Dr Stefan Emming
Dr

Stefan Emming

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Background

Stefan has a long-standing interest in trying to understand cellular processes at a detailed molecular level. He did his Master in Biochemistry in a Structural Biology lab, investigating the structure and function of the intracellular innate immune sensors AIM2 and STING. Following a short period at the Biozentrum in Basel (Switzerland), Stefan joined the Molecular Immunology lab of S. Monticelli at the Institute for Research in Biomedicine (Bellinzona, Switzerland) to conduct a PhD. After a deep dive into transcriptional and post-transcriptional regulation of gene expression in T cells during his PhD, Stefan joined the Inflammasome Lab in 2019 as a Postdoctoral Research Officer and was awarded an ARC DECRA fellowship starting in 2022. His research is focused on the multi-step mechanism of inflammasome activation and its regulation on a molecular level

Availability

Dr Stefan Emming is:
Available for supervision

Qualifications

  • Doctor of Philosophy, University of Bern

Search Professor Stefan Emming’s works on UQ eSpace

15 works between 2015 and 2024
All (15) Journal Article (14) Book Chapter (1)

1 - 15 of 15 works

2024

Journal Article

The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis

Holley, Caroline L., Emming, Stefan, Monteleone, Mercedes M., Mellacheruvu, Manasa, Kenney, Kirsten M., Lawrence, Grace M.E.P., Coombs, Jared R., Burgener, Sabrina S. and Schroder, Kate (2024). The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis. Cell Chemical Biology, 31 (5), 962-972.e4. doi: 10.1016/j.chembiol.2024.04.012

The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis

2024

Journal Article

NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome

Coombs, Jared R., Zamoshnikova, Alina, Holley, Caroline L., Maddugoda, Madhavi P., Teo, Daniel Eng Thiam, Chauvin, Camille, Poulin, Lionel F, Vitak, Nazarii, Ross, Connie M., Mellacheruvu, Manasa, Coll, Rebecca C., Heinz, Leonhard X., Burgener, Sabrina S., Emming, Stefan, Chamaillard, Mathias, Boucher, Dave and Schroder, Kate (2024). NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome. Science Signaling, 17 (820) abg8145, eabg8145. doi: 10.1126/scisignal.abg8145

NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome

2023

Journal Article

Oxidized thioredoxin 1 places a leash on <scp>NLRP1</scp> inflammasome activity

Yap, Jeremy KY, Emming, Stefan and Schroder, Kate (2023). Oxidized thioredoxin 1 places a leash on NLRP1 inflammasome activity. Immunology & Cell Biology, 102 (1), 5-7. doi: 10.1111/imcb.12710

Oxidized thioredoxin 1 places a leash on <scp>NLRP1</scp> inflammasome activity

2023

Journal Article

Reversing the mitochondrial hex that bewitches NLRP3

Mellacheruvu, Manasa, Lawrence, Grace M. E. P., Emming, Stefan and Schroder, Kate (2023). Reversing the mitochondrial hex that bewitches NLRP3. Science Immunology, 8 (84) eadh2967, 1-4. doi: 10.1126/sciimmunol.adh2967

Reversing the mitochondrial hex that bewitches NLRP3

2023

Journal Article

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

Labzin, Larisa I., Chew, Keng Yih, Eschke, Kathrin, Wang, Xiaohui, Esposito, Tyron, Stocks, Claudia J., Rae, James, Patrick, Ralph, Mostafavi, Helen, Hill, Brittany, Yordanov, Teodor E., Holley, Caroline L., Emming, Stefan, Fritzlar, Svenja, Mordant, Francesca L., Steinfort, Daniel P., Subbarao, Kanta, Nefzger, Christian M., Lagendijk, Anne K., Gordon, Emma J., Parton, Robert G., Short, Kirsty R., Londrigan, Sarah L. and Schroder, Kate (2023). Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling, 16 (782) eabq1366, eabq1366. doi: 10.1126/scisignal.abq1366

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

2023

Book Chapter

Quantifying Cell Death Induced by the NLRC4 Inflammasome

Emming, Stefan, Monteleone, Mercedes M., Kambara, Hiroto, Starchenko, Alina, Alley, Jennifer, Nolan, Michael A., Li, Wei, Kilty, Iain and Schroder, Kate (2023). Quantifying Cell Death Induced by the NLRC4 Inflammasome. NLR Proteins: Methods and Protocols. (pp. 199-210) New York, NY United States: Humana Press. doi: 10.1007/978-1-0716-3350-2_13

Quantifying Cell Death Induced by the NLRC4 Inflammasome

2021

Journal Article

Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R

De Simone, Marco, Chirichella, Michele, Emming, Stefan, Mazzara, Saveria, Ranzani, Valeria, Gruarin, Paola, Moschetti, Giorgia, Pulvirenti, Nadia, Maglie, Stefano, Vasco, Chiara, Crosti, Maria Cristina, Rossetti, Grazisa, Pagani, Massimiliano, Abrignani, Sergio, Monticelli, Silvia and Geginat, Jens (2021). Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R. European Journal of Immunology, 51 (12), 3243-3246. doi: 10.1002/eji.202149315

Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R

2020

Journal Article

Vitamin D and IFN-β modulate the inflammatory gene expression program of primary human T lymphocytes

Bianchi, Niccolò, Emming, Stefan, Zecca, Chiara and Monticelli, Silvia (2020). Vitamin D and IFN-β modulate the inflammatory gene expression program of primary human T lymphocytes. Frontiers in Immunology, 11 566781. doi: 10.3389/fimmu.2020.566781

Vitamin D and IFN-β modulate the inflammatory gene expression program of primary human T lymphocytes

2020

Journal Article

A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes

Emming, Stefan, Bianchi, Niccolò, Polletti, Sara, Balestrieri, Chiara, Leoni, Cristina, Montagner, Sara, Chirichella, Michele, Delaleu, Nicolas, Natoli, Gioacchino and Monticelli, Silvia (2020). A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes. Nature Immunology, 21 (4), 388-399. doi: 10.1038/s41590-020-0622-8

A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes

2020

Journal Article

Rebound of disease activity after fingolimod withdrawal: immunological and gene expression profiling

Sacco, Rosaria, Emming, Stefan, Gobbi, Claudio, Zecca, Chiara and Monticelli, Silvia (2020). Rebound of disease activity after fingolimod withdrawal: immunological and gene expression profiling. Multiple Sclerosis and Related Disorders, 40 101927, 101927. doi: 10.1016/j.msard.2020.101927

Rebound of disease activity after fingolimod withdrawal: immunological and gene expression profiling

2019

Journal Article

Tiered DNA sensors for escalating responses

Emming, Stefan and Schroder, Kate (2019). Tiered DNA sensors for escalating responses. Science, 365 (6460), 1375-1376. doi: 10.1126/science.aay2701

Tiered DNA sensors for escalating responses

2018

Journal Article

MicroRNAs as modulators of T cell functions in cancer

Emming, Stefan, Chirichella, Michele and Monticelli, Silvia (2018). MicroRNAs as modulators of T cell functions in cancer. Cancer Letters, 430, 172-178. doi: 10.1016/j.canlet.2018.05.019

MicroRNAs as modulators of T cell functions in cancer

2017

Journal Article

Erratum: TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities (Cell Reports (2016) 15 (7)(1566#x2013;1579) (S2211124716304715) (10.1016/j.celrep.2016.04.044))

Montagner, Sara, Leoni, Cristina, Emming, Stefan, Della Chiara, Giulia, Balestrieri, Chiara, Barozzi, Iros, Piccolo, Viviana, Togher, Susan, Ko, Myunggon, Rao, Anjana, Natoli, Gioacchino and Monticelli, Silvia (2017). Erratum: TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities (Cell Reports (2016) 15 (7)(1566#x2013;1579) (S2211124716304715) (10.1016/j.celrep.2016.04.044)). Cell Reports, 20 (7). doi: 10.1016/j.celrep.2017.08.011

Erratum: TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities (Cell Reports (2016) 15 (7)(1566#x2013;1579) (S2211124716304715) (10.1016/j.celrep.2016.04.044))

2016

Journal Article

TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities

Montagner, Sara, Leoni, Cristina, Emming, Stefan, Della Chiara, Giulia, Balestrieri, Chiara, Barozzi, Iros, Piccolo, Viviana, Togher, Susan, Ko, Myunggon, Rao, Anjana, Natoli, Gioacchino and Monticelli, Silvia (2016). TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities. Cell Reports, 15 (7), 1566-1579. doi: 10.1016/j.celrep.2016.04.044

TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities

2015

Journal Article

Epigenetics of T lymphocytes in health and disease

Leoni, Cristina, Vincenzetti, Lucia, Emming, Stefan and Monticelli, Silvia (2015). Epigenetics of T lymphocytes in health and disease. Swiss Medical Weekly, 145 w14191. doi: 10.4414/smw.2015.14191

Epigenetics of T lymphocytes in health and disease

Current funding

  • 2022 - 2024
    Elucidating ATPase function during NLRP3 inflammasome assembly
    ARC Discovery Early Career Researcher Award
    Open grant

Availability

Dr Stefan Emming is:
Available for supervision

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Supervision history

Current supervision

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