Emerita Professor Jenny Martin
Emerita Professor

Jenny Martin

Email: 

Background

Jenny Martin trained as a pharmacist at the Victorian College of Pharmacy (VCP), where she was awarded the Gold Medal for top student over the BPharm course. After completing an MPharm in computational chemistry at the College, Jenny moved to Oxford University for a PhD by research in protein crystallography and drug design. Her DPhil was supported by a prestigious 1851 Science Research Scholarship and several other competitive scholarships. Jenny then undertook two years of postdoctoral research at Rockefeller University in New York, before returning to Australia in 1993 to establish the first protein crystallography laboratory in Queensland. Since then, she has held ARC QEII, ARC Professorial and NHMRC Fellowships and is currently an ARC Australian Laureate Fellow at the Institute for Molecular Bioscience, University of Queensland. Jenny is the recipient of many honours including the ASBMB Roche Medal, the Queensland Smart Women Smart State Research Scientist award, and the Women in Biotech Outstanding Outstanding Biotechnology Achievement Award.

Availability

Emerita Professor Jenny Martin is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Pharmacy, Victoria University
  • Masters (Coursework), Victoria University
  • Doctor of Philosophy, University of Oxford

Research impacts

Prof Martin has contributed to knowledge through more than 110 crystal structures deposited into the protein data bank. She has also contributed to the development of patented antidiabetics, HIV-protease inhibitors, and patents leading to the development of conotoxin drugs that progressed to clinical trials. In addition, through a consultancy with PanBIO (now Inverness Medical Innovations) Prof Martin contributed to a patented diagnostic for herpes simplex virus. She has also held ARC Linkage projects with biotech companies Alchemia, Hexima and Biota leading to fundamental and applied research outcomes. As a leader in her field, Jenny has chaired the National Committee for Crystallography of the Australian Academy of Science, is a past President of the Society for Crystallographers in Australia and New Zealand and former member of the Scientific Advisory Committee of the Australian Synchrotron.

Search Professor Jenny Martin’s works on UQ eSpace

210 works between 1984 and 2022
All (210) Journal Article (177) Book Chapter (9) Conference Publication (19) Other Outputs (5)

61 - 80 of 210 works

2014

Journal Article

Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors

McMahon, Róisín M., Premkumar, Lakshmanane and Martin, Jennifer L. (2014). Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors. Biochimica et Biophysica Acta: Proteins and Proteomics, In Press, Uncorrected Proof (8), 1-11. doi: 10.1016/j.bbapap.2014.01.013

Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors

2014

Conference Publication

Characterization of the alpha-proteobacteria Wolbachia pipientis protein disulphide machinery reveals a regulatory mechanism absent in gamma-proteobacteria

Walden, Patricia M., Halili, Maria A., Archbold, Julia K., Lindahl, Fredrik, Fairlie, David P., Inaba, Kenji and Martin, Jennifer L. (2014). Characterization of the alpha-proteobacteria Wolbachia pipientis protein disulphide machinery reveals a regulatory mechanism absent in gamma-proteobacteria. 28th Annual Symposium of the Protein-Society, San Diego, California, 27-30 July 2014. Hoboken, NJ, United States : Wiley-Blackwell.

Characterization of the alpha-proteobacteria Wolbachia pipientis protein disulphide machinery reveals a regulatory mechanism absent in gamma-proteobacteria

2013

Journal Article

Milligram quantities of homogeneous recombinant full-length mouse Munc18c from Escherichia coli cultures

Rehman, Asma, Jarrott, Russell J., Whitten, Andrew E., King, Gordon J., Hu, Shu-Hong, Christie, Michelle P., Collins, Brett M. and Martin, Jennifer L. (2013). Milligram quantities of homogeneous recombinant full-length mouse Munc18c from Escherichia coli cultures. PloS One, 8 (12) e83499, e83499.1-e83499.12. doi: 10.1371/journal.pone.0083499

Milligram quantities of homogeneous recombinant full-length mouse Munc18c from Escherichia coli cultures

2013

Journal Article

Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor

Daly, Norelle L., Thorstholm, Louise, Greenwood, Kathryn P., King, Gordon J., Rosengren, K. Johan, Heras, Begona, Martin, Jennifer L. and Craik, David J. (2013). Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor. Journal of Biological Chemistry, 288 (50), 36141-36148. doi: 10.1074/jbc.M113.528240

Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor

2013

Journal Article

The multidrug resistance IncA/C transferable plasmid encodes a novel domain swapped dimeric protein disulfide isomerase

Premkumar, Lakshmanane, Kurth, Fabian, Neyer, Simon, Schembri, Mark A. and Martin, Jennifer L. (2013). The multidrug resistance IncA/C transferable plasmid encodes a novel domain swapped dimeric protein disulfide isomerase. Journal of Biological Chemistry, Papers in Press (5), 1-24. doi: 10.1074/jbc.M113.516898

The multidrug resistance IncA/C transferable plasmid encodes a novel domain swapped dimeric protein disulfide isomerase

2013

Journal Article

The alpha-proteobacteria Wolbachia pipientis protein disulfide machinery has a regulatory mechanism absent in gamma-proteobacteria

Walden, Patricia, Halili, Maria, Julia Archbold, Fredrik Lindahl, Fairlie, David P., Inaba, Kenji and Martin, Jennifer L. (2013). The alpha-proteobacteria Wolbachia pipientis protein disulfide machinery has a regulatory mechanism absent in gamma-proteobacteria. PloS One, 8 (11) e81440, e81440.1-e81440.9. doi: 10.1371/journal.pone.0081440

The alpha-proteobacteria Wolbachia pipientis protein disulfide machinery has a regulatory mechanism absent in gamma-proteobacteria

2013

Journal Article

Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes

Kurth, Fabian, Rimmer, Kieran, Premkumar, Lakshmanane, Mohanty, Biswaranjan, Duprez, Wilko, Halili, Maria A., Shouldice, Stephen R., Heras, Begoña, Fairlie, David P., Scanlon, Martin J. and Martin, Jennifer L. (2013). Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes. PloS One, 8 (11) e80210, e80210.1-e80210.15. doi: 10.1371/journal.pone.0080210

Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes

2013

Journal Article

Bread, Beer and Botox: the science behind the 2013 Nobel prize for medicine

Martin, Jennifer Louise (2013, 10 08). Bread, Beer and Botox: the science behind the 2013 Nobel prize for medicine

Bread, Beer and Botox: the science behind the 2013 Nobel prize for medicine

2013

Journal Article

Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases

Premkumar, Lakshmanane, Heras, Begoña, Duprez, Wilko, Walden, Patricia, Halili, Maria, Kurth, Fabian, Fairlie, David P. and Martin, Jennifer L. (2013). Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases. Acta Crystallographica Section D: Biological Crystallography, 69 (10), 1981-1994. doi: 10.1107/S0907444913017800

Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases

2013

Journal Article

Interrogating fragments using a protein thermal shift assay

McMahon, Róisín M., Scanlon, Martin J. and Martin, Jennifer L. (2013). Interrogating fragments using a protein thermal shift assay. Australian Journal of Chemistry, 66 (12), 1502-1506. doi: 10.1071/CH13279

Interrogating fragments using a protein thermal shift assay

2013

Journal Article

Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins

Yu, Haijia, Rathore, Shailendra S., Lopez, Jamie A., Davis, Eric M., James, David E., Martin, Jennifer L. and Shen, Jingshi (2013). Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins. Proceedings of the National Academy of Sciences of the United States of America, 110 (35), E3271-E3280. doi: 10.1073/pnas.1311232110

Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins

2013

Journal Article

Disarming Burkholderia pseudomallei: structural and functional characterization of a disulfide oxidoreductase (DsbA) required for virulence in vivo

Ireland, Philip M., McMahon, Róisín M., Marshall, Laura E., Halili, Maria, Furlong, Emily, Tay, Stephanie, Martin, Jennifer L. and Sarkar-Tyson, Mitali (2013). Disarming Burkholderia pseudomallei: structural and functional characterization of a disulfide oxidoreductase (DsbA) required for virulence in vivo. Antioxidants & Redox Signaling, Fast Track (4), 1-12. doi: 10.1089/ars.2013.5375

Disarming Burkholderia pseudomallei: structural and functional characterization of a disulfide oxidoreductase (DsbA) required for virulence in vivo

2013

Journal Article

The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane

Martin, Sally, Tomatis, Vanesa M., Papadopulos, Andreas, Christie, Michelle P., Malintan, Nancy T., Gormal, Rachel S., Sugita, Shuzo, Martin, Jennifer L., Collins, Brett M. and Meunier, Frederic A. (2013). The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane. Journal of Cell Science, 126 (11), 2353-2360. doi: 10.1242/jcs.126813

The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane

2013

Journal Article

The Arabidopsis B3 domain protein VERNALIZATION1 is involved in processes essential for development with structural and mutational studies revealing its DNA binding surface

King, Gordon J., Chanson, Aurelie H., McCallum, Emily J., Ohme-Takagi, Masaru, Byriel, Karl, Hill, Justine M., Martin, Jennifer L. and Mylne, Joshua S. (2013). The Arabidopsis B3 domain protein VERNALIZATION1 is involved in processes essential for development with structural and mutational studies revealing its DNA binding surface. Journal of Biological Chemistry, 288 (5), 3198-3207. doi: 10.1074/jbc.M112.438572

The Arabidopsis B3 domain protein VERNALIZATION1 is involved in processes essential for development with structural and mutational studies revealing its DNA binding surface

2013

Journal Article

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

Chen, Kai-En, Richards, Ayanthi A., Caradoc-Davies, Tom T., Vajjhala, Parimala R., Robin, Gautier, Lua, Linda H. L., Hill, Justine M., Schroder, Kate, Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer (2013). The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallographica Section D: Biological Crystallography, 69 (5), 774-784. doi: 10.1107/S0907444913001558

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

2012

Journal Article

Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase

King, Gordon J., Stoeckli, Jacqueline, Hu, Shu-Hong, Winnen, Brit, Duprez, Wilko G. A., Meoli, Christopher C., Junutula, Jagath R., Jarrott, Russell J., James, David E., Whitten, Andrew E. and Martin, Jennifer L. (2012). Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase. Journal of Biological Chemistry, 287 (49), 40996-41006. doi: 10.1074/jbc.M112.349803

Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase

2012

Journal Article

Bacterial resistance wars

Martin, Jennifer and Furlong, Emily (2012). Bacterial resistance wars. Biological Sciences Review, 25 (2), 27-29.

Bacterial resistance wars

2012

Journal Article

Professor Dame Louise Johnson: a personal perspective from a former student

Martin, Jenny (2012). Professor Dame Louise Johnson: a personal perspective from a former student. International Union of Crystallography

Professor Dame Louise Johnson: a personal perspective from a former student

2012

Journal Article

The 1.2 A resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production

Walden, Patricia M., Heras, Begona, Chen, Kai-En, Halili, Maria A., Rimmer, Kieran, Sharma, Pooja, Scanlon, Martin J. and Martin, Jennifer L. (2012). The 1.2 A resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production. Acta Crystallographica Section D-Biological Crystallography, 68 (10), 1290-1302. doi: 10.1107/S0907444912026388

The 1.2 A resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production

2012

Journal Article

The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 Has 1:2 stoichiometry and a single peptide binding mode

Hu, Shu-Hong, Whitten, Andrew E., King, Gordon J., Jones, Alun, Rowland, Alexander F., James, David E. and Martin, Jennifer L. (2012). The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 Has 1:2 stoichiometry and a single peptide binding mode. Plos One, 7 (8) e41731, 41731-1-41731-11. doi: 10.1371/journal.pone.0041731

The weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 Has 1:2 stoichiometry and a single peptide binding mode

Past funding

  • 2016
    Burkholderia pseudomallei disulfide-forming proteins: structure, function and inhibition (NHMRC Project Grant administered by Griffith University)
    Open grant
  • 2016
    Molecular dissection of the Munc18c:Syntaxin4 complex required for insulin-regulated exocytosis in adipocytes (NHMRC Project Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2016 - 2018
    DsbA inhibitors: from hits to leads
    NHMRC Project Grant
    Open grant
  • 2016
    Structure and function of human zinc transporter membrane proteins
    ARC Discovery Projects
    Open grant
  • 2015
    Protein Analysis Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Burkholderia pseudomallei disulfide-forming proteins: structure, function and inhibition
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Molecular dissection of the Munc18c:Syntaxin4 complex required for insulin-regulated exocytosis in adipocytes
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    Membrane proteins in innate immunity
    ARC Discovery Projects
    Open grant
  • 2012 - 2013
    Overcoming membrane protein research roadblocks: A Queensland facility for membrane protein production and crystallisation
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012
    High- throughput Fourier Transform Infrared (FTIR) spectrometer.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Auto-iTC200 microcalorimeter for high-throughput molecular interaction analyses
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Freedom Evo 150 robotic worktable: Automated high throughput and long-time course spectrophotometric multiwell plate assay system
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Queensland International Fellowship: Membrane Protein Structure Techniques
    Queensland International Fellowships
    Open grant
  • 2010 - 2013
    Targeting virulence of Pseudomonas aeruginosa by inhibiting oxidative protein folding (ARC Linkage Project Grant, administered by Monash University)
    Monash University
    Open grant
  • 2010
    Combinatorial chemistry (high throughput synthesizer and purification system)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    The development of peptides (mini-proteins) as drugs: improved purification capability
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2014
    Towards antibacterials without resistance
    ARC Australian Laureate Fellowships
    Open grant
  • 2009
    Characterization of the Munc 18c-Sx4 Complex
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2009 - 2013
    How the SNARE:SM machinery regulates glucose transport in fat cells
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Design and use of human hematopoietic prostaglandin D2 synthase inhibitors in allergic asthma and bone diseases
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    DsbA inhibitors as potential antimicrobials
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Inhibitors Of West Nile Virus Protease As Antiviral Drugs
    NHMRC Project Grant
    Open grant
  • 2007 - 2011
    Macrophage proteins: structure, function and e-science
    ARC Discovery Projects
    Open grant
  • 2007 - 2015
    NHMRC Senior Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2006 - 2008
    Deciphering the molecular basis of SM regulation of exocytosis
    NHMRC Project Grant
    Open grant
  • 2006
    e-Research Infrastructure for the Molecular and Materials Structure Sciences
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2006 - 2008
    Innovative Approaches to Membrane Protein Crystallography & Drug Discovery
    ARC Discovery Projects
    Open grant
  • 2006
    Small Angle Scattering Facility for the Materials and Biological Sciences
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2008
    Enhancement of plant proteinase inhibitors for the protection of crop plants against insect attack
    ARC Linkage Projects
    Open grant
  • 2005
    A New Generation Biosensor and Fluorescence Facility for Proteomic
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2007
    Deciphering the molecular steps leading to the potentiation of neuronal exocytosis by arachidonic acid
    NHMRC Project Grant
    Open grant
  • 2004
    Structural biology of macromolecular assemblies as part of the visual cell program
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2004 - 2006
    Structure and function of novel macrophage proteins using high throughput crystallography
    ARC Discovery Projects
    Open grant
  • 2004
    The Australian Protease Network
    ARC Seed Funding for Research Networks
    Open grant
  • 2003
    Application for Support for Access to Major Research Facilities Program - Project title: Structural Studies on PNMT, Mouse Latexin, Insect Ferritin
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2003
    Dynamic Light Scattering Instrument
    NHMRC Equipment Grant
    Open grant
  • 2003 - 2005
    Investigating the structure, function and inhibition of the adrenaline-synthesizing enzyme PNMT
    ARC Discovery Projects
    Open grant
  • 2003 - 2004
    Structural studies on carbohydrate modifying enzymes
    ARC Linkage Projects
    Open grant
  • 2003
    Structural Studies on the Regulation of SNARE Proteins by Munc18c
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003 - 2005
    Structure, Function And Regulation Of Human Cytosolic Sulfotransferases
    NHMRC Project Grant
    Open grant
  • 2002
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for access to the Advanced Photon Source to visit BIOCARS
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2000
    Chromatography system for structural biology
    Ramaciotti Foundation
    Open grant
  • 2000 - 2002
    Design and development of inhibitors of the dengue virus protease as antiviral agents
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Structural studies on SNARE proteins involved in insulin action
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Structural studies on the adrenaline-synthesising enzyme, PNMT
    ARC Australian Research Council (Large grants)
    Open grant
  • 1999 - 2000
    Structural determination of the protein folding factor CycY
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 1999 - 2003
    Applications of Protein Crystallography in Drug Design
    ARC Australian Senior Research Fellowships
    Open grant
  • 1999
    Expression and crystallization of SNARE proteins from adipocytes
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999 - 2001
    Protein Disulfide Exchange and Protein Folding in vivo: Structural Studies of Disulfide Oxidoreductases
    ARC Australian Research Council (Large grants)
    Open grant
  • 1999 - 2001
    Structural, Functional and Genetic Characterisation of Human Sulfotransferases
    NHMRC Project Grant
    Open grant
  • 1998
    Plant pyruvate phosphate dikinase and human aryl sulfotransferase 3
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 1997
    Structure-function studies on human phenylethanolamine N-methyltransferase
    UQ External Support Enabling Grant
    Open grant
  • 1996 - 1998
    Structural studies on purine phosphoribosyltransferases (PRTases)
    ARC Australian Research Council (Large grants)
    Open grant
  • 1996
    Structure determination by NMR of the disulfide-dithiol exchange protein TcpG
    ARC Australian Research Council (Small grants)
    Open grant
  • 1995 - 1997
    Structural studies on reduced DsbA and DsbA analogues
    ARC Australian Research Council (Large grants)
    Open grant
  • 1994 - 2006
    Design of inhibitors of epinephrine biosynthesis.
    University of Kansas
    Open grant

Availability

Emerita Professor Jenny Martin is:
Not available for supervision

Supervision history

Completed supervision

Enquiries

Contact Emerita Professor Jenny Martin directly for media enquiries about:

  • antibacterials
  • Antibiotic discovery
  • antibiotics
  • bacteria
  • bacterial infection
  • Crystallography - protein
  • diabetes
  • drug discovery
  • Enzyme inhibition
  • infection
  • inflammation
  • insulin
  • Protein crystallography
  • Protein function
  • Protein structure
  • Proteins
  • science policy
  • scientific leadership
  • superbugs
  • women in science

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