
Overview
Background
Jacob is an Honorary Research Fellow within the School of Biomedical Sciences at The University of Queensland and is looking to recruit prospective honours and RHD students interested in studying the neurophysiology of human movement. Potential students can send him an email (j.thorstensen@uq.edu.au) to chat about projects on offer, or to suggest an idea for a project.
Jacob’s PhD was in human neurophysiology (Griffith University, Australia), where he studied how endogenously released neuromodulators (e.g., monoamines such as serotonin and dopamine) control the excitability of cortico-motoneuronal pathways and muscle activation in healthy human subjects. Jacob also has postdoctoral training in clinical neuroscience (The University of Queensland, Australia), where he further developed his expertise in neuromodulation by investigating the use of non-invasive neurostimulation techniques (e.g., repetitive transcranial magnetic stimulation, rTMS) as a clinical intervention after nervous system injury.
Overall, Jacob’s research involves direct electrophysiological data collection from awake human participants, and his work spans across basic and clinical neurophysiology, neuropharmacology, and exercise science. He has a strong background in mechanistic human neurophysiology experiments, and extensive experience with non-invasive brain, spinal cord and peripheral nerve stimulation techniques that quantify or modulate the output of the human nervous system and muscles.
Availability
- Dr Jacob Thorstensen is:
- Available for supervision
- Media expert
Qualifications
- Bachelor of Exercise Science, Griffith University
- Bachelor (Honours), Griffith University
- Doctor of Philosophy of Neuroscience, Griffith University
Research interests
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Human Neurophysiology
-
Neuromodulation
-
Exercise Science
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Transcranial Magnetic Stimulation
Works
Search Professor Jacob Thorstensen’s works on UQ eSpace
2024
Journal Article
Are we underestimating the potential of neuroactive drugs to augment neuromotor function in sarcopenia?
Orssatto, Lucas B. R., Thorstensen, Jacob R., Scott, David and Daly, Robin M. (2024). Are we underestimating the potential of neuroactive drugs to augment neuromotor function in sarcopenia?. Metabolism, 154 155816, 1-4. doi: 10.1016/j.metabol.2024.155816
2024
Journal Article
Attention Please! Unravelling the link between brain network connectivity and cognitive attention following acquired brain injury: a systematic review of structural and functional measures
Stein, Athena, Thorstensen, Jacob R., Ho, Jonathan M., Ashley, Daniel P., Iyer, Kartik K. and Barlow, Karen M. (2024). Attention Please! Unravelling the link between brain network connectivity and cognitive attention following acquired brain injury: a systematic review of structural and functional measures. Brain Connectivity, 14 (1), 4-38. doi: 10.1089/brain.2023.0067
2024
Journal Article
Excitatory drive to spinal motoneurones is necessary for serotonin to modulate motoneurone excitability via 5-HT2 receptors in humans
Henderson, Tyler T., Taylor, Janet L., Thorstensen, Jacob R. and Kavanagh, Justin J. (2024). Excitatory drive to spinal motoneurones is necessary for serotonin to modulate motoneurone excitability via 5-HT2 receptors in humans. European Journal of Neuroscience, 59 (1), 17-35. doi: 10.1111/ejn.16190
2024
Journal Article
Serotonergic and noradrenergic contributions to motor cortical and spinal motoneuronal excitability in humans
Thorstensen, Jacob R., Henderson, Tyler T. and Kavanagh, Justin J. (2024). Serotonergic and noradrenergic contributions to motor cortical and spinal motoneuronal excitability in humans. Neuropharmacology, 242 109761. doi: 10.1016/j.neuropharm.2023.109761
2023
Journal Article
Muscle responses to motor cortical stimulation: Can we get more out of surface electromyography?
Thorstensen, Jacob R. (2023). Muscle responses to motor cortical stimulation: Can we get more out of surface electromyography?. The Journal of Physiology, 601 (14), 2763-2764. doi: 10.1113/jp284738
2022
Journal Article
Enhanced availability of serotonin limits muscle activation during high-intensity, but not low-intensity, fatiguing contractions
Henderson, Tyler T., Taylor, Janet L., Thorstensen, Jacob R., Tucker, Murray G. and Kavanagh, Justin J. (2022). Enhanced availability of serotonin limits muscle activation during high-intensity, but not low-intensity, fatiguing contractions. Journal of Neurophysiology, 128 (4), 751-762. doi: 10.1152/jn.00182.2022
2022
Journal Article
Persistent inward currents in spinal motoneurones: how can we study them in human participants?
Thorstensen, Jacob R. (2022). Persistent inward currents in spinal motoneurones: how can we study them in human participants?. The Journal of Physiology, 600 (13), 3021-3023. doi: 10.1113/jp283249
2022
Journal Article
5‐HT2 receptor antagonism reduces human motoneuron output to antidromic activation but not to stimulation of corticospinal axons
Thorstensen, Jacob R., Taylor, Janet L. and Kavanagh, Justin J. (2022). 5‐HT2 receptor antagonism reduces human motoneuron output to antidromic activation but not to stimulation of corticospinal axons. European Journal of Neuroscience, 56 (1), 3674-3686. doi: 10.1111/ejn.15672
2021
Journal Article
Physiological tremor is suppressed and force steadiness is enhanced with increased availability of serotonin regardless of muscle fatigue
Henderson, T. T., Thorstensen, J. R., Morrison, S., Tucker, M. G. and Kavanagh, J. J. (2021). Physiological tremor is suppressed and force steadiness is enhanced with increased availability of serotonin regardless of muscle fatigue. Journal of Neurophysiology, 127 (1), 27-37. doi: 10.1152/jn.00403.2021
2021
Journal Article
Human corticospinal-motoneuronal output is reduced with 5-HT<sub>2</sub> receptor antagonism
Thorstensen, Jacob R., Taylor, Janet L. and Kavanagh, Justin J. (2021). Human corticospinal-motoneuronal output is reduced with 5-HT2 receptor antagonism. Journal of Neurophysiology, 125 (4), 1279-1288. doi: 10.1152/jn.00698.2020
2020
Journal Article
Enhanced serotonin availability amplifies fatigue perception and modulates the TMS‐induced silent period during sustained low‐intensity elbow flexions
Thorstensen, Jacob R., Taylor, Janet L., Tucker, Murray G. and Kavanagh, Justin J. (2020). Enhanced serotonin availability amplifies fatigue perception and modulates the TMS‐induced silent period during sustained low‐intensity elbow flexions. The Journal of Physiology, 598 (13), 2685-2701. doi: 10.1113/jp279347
2018
Journal Article
Antagonism of the D2 dopamine receptor enhances tremor but reduces voluntary muscle activation in humans
Thorstensen, Jacob R., Tucker, Murray G. and Kavanagh, Justin J. (2018). Antagonism of the D2 dopamine receptor enhances tremor but reduces voluntary muscle activation in humans. Neuropharmacology, 141, 343-352. doi: 10.1016/j.neuropharm.2018.08.029
Supervision
Availability
- Dr Jacob Thorstensen is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Media
Enquiries
Contact Dr Jacob Thorstensen directly for media enquiries about:
- Brain stimulation
- Fatigue
- Motor control
- Motor cortex
- Motor neuron
- Muscle
- Neurology
- Neuromodulation
- Neuropharmacology
- Neurophysiology
- Neuroscience
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