Overview
Background
Jonathan Lee is a postdoctoral research fellow in the Molecular and Systems Medicine Group at the School of Biomedical Sciences and Queensland Brain Institute. His current work combines molecular biology, biochemistry and quantitative imaging techniques to unravel the nanoscale changes in the spatiotemporal organisation of key synaptic proteins implicated in neurodegenerative diseases.
Jonathan received his BSc (Hons) in Neuroscience from UQ in 2020 and began his research career as a neuroscience PhD student under the supervision of Dr Pranesh Padmanabhan and Prof. Jürgen Götz at the Queensland Brain Institute in 2021. In 2022, he was awarded the prestigious Prof. Bob Williamson PhD top-up scholarship funded by the Yulgilbar Foundation. During his PhD, he developed extensive expertise in super-resolution single-molecule microscopy and various other advanced microscopy techniques and analyses. He also developed a custom-built imaging platform to apply ultrasound to live cells within a high-resolution microscope. Using this platform, he identified a spatiotemporally interconnected sequence of biological responses underlying the different fates of sonoporated cells. His work has resulted in publications in top-ranking journals such as Journal of Controlled Release and Theranostics.
Availability
- Mr Jonathan Lee is:
- Available for supervision
Qualifications
- Bachelor of Biomedical Science, The University of Queensland
- Bachelor (Honours) of Neuroscience, The University of Queensland
Works
Search Professor Jonathan Lee’s works on UQ eSpace
Featured
2025
Journal Article
High-resolution imaging reveals a cascade of interconnected cellular bioeffects differentiating the long-term fates of sonoporated cells
Lee, Jonathan L. F., Song, Jae, Amor, Rumelo, Bolton, Jonathon, Thompson, Andrew, Götz, Jürgen and Padmanabhan, Pranesh (2025). High-resolution imaging reveals a cascade of interconnected cellular bioeffects differentiating the long-term fates of sonoporated cells. Journal of Controlled Release, 385 113974, 1-15. doi: 10.1016/j.jconrel.2025.113974
2025
Conference Publication
Live-cell single-molecule imaging of a new fluorescent C5a receptor antagonist reveals the heterogeneous spatiotemporal dynamics of C5aR1 at the plasma membrane
Sun, Jinda, Parker, Sandra, Lee, Jonathan, Gorman, Declan, Li, Xaria, Albornoz Balmaceda, Eduardo, Bellingham, Mark, Clark, Richard, Woodruff, Trent and Padmanabhan, Pranesh (2025). Live-cell single-molecule imaging of a new fluorescent C5a receptor antagonist reveals the heterogeneous spatiotemporal dynamics of C5aR1 at the plasma membrane. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.152969
2022
Journal Article
Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model
Chen, Liyu, Sutharsan, Ratneswary, Lee, Jonathan L. F., Cruz, Esteban, Asnicar, Blaise, Palliyaguru, Tishila, Wasielewska, Joanna M., Gaudin, Arnaud, Song, Jae, Leinenga, Gerhard and Götz, Jürgen (2022). Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics, 12 (5), 1952-1970. doi: 10.7150/thno.65539
Supervision
Availability
- Mr Jonathan Lee is:
- Available for supervision
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Media
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