Overview
Background
I completed my PhD at the Institute for Molecular Biology at UQ and have ~10 years experience in biochemistry and cell biology. I am currently a Post-doctoral Research Fellow in the lab of A Prof Fiona Simpson at UQ Frazer Institute, TRI. My current research interests are focussed on intracellular protein trafficking, in particular how this relates to monoclonal antibody therapies and biomarkers for cancer treatment with overall aspirations to improve patient outcomes. I lead Simpson lab teams involved in translating this work into clinical trials and analysing how drug pharmacokinetics can be improved.
Availability
- Dr Shannon Joseph is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Shannon Joseph’s works on UQ eSpace
2023
Journal Article
Endocytosis in cancer and cancer therapy
Banushi, Blerida, Joseph, Shannon R., Lum, Benedict, Lee, Jason J. and Simpson, Fiona (2023). Endocytosis in cancer and cancer therapy. Nature Reviews Cancer, 23 (7), 1-24. doi: 10.1038/s41568-023-00574-6
2022
Journal Article
Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages
Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166
2021
Journal Article
Germline ERBB3 mutation in familial non-small cell lung carcinoma: expanding ErbB’s role in oncogenesis
McInerney-Leo, Aideen M., Chew, Hui Yi, Inglis, Po-Ling, Leo, Paul J., Joseph, Shannon R., Cooper, Caroline L., Okano, Satomi, Hassall, Tim, Anderson, Lisa, Bowman, Rayleen V., Gattas, Michael, Harris, Jessica E., Marshall, Mhairi S., Shaw, Janet G., Wheeler, Lawrie, Yang, Ian A., Brown, Matthew A., Fong, Kwun M., Simpson, Fiona and Duncan, Emma L. (2021). Germline ERBB3 mutation in familial non-small cell lung carcinoma: expanding ErbB’s role in oncogenesis. Human Molecular Genetics, 30 (24), 2393-2401. doi: 10.1093/hmg/ddab172
2021
Journal Article
Epidermal growth factor receptor expression and resistance patterns to targeted therapy in non-small cell lung cancer: a review
Karlsen, Emma-Anne, Kahler, Sam, Tefay, Joan, Joseph, Shannon R. and Simpson, Fiona (2021). Epidermal growth factor receptor expression and resistance patterns to targeted therapy in non-small cell lung cancer: a review. Cells, 10 (5) 1206, 1206. doi: 10.3390/cells10051206
2020
Journal Article
Antibody/ligand-target receptor internalization assay protocol using fresh human or murine tumor ex vivo samples
Joseph, Shannon R., Lum, Benedict, Banushi, Blerida, Barry, Rachael, Panizza, Benedict, Walpole, Euan and Simpson, Fiona (2020). Antibody/ligand-target receptor internalization assay protocol using fresh human or murine tumor ex vivo samples. STAR Protocols, 1 (2) 100087, 100087. doi: 10.1016/j.xpro.2020.100087
2020
Journal Article
Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
Chew, Hui Yi, De Lima, Priscila O., Gonzalez Cruz, Jazmina L., Banushi, Blerida, Echejoh, Godwins, Hu, Lingbo, Joseph, Shannon R., Lum, Benedict, Rae, James, O'Donnell, Jake S., Merida de Long, Lilia, Okano, Satomi, King, Brigid, Barry, Rachael, Moi, Davide, Mazzieri, Roberta, Thomas, Ranjeny, Souza-Fonseca-Guimaraes, Fernando, Foote, Matthew, McCluskey, Adam, Robinson, Phillip J., Frazer, Ian H., Saunders, Nicholas A., Parton, Robert G., Dolcetti, Riccardo, Cuff, Katharine, Martin, Jennifer H., Panizza, Benedict, Walpole, Euan ... Simpson, Fiona (2020). Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. Cell, 180 (5), 895-914.e27. doi: 10.1016/j.cell.2020.02.019
2020
Journal Article
Epidermal Growth Factor Receptor’s Function in Cutaneous Squamous Cell Carcinoma and Its Role as a Therapeutic Target in the Age of Immunotherapies
de Lima, Priscila Oliveira, Joseph, Shannon, Panizza, Benedict and Simpson, Fiona (2020). Epidermal Growth Factor Receptor’s Function in Cutaneous Squamous Cell Carcinoma and Its Role as a Therapeutic Target in the Age of Immunotherapies. Current Treatment Options in Oncology, 21 (1) 9, 9. doi: 10.1007/s11864-019-0697-3
2018
Journal Article
An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes
Joseph, Shannon R., Gaffney, Daniel, Barry, Rachael, Hu, Lingbo, Banushi, Blerida, Wells, James W., Lambie, Duncan, Strutton, Geoff, Porceddu, Sandro V., Burmeister, Bryan, Leggatt, Graham R., Schaider, Helmut, Dolcetti, Riccardo, Frazer, Ian H., Saunders, Nicholas A., Foote, Matthew, Soyer, H. Peter and Simpson, Fiona (2018). An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes. Journal of Investigative Dermatology, 139 (1), 213-223. doi: 10.1016/j.jid.2018.06.190
2018
Journal Article
Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab
He, Xuzhi, Cruz, Jazmina L., Joseph, Shannon, Pett, Nicola, Chew, Hui Yi, Tuong, Zewen K., Okano, Satomi, Kelly, Gabrielle, Veitch, Margaret, Simpson, Fiona and Wells, James W. (2018). Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab. Oncotarget, 9 (15), 12250-12260. doi: 10.18632/oncotarget.24242
2015
Journal Article
Phenothiazine-derived antipsychotic drugs inhibit dynamin and vlathrin-mediated endocytosis
Daniel, James A., Chau, Ngoc, Abdel-Hamid, Mohammed K., Hu, Lingbo, von Kleist, Lisa, Whiting, Ainslie, Krishnan, Sai, Maamary, Peter, Joseph, Shannon R., Simpson, Fiona, Haucke, Volker, McCluskey, Adam and Robinson, Philip J. (2015). Phenothiazine-derived antipsychotic drugs inhibit dynamin and vlathrin-mediated endocytosis. Traffic, 16 (6), 635-654. doi: 10.1111/tra.12272
2015
Book Chapter
Dysregulation of epidermal growth factor receptor in actinic keratosis and squamous cell carcinoma
Joseph, Shannon R., Endo-Munoz, Liliana, Gaffney, Daniel C., Saunders, Nicholas A. and Simpson, Fiona (2015). Dysregulation of epidermal growth factor receptor in actinic keratosis and squamous cell carcinoma. Actinic keratosis. (pp. 20-27) edited by H. Peter Soyer, Tarl W. Prow and Gregor B.E. Jemec. Basel, Switzerland: S Karger AG. doi: 10.1159/000367959
2011
Journal Article
KIAA0101 (KIAA0101)
Joseph, Shannon, Hu, Lingbo and Simpson, Fiona (2011). KIAA0101 (KIAA0101). Atlas of Genetics and Cytogenetics in Oncology and Haematology
2008
Journal Article
Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis
Desclozeaux, Marion, Venturato, Juliana, Wylie, Fiona G., Kay, Jason G., Joseph, Shannon R., Le, Huong T. and Stow, Jennifer L. (2008). Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis. Americal Journal of Physiology: Cell Physiology, 295 (2), C545-C556. doi: 10.1152/ajpcell.00097.2008
2007
Journal Article
EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin
Bryant, D. M., Kerr, M. C., Hammond, L. A., Joseph, S. R., Mostov, K. E., Teasdale, R. D. and Stow, J. L. (2007). EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. Journal of Cell Science, 120 (10), 1818-1828. doi: 10.1242/jcs.000653
2007
Other Outputs
The exocytic and endocytic trafficking of E-cadherin in epithelial cells
Joseph, Shannon Rose (2007). The exocytic and endocytic trafficking of E-cadherin in epithelial cells. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/158535
2004
Conference Publication
Endocytosis of E-cadherin in polarized epithelia - Joint regulation of growth factor receptor internalisation and signaling
Stow, J, Bryant, D and Joseph, S (2004). Endocytosis of E-cadherin in polarized epithelia - Joint regulation of growth factor receptor internalisation and signaling. Experimental Biology 2004 Meeting, Washington Dc, Apr 17-21, 2004. BETHESDA: FEDERATION AMER SOC EXP BIOL.
2003
Journal Article
The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion
Pagan, J. K., Wylie, F. G., Joseph, S. R., Widberg, C., Bryant, N. J., James, D. E. and Stow, J. L. (2003). The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion. Current Biology, 13 (2), 156-160. doi: 10.1016/S0960-9822(03)00006-X
2003
Journal Article
Contextual binding of p120ctn to E-cadherin at the basolateral plasma membrane in polarized epithelia
Miranda, K. C., Joseph, S. R., Yap, A. S., Teasdale, R. D. and Stow, J. L. (2003). Contextual binding of p120ctn to E-cadherin at the basolateral plasma membrane in polarized epithelia. Journal of Biological Chemistry, 278 (44), 43480-43488. doi: 10.1074/jbc.M305525200
2002
Conference Publication
p120ctn binds to the cadherin/catenin complex only after delivery to the basolateral plasma membrane in MDCK cells
Joseph, SR, Miranda, KC and Stow, JL (2002). p120ctn binds to the cadherin/catenin complex only after delivery to the basolateral plasma membrane in MDCK cells. 42nd Annual Meeting of the American-Society-for-Cell-Biology, San Francisco California, Dec 14-18, 2002. BETHESDA: AMER SOC CELL BIOLOGY.
2002
Journal Article
Protein kinase C regulates endocytosis and recycling of E-cadherin
Le, T. L., Joseph, S. R., Yap, A. S. and Stow, J. L. (2002). Protein kinase C regulates endocytosis and recycling of E-cadherin. American Journal of Physiology-cell Physiology, 283 (2), C489-C499. doi: 10.1152/ajpcell.00566.2001
Supervision
Availability
- Dr Shannon Joseph is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Drug target stability and drug metabolism by tumour cells in vivo
Associate Advisor
Other advisors: Dr Janin Chandra, Associate Professor Fiona Simpson
-
Doctor Philosophy
The Ins and Outs of Endocytosis inhibition: Providing diverse opportunities for treatment of incurable cancers
Associate Advisor
Other advisors: Professor Gabrielle Belz, Associate Professor Fiona Simpson
-
Doctor Philosophy
Regulating immune system activity in oncology and auto-immune diseases.
Associate Advisor
Other advisors: Associate Professor Fiona Simpson
-
Doctor Philosophy
Novel Biomarkers and Therapy Approaches in Breast Cancer
Associate Advisor
Other advisors: Professor Chris Pyke, Associate Professor Fiona Simpson
Completed supervision
-
2019
Doctor Philosophy
EGFR and Treg targeted therapies for cutaneous squamous cell carcinoma
Associate Advisor
Other advisors: Associate Professor Fiona Simpson, Dr Jazmina Gonzalez Cruz, Associate Professor James Wells
Media
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