Overview
Background
Dr Loic Yengo is a Professor of Statistical Genomics at The University of Queensland (UQ) and Group Leader of the Statistical Genomics Laboratory within UQ’s Institute for Molecular Bioscience. He was awarded a prestigious Snow Medical Research Fellowship in 2024 to dramatically advance the use of genomics to prevent chronic disease such as type 2 diabetes, heart disease and Alzheimer’s, with a particular focus on increasing participation of people with diverse ancestries. After completing a PhD in applied mathematics and statistics at the University of Lille (France) in 2014, he joined UQ in 2016 for postdoctoral training in Quantitative and Statistical Genetics. Loic started his own lab in 2020 to investigate the causes and consequences of genetic variation within and between human populations. His group develops and applies novel statistical methods to analyse large volumes of genomic data. Loic’s research has contributed to improving understanding of the genetic and phenotypic consequences of non-random mating (inbreeding and assortative mating) in human populations and has led to identifying novel genetic variants associated with complex traits and diseases. Loic was named among the top 40 rising stars of research by The Australian newspaper in 2021 and received the UQ Foundation research excellence award the same year. Loic is the 2022 recipient of the Ruth Stephens Gani Medal of the Australian Academy of Science recognizing outstanding contributions to research in human genetics, and was named in Nature Medicine’s 2022 Yearbook among 11 early-career researchers “to watch”.
In 2024, he was the recipient of the American Society of Human Genetics Early Career Award and a Snow Medical Research Foundation Fellowship to accelerate the deployment of genomic risk prediction in the clinic and improve the benefit of genomic medicine in all populations.
Availability
- Professor Loic Yengo is:
- Not available for supervision
Qualifications
- Doctor of Philosophy, Université Lille 1 - Sciences et Technologies
Research impacts
The research in the Yengo Lab contributes to the discovery of genes and biological pathways involved in the etiology of multifactorial diseases such as obesity and type 2 diabetes. The ultimate goal of our research is to better understand what genes underlie inter-individual variation in disease susceptibility and help translate that knowledge into new and personalised therapies.
Works
Search Professor Loic Yengo’s works on UQ eSpace
2021
Journal Article
The trans-ancestral genomic architecture of glycemic traits
Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian'an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Chan, Kei Hang Katie, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng, Kaakinen, Marika A., Louie, Tin, März, Winfried, Moreno-Macias, Hortensia, Ndungu, Anne, Nelson, Sarah C. ... Barroso, Inês (2021). The trans-ancestral genomic architecture of glycemic traits. Nature genetics, 53 (6), 840-860. doi: 10.1038/s41588-021-00852-9
2021
Journal Article
Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals (vol 108, pg 786, 2021)
Hivert, Valentin, Sidorenko, Julia, Rohart, Florian, Goddard, Michael E., Yang, Jian, Wray, Naomi R., Yengo, Loic and Visscher, Peter M. (2021). Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals (vol 108, pg 786, 2021). American Journal of Human Genetics, 108 (5), 962-962. doi: 10.1016/j.ajhg.2021.04.012
2021
Journal Article
Erratum: Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: Association with more slow waves and daytime sleepiness (SLEEP DOI: 10.1093/sleep/zsaa137)
Muto, Vincenzo, Koshmanova, Ekaterina, Ghaemmaghami, Pouya, Jaspar, Mathieu, Meyer, Christelle, Elansary, Mahmoud, Van Egroo, Maxime, Chylinski, Daphne, Berthomier, Christian, Brandewinder, Marie, Mouraux, Charlotte, Schmidt, Christina, Hammad, Gregory, Coppieters, Wouter, Ahariz, Naima, Degueldre, Christian, Luxen, Andre, Salmon, Eric, Phillips, Christophe, Archer, Simon N, Yengo, Loic, Byrne, Enda, Collette, Fabienne, Georges, Michel, Dijk, Derk-Jan, Maquet, Pierre, Visscher, Peter M and Vandewalle, Gilles (2021). Erratum: Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: Association with more slow waves and daytime sleepiness (SLEEP DOI: 10.1093/sleep/zsaa137). Sleep, 44 (5) zsaa137. doi: 10.1093/sleep/zsab079
2021
Journal Article
Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals
Hivert, Valentin, Sidorenko, Julia, Rohart, Florian, Goddard, Michael E., Yang, Jian, Wray, Naomi R., Yengo, Loic and Visscher, Peter M. (2021). Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals. The American Journal of Human Genetics, 108 (5), 786-798. doi: 10.1016/j.ajhg.2021.02.014
2021
Journal Article
Quantifying genetic heterogeneity between continental populations for human height and body mass index
Guo, Jing, Bakshi, Andrew, Wang, Ying, Jiang, Longda, Yengo, Loic, Goddard, Michael E., Visscher, Peter M. and Yang, Jian (2021). Quantifying genetic heterogeneity between continental populations for human height and body mass index. Scientific Reports, 11 (1) 5240, 1-9. doi: 10.1038/s41598-021-84739-z
Featured
2021
Journal Article
Widespread signatures of natural selection across human complex traits and functional genomic categories
Zeng, Jian, Xue, Angli, Jiang, Longda, Lloyd-Jones, Luke R., Wu, Yang, Wang, Huanwei, Zheng, Zhili, Yengo, Loic, Kemper, Kathryn E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2021). Widespread signatures of natural selection across human complex traits and functional genomic categories. Nature Communications, 12 (1) 1164, 1-12. doi: 10.1038/s41467-021-21446-3
2021
Journal Article
Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals
Kemper, Kathryn E., Yengo, Loic, Zheng, Zhili, Abdellaoui, Abdel, Keller, Matthew C., Goddard, Michael E., Wray, Naomi R., Yang, Jian and Visscher, Peter M. (2021). Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals. Nature Communications, 12 (1) 1050, 1050. doi: 10.1038/s41467-021-21283-4
2021
Journal Article
Risk in relatives, heritability, SNP-based heritability and genetic correlations in psychiatric disorders: a review
Baselmans, Bart M.L., Yengo, Loic, van Rheenen, Wouter and Wray, Naomi R. (2021). Risk in relatives, heritability, SNP-based heritability and genetic correlations in psychiatric disorders: a review. Biological Psychiatry, 89 (1), 11-19. doi: 10.1016/j.biopsych.2020.05.034
2020
Journal Article
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
Vogelezang, Suzanne, Bradfield, Jonathan P., Ahluwalia, Tarunveer S., Curtin, John A., Lakka, Timo A., Grarup, Niels, Scholz, Markus, van der Most, Peter J., Monnereau, Claire, Stergiakouli, Evie, Heiskala, Anni, Horikoshi, Momoko, Fedko, Iryna O., Vilor-Tejedor, Natalia, Cousminer, Diana L., Standl, Marie, Wang, Carol A., Viikari, Jorma, Geller, Frank, Íñiguez, Carmen, Pitkänen, Niina, Chesi, Alessandra, Bacelis, Jonas, Yengo, Loic, Torrent, Maties, Ntalla, Ioanna, Helgeland, Øyvind, Selzam, Saskia, Vonk, Judith M. ... Felix, Janine F. (2020). Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genetics, 16 (10) e1008718, e1008718. doi: 10.1371/journal.pgen.1008718
2020
Journal Article
Pathogenic variants in actionable MODY genes are associated with type 2 diabetes
Bonnefond, Amélie, Boissel, Mathilde, Bolze, Alexandre, Durand, Emmanuelle, Toussaint, Bénédicte, Vaillant, Emmanuel, Gaget, Stefan, Graeve, Franck De, Dechaume, Aurélie, Allegaert, Frédéric, Guilcher, David Le, Yengo, Loïc, Dhennin, Véronique, Borys, Jean-Michel, Lu, James T., Cirulli, Elizabeth T., Elhanan, Gai, Roussel, Ronan, Balkau, Beverley, Marre, Michel, Franc, Sylvia, Charpentier, Guillaume, Vaxillaire, Martine, Canouil, Mickaël, Washington, Nicole L., Grzymski, Joseph J. and Froguel, Philippe (2020). Pathogenic variants in actionable MODY genes are associated with type 2 diabetes. Nature Metabolism, 2 (10), 1126-1134. doi: 10.1038/s42255-020-00294-3
2020
Journal Article
Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
Zhang, Qian, Sidorenko, Julia, Couvy-Duchesne, Baptiste, Marioni, Riccardo E., Wright, Margaret J., Goate, Alison M., Marcora, Edoardo, Huang, Kuan-lin, Porter, Tenielle, Laws, Simon M., Australian Imaging Biomarkers and Lifestyle (AIBL) Study, Sachdev, Perminder S., Mather, Karen A., Armstrong, Nicola J., Thalamuthu, Anbupalam, Brodaty, Henry, Yengo, Loic, Yang, Jian, Wray, Naomi R., McRae, Allan F. and Visscher, Peter M. (2020). Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture. Nature Communications, 11 (1) 4799, 1-11. doi: 10.1038/s41467-020-18534-1
2020
Journal Article
Using prior information from humans to prioritize genes and gene-associated variants for complex traits in livestock
Raymond, Biaty, Yengo, Loic, Costilla, Roy, Schrooten, Chris, Bouwman, Aniek C., Hayes, Ben J., Veerkamp, Roel F. and Visscher, Peter M. (2020). Using prior information from humans to prioritize genes and gene-associated variants for complex traits in livestock. PLoS Genetics , 16 (9) e1008780, 1-20. doi: 10.1371/journal.pgen.1008780
2020
Journal Article
Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
Wang, Ying, Guo, Jing, Ni, Guiyan, Yang, Jian, Visscher, Peter M. and Yengo, Loic (2020). Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations. Nature Communications, 11 (1) 3865, 3865. doi: 10.1038/s41467-020-17719-y
2020
Journal Article
A unified framework for association and prediction from vertex‐wise grey‐matter structure
Couvy‐Duchesne, Baptiste, Strike, Lachlan T., Zhang, Futao, Holtz, Yan, Zheng, Zhili, Kemper, Kathryn E., Yengo, Loic, Colliot, Olivier, Wright, Margaret J., Wray, Naomi R., Yang, Jian and Visscher, Peter M. (2020). A unified framework for association and prediction from vertex‐wise grey‐matter structure. Human Brain Mapping, 41 (14) hbm.25109, 4062-4076. doi: 10.1002/hbm.25109
2019
Journal Article
No evidence for social genetic effects or genetic similarity among friends beyond that due to population stratification: A reappraisal of Domingue et al (2018)
Yengo, Loic, Sidari, Morgan, Verweij, Karin J. H., Visscher, Peter M., Keller, Matthew C. and Zietsch, Brendan P. (2019). No evidence for social genetic effects or genetic similarity among friends beyond that due to population stratification: A reappraisal of Domingue et al (2018). Behavior Genetics, 50 (1), 67-71. doi: 10.1007/s10519-019-09979-2
Featured
2019
Journal Article
Improved polygenic prediction by Bayesian multiple regression on summary statistics
Lloyd-Jones, Luke R., Zeng, Jian, Sidorenko, Julia, Yengo, Loïc, Moser, Gerhard, Kemper, Kathryn E., Wang, Huanwei, Zheng, Zhili, Magi, Reedik, Esko, Tõnu, Metspalu, Andres, Wray, Naomi R., Goddard, Michael E., Yang, Jian and Visscher, Peter M. (2019). Improved polygenic prediction by Bayesian multiple regression on summary statistics. Nature Communications, 10 (1) 5086, 1-10. doi: 10.1038/s41467-019-12653-0
2019
Journal Article
Genetic correlates of social stratification in Great Britain
Abdellaoui, Abdel, Hugh-Jones, David, Yengo, Loic, Kemper, Kathryn E., Nivard, Michel G., Veul, Laura, Holtz, Yan, Zietsch, Brendan P., Frayling, Timothy M., Wray, Naomi R., Yang, Jian, Verweij, Karin J. H. and Visscher, Peter M. (2019). Genetic correlates of social stratification in Great Britain. Nature Human Behaviour, 3 (12), 1332-1342. doi: 10.1038/s41562-019-0757-5
2019
Journal Article
Extreme inbreeding in a European ancestry sample from the contemporary UK population
Yengo, Loic, Wray, Naomi R. and Visscher, Peter M. (2019). Extreme inbreeding in a European ancestry sample from the contemporary UK population. Nature Communications, 10 (1) 3719, 3719. doi: 10.1038/s41467-019-11724-6
2019
Journal Article
Assortative mating in autism spectrum disorder: toward an evidence base from DNA data, but not there yet
Wray, Naomi R. and Yengo, Loic (2019). Assortative mating in autism spectrum disorder: toward an evidence base from DNA data, but not there yet. Biological Psychiatry, 86 (4), 250-252. doi: 10.1016/j.biopsych.2019.06.007
2019
Journal Article
Genome-wide association study of change in fasting glucose over time in 13,807 non-diabetic European ancestry individuals
Liu, Ching-Ti, Merino, Jordi, Rybin, Denis, DiCorpo, Daniel, Benke, Kelly S., Bragg-Gresham, Jennifer L., Canouil, Mickaël, Corre, Tanguy, Grallert, Harald, Isaacs, Aaron, Kutalik, Zoltan, Lahti, Jari, Marullo, Letizia, Marzi, Carola, Rasmussen-Torvik, Laura J., Rocheleau, Ghislain, Rueedi, Rico, Scapoli, Chiara, Verweij, Niek, Vogelzangs, Nicole, Willems, Sara M., Yengo, Loïc, Bakker, Stephan J. L., Beilby, John, Hui, Jennie, Kajantie, Eero, Müller-Nurasyid, Martina, Rathmann, Wolfgang, Balkau, Beverley ... Bouatia-Naji, Nabila (2019). Genome-wide association study of change in fasting glucose over time in 13,807 non-diabetic European ancestry individuals. Scientific Reports, 9 (1) 9439. doi: 10.1038/s41598-019-45823-7
Funding
Current funding
Past funding
Supervision
Availability
- Professor Loic Yengo is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
Investigating the time and tissue dependent genetic architecture of complex traits
Principal Advisor
Other advisors: Dr Nicole Warrington
-
Doctor Philosophy
Genomic Selection for Bull Fertility Traits
Associate Advisor
Other advisors: Associate Professor Marina Fortes
-
Doctor Philosophy
New approaches to quantify the genetic cause of disease
Associate Advisor
Other advisors: Professor Nathan Palpant
Completed supervision
-
2024
Doctor Philosophy
Genomic signature of non-random mating in human complex traits
Principal Advisor
Other advisors: Professor Peter Visscher
-
2021
Doctor Philosophy
Within and Across Populations Complex Traits and Diseases Prediction Using Summary Statistics from Large-scale Genome-wide Association Studies
Principal Advisor
Other advisors: Professor Peter Visscher
Media
Enquiries
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