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2023

Journal Article

REstrictive versus StandarD FlUid Management in Mechanically Ventilated ChildrEn Admitted to PICU: study protocol for a pilot randomised controlled trial (REDUCE-1)

Raman, Sainath, Rahiman, Sarfaraz, Kennedy, Melanie, Mattke, Adrian, Venugopal, Prem, McBride, Craig, Tu, Quyen, Zapf, Florian, Kuhlwein, Eva, Woodgate, Jemma, Singh, Puneet, Schlapbach, Luregn J. and Gibbons, Kristen S. (2023). REstrictive versus StandarD FlUid Management in Mechanically Ventilated ChildrEn Admitted to PICU: study protocol for a pilot randomised controlled trial (REDUCE-1). BMJ Open, 13 (11) e076460, 1-8. doi: 10.1136/bmjopen-2023-076460

REstrictive versus StandarD FlUid Management in Mechanically Ventilated ChildrEn Admitted to PICU: study protocol for a pilot randomised controlled trial (REDUCE-1)

2023

Journal Article

A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study

Jackson, Heather R., Zandstra, Judith, Menikou, Stephanie, Hamilton, Melissa Shea, McArdle, Andrew J., Fischer, Roman, Thorne, Adam M., Huang, Honglei, Tanck, Michael W., Jansen, Machiel H., De, Tisham, Agyeman, Philipp K A, Von Both, Ulrich, Carrol, Enitan D., Emonts, Marieke, Eleftheriou, Irini, Van der Flier, Michiel, Fink, Colin, Gloerich, Jolein, De Groot, Ronald, Moll, Henriette A., Pokorn, Marko, Pollard, Andrew J., Schlapbach, Luregn J. (PERFORM consortium), Tsolia, Maria N., Usuf, Effua, Wright, Victoria J., Yeung, Shunmay, Zavadska, Dace ... Kaforou, Myrsini (2023). A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study. The Lancet. Digital health, 5 (11), e774-e785. doi: 10.1016/S2589-7500(23)00149-8

A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study

2023

Journal Article

Clinical decision support tools for paediatric sepsis in resource-poor settings: an international qualitative study

Jimenez-Zambrano, Andrea, Ritger, Carly, Rebull, Margaret, Wiens, Matthew O., Kabajaasi, Olive, Jaramillo-Bustamante, Juan Camilo, Argent, Andrew C., Kissoon, Niranjan, Schlapbach, Luregn J., Sorce, Lauren R., Watson, R Scott, Dorsey Holliman, Brooke, Sanchez-Pinto, Lazaro N. and Bennett, Tellen D. (2023). Clinical decision support tools for paediatric sepsis in resource-poor settings: an international qualitative study. BMJ open, 13 (10) e074458, 1-9. doi: 10.1136/bmjopen-2023-074458

Clinical decision support tools for paediatric sepsis in resource-poor settings: an international qualitative study

2023

Journal Article

Diagnosis of childhood febrile illness using a multi-class blood RNA molecular signature

Habgood-Coote, Dominic, Wilson, Clare, Shimizu, Chisato, Barendregt, Anouk M., Philipsen, Ria, Galassini, Rachel, Calle, Irene Rivero, Workman, Lesley, Agyeman, Philipp K.A., Ferwerda, Gerben, Anderson, Suzanne T., van den Berg, J. Merlijn, Emonts, Marieke, Carrol, Enitan D., Fink, Colin G., de Groot, Ronald, Hibberd, Martin L., Kanegaye, John, Nicol, Mark P., Paulus, Stéphane, Pollard, Andrew J., Salas, Antonio, Secka, Fatou, Schlapbach, Luregn J., Tremoulet, Adriana H., Walther, Michael, Zenz, Werner, Van der Flier, Michiel, Zar, Heather J. ... Kaforou, Myrsini (2023). Diagnosis of childhood febrile illness using a multi-class blood RNA molecular signature. Med, 4 (9), 635-654.e5. doi: 10.1016/j.medj.2023.06.007

Diagnosis of childhood febrile illness using a multi-class blood RNA molecular signature

2023

Journal Article

Adaptive clinical trials in pediatric critical care: a systematic review

Gilholm, Patricia, Ergetu, Endrias, Gelbart, Ben, Raman, Sainath, Festa, Marino, Schlapbach, Luregn J., Long, Debbie, Gibbons, Kristen S. and on behalf of the Australian and New Zealand Intensive Care Society Paediatric Study Group (2023). Adaptive clinical trials in pediatric critical care: a systematic review. Pediatric Critical Care Medicine, 24 (9), 738-749. doi: 10.1097/pcc.0000000000003273

Adaptive clinical trials in pediatric critical care: a systematic review

2023

Journal Article

Relationship between molecular pathogen detection and clinical disease in febrile children across Europe: a multicentre, prospective observational study

Shah, Priyen, Voice, Marie, Calvo-Bado, Leonides, Rivero-Calle, Irene, Morris, Sophie, Nijman, Ruud, Broderick, Claire, De, Tisham, Eleftheriou, Irini, Galassini, Rachel, Khanijau, Aakash, Kolberg, Laura, Kolnik, Mojca, Rudzate, Aleksandra, Sagmeister, Manfred G., Schweintzger, Nina A., Secka, Fatou, Thakker, Clare, van der Velden, Fabian, Vermont, Clementien, Vincek, Katarina, Agyeman, Philipp K.A., Cunnington, Aubrey J., De Groot, Ronald, Emonts, Marieke, Fidler, Katy, Kuijpers, Taco W., Mommert-Tripon, Marine, Brengel-Pesce, Karen ... Geissler, J. (2023). Relationship between molecular pathogen detection and clinical disease in febrile children across Europe: a multicentre, prospective observational study. The Lancet Regional Health - Europe, 32 100682, 100682. doi: 10.1016/j.lanepe.2023.100682

Relationship between molecular pathogen detection and clinical disease in febrile children across Europe: a multicentre, prospective observational study

2023

Journal Article

Longitudinal cohort study investigating neurodevelopmental and socioemotional outcomes in school-entry aged children after open heart surgery in Australia and New Zealand: the NITRIC follow-up study protocol

Long, Debbie, Anderson, Vicki A., Crossley, Louise, Sood, Nikita Tuli, Charles, Karina R., MacDonald, Anna D., Bora, Samudragupta, Pestell, Carmela F., Murrell, Kathryn, Pride, Natalie A., Anderson, Peter J., Badawi, Nadia, Rose, Brian, Baillie, Heidi, Masterson, Kate, Chumbes Flores, Jenipher, Sherring, Claire, Raman, Sainath, Beca, John, Erickson, Simon, Festa, Marino, Anderson, Benjamin W., Venugopal, Prem, Yim, Deane, Andrews, David, Cheung, Michael, Brizard, Christian, Gentles, Thomas L., Iyengar, Ajay ... Gibbons, Kristen S. (2023). Longitudinal cohort study investigating neurodevelopmental and socioemotional outcomes in school-entry aged children after open heart surgery in Australia and New Zealand: the NITRIC follow-up study protocol. BMJ Open, 13 (8) e075429, e075429. doi: 10.1136/bmjopen-2023-075429

Longitudinal cohort study investigating neurodevelopmental and socioemotional outcomes in school-entry aged children after open heart surgery in Australia and New Zealand: the NITRIC follow-up study protocol

2023

Journal Article

External validation of a multivariable prediction model for identification of pneumonia and other serious bacterial infections in febrile immunocompromised children

Martin, Alexander James, van der Velden, Fabian Johannes Stanislaus, von Both, Ulrich, Tsolia, Maria N, Zenz, Werner, Sagmeister, Manfred, Vermont, Clementien, de Vries, Gabriella, Kolberg, Laura, Lim, Emma, Pokorn, Marko, Zavadska, Dace, Martinón-Torres, Federico, Rivero-Calle, Irene, Hagedoorn, Nienke N, Usuf, Effua, Schlapbach, Luregn, Kuijpers, Taco W, Pollard, Andrew J, Yeung, Shunmay, Fink, Colin, Voice, Marie, Carrol, Enitan, Agyeman, Philipp K A, Khanijau, Aakash, Paulus, Stephane, De, Tisham, Herberg, Jethro Adam, Levin, Michael ... Emonts, Marieke (2023). External validation of a multivariable prediction model for identification of pneumonia and other serious bacterial infections in febrile immunocompromised children. Archives of Disease in Childhood, 109 (1), 58-66. doi: 10.1136/archdischild-2023-325869

External validation of a multivariable prediction model for identification of pneumonia and other serious bacterial infections in febrile immunocompromised children

2023

Journal Article

Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens

Willems, Esther, Gloerich, Jolein, Suppers, Anouk, van der Flier, Michiel, van den Heuvel, Lambert P., van de Kar, Nicole, Philipsen, Ria H.L.A., van Dael, Maurice, Kaforou, Myrsini, Wright, Victoria J., Herberg, Jethro A., Torres, Federico Martinon, Levin, Michael, de Groot, Ronald, van Gool, Alain J., Lefeber, Dirk J., Wessels, Hans J.C.T., de Jonge, Marien I., Abdulla, Amina, Aebi, Christoph, van Aerde, Koen, Agbeko, Rachel, Agyeman, Philipp, D'alessandro, Umberto, Ali, Ladan, Alkema, Wynand, Allen, Karen, González, Fernando Álvez, Anderson, Suzanne ... on behalf of the PERFORM consortium (2023). Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens. iScience, 26 (8) 107257, 107257. doi: 10.1016/j.isci.2023.107257

Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens

2023

Journal Article

Haemodynamic support for paediatric septic shock: a global perspective

Ranjit, Suchitra, Kissoon, Niranjan, Argent, Andrew, Inwald, David, Ventura, Andréa Maria Cordeiro, Jaborinsky, Roberto, Sankar, Jhuma, de Souza, Daniela Carla, Natraj, Rajeswari, De Oliveira, Claudio Flauzino, Samransamruajkit, Rujipat, Jayashree, Muralidharan and Schlapbach, Luregn J. (2023). Haemodynamic support for paediatric septic shock: a global perspective. The Lancet Child and Adolescent Health, 7 (8), 588-598. doi: 10.1016/s2352-4642(23)00103-7

Haemodynamic support for paediatric septic shock: a global perspective

2023

Journal Article

Correction: ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children— a systematic review and meta-analysis

Brossier, David W., Tume, Lyvonne N., Briant, Anais R., Jotterand Chaparro, Corinne, Moullet, Clémence, Rooze, Shancy, Verbruggen, Sascha C. A. T., Marino, Luise V., Alsohime, Fahad, Beldjilali, Sophie, Chiusolo, Fabrizio, Costa, Leonardo, Didier, Capucine, Ilia, Stavroula, Joram, Nyandat L., Kneyber, Martin C. J., Kühlwein, Eva, Lopez, Jorge, López-Herce, Jesus, Mayberry, Huw F., Mehmeti, Fortesa, Mierzewska-Schmidt, Magdalena, Miñambres Rodríguez, Maria, Morice, Claire, Pappachan, John V., Porcheret, Florence, Reis Boto, Leonor, Schlapbach, Luregn J., Tekguc, Hakan ... the Metabolism Endocrinology and Nutrition section of the European Society of Pediatric and Neonatal Intensive Care (ESPNIC) (2023). Correction: ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children— a systematic review and meta-analysis. Intensive Care Medicine, 49 (9), 1151-1153. doi: 10.1007/s00134-023-07119-3

Correction: ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children— a systematic review and meta-analysis

2023

Journal Article

A qualitative investigation of paediatric intensive care staff attitudes towards the diagnosis of lower respiratory tract infection in the molecular diagnostics era

Clark, John A., Conway Morris, Andrew, Kanaris, Constantinos, Inwald, David, Butt, Warwick, Osowicki, Joshua, Schlapbach, Luregn J., Curran, Martin D., White, Deborah, Daubney, Esther, Agrawal, Shruti, Navapurkar, Vilas, Török, M. Estée, Baker, Stephen and Pathan, Nazima (2023). A qualitative investigation of paediatric intensive care staff attitudes towards the diagnosis of lower respiratory tract infection in the molecular diagnostics era. Intensive Care Medicine – Paediatric and Neonatal, 1 (1) 10, 1-12. doi: 10.1007/s44253-023-00008-z

A qualitative investigation of paediatric intensive care staff attitudes towards the diagnosis of lower respiratory tract infection in the molecular diagnostics era

2023

Journal Article

Machine learning to predict poor school performance in paediatric survivors of intensive care: a population-based cohort study

Gilholm, Patricia, Gibbons, Kristen, Brüningk, Sarah, Klatt, Juliane, Vaithianathan, Rhema, Long, Debbie, Millar, Johnny, Tomaszewski, Wojtek, Schlapbach, Luregn J., Ganeshalingam, Anusha, Sherring, Claire, Erickson, Simon, Barr, Samantha, Raman, Sainath, Long, Debbie, Schlapbach, Luregn, Gibbons, Kristen, George, Shane, Singh, Puneet, Smith, Vicky, Butt, Warwick, Delzoppo, Carmel, Millar, Johnny, Gelbart, Ben, Oberender, Felix, Ganu, Subodh, Letton, Georgia, Festa, Marino, Harper, Gail and the Australian and New Zealand Intensive Care Society (ANZICS) Centre for Outcomes & Resource Evaluation (CORE) and ANZICS Paediatric Study Group (ANZICS PSG) (2023). Machine learning to predict poor school performance in paediatric survivors of intensive care: a population-based cohort study. Intensive Care Medicine, 49 (7), 785-795. doi: 10.1007/s00134-023-07137-1

Machine learning to predict poor school performance in paediatric survivors of intensive care: a population-based cohort study

2023

Journal Article

Sensitivity of ICD coding for sepsis in children—a population-based study

Endrich, Olga, Triep, Karen, Schlapbach, Luregn J., Posfay-Barbe, Klara M., Heininger, Ulrich, Giannoni, Eric, Stocker, Martin, Niederer-Loher, Anita, Kahlert, Christian R., Natalucci, Giancarlo, Relly, Christa, Riedel, Thomas, Aebi, Christoph, Berger, Christoph, Agyeman, Philipp K. A., Bär, Walter, Bernhard-Stirnemann, Sara, Hasters, Paul, Konetzny, Gabriel, Leone, Antonio and on behalf of the Swiss Pediatric Sepsis Study (2023). Sensitivity of ICD coding for sepsis in children—a population-based study. Intensive Care Medicine – Paediatric and Neonatal, 1 (1) 5, 1-11. doi: 10.1007/s44253-023-00006-1

Sensitivity of ICD coding for sepsis in children—a population-based study

2023

Journal Article

Long‐term outcomes after paediatric sepsis (LOTUS)–A protocol for an Australian cohort study

Minogue, Jessicah, Schlapbach, Luregn J., Keogh, Samantha, Gibbons, Kristen and Long, Debbie (2023). Long‐term outcomes after paediatric sepsis (LOTUS)–A protocol for an Australian cohort study. Nursing in Critical Care, 29 (2), 438-443. doi: 10.1111/nicc.12938

Long‐term outcomes after paediatric sepsis (LOTUS)–A protocol for an Australian cohort study

2023

Journal Article

Diagnosis of Multisystem Inflammatory Syndrome in Children by a Whole-Blood Transcriptional Signature

Jackson, Heather R., Miglietta, Luca, Habgood-Coote, Dominic, D'Souza, Giselle, Shah, Priyen, Nichols, Samuel, Vito, Ortensia, Powell, Oliver, Davidson, Maisey Salina, Shimizu, Chisato, Agyeman, Philipp K. A., Beudeker, Coco R., Brengel-Pesce, Karen, Carrol, Enitan D., Carter, Michael J., De, Tisham, Eleftheriou, Irini, Emonts, Marieke, Epalza, Cristina, Georgiou, Pantelis, De Groot, Ronald, Fidler, Katy, Fink, Colin, van Keulen, Daniëlle, Kuijpers, Taco, Moll, Henriette, Papatheodorou, Irene, Paulus, Stephane, Pokorn, Marko ... EUCLIDS, PERFORM and DIAMONDS Consortia (2023). Diagnosis of Multisystem Inflammatory Syndrome in Children by a Whole-Blood Transcriptional Signature. Journal of the Pediatric Infectious Diseases Society, 12 (6), 322-331. doi: 10.1093/jpids/piad035

Diagnosis of Multisystem Inflammatory Syndrome in Children by a Whole-Blood Transcriptional Signature

2023

Journal Article

Genomic investigations of unexplained acute hepatitis in children

Morfopoulou, Sofia, Buddle, Sarah, Torres Montaguth, Oscar Enrique, Atkinson, Laura, Guerra-Assunção, José Afonso, Moradi Marjaneh, Mahdi, Zennezini Chiozzi, Riccardo, Storey, Nathaniel, Campos, Luis, Hutchinson, J. Ciaran, Counsell, John R., Pollara, Gabriele, Roy, Sunando, Venturini, Cristina, Antinao Diaz, Juan F., Siam, Ala’a, Tappouni, Luke J., Asgarian, Zeinab, Ng, Joanne, Hanlon, Killian S., Lennon, Alexander, McArdle, Andrew, Czap, Agata, Rosenheim, Joshua, Andrade, Catarina, Anderson, Glenn, Lee, Jack C. D., Williams, Rachel, Williams, Charlotte A. ... Breuer, Judith (2023). Genomic investigations of unexplained acute hepatitis in children. Nature, 617 (7961), 564-573. doi: 10.1038/s41586-023-06003-w

Genomic investigations of unexplained acute hepatitis in children

2023

Journal Article

Estimating antibiotic coverage from linked microbiological and clinical data from the Swiss Paediatric Sepsis Study to support empiric antibiotic regimen selection

Cook, Aislinn, Atkinson, Andrew, Kronenberg, Andreas, Agyeman, Philipp K. A., Schlapbach, Luregn J., Berger, Christoph, Bielicki, Julia Anna and Swiss Pediatric Sepsis Study Group (2023). Estimating antibiotic coverage from linked microbiological and clinical data from the Swiss Paediatric Sepsis Study to support empiric antibiotic regimen selection. Frontiers in Pediatrics, 11 1124165, 1-10. doi: 10.3389/fped.2023.1124165

Estimating antibiotic coverage from linked microbiological and clinical data from the Swiss Paediatric Sepsis Study to support empiric antibiotic regimen selection

2023

Journal Article

Long-term outcomes after paediatric sepsis: A narrative review

Minogue, Jessicah, Keogh, Samantha, Schlapbach, Luregn J. and Long, Debbie (2023). Long-term outcomes after paediatric sepsis: A narrative review. Australian Critical Care, 37 (3), 499-507. doi: 10.1016/j.aucc.2023.04.002

Long-term outcomes after paediatric sepsis: A narrative review

2023

Journal Article

Operationalizing appropriate sepsis definitions in children worldwide: considerations for the pediatric sepsis definition taskforce

Carrol, Enitan D., Ranjit, Suchitra, Menon, Kusum, Bennett, Tellen D., Sanchez-Pinto, L. Nelson, Zimmerman, Jerry J., Souza, Daniela C., Sorce, Lauren R., Randolph, Adrienne G., Ishimine, Paul, Flauzino de Oliveira, Claudio, Lodha, Rakesh, Harmon, Lori, Watson, R. Scott, Schlapbach, Luregn J., Kissoon, Niranjan, Argent, Andrew C. and on behalf of the Society of Critical Care Medicine’s Pediatric Sepsis Definition Taskforce (2023). Operationalizing appropriate sepsis definitions in children worldwide: considerations for the pediatric sepsis definition taskforce. Pediatric Critical Care Medicine, 24 (6), e263-e271. doi: 10.1097/pcc.0000000000003263

Operationalizing appropriate sepsis definitions in children worldwide: considerations for the pediatric sepsis definition taskforce