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Dr Mark Allenby
Dr

Mark Allenby

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Overview

Background

Dr Mark C Allenby is a Senior Lecturer in Biomedical Engineering (2021-ongoing) and an ARC DECRA Fellow (2022-2025) within UQ's School of Chemical Engineering. Mark is also an Adjunct Senior Lecturer at QUT and previously an Advance Queensland Fellow (2019-2022). Mark has principally supervised 5 PhDs and 2 MPhil/RAs, co-supervised 7 PhDs, and has been awarded over $2.8M of funding as chief investigator across 20 competitive funding rounds in 4 years. Mark received a PhD and MSc in chemical engineering from Imperial College London, UK and bachelors degrees in mathematics and chemistry from Pepperdine University, USA. Mark's leadership is exhibited by the:

Research Interests: Mark leads the BioMimetic Systems Engineering (BMSE) Lab. In the BMSE Lab, we combine Tissue Engineering, Biomedical Image Analysis, and Computational Biology to study and solve biological and medical problems using advanced cell culture and computer models. Initially, we will focus on Systems of Blood, Blood Vessels, and Vascularised Tissue as these are essential building blocks for human and mammalian function. Our work aligns with bioprocess engineering fundamentals, cell therapy or medical device manufacturing, and clinical collaborators in haematology, vascular surgery, neurosurgery, and radiology. Our systems engineering approaches allow us to examine, computationally model, experimentally engineer, optimise, control, scale, and automate dynamic systems of several entities such as multi-cellular tissues or cell-material and cell-fluid systems.

Academic Interests: Mark is the Convener of UQ's Biomedical Engineering (BME) major, ranked #2 in Australia. BME at UQ spans schools of Chemical Engineering (ChE; #1 in Australia), Electrical Engineering, and Mechanical Engineering, and engages with UQ's Faculty of Medicine and associated healthcare services. Mark is part of ChE teaching and scholarship committees, and Mark acts as the academic advisor for ChE-BME undergraduates. Mark is the creator and coordinator of Quantitative Methods in Biomedical Engineering, and is a lecturer of Process Modeling & Dynamics. Mark has previously taught courses in biomaterials, process modelling, and reaction engineering in ChE and BME departments at three universities in the UK and Australia.

Our BMSE Lab is currently looking for excellent computational researchers. These include candidates and collaborators with experience in microscopy and medical image processing, cell population dynamics simulation, and/or biomechanics simulations (Python, MATLAB, R, ANSYS) to analyse high-content experimental data. Postdoc candidates are welcome to contact us to explore fellowship applications. Interested PhD and MPhil candidates should consider applying with us to the UQ Annual HDR Scholarship Round. We are always recruiting masters and undergraduate thesis project students for thesis projects advertised on our lab website.

Availability

Dr Mark Allenby is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, Imperial College

Research interests

  • Diagnostic Cell Culture Models to Screen Graft Versus Host Disease

    Bone marrow and organ transplants have been a lifesaving option for 200,000 patients per year. Patients and infants in need of blood, stem cells or solid organs often rely on donations from unrelated donors, despite their substantial risk of graft versus host disease (GVHD) which may lead to transplant rejection. By using rare stem cells from donated blood units, this project aims to engineer cell culture models which can accurately predict whether a patient would negatively react to a specific donor's cell or organ transplant, providing insights which could save thousands of Australian lives.  Researchers: Rose Ann Franco (Lead), Sara Chiaretti. Partners: Australian Red Cross Lifeblood, Queensland Cord Blood Bank at the Mater Hospital.  Funding: Australian Research Council, Ramaciotti Philanthropy, UQ Internal Funding.

  • Bone Marrow Mimicry Bioreactors for Blood Cell Therapy Manufacturing

    Cell therapies are widely considered to be the next step-change in clinical medicine, curing previously uncurable disease. However, many cell therapies cost $100,000 to $3,000,000 per dose, an expense which patients and healthcare systems cannot afford. If we could manufacture lab-grown cell therapies as efficiently as our body does, we could reduce the cost of cell therapies 10x-100x and deliver more curative treatments to more patients in need. Specifically, we are using our body's bone marrow as an inspiration for growing blood cell therapies such as blood stem cells (HSPCs) and red blood cells (RBCs).  Researchers: Astrid Nausa Galeano (Lead), Rose Ann Franco, Susana Costa Maia. Partners: Australian Red Cross Lifeblood, Queensland University of Technology, University of Maastricht.  Funding: Australian Research Council, Ramaciotti Philanthropy, UQ Internal Funding.

  • High-Content Microphysiological Systems for Cell Culture Screening

    3D culture systems can grow greater numbers of higher-quality cells at lower costs than traditional liquid suspension or 2D cultures, however the adoption of 3D culture systems in biopharmacuetical industries remains limited due to current dependenance on culture high content screening (HCS). Our lab is engineering the first experimental platforms and compuational models to preform HCS on 3D cell cultures for process optimisation and drug screening. Specifically, we are engineering live-imaged high-throughput hydrogel microchip platforms to optimise stem cell expansion and angiogenesis.  Researchers: Ryan McKinnon (Lead), Ashley Murphy, Rose Ann Franco.  Partners: Queensland Cord Blood Bank at the Mater, Royal Brisbane & Women's Hospital Dept of Haematology, Queensland University of Technology.  Funding: Australian Research Council, Ramaciotti Philanthropy, UQ Internal Funding.

  • Additive Manufacturing to Predict Patient-Specific Cardiovascular Disease

    The ability to diagnose and medically or surgically treat cardiovascular disease is particularly dependent on the anatomy and biology of our body's vessels. Additive manufacturing leverages medical imaging, computational simulations, and 3D printing to fabricate patient-specific models of cardiovascular disease useful for identifying disease, predicting disease progression, or simulating treatments. Specifically, we are computationally simulating and 3D printing perfusable cell culture models to simulate intracranial aneurysm rupture risk and predict peripheral artery graft success. Researchers: Chloe de Nys (Lead), Sabrina Schoenborn, Ryan McKinnon.  Partners: Royal Brisbane & Women's Hospital Dept of Neurosurgery, Herston Biofabrication Institute, Princess Alexandra Hospital Dept of Vascular Surgery, Queensland University of Technology.  Funding: Advance Queensland Industry Research Fellowship, Royal Brisbane & Women's Hospital Foundation, Bionics Gamechangers Australia, UQ Internal Funding.

Works

Search Professor Mark Allenby’s works on UQ eSpace

51 works between 2012 and 2024

21 - 40 of 51 works

2021

Journal Article

The effects of COVID-19 on the placenta during pregnancy

Rad, Habib Sadeghi, Röhl, Joan, Stylianou, Nataly, Allenby, Mark C., Bazaz, Sajad Razavi, Warkiani, Majid E., Guimaraes, Fernando S. F., Clifton, Vicki L. and Kulasinghe, Arutha (2021). The effects of COVID-19 on the placenta during pregnancy. Frontiers in Immunology, 12 743022. doi: 10.3389/fimmu.2021.743022

The effects of COVID-19 on the placenta during pregnancy

2021

Journal Article

Using melt-electrowritten microfibres for tailoring scaffold mechanics of 3D bioprinted chondrocyte-laden constructs

Ross, Maureen T., Kilian, David, Lode, Anja, Ren, Jiongyu, Allenby, Mark C., Gelinsky, Michael and Woodruff, Maria A. (2021). Using melt-electrowritten microfibres for tailoring scaffold mechanics of 3D bioprinted chondrocyte-laden constructs. Bioprinting, 23 e00158, 1-13. doi: 10.1016/j.bprint.2021.e00158

Using melt-electrowritten microfibres for tailoring scaffold mechanics of 3D bioprinted chondrocyte-laden constructs

2021

Journal Article

A spatiotemporal microenvironment model to improve design of a 3D bioreactor for red cell production

Allenby, Mark C., Okutsu, Naoki, Brailey, Kate, Guasch, Joana, Zhang, Qiming, Panoskaltsis, Naoki and Mantalaris, Athanasios (2021). A spatiotemporal microenvironment model to improve design of a 3D bioreactor for red cell production. Tissue Engineering. Part A, 28 (1-2), 38-53. doi: 10.1089/ten.TEA.2021.0028

A spatiotemporal microenvironment model to improve design of a 3D bioreactor for red cell production

2021

Journal Article

Detection of clustered anomalies in single-voxel morphometry as a rapid automated method for identifying intracranial aneurysms

Allenby, Mark C., Liang, Ee Shern, Harvey, James, Woodruff, Maria A., Prior, Marita, Winter, Craig D. and Alonso-Caneiro, David (2021). Detection of clustered anomalies in single-voxel morphometry as a rapid automated method for identifying intracranial aneurysms. Computerized Medical Imaging and Graphics, 89 101888, 1-12. doi: 10.1016/j.compmedimag.2021.101888

Detection of clustered anomalies in single-voxel morphometry as a rapid automated method for identifying intracranial aneurysms

2021

Journal Article

Additive manufacturing enables personalised porous high-density polyethylene surgical implant manufacturing with improved tissue and vascular ingrowth

Paxton, Naomi C., Dinoro, Jeremy, Ren, Jiongyu, Ross, Maureen T., Daley, Ryan, Zhou, Renwu, Bazaka, Kateryna, Thompson, Robert G., Yue, Zhilian, Beirne, Stephen, Harkin, Damien G., Allenby, Mark C., Wong, Cynthia S., Wallace, Gordon G. and Woodruff, Maria A. (2021). Additive manufacturing enables personalised porous high-density polyethylene surgical implant manufacturing with improved tissue and vascular ingrowth. Applied Materials Today, 22 100965, 100965. doi: 10.1016/j.apmt.2021.100965

Additive manufacturing enables personalised porous high-density polyethylene surgical implant manufacturing with improved tissue and vascular ingrowth

2021

Journal Article

A protocol for clinically accessible three-dimensional ear scanning using smartphones

Nightingale, Renee C., Ross, Maureen T., Cruz, Rena L.J., Allenby, Mark C., Powell, Sean K. and Woodruff, Maria A. (2021). A protocol for clinically accessible three-dimensional ear scanning using smartphones. Plastic and Reconstructive Surgery, 148 (5), 863e-865e. doi: 10.1097/PRS.0000000000008469

A protocol for clinically accessible three-dimensional ear scanning using smartphones

2021

Journal Article

Frugal 3D scanning using smartphones provides an accessible framework for capturing the external ear

Nightingale, Renee C., Ross, Maureen T., Cruz, Rena L.J., Allenby, Mark C., Powell, Sean K. and Woodruff, Maria A. (2021). Frugal 3D scanning using smartphones provides an accessible framework for capturing the external ear. Journal of Plastic, Reconstructive and Aesthetic Surgery, 74 (11), 3066-3072. doi: 10.1016/j.bjps.2021.03.131

Frugal 3D scanning using smartphones provides an accessible framework for capturing the external ear

2020

Journal Article

A Method for Economical Smartphone-Based Clinical 3D Facial Scanning

Nightingale, Renee Christine, Ross, Maureen Therese, Allenby, Mark Colin, Woodruff, Maria Ann and Powell, Sean Keiran (2020). A Method for Economical Smartphone-Based Clinical 3D Facial Scanning. Journal of Prosthodontics, 29 (9), 818-825. doi: 10.1111/jopr.13274

A Method for Economical Smartphone-Based Clinical 3D Facial Scanning

2020

Journal Article

An advanced prosthetic manufacturing framework for economic personalised ear prostheses

Cruz, Rena L. J., Ross, Maureen T., Skewes, Jacob, Allenby, Mark C., Powell, Sean K. and Woodruff, Maria A. (2020). An advanced prosthetic manufacturing framework for economic personalised ear prostheses. Scientific Reports, 10 (1) 11453. doi: 10.1038/s41598-020-67945-z

An advanced prosthetic manufacturing framework for economic personalised ear prostheses

2020

Journal Article

Cell proliferation and migration explain pore bridging dynamics in 3D printed scaffolds of different pore size

Buenzli, Pascal R., Lanaro, Matthew, Wong, Cynthia S., McLaughlin, Maximilian P., Allenby, Mark C., Woodruff, Maria A. and Simpson, Matthew J. (2020). Cell proliferation and migration explain pore bridging dynamics in 3D printed scaffolds of different pore size. Acta Biomaterialia, 114, 285-295. doi: 10.1016/j.actbio.2020.07.010

Cell proliferation and migration explain pore bridging dynamics in 3D printed scaffolds of different pore size

2020

Journal Article

Auxetic tubular scaffolds via melt electrowriting

Paxton, Naomi C., Daley, Ryan, Forrestal, David P., Allenby, Mark C. and Woodruff, Maria A. (2020). Auxetic tubular scaffolds via melt electrowriting. Materials and Design, 193 108787, 108787. doi: 10.1016/j.matdes.2020.108787

Auxetic tubular scaffolds via melt electrowriting

2020

Journal Article

Design tools for patient specific and highly controlled melt electrowritten scaffolds

Paxton, Naomi C., Lanaro, Matthew, Bo, Arixin, Crooks, Nathan, Ross, Maureen T., Green, Nicholas, Tetsworth, Kevin, Allenby, Mark C., Gu, YuanTong, Wong, Cynthia S., Powell, Sean K. and Woodruff, Maria A. (2020). Design tools for patient specific and highly controlled melt electrowritten scaffolds. Journal of the Mechanical Behavior of Biomedical Materials, 105 103695, 103695. doi: 10.1016/j.jmbbm.2020.103695

Design tools for patient specific and highly controlled melt electrowritten scaffolds

2020

Book Chapter

Bone morphogenetic protein–assisted bone regeneration and applications in biofabrication

Paxton, Naomi C., Wong, Cynthia S., Desselle, Mathilde R., Allenby, Mark C. and Woodruff, Maria A. (2020). Bone morphogenetic protein–assisted bone regeneration and applications in biofabrication. Biomaterials for organ and tissue regeneration: new technologies and future prospects. (pp. 363-391) edited by Nihal Engin Vrana, Helena Knopf-Marques and Julien Barthes. Duxford, United Kingdom: Woodhead Publishing. doi: 10.1016/b978-0-08-102906-0.00016-7

Bone morphogenetic protein–assisted bone regeneration and applications in biofabrication

2020

Journal Article

Engineering inkjet bioprinting processes toward translational therapies

Angelopoulos, Ioannis, Allenby, Mark C., Lim, Mayasari and Zamorano, Mauricio (2020). Engineering inkjet bioprinting processes toward translational therapies. Biotechnology and Bioengineering, 117 (1), 272-284. doi: 10.1002/bit.27176

Engineering inkjet bioprinting processes toward translational therapies

2019

Journal Article

Biomedical applications of polyethylene

Paxton, Naomi C., Allenby, Mark C., Lewis, Philip M. and Woodruff, Maria A. (2019). Biomedical applications of polyethylene. European Polymer Journal, 118, 412-428. doi: 10.1016/j.eurpolymj.2019.05.037

Biomedical applications of polyethylene

2019

Journal Article

Rheological characterization of biomaterials directs additive manufacturing of strontium-substituted bioactive glass/polycaprolactone microfibers

Paxton, Naomi C., Ren, Jiongyu, Ainsworth, Madison J., Solanki, Anu K., Jones, Julian R., Allenby, Mark C., Stevens, Molly M. and Woodruff, Maria A. (2019). Rheological characterization of biomaterials directs additive manufacturing of strontium-substituted bioactive glass/polycaprolactone microfibers. Macromolecular Rapid Communications, 40 (11) 1900019, 1900019. doi: 10.1002/marc.201900019

Rheological characterization of biomaterials directs additive manufacturing of strontium-substituted bioactive glass/polycaprolactone microfibers

2019

Journal Article

Biofabrication of personalised anatomical models and tools for the clinic

Allenby, Mark C. and Woodruff, Maria A. (2019). Biofabrication of personalised anatomical models and tools for the clinic. Journal of Cystic Fibrosis, 18 (2), 161-162. doi: 10.1016/j.jcf.2019.02.005

Biofabrication of personalised anatomical models and tools for the clinic

2019

Journal Article

RGD-functionalized polyurethane scaffolds promote umbilical cord blood mesenchymal stem cell expansion and osteogenic differentiation

Tahlawi, Asma, Klontzas, Michail E., Allenby, Mark C., Morais, José C. F., Panoskaltsis, Nicki and Mantalaris, Athanasios (2019). RGD-functionalized polyurethane scaffolds promote umbilical cord blood mesenchymal stem cell expansion and osteogenic differentiation. Journal of Tissue Engineering and Regenerative Medicine, 13 (2) term.2784, 232-243. doi: 10.1002/term.2784

RGD-functionalized polyurethane scaffolds promote umbilical cord blood mesenchymal stem cell expansion and osteogenic differentiation

2019

Book Chapter

Differentiation of human pluripotent stem cells for red blood cell production

Allenby, Mark C., Dos Santos, Susana Brito, Panoskaltsis, Nicki and Mantalaris, Athanasios (2019). Differentiation of human pluripotent stem cells for red blood cell production. Bioreactors for stem cell expansion and differentiation. (pp. 47-62) edited by Joaquim M. S. Cabral and Cláudia Lobato da Silva. Boca Raton, FL, United States: CRC Press. doi: 10.1201/9780429453144-3

Differentiation of human pluripotent stem cells for red blood cell production

2019

Journal Article

Dynamic human erythropoiesis in a three-dimensional perfusion bone marrow biomimicry

Allenby, Mark C., Panoskaltsis, Nicki, Tahlawi, Asma, Dos Santos, Susana Brito and Mantalaris, Athanasios (2019). Dynamic human erythropoiesis in a three-dimensional perfusion bone marrow biomimicry. Biomaterials, 188, 24-37. doi: 10.1016/j.biomaterials.2018.08.020

Dynamic human erythropoiesis in a three-dimensional perfusion bone marrow biomimicry

Funding

Current funding

  • 2022 - 2025
    Scalable high-density cell therapy manufacturing through engineering vascularised tissue biofactories
    Ramaciotti Health Investment Grants
    Open grant
  • 2022 - 2025
    Engineering Tissue Organisation Using Intelligent Additive Biomanufacturing
    ARC Discovery Early Career Researcher Award
    Open grant

Past funding

  • 2022 - 2023
    Mechanically Programmable Cell Culture Platforms for Cell and Tissue Modelling
    Strategic Partnerships for Research Collaboration Scheme
    Open grant
  • 2021 - 2022
    Biofabrication for personalised vascular surgery prognosis, training, and treatment
    Advance Queensland Industry Research Fellowships
    Open grant

Supervision

Availability

Dr Mark Allenby is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Engineering vascular conduits in grafts to control mass transport for tissue regeneration

    Principal Advisor

  • Doctor Philosophy

    Engineering cerebrovascular models for surgical decision-making

    Principal Advisor

  • Doctor Philosophy

    Engineering tissue organisation using intelligent additive biomanufacturing

    Principal Advisor

    Other advisors: Professor Justin Cooper-White

  • Doctor Philosophy

    Fluid-Structure Interactions in Peripheral Arteries: Biomechanical Coupling of In-Silico, In-Vitro, and Cellular Models with Application to Patient-Specific Femoral-Popliteal Bypass Graft Anastomoses

    Principal Advisor

Media

Enquiries

Contact Dr Mark Allenby directly for media enquiries about:

  • BioImage Analysis
  • Bioprocess Modelling
  • Bioreactor Engineering
  • Cell Therapy Biomanufacturing
  • Tissue Engineering

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au