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Emerita Professor Mary Fletcher
Emerita Professor

Mary Fletcher

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Overview

Background

Professor Mary Fletcher is a natural product organic chemist, and led the Natural Toxin group within the Centre for Animal Science, Queensland Alliance for Agricultural and Food Innovation (QAAFI) 2010-2024,before being appointed Emeritus Professor in 2024. She previously worked as a research chemist at both The University Queensland and Queensland Primary Industries (Biosecurity Queensland), before joining the Queensland Alliance for Agricultural and Food Innovation in 2010. Prof Fletcher's current interest focuses on bioactives that reduce enteric methane and the application of slow release delivery systems appropriate to rangeland grazing systems. Prof Fletcher has an industry recognised expertise as an applied organic chemist with a specialist interest in the identification and analysis of natural toxins and other bioactives in a range of plants, fungi and agricultural products. Such toxins and bioactives can affect both human and animal health posing risks to livestock production, food safety and market access.

Prof Fletcher is also an Affiliate Professor in the School of Chemistry and Molecular Biosciences (http://www.scmb.uq.edu.au/index.html), and an Affiliated Scientist at the Biosciences eastern & central Africa-International Livestock Research Institute (BecA-ILRI) Hub in Nairobi, Kenya (http://hub.africabiosciences.org/).

Prof Fletcher is a Fellow of the Royal Australian Chemical Institute and in 2016 was elected President of the Queensland Branch of the Royal Australian Chemical Institute (http://www.raci.org.au/branches/qld-branch).

Availability

Emerita Professor Mary Fletcher is:
Not available for supervision

Qualifications

  • Bachelor of Science, The University of Queensland
  • Bachelor (Honours) of Chemistry, The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Slow release inserts to deliver bioactive compounds that reduce enteric methane

    Methane emissions from the beef cattle sector accounts for ~7% of Australia’s greenhouse gas emissions. This collaborative UQ-DAF project brings together a team of interdisciplinary scientists and applies novel technologies to progress the industry goal of achieving a carbon neutral beef industry by 2030. The synthetic feed additive 3 nitrooxypropanol (3-NOP) has shown promise in enteric methane mitigation. This compound targets the nickel enzyme methyl-coenzyme M reductase (MCR) in rumen archea, thereby inhibiting the last step of CH4 formation by reversibly oxidizing the nickel cofactor from Ni(I) to Ni(II). Applications to date have necessitated daily dosing regimes relevant mostly for intensive cattle systems, and this project seeks to provide alternate delivery mechanisms to enable application in extensive systems. In extensive grazing systems, most supplements are normally delivered through licks, with little or no control of intake by individual animals. Many methane mitigating active-agents including 3-NOP are required to be delivered consistently to the rumen to be effective. This project seeks to deliver a novel rumen insert for controlled release of active-agents to provide a sustained slow-release dose. Such technology avoids any process issues associated with traditional bolus capsule systems, where the capsule itself presents problems at abattoir. It is envisaged that the novel insert by comparison would be completely biodegraded with no problematic remains at abattoir.

  • Beneficial Sugars in Stingless Bee Honey

    Stingless bees (Meliponini) occur in all tropical and sub-tropical regions, and honey from these native bees has a long history of traditional indigenous use with a range of purported therapeutic properties. Prof Fletcher's research has identified the unusual low GI disaccharide trehalulose as a predominant sugar and distinctive marker of stingless bee honey in five species across three continents Australia, Malaysia and Brazil. The presence of this beneficial sugar has added support to the health claims of these native Meliponini honeys and provided impetus to this emerging industry. This is the first report of this unusual disaccharide as a major component of honey, and indeed the first significant natural occurrence in any food. Prof Fletcher's research team has further demonstrated that this rare sugar is produced by the bees themselves via an enzymatic isomerisation of nectar sucrose - further evidence of the unique characteristics of these stingless bees and the honey they produce.

  • Natural Toxins

    Prof Fletcher's research interests also encompass the identification and analysis of natural toxins and bioactives in a range of plants, fungi and agricultural products. Such toxins have the potential to form residues in agricultural products and pose a risk to both livestock and human consumers. Toxins of particular interest include mycotoxins, pyrrolizidine alkaloids, indospicine and simplexin. Her natural toxin research focusses on minimising the impacts of plant toxins on Australian livestock production. Plant toxins can have wide ranging animal impacts, depending on their chemical structure and have the potential to contribute to ill thrift through specific toxicoses such as Pimelea poisoning and pyrrolizidine alkaloid associated liver disease, and reproductive losses through abortion and teratogenic effects, or calf losses associated with premature births, weak calves, or failure to suckle. Devising strategies to deal with diverse plant toxins is not easy, as the chemical action and target organ varies considerably, and the best line of action is prevention rather than remedial treatment. In pasture systems, it is difficult to prevent consumption of poisonous plants, other than by total removal from the pasture which is generally not possible. However, plant consumption does not necessarily equal uptake of the toxin, and the approach of the proposed research is to devise strategies to enable toxin breakdown within the rumen before absorption into the animals circulatory systems. Our research approach is to capitalise on natural rumen response by isolating microbes capable of degrading toxins (for use as preventative probiotics), and investigating toxin absorbents and/or biopolymers to foster toxin-degrading microbe populations. Initially this research will be applied to the Pimelea toxin, simplexin, which causes frequently fatal poisoning in cattle grazing inland pastures of Australia with productivity losses estimated to be up to $50 million in bad years. Further interests include the presence of pyrrolizidine alkaloids in Australian honey and identification of diverse floral sources of these alkaloids using LCMS technologies to confirm alkaloid profiles. A collaborative project with Queensland Health is also investigating authenticity, adulteration and providence of these honeys using stable isotope MS techniques.

Research impacts

Throughout her career Prof Fletcher has applied her chemical skills to address diverse problems that pose threats to agricultural industries, from the identification of fruit fly pheromones to the determination of plant toxins responsible for livestock deaths, to the identification of bone volatiles attractive to phosphorous deficient cattle and more recently the identification of unusual beneficial sugars in stingless bee honey and the application of slow release devices for the release of bioactives to control enteric methane production in rangeland cattle. Her work has particular application in the areas of food safety and food security, both in Australia and overseas, including projects addressing the impacts of carcinogenic mycotoxin contamination of staple foods in sub-saharan Africa.

Current research funded by Meat and Livestock Australia (MLA) aims to develop a rumen insert that is applicable in extensive production systems to reduce methane emissions from northern Australia beef herds and applies novel biopolmyer technologies to progress the industry goal of achieving a carbon neutral beef industry by 2030. This collaborative UQ-DAF project aims to produce a rumen insert that slowly releases active-agents (such as 3-NOP) into the rumen over an extended period of time. The use of a rumen insert will mean that each animal will receive the treatment and should establish a more consistent reduced methane emission, when compared to other methods.

Works

Search Professor Mary Fletcher’s works on UQ eSpace

281 works between 1983 and 2025

221 - 240 of 281 works

2010

Conference Publication

Hepatotoxicosis in dogs consuming indospicine-contaminated camel meat

Fletcher, M. T., Fitzgerald, L. M., Paul, A. E. H., Mansfield, C. S. and O'Hara, A. J. (2010). Hepatotoxicosis in dogs consuming indospicine-contaminated camel meat. Australian Association of Veterinary Diagnosticians Conference, Brisbane Qld., Australia, 25-26 November 2010.

Hepatotoxicosis in dogs consuming indospicine-contaminated camel meat

2010

Conference Publication

Hepatotoxicosis in dogs following consumption of indospicine contaminated camel meat

Fitzgerald, Louise, Fletcher, Mary, Paul, Amanda, Mansfield, Caroline and O'Hara, Amanda (2010). Hepatotoxicosis in dogs following consumption of indospicine contaminated camel meat. Annual Conference of the Australian Society for Veterinary Pathology, Freemantle, Western Australia, September 3 - 5 2010. Australia: Australian Society of Veterinary Pathology.

Hepatotoxicosis in dogs following consumption of indospicine contaminated camel meat

2009

Journal Article

Pimelotides A and B, diterpenoid ketal-lactone orthoesters with an unprecedented skeleton from Pimelea elongata

Hayes, Patricia Y., Chow, Sharon, Somerville, Michael J., De Voss, James J. and Fletcher, Mary T. (2009). Pimelotides A and B, diterpenoid ketal-lactone orthoesters with an unprecedented skeleton from Pimelea elongata. Journal of Natural Products, 72 (12), 2081-2083. doi: 10.1021/np900573k

Pimelotides A and B, diterpenoid ketal-lactone orthoesters with an unprecedented skeleton from Pimelea elongata

2009

Conference Publication

Risks from Plants containing Pyrrolizidine Alkaloids for Livestock and Meat Quality in Northern Australia.

Fletcher, M.T., McKenzie, R.A., Reichmann, K.G. and Blaney, B.J. (2009). Risks from Plants containing Pyrrolizidine Alkaloids for Livestock and Meat Quality in Northern Australia.. International Symposium on Poisonous Plants 8, Joao Pessoa, Brazil, 4-8 May 2009. WALLINGFORD: CABI PUBLISHING-C A B INT.

Risks from Plants containing Pyrrolizidine Alkaloids for Livestock and Meat Quality in Northern Australia.

2009

Book

Understanding Pimelea poisoning of cattle

Fletcher, Mary, Silcock, Richard, Ossedryver, Selina, Milson, Jenny and Chow, Sharon (2009). Understanding Pimelea poisoning of cattle. Brisbane, QLD, Australia: State of Queensland through the Department of Employment, Economic Development and Innovation.

Understanding Pimelea poisoning of cattle

2009

Journal Article

Pyrrolizidine alkaloids in Crotalaria taxa from Northern Australia: Risk to grazing livestock

Fletcher, Mary T., Mckenzie, Ross A., Blaney, Barry J. and Reichmann, Keith G. (2009). Pyrrolizidine alkaloids in Crotalaria taxa from Northern Australia: Risk to grazing livestock. Journal of Agricultural and Food Chemistry, 57 (1), 311-319. doi: 10.1021/jf8026099

Pyrrolizidine alkaloids in Crotalaria taxa from Northern Australia: Risk to grazing livestock

2009

Book

Microbital contaminants associated with sago processing and storage in Papua New Guinea

Warner, J., Greenhill, A. and Fletcher, M. (2009). Microbital contaminants associated with sago processing and storage in Papua New Guinea. Project ASEM/2001/016 Canberra, ACT, Australia: ACIAR.

Microbital contaminants associated with sago processing and storage in Papua New Guinea

2009

Conference Publication

LCMSMS Analysis of the Daphnane Orthoester Simplexin in Poisonous Pimelea Species of Australian Rangelands.

Fletcher, M.T., Chow, K.Y.S., Silcock, R.G. and Milson, J.A. (2009). LCMSMS Analysis of the Daphnane Orthoester Simplexin in Poisonous Pimelea Species of Australian Rangelands.. International Symposium on Poisonous Plants 8, Joao Pessoa, Brazil, 4-8 May 2009. WALLINGFORD: CABI PUBLISHING-C A B INT.

LCMSMS Analysis of the Daphnane Orthoester Simplexin in Poisonous Pimelea Species of Australian Rangelands.

2008

Journal Article

Diverse cuticular hydrocarbons from Australian canebeetles (Coleoptera: Scarabaeidae)

Fletcher, M.T., Allsopp, P.G., McGrath, M.J., Chow, S., Gallagher, O.P., Hull, C.D., Cribb, B.W., Moore, C.J. and Kitching, W. (2008). Diverse cuticular hydrocarbons from Australian canebeetles (Coleoptera: Scarabaeidae). Australian Journal of Entomology, 47 (2), 153-159. doi: 10.1111/j.1440-6055.2008.00643.x

Diverse cuticular hydrocarbons from Australian canebeetles (Coleoptera: Scarabaeidae)

2008

Conference Publication

Progress Towards Identification of Haemolytic Agents Responsible for Sago Haemolytic Disease in Papua New Guinea.

Pue, A., Fletcher, M., Greenhill, A, Warner, J., Ng, J., Blaney, B., Atagazli, L. and Gena, M. (2008). Progress Towards Identification of Haemolytic Agents Responsible for Sago Haemolytic Disease in Papua New Guinea.. 44th Papua New Guinea Medical Conference, Rabaul, Papua New Guinea, 1-5 September 2008.

Progress Towards Identification of Haemolytic Agents Responsible for Sago Haemolytic Disease in Papua New Guinea.

2008

Conference Publication

Pimelea Poisoning – Still a Confusing Story

Silcock, Richard , Chow, Ka Yin Sharon , Fletcher, Mary T. and Wingett, M. (2008). Pimelea Poisoning – Still a Confusing Story. The Australian and New Zealand Societies of Animal Production First Joint Conference: The 27th Biennial Conference of the Australian Society of Animal Production with The 68th Annual Conference of the New Zealand Society of Animal Production: "From Science to Application", The University of Queensland, Brisbane, Queensland, Australia, 2008. Australian Society of Animal Production.

Pimelea Poisoning – Still a Confusing Story

2006

Journal Article

A diverse suite of spiroacetals, including a novel branched representative, is released by female Bactrocera tryoni (Queensland fruit fly)

Booth, Yvonne K., Schwartz, Brett D., Fletcher, Mary T., Lambert, Lynette K., Kitching, William and De Voss, James J. (2006). A diverse suite of spiroacetals, including a novel branched representative, is released by female Bactrocera tryoni (Queensland fruit fly). Chemical Communications (38), 3975-3977. doi: 10.1039/b611953k

A diverse suite of spiroacetals, including a novel branched representative, is released by female Bactrocera tryoni (Queensland fruit fly)

2006

Conference Publication

Mycotoxicology of sago haemolytic disease in Papua New Guinea

Greenhill, Andrew, Blaney, Barry, Shipton, Warren, Pue, Aisak, Fletcher, Mary and Amoa, Betty (2006). Mycotoxicology of sago haemolytic disease in Papua New Guinea. Australia-Europe Symposium on Mycotoxins and Food Safety, Sydney, NSW, Australia, 15-17 February 2006.

Mycotoxicology of sago haemolytic disease in Papua New Guinea

2005

Journal Article

Novel cuticular hydrocarbons from the cane beetle Antitrogus parvulus - 4,6,8,10,16-penta- and 4,6,8,10,16,18-hexamethyldocosanes - Unprecedented anti-anti-anti-stereochemistry in the 4,6,8,10-methyltetrad

Chow, Sharon, Fletcher, Mary T., Lambert, Lynette K., Gallagher, Oliver P., Moore, Christopher J., Cribb, Bronwen W., Allsopp, Peter G. and Kitching, William (2005). Novel cuticular hydrocarbons from the cane beetle Antitrogus parvulus - 4,6,8,10,16-penta- and 4,6,8,10,16,18-hexamethyldocosanes - Unprecedented anti-anti-anti-stereochemistry in the 4,6,8,10-methyltetrad. Journal of Organic Chemistry, 70 (5), 1808-1827. doi: 10.1021/jo0481093

Novel cuticular hydrocarbons from the cane beetle Antitrogus parvulus - 4,6,8,10,16-penta- and 4,6,8,10,16,18-hexamethyldocosanes - Unprecedented anti-anti-anti-stereochemistry in the 4,6,8,10-methyltetrad

2005

Conference Publication

Spiroacetal biosynthesis in Bactrocera tryoni (Queensland fruit fly)

Booth, Y. K., Schwartz, B. D., Fletcher, M. T., Hayes, P. Y. N., Kitching, W. and De Voss, J. J. (2005). Spiroacetal biosynthesis in Bactrocera tryoni (Queensland fruit fly). 14th European Symposium in Organic Chemistry, Helsinki, 4-8 July, 2005.

Spiroacetal biosynthesis in Bactrocera tryoni (Queensland fruit fly)

2005

Conference Publication

Mycotoxicology of sago haemolytic disease in Papua New Guinea

Greenhill, Andrew, Blaney, Barry, Shipton, Warren, Pue, Aisak and Fletcher, Mary (2005). Mycotoxicology of sago haemolytic disease in Papua New Guinea. 20th Conference of Residue Chemists, Wellington, New Zealand, 4-7 October 2005.

Mycotoxicology of sago haemolytic disease in Papua New Guinea

2005

Conference Publication

Novel Cuticular Hydrocarbons from the Cane Beetle Antitrogus parvulus: 4,6,8,10,16-Penta ands 4,6,8,10,16,18-Hexamethyldocosanes.

Fletcher, Mary T., Chow, Sharon, Lambert, Lynette, Moore, Christopher J., Cribb, Bronwen, Allsopp, Peter G. and Kitching, William (2005). Novel Cuticular Hydrocarbons from the Cane Beetle Antitrogus parvulus: 4,6,8,10,16-Penta ands 4,6,8,10,16,18-Hexamethyldocosanes.. 5th Asia-Pacific Congress of Entomology, Jeju, Korea, 18-21 October 2005.

Novel Cuticular Hydrocarbons from the Cane Beetle Antitrogus parvulus: 4,6,8,10,16-Penta ands 4,6,8,10,16,18-Hexamethyldocosanes.

2005

Conference Publication

Assessing the risk of plant toxin residues in livestock grazed in northern Australia

Blaney, B.J., McKenzie, R.A., Fletcher,M., Reichmann, K. and Bricknell, L. (2005). Assessing the risk of plant toxin residues in livestock grazed in northern Australia. 20th Conference of Residue Chemists, Wellington New Zealand, 4-7 October 2005.

Assessing the risk of plant toxin residues in livestock grazed in northern Australia

2005

Journal Article

Spiroacetal biosynthesis: ()-1,7-dioxaspiro[5.5]undecane in Bactrocera cacuminata and Bactrocera oleae (olive fruit fly)

Schwartz, B. D., McErlean, C. S. P., Fletcher, M. T., Mazomenos, B. E., Konstantopoulou, M. A., Kitching, W. and De Voss, J. J. (2005). Spiroacetal biosynthesis: ()-1,7-dioxaspiro[5.5]undecane in Bactrocera cacuminata and Bactrocera oleae (olive fruit fly). Organic Letters, 7 (6), 1173-1176. doi: 10.1021/ol050143w

Spiroacetal biosynthesis: ()-1,7-dioxaspiro[5.5]undecane in Bactrocera cacuminata and Bactrocera oleae (olive fruit fly)

2004

Journal Article

A precision apparatus, with solid phase micro-extraction monitoring capability, for incorporation studies of gaseous precursors into insect-derived metabolites

Fletcher, Mary T., Wood, Barry J., Schwartz, Brett D., Rahm, Fredrik, Lambert, Lynette K., Brereton, Ian M., Moore, Christopher J., De Voss, James J. and Kitching, William (2004). A precision apparatus, with solid phase micro-extraction monitoring capability, for incorporation studies of gaseous precursors into insect-derived metabolites. Arkivoc, 2004 (x), 109-117. doi: 10.3998/ark.5550190.0005.a12

A precision apparatus, with solid phase micro-extraction monitoring capability, for incorporation studies of gaseous precursors into insect-derived metabolites

Funding

Current funding

  • 2023 - 2025
    Harnessing the synbio potential of Australia's stingless bees, the first step
    Sugar Research Australia Limited
    Open grant
  • 2022 - 2025
    Developing cutting-edge capability for atypical saccharides in emerging and novel foods
    Queensland Health Forensic and Scientific Services
    Open grant
  • 2022 - 2027
    EAP - Biopolymers to deliver bioactive compounds that reduce enteric methane
    Meat & Livestock Australia
    Open grant

Past funding

  • 2023 - 2024
    Indospicine from the Australian plant Indigofera spicata as potential anticancer agent
    Ukraine-Australia Research Fund
    Open grant
  • 2021
    Rapid and Non-destructive Identification of Mycotoxins in Animal Feed Ingredients
    Queensland Department of Agriculture and Fisheries
    Open grant
  • 2020 - 2021
    Authentication of Australian stingless bee honey - proof of concept study
    Queensland Health
    Open grant
  • 2020 - 2021
    Optimising bioactive content of Australian stingless bee honey
    Agrifutures Australia
    Open grant
  • 2018 - 2019
    Improving nitrogen usage efficiency to reduce the environmental impact of beef cattle
    UQ-FAPESP Strategic Research Fund SPRINT
    Open grant
  • 2018 - 2023
    Nitrogen recycling as determinant for feed efficiency of Bos indicus cattle
    Meat & Livestock Australia
    Open grant
  • 2018 - 2022
    Improving beef production through management of plant toxins
    Meat & Livestock Australia
    Open grant
  • 2017 - 2018
    Analysis of environmental contaminants in Australian/Queensland honey
    Queensland Health Forensic and Scientific Services
    Open grant
  • 2017 - 2018
    Pimelea toxicity - finding potential solutions for managing cattle poisoning
    Meat & Livestock Australia
    Open grant
  • 2016 - 2018
    The risk of pyrollizidine alkaloids in Queensland honey
    Queensland Health Forensic and Scientific Services
    Open grant
  • 2016 - 2017
    Bio-actives: Value-adding to industrial hemp production
    UQ Collaboration and Industry Engagement Fund - FirstLink
    Open grant
  • 2015 - 2017
    Indospicine - managing the risk of residues in Western Australia meat
    Western Australian Department of Primary Industries and Rural Development
    Open grant
  • 2014 - 2016
    Native plant extracts for extended shelf life in corn
    Rural Industries Research & Development Corporation
    Open grant
  • 2012 - 2017
    Improved management of cattle phosphorus status through applied physiology
    Meat & Livestock Australia
    Open grant
  • 2011 - 2015
    Capacity and Action for Aflatoxin Reduction in Eastern Africa
    CSIRO
    Open grant
  • 2003 - 2004
    Linking structure to activity: identification of fruit fly sex pheromones with potential for pest management
    UQ New Staff Research Start-Up Fund
    Open grant

Supervision

Availability

Emerita Professor Mary Fletcher is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

Media

Enquiries

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