Honorary Professor John Upham
Honorary Professor

John Upham

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Background

John Upham is a clinical scientist and physician with longstanding research interests in the immunological basis of asthma and chronic lung disease, the role of dendritic cells in allergy and virus infections of the lung, and the development of novel approaches to severe asthma treatment.

John is highly influential in his field, with > 195 publications, > 5,400 citations and an H index of 46. Since 2009, he has 112 publications (1st/senior author on 45%) with a Field-Weighted Citation Impact of 2.03. Moreover, 21.5% of publications are in the top 10% of most-cited publications worldwide (field-weighted). His publications have been cited in >20 different subject areas, demonstrating translation to fields other than Medicine. His research has international reach with citations in 80 countries (Scopus Dec 2018).

In the last 10 years, he has secured over $24 million in research funding. John has been awarded 8 NHMRC Project grants (4 as CIA in the last 5 years), 2 NHMRC CRE (“Closing the gap in Indigenous Lung Health” and “Severe Asthma”), and 1 NHMRC Development Grant. He currently holds NHMRC grants of $7.5 million, including $2.96 million as CIA. John was regularly an invited (9x), plenary (3x) and Chair (9x) at national and international conferences in the last 5 years. In recognition of his international standing and influence in the field, he was elected Fellow of the American Academy of Allergy, Asthma & Immunology (2004) and the Thoracic Society of Australia and New Zealand (2015).

Availability

Honorary Professor John Upham is:
Available for supervision
Media expert

Fields of research

Biomedical and Clinical Sciences Cardiovascular medicine and haematology Clinical sciences Immunology Respiratory diseases

Qualifications

  • Doctor of Philosophy, University of Western Australia

Research interests

  • Immune function and susceptibility to virus infections in asthma and COPD

  • Plasmacytoid dendritic cells

    Type I interferon production Immune regulation

  • Severe asthma: towards evidence-based assessment and management

  • Innate immunity and bacterial infections of the lungs

    Bronchiectasis and chronic suppurative lung disease in children Lung health in Indigenous children

  • Allergy and immune tolerance

Research impacts

John is currently the President (2021-22) of the Thoracic Society of Australia and Zealand and is a key member of the NHMRC funded Centre of Research Excellence (CRE) in Asthma Treatable Traits. He has played a leadership role in organising and co-chairing three recent national symposia on severe asthma to facilitate research collaboration, build research and clinical capacity, and improve models of care for severe asthma. He has been a member of multiple advisory boards to pharmaceutical companies, both international and national (AstraZeneca, GSK, Novartis, Nycomed, Boehringer-Ingelheim, Mundipharma, Menarini), and has provided advice to the Pharmaceutical Benefits Advisory Committee. His research has provided new treatment options for severe asthma, and guided the appropriate length of antibiotic treatment for Indigenous children with pneumonia, protracted bacterial bronchitis and bronchiectasis. John's research will inform best use of influenza vaccination in COPD, and guide the use of conjugate vaccines to improve immunity to Haemophilus in Indigenous children. He contributed to Clinical Practice Guidelines for the use of omalizumab and mepolizumab in Australia and he was part of the working group that prepared a web-based Severe Asthma Toolkit for the Severe Asthma CRE.

Search Professor John Upham’s works on UQ eSpace

381 works between 1983 and 2025
All (381) Journal Article (234) Book Chapter (5) Conference Publication (142)

161 - 180 of 381 works

2016

Conference Publication

CLINICAL EFFECTIVENESS OF OMALIZUMAB IN SEVERE ALLERGIC ASTHMA ABOVE THE STANDARD DOSING RANGE: THE AUSTRALIAN XOLAIR REGISTRY

Hew, M., Gillman, A., Sutherland, M., Wark, P., Bowden, J., Macdonald, , Guo, M., Reddel, H., Jenkins, C., Marks, G., Upham, J., Thien, F., Rimmer, J., Katsoulotos, G., Cook, M., Yang, , Katelaris, C., Bowler, S., Langton, D., Gibson, P., Robinson, P., Wright, C., Bint, M., Yozghatlian, V., Burgess, S., Sivakumaran, P., Jaffe, A., Yan, K. Y., Kritikos, V. ... Aminazad, A. (2016). CLINICAL EFFECTIVENESS OF OMALIZUMAB IN SEVERE ALLERGIC ASTHMA ABOVE THE STANDARD DOSING RANGE: THE AUSTRALIAN XOLAIR REGISTRY. HOBOKEN: WILEY-BLACKWELL.

CLINICAL EFFECTIVENESS OF OMALIZUMAB IN SEVERE ALLERGIC ASTHMA ABOVE THE STANDARD DOSING RANGE: THE AUSTRALIAN XOLAIR REGISTRY

2016

Conference Publication

Anti-Il-33 Partly Ameliorates a Rhinovirus-Induced Exacerbation of Asthma in Predisposed Mice

Werder, R., Zhang, V, Lynch, J., Spann, K., Upham, J. and Phipps, S. (2016). Anti-Il-33 Partly Ameliorates a Rhinovirus-Induced Exacerbation of Asthma in Predisposed Mice. HOBOKEN: WILEY-BLACKWELL.

Anti-Il-33 Partly Ameliorates a Rhinovirus-Induced Exacerbation of Asthma in Predisposed Mice

2016

Journal Article

Vitamin D in asthma: is the golden bullet losing its luster?

Upham, John W. and Sly, Peter D. (2016). Vitamin D in asthma: is the golden bullet losing its luster?. American Journal of Respiratory and Critical Care Medicine, 193 (6), 598-600. doi: 10.1164/rccm.201511-2213ED

Vitamin D in asthma: is the golden bullet losing its luster?

2016

Journal Article

Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma

Simpson, Jodie L., Daly, Joshua, Baines, Katherine J., Yang, Ian A., Upham, John W., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Hugenholtz, Philip, Willner, Dana and Gibson, Peter G. (2016). Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma. European Respiratory Journal, 47 (3), 792-800. doi: 10.1183/13993003.00405-2015

Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma

2016

Journal Article

Protracted bacterial bronchitis: the last decade and the road ahead

Chang, Anne B., Upham, John W., Masters, I. Brent, Redding, Gregory R., Gibson, Peter G., Marchant, Julie M. and Grimwood, Keith (2016). Protracted bacterial bronchitis: the last decade and the road ahead. Pediatric Pulmonology, 51 (3), 225-242. doi: 10.1002/ppul.23351

Protracted bacterial bronchitis: the last decade and the road ahead

2016

Journal Article

Reduced antiviral interferon production in poorly controlled asthma is associated with neutrophilic inflammation and high-dose inhaled corticosteroids

Simpson, Jodie L., Carroll, Melanie, Yang, Ian A., Reynolds, Paul N., Hodge, Sandra, James, Alan L., Gibson, Peter G. and Upham, John W. (2016). Reduced antiviral interferon production in poorly controlled asthma is associated with neutrophilic inflammation and high-dose inhaled corticosteroids. Chest, 149 (3), 704-713. doi: 10.1016/j.chest.2015.12.018

Reduced antiviral interferon production in poorly controlled asthma is associated with neutrophilic inflammation and high-dose inhaled corticosteroids

2016

Journal Article

Is alveolar macrophage phagocytic dysfunction in children with protracted bacterial bronchitis a forerunner to bronchiectasis?

Hodge, Sandra, Upham, John W., Pizzutto, Susan, Petsky, Helen L., Yerkovich, Stephanie, Baines, Katherine J., Gibson, Peter, Simpson, Jodie L., Buntain, Helen, Chen, Alice C. H., Hodge, Greg and Chang, Anne B. (2016). Is alveolar macrophage phagocytic dysfunction in children with protracted bacterial bronchitis a forerunner to bronchiectasis?. Chest, 149 (2), 508-515. doi: 10.1016/j.chest.2015.10.066

Is alveolar macrophage phagocytic dysfunction in children with protracted bacterial bronchitis a forerunner to bronchiectasis?

2016

Journal Article

Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis(Review)

Pizzutto, Susan J., Upham, John W., Yerkovich, Stephanie T. and Chang, Anne B. (2016). Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis(Review). Cochrane Database of Systematic Reviews, 2016 (1) CD007525. doi: 10.1002/14651858.CD007525.pub3

Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis(Review)

2016

Conference Publication

Prostaglandin D2 contributes to severity of pneumoviral bronchiolitis

Werder, R., Hodge, N., Lynch, J., Simpson, J., Zhang, V, Forbes-Blom, E., Upham, J., Spann, K., Everard, M. and Phipps, S. (2016). Prostaglandin D2 contributes to severity of pneumoviral bronchiolitis. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Perth, WA Australia, 1-6 April 2016. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.

Prostaglandin D2 contributes to severity of pneumoviral bronchiolitis

2016

Conference Publication

Alveolar macrophage in protracted bacterial bronchitis

Chen, Alice, Pena, Olga, Nel, Hanno, Pizzuto, Susan, Petsky, Helen, Gardiner, Samantha, Yerkovich, Stephanie, Baines, Katie, Gibson, Peter, Hodge, Greg, Hodge, Sandra, Buntain, Helen, Chang, Anne and Upham, John (2016). Alveolar macrophage in protracted bacterial bronchitis. ERS International Congress 2016, London, United Kingdom, 2016. Lausanne, Switzerland: European Respiratory Society. doi: 10.1183/13993003.congress-2016.PA3977

Alveolar macrophage in protracted bacterial bronchitis

2016

Journal Article

Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma

Hodge, S., Hodge, G., Simpson, J. L., Yang, I. A., Upham, J., James, A., Gibson, P. G. and Reynolds, P. N. (2016). Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma. Clinical and Experimental Allergy, 46 (1), 60-70. doi: 10.1111/cea.12634

Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma

2016

Conference Publication

Plasmacytoid Dendritic Cells Play a Critical Role in Regulating Rhinovirus Induced Gene Expression Pathways

Upham, J., Xi, Y., Pena, O. and Bosco, A. (2016). Plasmacytoid Dendritic Cells Play a Critical Role in Regulating Rhinovirus Induced Gene Expression Pathways. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Perth, WA Australia, 1-6 April 2016. HOBOKEN: European Respiratory Society. doi: 10.1183/13993003.congress-2016.pp236

Plasmacytoid Dendritic Cells Play a Critical Role in Regulating Rhinovirus Induced Gene Expression Pathways

2016

Conference Publication

Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening Type I and III interferon production

Werder, R. B., Lynch, J., Simpson, J., Loh, Z., Zhang, V., Spann, K., Sly, P., Mazzone, S., Upham, J. and Phipps, S. (2016). Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening Type I and III interferon production. 4th Annual Meeting of The International Cytokine and Interferon Society (ICIS), San Francisco, CA, United States, October 16 - 19 2016. London, United Kingdom: Academic Press.

Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening Type I and III interferon production

2016

Conference Publication

The Lung Microbiota In Stable Adult Asthma Differs According To Inflammatory Phenotype, Sex, And Atopy

Rogers, G. B., Leong, L. E., Gibson, P. G., Yang, I. A., Hodge, S. J., Reynolds, P. N., James, A. L., Upham, J. W., Jenkins, C., Peters, M., Baraket, M. and Simpsons, J. L. (2016). The Lung Microbiota In Stable Adult Asthma Differs According To Inflammatory Phenotype, Sex, And Atopy. International Conference of the American-Thoracic-Society (ATS), San Francisco, Ca, United States, May 13-18, 2016. NEW YORK: AMER THORACIC SOC.

The Lung Microbiota In Stable Adult Asthma Differs According To Inflammatory Phenotype, Sex, And Atopy

2016

Conference Publication

Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening type I and III interferon production

Werder, R., Lynch, J., Simpson, J., Loh, Z., Zhang, V., Spann, K., Sly, P., Mazzone, S., Upham, J. and Phipps, S. (2016). Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening type I and III interferon production. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200

Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening type I and III interferon production

2016

Conference Publication

Plasmacytoid Dendritic Cells Play A Critical Role In Regulating Gene Expression Patterns Induced By Human Rhinoviruses

Upham, J., Xi, C., Pena, O. and Bosco, A. (2016). Plasmacytoid Dendritic Cells Play A Critical Role In Regulating Gene Expression Patterns Induced By Human Rhinoviruses. International Conference of the American-Thoracic-Society (ATS), San Francisco Ca United States, 13-18 May 2016. New York, NY United States: American Thoracic Society.

Plasmacytoid Dendritic Cells Play A Critical Role In Regulating Gene Expression Patterns Induced By Human Rhinoviruses

2016

Conference Publication

Clinical Effectiveness Of Omalizumab In Severe Allergic Asthma Above The Recommended Dosing Range: The Australian Xolair Registry

Hew, M., Gillman, A., Sutherland, M., Wark, P., Bowden, J., McDonald, V., Guo, M., Reddel, H., Jenkins, C., Marks, G., Upham, J., Thien, F., Rimmer, J., Katsoulotos, G. P., Cook, M., Yang, I., Katelaris, C., Bowler, S., Langton, D., Gibson, P. G., Robinson, P. D., Wright, C., Bint, M., Yozghatlian, V., Burgess, S., Sivakumaran, P., Jaffe, A., Yan, K., Peters, M. ... Aminazad, A. (2016). Clinical Effectiveness Of Omalizumab In Severe Allergic Asthma Above The Recommended Dosing Range: The Australian Xolair Registry. International Conference of the American-Thoracic-Society (ATS), San Francisco Ca, May 13-18, 2016. NEW YORK: AMER THORACIC SOC.

Clinical Effectiveness Of Omalizumab In Severe Allergic Asthma Above The Recommended Dosing Range: The Australian Xolair Registry

2016

Conference Publication

Il-33 Augments Rhinovirus-Induced Type 2 Immune Responses in Subjects with Asthma, But Not in Healthy Individuals

Upham, J., Landgraf, M., Xi, Y. and Carroll, M. (2016). Il-33 Augments Rhinovirus-Induced Type 2 Immune Responses in Subjects with Asthma, But Not in Healthy Individuals. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Perth, WA Australia, 1-6 April 2016. HOBOKEN: WILEY-BLACKWELL.

Il-33 Augments Rhinovirus-Induced Type 2 Immune Responses in Subjects with Asthma, But Not in Healthy Individuals

2016

Conference Publication

Critical role of pDC in regulating gene expression and innate immune responses to human rhinovirus

Xi, Y., Bosco, A. and Upham, J. W. (2016). Critical role of pDC in regulating gene expression and innate immune responses to human rhinovirus. International Congress of Immunology (ICI), Melbourne Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Critical role of pDC in regulating gene expression and innate immune responses to human rhinovirus

2016

Conference Publication

Critical Role of pDC in regulating gene expression and innate immune responses to human rhinovirus

Xi, Yang , Anthony, Bosco and Upham, John (2016). Critical Role of pDC in regulating gene expression and innate immune responses to human rhinovirus. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016.

Critical Role of pDC in regulating gene expression and innate immune responses to human rhinovirus

Current funding

  • 2023 - 2028
    Minimising Oral Corticosteroid use in Asthma using Treatable Traits (2021 MRFF Chronic Respiratory Conditions grant Administering Institution University of Newcastle)
    University of Newcastle
    Open grant
  • 2020 - 2025
    Centre of Research Excellence in Asthma Treatable Traits (CREATT) (administered by University of Newcastle)
    University of Newcastle
    Open grant

Past funding

  • 2021 - 2024
    Diagnostic utility of tests of latent tuberculosis in immune compromised contacts exposed to multi-drug resistant tuberculosis (2021 Metro South SERTA Novice Researcher Grant administered by MSHHS)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2021
    Reducing acute severe respiratory events in health care workers during the Covid-19 pandemic with OM85
    NHMRC MRFF Coronavirus Research Response
    Open grant
  • 2018 - 2022
    Understanding how azithromycin prevents exacerbations in severe asthma
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Anti-viral immune dysfunction in severe asthma varies across inflammatory phenotypes
    NHMRC Project Grant
    Open grant
  • 2017 - 2020
    Multicentre randomised controlled trial on duration of antibiotics for children with chronic wet cough - (Children's Hospital Foundation grant administered by QUT)
    Queensland University of Technology
    Open grant
  • 2016
    Abberant immune responses to viruses in severe asthma: what role does IL-33 play? (Seed Grant awarded by NHMRC CCRE in Severe Asthma APP1078579 administered by the University of Newcastle)
    University of Newcastle
    Open grant
  • 2016 - 2022
    A multi-centre double-blind RCT on community-acquired pneumonia in Indigenous children and a developing country (NHMRC Project Grant administered by Menzies School of Health Research)
    Menzies School of Health Research
    Open grant
  • 2015 - 2019
    Improving asthma through lifestyle interventions: how much exercise is best?
    Asthma Australia Incorporated
    Open grant
  • 2015 - 2019
    Using influenza vaccination to understand and improve anti-viral immunity in COPD
    NHMRC Project Grant
    Open grant
  • 2014 - 2020
    National Clinical Centre of Research Excellence in Severe Asthma (NHMRC CRE administered by the University of Newcastle)
    University of Newcastle
    Open grant
  • 2013 - 2015
    Anti-viral immunity in asthma: a detailed assessment of TLR7 function and the regulation of interferon a/B synthesis
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Protracted bacterial bronchitis: long term outcomes, systemic and airway predictors of recurrence (NHMRC Project Grant administered by Menzies)
    The Menzies Foundation
    Open grant
  • 2012 - 2017
    Centre of Research Excellence in Lung Health of Aboriginal and Torres Strait Islander Children (NHMRC CRE administered by Menzies School of Health Research)
    Menzies School of Health Research
    Open grant
  • 2012 - 2015
    Defective toll-like receptor 7 signalling in plasmacytoid dendritic cells underlies the inception of virus-associated asthma
    NHMRC Project Grant
    Open grant
  • 2012
    Influenza vaccination and asthma
    Asthma Foundation of Queensland
    Open grant
  • 2012
    Microbial immunity in a large population of adult asthmatics with suboptimal disease control
    PA Research Foundation Private Practice Trust Fund Research Support Grants
    Open grant
  • 2012 - 2013
    The airway epithelium in paediatric respiratory diseases
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2011
    Allergic sensitization to grass pollens in patients with allergic rhinitis and asthma in subtropical regions of Australia (Year 2)
    Asthma Foundation of Queensland
    Open grant
  • 2011
    Understanding immune responses to influenza vaccination in people with asthma
    Asthma Foundation of Queensland
    Open grant
  • 2010 - 2011
    Development of the major Bahia grass pollen allergen, Pas n 1, as an immunodiagnostic test for subtropical grass pollen allergy
    UQ FirstLink Scheme
    Open grant
  • 2010 - 2012
    Protracted bacterial bronchitis in children: what is the natural history and role of innate immunity dysfunction?
    Financial Markets Foundation for Children
    Open grant
  • 2010
    Allergic sensitization to grass pollens in patients with allergic rhinitis and asthma in subtropical regions of Australia
    Asthma Foundation of Queensland
    Open grant
  • 2010
    Allergy to subtropical grass pollens in Australia: IgE cross-reactivity between subtropical and temperate grass pollens
    Open grant
  • 2009
    Antiviral innate immunity in asthma: why are some people with asthma susceptible to virus infections?
    Asthma Foundation of Queensland
    Open grant
  • 2009
    Prevention of allergic asthma through induction of tolerance in allergen-sensitised T cells
    Asthma Foundation of Queensland
    Open grant
  • 2009 - 2015
    The AMAZES Study: Asthma and Macrolides: the AZithromycin Efficacy and Safety study (NHMRC Project Grant administered by University of Newcastle)
    University of Newcastle
    Open grant
  • 2008 - 2010
    Anti-viral immunity in asthma and chronic obstructive pulmonary disease (COPD)
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2008
    Antiviral innate immunity in asthma: why are some people with asthma susceptible to virus infections?
    Asthma Foundation of Queensland
    Open grant
  • 2008 - 2012
    NHMRC Practitioner Fellowship
    NHMRC Practitioner Fellowship
    Open grant
  • 2008 - 2009
    Protracted bronchitis in children: what is the natural history and role of innate immunity dysfunction?
    Royal Children's Hospital Foundation
    Open grant
  • 2007
    NHMRC Practitioner Fellowship
    NHMRC Practitioner Fellowship
    Open grant
  • 2007 - 2011
    Developmental aspects of respiratory inflammation, allergy and asthma (UWA_lead institution)
    University of Western Australia
    Open grant

Availability

Honorary Professor John Upham is:
Available for supervision

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Available projects

  • Immune dysregulation in asthma and host defence against respiratory viruses

    Our program of translational research is focussed on the study of immune function and dysfunction in asthma, and host defence against respiratory viruses, especially human rhinoviruses. We are interested in the mechanisms leading to excessive airway inflammation in asthma, and why people with asthma are unusually susceptible to asthma attacks during respiratory viral infections. Our aim is to discover new therapeutic targets in severe asthma.

    Research Projects

    • The function of key immune cells such as antigen presenting cells and NK cells
    • The role of polarizing cytokines such as IL-33, IL-25 and TSLP in altering host defence against viruses.
    • How macrolide antibiotics alter immune function

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Honorary Professor John Upham directly for media enquiries about:

  • Allergies
  • Asthma
  • Chronic obstructive pulmonary disease
  • Dendritic cells
  • Immunity
  • Lung infections
  • Lungs - virus infections
  • Virus infections of the lung

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