Emerita Professor Jenny Martin
Emerita Professor

Jenny Martin

Email: 

Background

Jenny Martin trained as a pharmacist at the Victorian College of Pharmacy (VCP), where she was awarded the Gold Medal for top student over the BPharm course. After completing an MPharm in computational chemistry at the College, Jenny moved to Oxford University for a PhD by research in protein crystallography and drug design. Her DPhil was supported by a prestigious 1851 Science Research Scholarship and several other competitive scholarships. Jenny then undertook two years of postdoctoral research at Rockefeller University in New York, before returning to Australia in 1993 to establish the first protein crystallography laboratory in Queensland. Since then, she has held ARC QEII, ARC Professorial and NHMRC Fellowships and is currently an ARC Australian Laureate Fellow at the Institute for Molecular Bioscience, University of Queensland. Jenny is the recipient of many honours including the ASBMB Roche Medal, the Queensland Smart Women Smart State Research Scientist award, and the Women in Biotech Outstanding Outstanding Biotechnology Achievement Award.

Availability

Emerita Professor Jenny Martin is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Pharmacy, Victoria University
  • Masters (Coursework), Victoria University
  • Doctor of Philosophy, University of Oxford

Research impacts

Prof Martin has contributed to knowledge through more than 110 crystal structures deposited into the protein data bank. She has also contributed to the development of patented antidiabetics, HIV-protease inhibitors, and patents leading to the development of conotoxin drugs that progressed to clinical trials. In addition, through a consultancy with PanBIO (now Inverness Medical Innovations) Prof Martin contributed to a patented diagnostic for herpes simplex virus. She has also held ARC Linkage projects with biotech companies Alchemia, Hexima and Biota leading to fundamental and applied research outcomes. As a leader in her field, Jenny has chaired the National Committee for Crystallography of the Australian Academy of Science, is a past President of the Society for Crystallographers in Australia and New Zealand and former member of the Scientific Advisory Committee of the Australian Synchrotron.

Search Professor Jenny Martin’s works on UQ eSpace

210 works between 1984 and 2022
All (210) Journal Article (177) Book Chapter (9) Conference Publication (19) Other Outputs (5)

41 - 60 of 210 works

2017

Journal Article

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

Mohanty, Biswaranjan, Rimmer, Kieran, McMahon, Roisın M., Headey, Stephen J., Vazirani, Mansha, Shouldice, Stephen R., Coincon, Mathieu, Tay, Stephanie, Morton, Craig J., Simpson, Jamie S., Martin, Jennifer L. and Scanlon, Martin J. (2017). Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1. PLoS ONE, 12 (3) e0173436, e0173436. doi: 10.1371/journal.pone.0173436

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

2016

Journal Article

Structural and biochemical characterization of Chlamydia trachomatis DsbA reveals a cysteine-rich and weakly oxidising oxidoreductase

Christensen, Signe, Groftehauge, Morten K., Byriel, Karl, Huston, Wilhelmina M., Furlong, Emily, Heras, Begoña, Martin, Jennifer L. and McMahon, Roisin M. (2016). Structural and biochemical characterization of Chlamydia trachomatis DsbA reveals a cysteine-rich and weakly oxidising oxidoreductase. PLoS ONE, 11 (12) e0168485, e0168485. doi: 10.1371/journal.pone.0168485

Structural and biochemical characterization of Chlamydia trachomatis DsbA reveals a cysteine-rich and weakly oxidising oxidoreductase

2016

Journal Article

Rural–urban disparities in stage of breast cancer at diagnosis in Australian women

Leung, Janni, Martin, Jennifer and McLaughlin, Deirdre (2016). Rural–urban disparities in stage of breast cancer at diagnosis in Australian women. Australian Journal of Rural Health, 24 (5), 326-332. doi: 10.1111/ajr.12271

Rural–urban disparities in stage of breast cancer at diagnosis in Australian women

2016

Journal Article

Valproate in adjuvant glioblastoma treatment

Fay, Michael F., Head, Richard, Sminia, Peter, Dowson, Nicholas, Cosgrove, Leah, Rose, Stephen E. and Martin, Jenny H. (2016). Valproate in adjuvant glioblastoma treatment. Journal of Clinical Oncology, 34 (25), 3105-3107. doi: 10.1200/JCO.2016.67.2162

Valproate in adjuvant glioblastoma treatment

2016

Journal Article

Expanding beyond biological crystallography

Martin, Jennifer L., Read, Randy J. and Watatsuki, Soichi (2016). Expanding beyond biological crystallography. Acta Crystallographica Section D: Structural Biology, 72 (1), 1-1. doi: 10.1107/S2059798315023761

Expanding beyond biological crystallography

2016

Other Outputs

Crystal structure of CtDsbA

McMahon, Roisin M. and Martin, Jennifer L. (2016). Crystal structure of CtDsbA. The University of Queensland. (Dataset) doi: 10.14264/uql.2016.1082

Crystal structure of CtDsbA

2015

Journal Article

SEC-uring membrane fusion: a sneak peek at SNARE-complex assembly driven by Sec1-Munc18 proteins

Collins, Brett M. and Martin, Jennifer Louise (2015). SEC-uring membrane fusion: a sneak peek at SNARE-complex assembly driven by Sec1-Munc18 proteins. Nature Structural and Molecular Biology, 22 (10), 756-758. doi: 10.1038/nsmb.3094

SEC-uring membrane fusion: a sneak peek at SNARE-complex assembly driven by Sec1-Munc18 proteins

2015

Journal Article

Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA

Duprez, Wilko, Bachu, Prabhakar, Stoermer, Martin J, Tay, Stephanie, McMahon, Roisin M, Fairlie, David P and Martin, Jennifer L (2015). Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA. Plos One, 10 (7) e0133805, e0133805. doi: 10.1371/journal.pone.0133805

Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA

2015

Journal Article

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system

Halili, Maria A., Bachu, Prabhakar, Lindahl, Fredrik, Bechara, Cherine, Mohanty, Biswaranjan, Reid, Robert C., Scanlon, Martin, Robinson, Carol V., Fairlie, David P. and Martin, Jennifer L. (2015). Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system. ACS Chemical Biology, 10 (4), 957-964. doi: 10.1021/cb500988r

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system

2015

Journal Article

Sent packing: Protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

McMahon, Roisin M., Coincon, Mathieu, Tay, Stephanie, Heras, Begona, Morton, Craig J., Scanlon, Martin J. and Martin, Jennifer L. (2015). Sent packing: Protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility. Acta Crystallographica Section D: Biological Crystallography, 71 (Pt 12), 2386-2395. doi: 10.1107/S1399004715018519

Sent packing: Protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

2014

Journal Article

Application of Fragment-Based Screening to the Design of Inhibitors of Escherichia coli DsbA

Adams, Luke A., Sharma, Pooja, Mohanty, Biswaranjan, Ilyichova, Olga V., Mulcair, Mark D., Williams, Martin L., Gleeson, Ellen C., Totsika, Makrina, Doak, Bradley C., Caria, Sofia, Rimmer, Kieran, Horne, James, Shouldice, Stephen R., Vazirani, Mansha, Headey, Stephen J., Vazirani, Mansha, Headey, Stephen J., Plumb, Brent R., Martin, Jennifer L., Heras, Begona, Simpson, Jamie S. and Scanlon, Martin J. (2014). Application of Fragment-Based Screening to the Design of Inhibitors of Escherichia coli DsbA. Angewandte Chemie, 54 (7), 2179-2184. doi: 10.1002/ange.201410341

Application of Fragment-Based Screening to the Design of Inhibitors of Escherichia coli DsbA

2014

Journal Article

Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence

Duprez, Wilko, Premkumar, Lakshmanane, Halili, Maria A., Lindahl, Fredrik, Reid, Robert C., Fairlie, David P. and Martin, Jennifer L. (2014). Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence. Journal of Medicinal Chemistry, 58 (2), 577-587. doi: 10.1021/jm500955s

Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence

2014

Journal Article

SNARE-ing the structures of Sec1/Munc18 proteins

Archbold, Julia K., Whitten, Andrew E., Hu, Shu-Hong, Collins, Brett M. and Martin, Jennifer L. (2014). SNARE-ing the structures of Sec1/Munc18 proteins. Current Opinion in Structural Biology, 29, 44-51. doi: 10.1016/j.sbi.2014.09.003

SNARE-ing the structures of Sec1/Munc18 proteins

2014

Journal Article

Ten Simple Rules to Achieve Conference Speaker Gender Balance

Martin, Jennifer L. (2014). Ten Simple Rules to Achieve Conference Speaker Gender Balance. PLoS Computational Biology, 10 (11), e1003903-e1003903. doi: 10.1371/journal.pcbi.1003903

Ten Simple Rules to Achieve Conference Speaker Gender Balance

2014

Journal Article

Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly

Rehman, Asma, Archbold, Julia, Hu, Shu-Hong, Norwood, Suzanne, Collins, Brett and Martin, Jennifer L. (2014). Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly. IUCrJ, 1 (6), 505-513. doi: 10.1107/S2052252514020727

Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly

2014

Journal Article

Structure of the Acinetobacter baumannii dithiol oxidase DsbA bound to EF-Tu reveals a novel protein interaction site

Premkumar, Lakshmanane, Kurth, Fabian, Duprez, Wilko, Grøftehauge, Morten K., King, Gordon J., Halili, Maria A., Heras, Begoña and Martin, Jennifer L. (2014). Structure of the Acinetobacter baumannii dithiol oxidase DsbA bound to EF-Tu reveals a novel protein interaction site. Journal of Biological Chemistry, 289 (29), 19869-19880. doi: 10.1074/jbc.M114.571737

Structure of the Acinetobacter baumannii dithiol oxidase DsbA bound to EF-Tu reveals a novel protein interaction site

2014

Journal Article

Crystal Structure of the Dithiol Oxidase DsbA Enzyme from Proteus Mirabilis Bound Non-covalently to an Active Site Peptide Ligand.

Kurth, Fabian, Duprez, Wilko, Premkumar, Lakshmanane, Schembri, Mark A., Fairlie, David P. and Martin, Jennifer L. (2014). Crystal Structure of the Dithiol Oxidase DsbA Enzyme from Proteus Mirabilis Bound Non-covalently to an Active Site Peptide Ligand.. Journal of Biological Chemistry, 289 (28), 19810-19822. doi: 10.1074/jbc.M114.552380

Crystal Structure of the Dithiol Oxidase DsbA Enzyme from Proteus Mirabilis Bound Non-covalently to an Active Site Peptide Ligand.

2014

Journal Article

Towards selective lysophospholipid GPCR modulators

Archbold, Julia K., Martin, Jennifer L. and Sweet, Matthew J. (2014). Towards selective lysophospholipid GPCR modulators. Trends in Pharmacological Sciences, 35 (5), 219-226. doi: 10.1016/j.tips.2014.03.004

Towards selective lysophospholipid GPCR modulators

2014

Journal Article

Proteins to plastics: chemistry as a dynamic discipline

Martin, Jennifer Louise, Holmes, Andrew and Buntine, Mark (2014, 02 25). Proteins to plastics: chemistry as a dynamic discipline

Proteins to plastics: chemistry as a dynamic discipline

2014

Journal Article

Targeting virulence not viability in the search for future antibacterials

Heras, Begona, Scanlon, Martin J. and Martin, Jennifer L. (2014). Targeting virulence not viability in the search for future antibacterials. British Journal of Clinical Pharmacology, 79 (2), 208-215. doi: 10.1111/bcp.12356

Targeting virulence not viability in the search for future antibacterials

Past funding

  • 2016
    Burkholderia pseudomallei disulfide-forming proteins: structure, function and inhibition (NHMRC Project Grant administered by Griffith University)
    Open grant
  • 2016
    Molecular dissection of the Munc18c:Syntaxin4 complex required for insulin-regulated exocytosis in adipocytes (NHMRC Project Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2016 - 2018
    DsbA inhibitors: from hits to leads
    NHMRC Project Grant
    Open grant
  • 2016
    Structure and function of human zinc transporter membrane proteins
    ARC Discovery Projects
    Open grant
  • 2015
    Protein Analysis Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Burkholderia pseudomallei disulfide-forming proteins: structure, function and inhibition
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Molecular dissection of the Munc18c:Syntaxin4 complex required for insulin-regulated exocytosis in adipocytes
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    Membrane proteins in innate immunity
    ARC Discovery Projects
    Open grant
  • 2012 - 2013
    Overcoming membrane protein research roadblocks: A Queensland facility for membrane protein production and crystallisation
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012
    High- throughput Fourier Transform Infrared (FTIR) spectrometer.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Auto-iTC200 microcalorimeter for high-throughput molecular interaction analyses
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Freedom Evo 150 robotic worktable: Automated high throughput and long-time course spectrophotometric multiwell plate assay system
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Queensland International Fellowship: Membrane Protein Structure Techniques
    Queensland International Fellowships
    Open grant
  • 2010 - 2013
    Targeting virulence of Pseudomonas aeruginosa by inhibiting oxidative protein folding (ARC Linkage Project Grant, administered by Monash University)
    Monash University
    Open grant
  • 2010
    Combinatorial chemistry (high throughput synthesizer and purification system)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    The development of peptides (mini-proteins) as drugs: improved purification capability
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2014
    Towards antibacterials without resistance
    ARC Australian Laureate Fellowships
    Open grant
  • 2009
    Characterization of the Munc 18c-Sx4 Complex
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2009 - 2013
    How the SNARE:SM machinery regulates glucose transport in fat cells
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Design and use of human hematopoietic prostaglandin D2 synthase inhibitors in allergic asthma and bone diseases
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    DsbA inhibitors as potential antimicrobials
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Inhibitors Of West Nile Virus Protease As Antiviral Drugs
    NHMRC Project Grant
    Open grant
  • 2007 - 2011
    Macrophage proteins: structure, function and e-science
    ARC Discovery Projects
    Open grant
  • 2007 - 2015
    NHMRC Senior Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2006 - 2008
    Deciphering the molecular basis of SM regulation of exocytosis
    NHMRC Project Grant
    Open grant
  • 2006
    e-Research Infrastructure for the Molecular and Materials Structure Sciences
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2006 - 2008
    Innovative Approaches to Membrane Protein Crystallography & Drug Discovery
    ARC Discovery Projects
    Open grant
  • 2006
    Small Angle Scattering Facility for the Materials and Biological Sciences
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2008
    Enhancement of plant proteinase inhibitors for the protection of crop plants against insect attack
    ARC Linkage Projects
    Open grant
  • 2005
    A New Generation Biosensor and Fluorescence Facility for Proteomic
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2007
    Deciphering the molecular steps leading to the potentiation of neuronal exocytosis by arachidonic acid
    NHMRC Project Grant
    Open grant
  • 2004
    Structural biology of macromolecular assemblies as part of the visual cell program
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2004 - 2006
    Structure and function of novel macrophage proteins using high throughput crystallography
    ARC Discovery Projects
    Open grant
  • 2004
    The Australian Protease Network
    ARC Seed Funding for Research Networks
    Open grant
  • 2003
    Application for Support for Access to Major Research Facilities Program - Project title: Structural Studies on PNMT, Mouse Latexin, Insect Ferritin
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2003
    Dynamic Light Scattering Instrument
    NHMRC Equipment Grant
    Open grant
  • 2003 - 2005
    Investigating the structure, function and inhibition of the adrenaline-synthesizing enzyme PNMT
    ARC Discovery Projects
    Open grant
  • 2003 - 2004
    Structural studies on carbohydrate modifying enzymes
    ARC Linkage Projects
    Open grant
  • 2003
    Structural Studies on the Regulation of SNARE Proteins by Munc18c
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003 - 2005
    Structure, Function And Regulation Of Human Cytosolic Sulfotransferases
    NHMRC Project Grant
    Open grant
  • 2002
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for access to the Advanced Photon Source to visit BIOCARS
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2000
    Chromatography system for structural biology
    Ramaciotti Foundation
    Open grant
  • 2000 - 2002
    Design and development of inhibitors of the dengue virus protease as antiviral agents
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Structural studies on SNARE proteins involved in insulin action
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Structural studies on the adrenaline-synthesising enzyme, PNMT
    ARC Australian Research Council (Large grants)
    Open grant
  • 1999 - 2000
    Structural determination of the protein folding factor CycY
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 1999 - 2003
    Applications of Protein Crystallography in Drug Design
    ARC Australian Senior Research Fellowships
    Open grant
  • 1999
    Expression and crystallization of SNARE proteins from adipocytes
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999 - 2001
    Protein Disulfide Exchange and Protein Folding in vivo: Structural Studies of Disulfide Oxidoreductases
    ARC Australian Research Council (Large grants)
    Open grant
  • 1999 - 2001
    Structural, Functional and Genetic Characterisation of Human Sulfotransferases
    NHMRC Project Grant
    Open grant
  • 1998
    Plant pyruvate phosphate dikinase and human aryl sulfotransferase 3
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 1997
    Structure-function studies on human phenylethanolamine N-methyltransferase
    UQ External Support Enabling Grant
    Open grant
  • 1996 - 1998
    Structural studies on purine phosphoribosyltransferases (PRTases)
    ARC Australian Research Council (Large grants)
    Open grant
  • 1996
    Structure determination by NMR of the disulfide-dithiol exchange protein TcpG
    ARC Australian Research Council (Small grants)
    Open grant
  • 1995 - 1997
    Structural studies on reduced DsbA and DsbA analogues
    ARC Australian Research Council (Large grants)
    Open grant
  • 1994 - 2006
    Design of inhibitors of epinephrine biosynthesis.
    University of Kansas
    Open grant

Availability

Emerita Professor Jenny Martin is:
Not available for supervision

Supervision history

Completed supervision

Enquiries

Contact Emerita Professor Jenny Martin directly for media enquiries about:

  • antibacterials
  • Antibiotic discovery
  • antibiotics
  • bacteria
  • bacterial infection
  • Crystallography - protein
  • diabetes
  • drug discovery
  • Enzyme inhibition
  • infection
  • inflammation
  • insulin
  • Protein crystallography
  • Protein function
  • Protein structure
  • Proteins
  • science policy
  • scientific leadership
  • superbugs
  • women in science

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