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Dr Jacob Thorstensen
Dr

Jacob Thorstensen

Email: 

Overview

Background

Jacob is an Honorary Research Fellow within the School of Biomedical Sciences at The University of Queensland and is looking to recruit prospective honours and RHD students interested in studying the neurophysiology of human movement. Potential students can send him an email (j.thorstensen@uq.edu.au) to chat about projects on offer, or to suggest an idea for a project.

Jacob’s PhD was in human neurophysiology (Griffith University, Australia), where he studied how endogenously released neuromodulators (e.g., monoamines such as serotonin and dopamine) control the excitability of cortico-motoneuronal pathways and muscle activation in healthy human subjects. Jacob also has postdoctoral training in clinical neuroscience (The University of Queensland, Australia), where he further developed his expertise in neuromodulation by investigating the use of non-invasive neurostimulation techniques (e.g., repetitive transcranial magnetic stimulation, rTMS) as a clinical intervention after nervous system injury.

Overall, Jacob’s research involves direct electrophysiological data collection from awake human participants, and his work spans across basic and clinical neurophysiology, neuropharmacology, and exercise science. He has a strong background in mechanistic human neurophysiology experiments, and extensive experience with non-invasive brain, spinal cord and peripheral nerve stimulation techniques that quantify or modulate the output of the human nervous system and muscles.

Availability

Dr Jacob Thorstensen is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Exercise Science, Griffith University
  • Bachelor (Honours), Griffith University
  • Doctor of Philosophy of Neuroscience, Griffith University

Research interests

  • Human Neurophysiology

  • Neuromodulation

  • Exercise Science

  • Transcranial Magnetic Stimulation

Works

Search Professor Jacob Thorstensen’s works on UQ eSpace

12 works between 2018 and 2024

1 - 12 of 12 works

2024

Journal Article

Are we underestimating the potential of neuroactive drugs to augment neuromotor function in sarcopenia?

Orssatto, Lucas B. R., Thorstensen, Jacob R., Scott, David and Daly, Robin M. (2024). Are we underestimating the potential of neuroactive drugs to augment neuromotor function in sarcopenia?. Metabolism, 154 155816, 1-4. doi: 10.1016/j.metabol.2024.155816

Are we underestimating the potential of neuroactive drugs to augment neuromotor function in sarcopenia?

2024

Journal Article

Attention Please! Unravelling the link between brain network connectivity and cognitive attention following acquired brain injury: a systematic review of structural and functional measures

Stein, Athena, Thorstensen, Jacob R., Ho, Jonathan M., Ashley, Daniel P., Iyer, Kartik K. and Barlow, Karen M. (2024). Attention Please! Unravelling the link between brain network connectivity and cognitive attention following acquired brain injury: a systematic review of structural and functional measures. Brain Connectivity, 14 (1), 4-38. doi: 10.1089/brain.2023.0067

Attention Please! Unravelling the link between brain network connectivity and cognitive attention following acquired brain injury: a systematic review of structural and functional measures

2024

Journal Article

Excitatory drive to spinal motoneurones is necessary for serotonin to modulate motoneurone excitability via 5-HT2 receptors in humans

Henderson, Tyler T., Taylor, Janet L., Thorstensen, Jacob R. and Kavanagh, Justin J. (2024). Excitatory drive to spinal motoneurones is necessary for serotonin to modulate motoneurone excitability via 5-HT2 receptors in humans. European Journal of Neuroscience, 59 (1), 17-35. doi: 10.1111/ejn.16190

Excitatory drive to spinal motoneurones is necessary for serotonin to modulate motoneurone excitability via 5-HT2 receptors in humans

2024

Journal Article

Serotonergic and noradrenergic contributions to motor cortical and spinal motoneuronal excitability in humans

Thorstensen, Jacob R., Henderson, Tyler T. and Kavanagh, Justin J. (2024). Serotonergic and noradrenergic contributions to motor cortical and spinal motoneuronal excitability in humans. Neuropharmacology, 242 109761. doi: 10.1016/j.neuropharm.2023.109761

Serotonergic and noradrenergic contributions to motor cortical and spinal motoneuronal excitability in humans

2023

Journal Article

Muscle responses to motor cortical stimulation: Can we get more out of surface electromyography?

Thorstensen, Jacob R. (2023). Muscle responses to motor cortical stimulation: Can we get more out of surface electromyography?. The Journal of Physiology, 601 (14), 2763-2764. doi: 10.1113/jp284738

Muscle responses to motor cortical stimulation: Can we get more out of surface electromyography?

2022

Journal Article

Enhanced availability of serotonin limits muscle activation during high-intensity, but not low-intensity, fatiguing contractions

Henderson, Tyler T., Taylor, Janet L., Thorstensen, Jacob R., Tucker, Murray G. and Kavanagh, Justin J. (2022). Enhanced availability of serotonin limits muscle activation during high-intensity, but not low-intensity, fatiguing contractions. Journal of Neurophysiology, 128 (4), 751-762. doi: 10.1152/jn.00182.2022

Enhanced availability of serotonin limits muscle activation during high-intensity, but not low-intensity, fatiguing contractions

2022

Journal Article

Persistent inward currents in spinal motoneurones: how can we study them in human participants?

Thorstensen, Jacob R. (2022). Persistent inward currents in spinal motoneurones: how can we study them in human participants?. The Journal of Physiology, 600 (13), 3021-3023. doi: 10.1113/jp283249

Persistent inward currents in spinal motoneurones: how can we study them in human participants?

2022

Journal Article

5‐HT2 receptor antagonism reduces human motoneuron output to antidromic activation but not to stimulation of corticospinal axons

Thorstensen, Jacob R., Taylor, Janet L. and Kavanagh, Justin J. (2022). 5‐HT2 receptor antagonism reduces human motoneuron output to antidromic activation but not to stimulation of corticospinal axons. European Journal of Neuroscience, 56 (1), 3674-3686. doi: 10.1111/ejn.15672

5‐HT2 receptor antagonism reduces human motoneuron output to antidromic activation but not to stimulation of corticospinal axons

2021

Journal Article

Physiological tremor is suppressed and force steadiness is enhanced with increased availability of serotonin regardless of muscle fatigue

Henderson, T. T., Thorstensen, J. R., Morrison, S., Tucker, M. G. and Kavanagh, J. J. (2021). Physiological tremor is suppressed and force steadiness is enhanced with increased availability of serotonin regardless of muscle fatigue. Journal of Neurophysiology, 127 (1), 27-37. doi: 10.1152/jn.00403.2021

Physiological tremor is suppressed and force steadiness is enhanced with increased availability of serotonin regardless of muscle fatigue

2021

Journal Article

Human corticospinal-motoneuronal output is reduced with 5-HT<sub>2</sub> receptor antagonism

Thorstensen, Jacob R., Taylor, Janet L. and Kavanagh, Justin J. (2021). Human corticospinal-motoneuronal output is reduced with 5-HT2 receptor antagonism. Journal of Neurophysiology, 125 (4), 1279-1288. doi: 10.1152/jn.00698.2020

Human corticospinal-motoneuronal output is reduced with 5-HT<sub>2</sub> receptor antagonism

2020

Journal Article

Enhanced serotonin availability amplifies fatigue perception and modulates the TMS‐induced silent period during sustained low‐intensity elbow flexions

Thorstensen, Jacob R., Taylor, Janet L., Tucker, Murray G. and Kavanagh, Justin J. (2020). Enhanced serotonin availability amplifies fatigue perception and modulates the TMS‐induced silent period during sustained low‐intensity elbow flexions. The Journal of Physiology, 598 (13), 2685-2701. doi: 10.1113/jp279347

Enhanced serotonin availability amplifies fatigue perception and modulates the TMS‐induced silent period during sustained low‐intensity elbow flexions

2018

Journal Article

Antagonism of the D2 dopamine receptor enhances tremor but reduces voluntary muscle activation in humans

Thorstensen, Jacob R., Tucker, Murray G. and Kavanagh, Justin J. (2018). Antagonism of the D2 dopamine receptor enhances tremor but reduces voluntary muscle activation in humans. Neuropharmacology, 141, 343-352. doi: 10.1016/j.neuropharm.2018.08.029

Antagonism of the D2 dopamine receptor enhances tremor but reduces voluntary muscle activation in humans

Supervision

Availability

Dr Jacob Thorstensen is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Media

Enquiries

Contact Dr Jacob Thorstensen directly for media enquiries about:

  • Brain stimulation
  • Fatigue
  • Motor control
  • Motor cortex
  • Motor neuron
  • Muscle
  • Neurology
  • Neuromodulation
  • Neuropharmacology
  • Neurophysiology
  • Neuroscience

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au