) Book Chapter (2) Conference Publication (17)

61 - 80 of 84 works

2007

Journal Article

Murine embryonic expression of the gene for the UV-responsive protein p15(PAF)

Lammerts van Bueren, Kelly, Bennetts, Jennifer S., Fowles, Lindsay F., Berkman, Jennifer L., Simpson, Fiona and Wicking, Carol (2007). Murine embryonic expression of the gene for the UV-responsive protein p15(PAF). Gene Expression Patterns, 7 (1-2), 47-50. doi: 10.1016/j.modgep.2006.05.006

Murine embryonic expression of the gene for the UV-responsive protein p15(PAF)

2007

Conference Publication

A novel RhoA inhibitor implicated in lip and palate formation

Town, L. J., Simpson, F., McGlinn, E. C., Butterfield, N., Richman, J. M. and Wicking, C. (2007). A novel RhoA inhibitor implicated in lip and palate formation. Society for Developmental Biology 66th Annual Meeting, Gran Meliá Hotel, Cancún, México, 16th – 20th June, 2007. Oxford: Elsevier Inc.. doi: 10.1016/j.ydbio.2007.03.512

A novel RhoA inhibitor implicated in lip and palate formation

2006

Journal Article

Visualisation of macropinosome maturation by the recruitment of sorting nexins

Kerr, Markus C., Lindsay, Margaret R., Luetterforst, Robert, Hamilton, Nicholas, Simpson, Fiona, Parton, Robert G., Gleeson, Paul A. and Teasdale, Rohan D. (2006). Visualisation of macropinosome maturation by the recruitment of sorting nexins. Journal Of Cell Science, 119 (19), 3967-3980. doi: 10.1242/jcs.03167

Visualisation of macropinosome maturation by the recruitment of sorting nexins

2006

Journal Article

Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP)

Bennetts, Jennifer S., Fowles, Lindsay F., Berkman, Jennifer L., Lammerts van Bueren, Kelly, Richman, Joy M., Simpson, Fiona and Wicking, Carol (2006). Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP). Gene, 374 (1-2), 153-165. doi: 10.1016/j.gene.2006.01.027

Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP)

2006

Journal Article

A rapidly evolving secretome builds and patterns a sea shell

Jackson, Daniel J., McDougall, Carmel, Green, Kathryn, Simpson, Fiona, Worheide, Gert and Degnan, Bernard M. (2006). A rapidly evolving secretome builds and patterns a sea shell. BMC Biology, 4 (40) 40, 40-49. doi: 10.1186/1741-7007-4-40

A rapidly evolving secretome builds and patterns a sea shell

2006

Journal Article

The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b

Simpson, Fiona, Lammerts van Bueren, Kelly L., Butterfield, Natalie, Bennetts, Jennifer S., Bowles, Josephine, Adolphe, Christelle, Simms, Lisa A., Young, Joanne, Walsh, Michael D., Leggett, Barbara, Fowles, Lindsay F. and Wicking, Carol (2006). The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. Experimental Cell Research, 312 (1), 73-85. doi: 10.1016/j.yexcr.2005.09.020

The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b

2006

Journal Article

Identification and analysis of novel genes expressed in the mouse embryonic facial primordia

Bennetts, Jennifer S., Fowles, Lindsay F., Butterfield, Natalie C., Berkman, Jennifer L., Teasdale, Rohan D., Simpson, Fiona and Wicking, Carol (2006). Identification and analysis of novel genes expressed in the mouse embryonic facial primordia. Frontiers In Bioscience, 11 (SUPPL. 2), 2631-2646. doi: 10.2741/1997

Identification and analysis of novel genes expressed in the mouse embryonic facial primordia

2005

Journal Article

A Novel Mammalian Retromer Component, Vps26B

Kerr, Markus C., Bennetts, Jennifer S., Simpson, Fiona, Thomas, Elaine C., Flegg, Cameron, Gleeson, Paul A., Wicking, Carol and Teasdale, Rohan D. (2005). A Novel Mammalian Retromer Component, Vps26B. Traffic, 6 (11), 991-1001. doi: 10.1111/j.1600-0854.2005.00328.x

A Novel Mammalian Retromer Component, Vps26B

2005

Conference Publication

The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumour suppressor product p33ING1

Simpson, F., van Bueren, Lammerts K., Fowles, L., Berkman, J., Butterfield, N., Bowles, J., Adolphe, C., Simms, L., Young, J., Walsh, M. and Wicking, C. (2005). The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumour suppressor product p33ING1. Unknown, Unknown, Unknown. Amsterdam, Netherlands: Elsevier Science.

The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumour suppressor product p33ING1

2005

Conference Publication

Analysis of the subcellular role of a gene isolated from the craniofacial region of the mouse

Butterfield, N. C., Simpson, F., Bennetts, J. S., Fowles, L. F. and Wicking, C. A. (2005). Analysis of the subcellular role of a gene isolated from the craniofacial region of the mouse. Unknown, Unknown, Unknown. Amsterdam, Netherlands: Elsevier Science.

Analysis of the subcellular role of a gene isolated from the craniofacial region of the mouse

2005

Conference Publication

A novel Gli3-regulated gene implicated in lip and palate formation

Town, L., McGlinn, E., Simpson, F., Richman, J. and Wicking, C. (2005). A novel Gli3-regulated gene implicated in lip and palate formation. AMSTERDAM: ELSEVIER SCIENCE BV.

A novel Gli3-regulated gene implicated in lip and palate formation

2005

Journal Article

A novel hook-related protein family and the characterization of Hook-related protein 1

Simpson, Fiona, Martin, Sally, Evans, Timothy M., Kerr, Markus, James, David E., Parton, Robert G., Teasdale, Rohan D. and Wicking, Carol (2005). A novel hook-related protein family and the characterization of Hook-related protein 1. Traffic, 6 (6), 442-458. doi: 10.1111/j.1600-0854.2005.00289.x

A novel hook-related protein family and the characterization of Hook-related protein 1

2005

Book Chapter

Characterization of Rab23, a negative regulator of sonic hedgehog signaling

Evans, Timothy M., Simpson, Fiona, Parton, Robert G. and Wicking, Carol (2005). Characterization of Rab23, a negative regulator of sonic hedgehog signaling. GTPases regulating membrane targeting and fusion. (pp. 759-777) edited by William E. Balch, Channing J. Der and Alan Hall. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/S0076-6879(05)03066-1

Characterization of Rab23, a negative regulator of sonic hedgehog signaling

2005

Conference Publication

Identification and characterisation of novel genes with developmental significance

Bennetts, J., Fowles, L., Butterfield, N., van Bueren, Lammerts K., Berkman, J., Simpson, F. and Wicking, C. (2005). Identification and characterisation of novel genes with developmental significance. Unknown, Unknown, Unknown. Shannon, Co. Clare, Ireland: Elsevier Ireland.

Identification and characterisation of novel genes with developmental significance

2005

Journal Article

Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking

Larance, Mark, Ramm, Georg, Stockli, Jacqueline, van Dam, Ellen M., Winata, Stephanie, Wasinger, Valerie, Simpson, Fiona, Graham, Michael, Junutula, Jagath R., Guilhaus, Michael and James, David E. (2005). Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking. Journal Of Biological Chemistry, 280 (45), 37803-37813. doi: 10.1074/jbc.M503897200

Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking

2004

Journal Article

Insulin and Oleate Promote Translocation of Inosine-5' Monophosphate Dehydrogenase to Lipid Bodies

Whitehead, Jonathan P., Simpson, Fiona, Hill, Michelle M., Thomas, Elaine C., Connolly, Lisa M., Collart, Frank, Simpson, Richard J. and James, David E. (2004). Insulin and Oleate Promote Translocation of Inosine-5' Monophosphate Dehydrogenase to Lipid Bodies. Traffic, 5 (10), 739-749. doi: 10.1111/j.1600-0854.2004.00217.x

Insulin and Oleate Promote Translocation of Inosine-5' Monophosphate Dehydrogenase to Lipid Bodies

2001

Journal Article

GLUT4 - At the cross roads between membrane trafficking and signal transduction

Simpson, Fiona, Whitehead, Jonathan P. and James, David E. (2001). GLUT4 - At the cross roads between membrane trafficking and signal transduction. Traffic, 2 (1), 2-11. doi: 10.1034/j.1600-0854.2001.020102.x

GLUT4 - At the cross roads between membrane trafficking and signal transduction

1999

Journal Article

Casein kinase II activity is required for transferrin receptor endocytosis

Cotlin, LF, Siddiqui, MA, Simpson, F and Collawn, JF (1999). Casein kinase II activity is required for transferrin receptor endocytosis. Journal of Biological Chemistry, 274 (43), 30550-30556. doi: 10.1074/jbc.274.43.30550

Casein kinase II activity is required for transferrin receptor endocytosis

1999

Journal Article

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

Simpson, F., Hussain, N. K., Qualmann, B., Kelly, R. B., Kay, B. K., McPherson, P. S. and Schmid, S. L. (1999). SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation. Nature Cell Biology, 1 (2), 119-124.

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

1999

Journal Article

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

Simpson, F., Hussain, N. K., Qualmann, B., Kelly, R. B., Kay, B. K., McPherson, P. S. and Schmid, S. L. (1999). SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation. Nature Cell Biology, 1 (2), 119-24. doi: 10.1038/10091

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

Current funding

  • 2024 - 2025
    Efficacy and safety of cetuximab and prochlorperazine combined for solid organ transplant patients with advanced Cutaneous Squamous Cell Carcinoma: CetPro study
    Metro South Hospital and Health Service
    Open grant
  • 2024 - 2029
    Building mRNA Cancer Vaccines for Australia.
    MRFF - National Critical Infrastructure Initiative
    Open grant
  • 2024 - 2028
    Traffic calming: Clinically applicable ways of altering endocytosis (cell uptake) to improve drug pharmacology and efficacy.
    NHMRC Investigator Grants
    Open grant
  • 2023 - 2026
    Personalising Innate-immunotherapy for Superior Treatment Outcomes with Large anticancer applicability (PISTOL)
    NHMRC MRFF EMCR - Early to Mid-Career Researchers
    Open grant
  • 2023 - 2025
    Cold atmospheric Plasma in the treatment and sensitisation of Radiation Therapy in extensive skin field cancerisation - PlasmaRT study
    Metro South Health Research Support Scheme Early Career Researcher Grant
    Open grant
  • 2019 - 2025
    Improving immune memory responses to monoclonal antibody therapies.
    Merchant Charitable Foundation
    Open grant
  • 2019 - 2029
    Donation to support the research of Fiona Simpson
    PA Research Foundation
    Open grant

Past funding

  • 2022 - 2023
    Laser capture microdissection to empower cancer discoveries, improve diagnosis, treatment and outcomes in amyloidosis patients
    IPF Healthy - Medical Research
    Open grant
  • 2021 - 2024
    The Ins and Outs of Endocytosis inhibition: Providing diverse opportunities for treatment of incurable cancers
    NHMRC IDEAS Grants
    Open grant
  • 2020
    Increasing the number of breast cancer therapeutic antibody possibilities, patient choices and success rates.
    PA Research Foundation
    Open grant
  • 2019 - 2021
    Towards effective treatment of cutaneous SCC of the head and neck with perineural invasion.
    PA Research Foundation
    Open grant
  • 2019 - 2022
    Dynamin modulators for reversing immunotherapy resistance in head and neck cancer (NHMRC Project Grants led by The University of Newcastle)
    University of Newcastle
    Open grant
  • 2018 - 2019
    Pre-clinical testing for combination therapy
    PA Research Foundation
    Open grant
  • 2018 - 2020
    Increasing the number of breast cancer therapeutic antibody possibilities, patient choices and success
    PA Research Foundation
    Open grant
  • 2017 - 2018
    Adjuvant therapy for checkpoint inhibitor efficacy in murine oncology models
    UniQuest Pty Ltd
    Open grant
  • 2017 - 2022
    CESTEM-1 research support
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2016 - 2017
    Cell biological mechanism of reversing resistance to cancer therapeutic antibodies
    Research Donation Generic
    Open grant
  • 2016
    Molecular mechanisms of perineural invasion in cutaneous squamous cell carcinoma of the head and neck
    PA Research Foundation
    Open grant
  • 2015 - 2016
    Making Herceptin-resistant tumours Herceptin responsive: adapting new therapeutic potential from Head and Neck Cancer research to improve breast cancer outcomes
    National Breast Cancer Foundation
    Open grant
  • 2015
    Next-generation cell analysis: Automated high-throughput 3D microscope and multimode microplate reader
    NHMRC Equipment Grant
    Open grant
  • 2013 - 2015
    The role of epidermal growth factor receptor trafficking in tumor progression and patient therapy resistance
    Cancer Council Queensland
    Open grant
  • 2011 - 2013
    ResTeach 2011 0.1 FTE School of Chemistry and Molecular Biosciences
    UQ ResTeach
    Open grant
  • 2010 - 2011
    Growth factor signalling in health and squamous cell carcinoma.
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2007 - 2012
    NHMRC Career Development Award: Endosomal tubule formation in health and disease
    NHMRC Career Development Award
    Open grant
  • 2005 - 2007
    The making of a sea shell: function and evolution of genes encoding calcareous architectures of phenomenal strength purity and beauty
    ARC Discovery Projects
    Open grant
  • 2003
    Building Bridges at the Nexus of Cell and Developmental Biology
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2001 - 2002
    Development of an in vitro assay for GLUT4 trafficking to the cell surface
    Pfizer Pty Ltd
    Open grant
  • 2000 - 2002
    Postdoctoral Research Fellowship: the molecular mechanism of GLUT4 translocation in response to insulin receptor activation
    Juvenile Diabetes Research Foundation - International
    Open grant

Availability

Professor Fiona Simpson is:
Available for supervision

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Available projects

Supervision history

Current supervision

Completed supervision

Enquiries

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