Emerita Professor Jenny Martin
Emerita Professor

Jenny Martin

Email: 

Background

Jenny Martin trained as a pharmacist at the Victorian College of Pharmacy (VCP), where she was awarded the Gold Medal for top student over the BPharm course. After completing an MPharm in computational chemistry at the College, Jenny moved to Oxford University for a PhD by research in protein crystallography and drug design. Her DPhil was supported by a prestigious 1851 Science Research Scholarship and several other competitive scholarships. Jenny then undertook two years of postdoctoral research at Rockefeller University in New York, before returning to Australia in 1993 to establish the first protein crystallography laboratory in Queensland. Since then, she has held ARC QEII, ARC Professorial and NHMRC Fellowships and is currently an ARC Australian Laureate Fellow at the Institute for Molecular Bioscience, University of Queensland. Jenny is the recipient of many honours including the ASBMB Roche Medal, the Queensland Smart Women Smart State Research Scientist award, and the Women in Biotech Outstanding Outstanding Biotechnology Achievement Award.

Availability

Emerita Professor Jenny Martin is:
Not available for supervision
Media expert

Qualifications

  • Bachelor of Pharmacy, Victoria University
  • Masters (Coursework), Victoria University
  • Doctor of Philosophy, University of Oxford

Research impacts

Prof Martin has contributed to knowledge through more than 110 crystal structures deposited into the protein data bank. She has also contributed to the development of patented antidiabetics, HIV-protease inhibitors, and patents leading to the development of conotoxin drugs that progressed to clinical trials. In addition, through a consultancy with PanBIO (now Inverness Medical Innovations) Prof Martin contributed to a patented diagnostic for herpes simplex virus. She has also held ARC Linkage projects with biotech companies Alchemia, Hexima and Biota leading to fundamental and applied research outcomes. As a leader in her field, Jenny has chaired the National Committee for Crystallography of the Australian Academy of Science, is a past President of the Society for Crystallographers in Australia and New Zealand and former member of the Scientific Advisory Committee of the Australian Synchrotron.

Search Professor Jenny Martin’s works on UQ eSpace

218 works between 1984 and 2023
All (218) Journal Article (180) Other Outputs (7) Conference Publication (22) Book Chapter (9)

101 - 120 of 218 works

2010

Journal Article

In vivo oxidative protein folding can be facilitated by oxidation-reduction cycling

Shouldice, S. R., Cho, S. H., Boyd, D, Heras, B, Eser, M, Beckwith, J, Riggs, P, Martin, J. L. and Berkmen, M (2010). In vivo oxidative protein folding can be facilitated by oxidation-reduction cycling. Molecular Microbiology, 75 (1), 13-28. doi: 10.1111/j.1365-2958.2009.06952.x

In vivo oxidative protein folding can be facilitated by oxidation-reduction cycling

2010

Conference Publication

Potent inhibitors of West Nile Virus NS2B/NS3 protease

Chappell, K. J., Fairlie, D. P., Gan, C. H., Gupta, P. K., Hu, S., Jensen, C. M., Liebscher, S., Martin, J. L., Robin, G., Stoermer M. J., Xu, W. and Young, P. R. (2010). Potent inhibitors of West Nile Virus NS2B/NS3 protease. 6th General Meeting of the International Proteolysis Society, Gold Coast, QLD, Australia, 26-30 October 2009. Berlin, Germany: Walter De Gruyter.

Potent inhibitors of West Nile Virus NS2B/NS3 protease

2009

Journal Article

Interaction between plate make and protein in protein crystallisation screening

King, Gordon J., Chen, Kai-En, Robin, Gautier, Forwood, Jade K., Heras, Begoña, Thakur, Anil S., Kobe, Bostjan, Blomberg, Simon P. and Martin, Jennifer L. (2009). Interaction between plate make and protein in protein crystallisation screening. PLoS One, 4 (11) e7851, x-x. doi: 10.1371/journal.pone.0007851

Interaction between plate make and protein in protein crystallisation screening

2009

Journal Article

Structural and functional characterization of the oxidoreductase alpha-DsbA1 from wolbachia pipientis

Kurz, Mareike, Iturbe-Ormaetxe, Iñaki, Jarrott, Russell, Shouldice, Stephen R., Wouters, Merridee A., Frei, Patrick, Glockshuber, Rudi, O'Neill, Scott L., Heras, Begoña and Martin, Jennifer L. (2009). Structural and functional characterization of the oxidoreductase alpha-DsbA1 from wolbachia pipientis. Antioxidants and Redox Signaling, 11 (7), 1485-1500. doi: 10.1089/ars.2008.2420

Structural and functional characterization of the oxidoreductase alpha-DsbA1 from wolbachia pipientis

2009

Journal Article

Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity

Drinkwater, N, Gee, C. L., Puri, M, Criscione, K. R., McLeish, M. J., Grunewald, G. L. and Martin, J. L. (2009). Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochemical Journal, 422 (3), 463-471. doi: 10.1042/BJ20090702

Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity

2009

Journal Article

Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold

Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T, Hajdu, J, Bohlin, L, Claeson, P, Goransson, U, Rosengren, K. J., Tang, J, Tan, N. H. and Craik, D. J. (2009). Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 284 (16), 10672-10683. doi: 10.1074/jbc.M900021200

Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold

2009

Journal Article

Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue

Ren, G. P., Stephan, D., Xu, Z. H., Zheng, Y., Tang, D. M., Harrison, R. S., Kurz, M, Jarrott, R, Shouldice, S. R., Hiniker, A., Martin, J. L., Heras, B. and Bardwell, J. C. A. (2009). Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue. Journal of Biological Chemistry, 284 (15), 10150-10159. doi: 10.1074/jbc.M809509200

Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue

2009

Journal Article

Expression, purification and preliminary X-ray diffraction studies of VERNALIZATION1208–341 from Arabidopsis thaliana

King, Gordon, Hill, Justine M., Martin, Jennifer L. and Mylne, Joshua S. (2009). Expression, purification and preliminary X-ray diffraction studies of VERNALIZATION1208–341 from Arabidopsis thaliana. Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 65 (3), 291-294. doi: 10.1107/S1744309109004217

Expression, purification and preliminary X-ray diffraction studies of VERNALIZATION1208–341 from Arabidopsis thaliana

2009

Journal Article

Structure of West Nile virus NS3 protease: Ligand stabilization of the catalytic conformation

Robin, Gautier, Chappell, Keith, Stoermer, Martin J., Hu, Shu-Hong, Young, Paul R., Fairlie, David P. and Martin, Jennifer L. (2009). Structure of West Nile virus NS3 protease: Ligand stabilization of the catalytic conformation. Journal of Molecular Biology, 385 (5), 1568-1577. doi: 10.1016/j.jmb.2008.11.026

Structure of West Nile virus NS3 protease: Ligand stabilization of the catalytic conformation

2009

Conference Publication

Comparing METS and OAI-ORE for encapsulating scientific data products: A protein crystallography case study

Brooking, Charles, Shouldice, Stephen R., Robin, Gautier, Kobe, Bostjan, Martin, Jennifer L. and Hunter, Jane (2009). Comparing METS and OAI-ORE for encapsulating scientific data products: A protein crystallography case study. IEEE International Conference on e-Science and Grid Computing [e-Science], Oxford, U.K., 9-11 December 2009. Los Alamitos, CA, U.S.A.: Institute for Electrical and Electronic Engineers (IEEE). doi: 10.1109/e-Science.2009.29

Comparing METS and OAI-ORE for encapsulating scientific data products: A protein crystallography case study

2008

Journal Article

Crystallography and protein-protein interactions: Biological interfaces and crystal contacts

Kobe, Bostjan, Guncar, Gregor, Buchholz, Rebecca, Huber, Thomas, Maco, Bohumil, Cowieson, Nathan, Martin, Jennifer L., Marfori, Mary and Forwood, Jade K. (2008). Crystallography and protein-protein interactions: Biological interfaces and crystal contacts. Biochemical Society Transactions, 36 (6), 1438-1441. doi: 10.1042/BST0361438

Crystallography and protein-protein interactions: Biological interfaces and crystal contacts

2008

Journal Article

United we stand: combining structural methods

Cowieson, Nathan P., Kobe, Bostjan and Martin, Jennifer L. (2008). United we stand: combining structural methods. Current Opinion in Structural Biology, 18 (5), 617-622. doi: 10.1016/j.sbi.2008.07.004

United we stand: combining structural methods

2008

Journal Article

Increasing protein crystallization screening success with heterogeneous nucleating agents

Thakur, Anil S, Newman, Janet, Martin, Jennifer L and Kobe, Bostjan (2008). Increasing protein crystallization screening success with heterogeneous nucleating agents. Methods in molecular biology (Clifton, N.J.), 426, 403-409. doi: 10.1007/978-1-60327-058-8_26

Increasing protein crystallization screening success with heterogeneous nucleating agents

2008

Journal Article

Federated repositories of X-ray diffraction images

Androulakis, S., Schmidberger, J., Bate, M. A., DeGori, R., Beitz, A., Keong, C., Cameron, B., McGowan, S., Porter, C. J., Harrison, A., Hunter, J., Martin, J. L., Kobe, B., Dobson, R. C. J., Parker, M. W., Whisstock, J. C., Gray, J., Treloar, A., Groenewegen, D., Dickson, N. and Buckle, A. M. (2008). Federated repositories of X-ray diffraction images. Acta Crystallographica Section D: Biological Crystallography, 64 (7), 810-814. doi: 10.1107/S0907444908015540

Federated repositories of X-ray diffraction images

2008

Journal Article

Cortactin adopts a globular conformation and bundles actin into sheets

Cowieson, Nathan P., King, Gordon, Cookson, David, Ross, Ian, Huber, Thomas, Hume, David A., Kobe, Bostjan and Martin, Jennifer L. (2008). Cortactin adopts a globular conformation and bundles actin into sheets. The Journal of Biological Chemistry, 283 (23), 16187-16193. doi: 10.1074/jbc.M708917200

Cortactin adopts a globular conformation and bundles actin into sheets

2008

Journal Article

Cloning, expression, purification and characterization of a DsbA-like protein from Wolbachia pipientis

Kurz, Mareike, Iturbe-Ormaetxe, Inaki, Jarrott, Russell, Cowieson, Nathan, Robin, Gautier, Jones, Alun, King, Gordon J., Frei, Patrick, Glockshuber, Rudi, O'Neill, Scott L., Heras, Begona and Martin, Jennifer L. (2008). Cloning, expression, purification and characterization of a DsbA-like protein from Wolbachia pipientis. Protein Expression and Purification, 59 (2), 266-273. doi: 10.1016/j.pep.2008.02.008

Cloning, expression, purification and characterization of a DsbA-like protein from Wolbachia pipientis

2008

Journal Article

Evaluating protein: Protein complex formation using synchrotron radiation circular dichroism spectroscopy

Cowieson, Nathan P., Miles, Andrew J., Robin, Gautier, Forwood, Jade K., Kobe, Bostjan, Martin, Jennifer L. and Wallace, B. A. (2008). Evaluating protein: Protein complex formation using synchrotron radiation circular dichroism spectroscopy. Proteins: Structure Function Bioinformatics, 70 (4), 1142-1146. doi: 10.1002/prot.21631

Evaluating protein: Protein complex formation using synchrotron radiation circular dichroism spectroscopy

2008

Journal Article

Staphylococcus aureus DsbA does not have a destabilizing disulfide: A new paradigm for bacterial oxidative folding

Heras, Begona, Kurz, Mareike, Jarrott, Russell, Shouldice, Stephen R., Frei, Patrick, Robin, Gautier, Cemazar, Masa, Thony-Meyer, Linda, Glockshuber, Rudi and Martin, Jennifer L. (2008). Staphylococcus aureus DsbA does not have a destabilizing disulfide: A new paradigm for bacterial oxidative folding. The Journal of Biological Chemistry, 283 (7), 4261-4271. doi: 10.1074/jbc.M707838200

Staphylococcus aureus DsbA does not have a destabilizing disulfide: A new paradigm for bacterial oxidative folding

2008

Journal Article

Crystallization and preliminary diffraction analysis of a DsbA homologue from Wolbachia pipientis

Kurz, M., Iturbe-Ormaetxe, I., Jarrott, R., O'Neill, S. L., Byriel, K. A., Martin, J. L. and Heras, B. (2008). Crystallization and preliminary diffraction analysis of a DsbA homologue from Wolbachia pipientis. Acta Crystallographica. Section F, Structural Biology and Crystallization communications, 64 (part 2), 94-97. doi: 10.1107/S1744309108000055

Crystallization and preliminary diffraction analysis of a DsbA homologue from Wolbachia pipientis

2008

Journal Article

Crystal structures of highly constrained Substrate and Hydrolysis products bound to HIV-1 Protease. Implications for the Catalytic Mechanism

Tyndall, Joel D. A., Pattenden, Leonard K., Reid, Robert C., Hu, Shu-Hong, Alewood, Dianne, Alewood, Paul F., Walsh, Terry, Fairlie, David P. and Martin, Jennifer L. (2008). Crystal structures of highly constrained Substrate and Hydrolysis products bound to HIV-1 Protease. Implications for the Catalytic Mechanism. Biochemistry, 47 (12), 3736-3744. doi: 10.1021/bi7023157

Crystal structures of highly constrained Substrate and Hydrolysis products bound to HIV-1 Protease. Implications for the Catalytic Mechanism

Past funding

  • 2016
    Burkholderia pseudomallei disulfide-forming proteins: structure, function and inhibition (NHMRC Project Grant administered by Griffith University)
    Open grant
  • 2016
    Molecular dissection of the Munc18c:Syntaxin4 complex required for insulin-regulated exocytosis in adipocytes (NHMRC Project Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2016 - 2018
    DsbA inhibitors: from hits to leads
    NHMRC Project Grant
    Open grant
  • 2016
    Structure and function of human zinc transporter membrane proteins
    ARC Discovery Projects
    Open grant
  • 2015
    Protein Analysis Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    Unraveling the dynamic Munc18a:Syntaxin1 interaction required for neurotransmission
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Burkholderia pseudomallei disulfide-forming proteins: structure, function and inhibition
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Molecular dissection of the Munc18c:Syntaxin4 complex required for insulin-regulated exocytosis in adipocytes
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    Membrane proteins in innate immunity
    ARC Discovery Projects
    Open grant
  • 2012 - 2013
    Overcoming membrane protein research roadblocks: A Queensland facility for membrane protein production and crystallisation
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2012
    High- throughput Fourier Transform Infrared (FTIR) spectrometer.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2013
    Multi angle light scattering detector for the measurement of absolute molecular weight, size, and conformation of macromolecules in solution
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Auto-iTC200 microcalorimeter for high-throughput molecular interaction analyses
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011
    Freedom Evo 150 robotic worktable: Automated high throughput and long-time course spectrophotometric multiwell plate assay system
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Queensland International Fellowship: Membrane Protein Structure Techniques
    Queensland International Fellowships
    Open grant
  • 2010 - 2013
    Targeting virulence of Pseudomonas aeruginosa by inhibiting oxidative protein folding (ARC Linkage Project Grant, administered by Monash University)
    Monash University
    Open grant
  • 2010
    Combinatorial chemistry (high throughput synthesizer and purification system)
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    The development of peptides (mini-proteins) as drugs: improved purification capability
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2014
    Towards antibacterials without resistance
    ARC Australian Laureate Fellowships
    Open grant
  • 2009
    Characterization of the Munc 18c-Sx4 Complex
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2009 - 2013
    How the SNARE:SM machinery regulates glucose transport in fat cells
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Design and use of human hematopoietic prostaglandin D2 synthase inhibitors in allergic asthma and bone diseases
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    DsbA inhibitors as potential antimicrobials
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    Inhibitors Of West Nile Virus Protease As Antiviral Drugs
    NHMRC Project Grant
    Open grant
  • 2007 - 2011
    Macrophage proteins: structure, function and e-science
    ARC Discovery Projects
    Open grant
  • 2007 - 2015
    NHMRC Senior Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2006 - 2008
    Deciphering the molecular basis of SM regulation of exocytosis
    NHMRC Project Grant
    Open grant
  • 2006
    e-Research Infrastructure for the Molecular and Materials Structure Sciences
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2006 - 2008
    Innovative Approaches to Membrane Protein Crystallography & Drug Discovery
    ARC Discovery Projects
    Open grant
  • 2006
    Small Angle Scattering Facility for the Materials and Biological Sciences
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2008
    Enhancement of plant proteinase inhibitors for the protection of crop plants against insect attack
    ARC Linkage Projects
    Open grant
  • 2005
    A New Generation Biosensor and Fluorescence Facility for Proteomic
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2007
    Deciphering the molecular steps leading to the potentiation of neuronal exocytosis by arachidonic acid
    NHMRC Project Grant
    Open grant
  • 2004
    Structural biology of macromolecular assemblies as part of the visual cell program
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2004 - 2006
    Structure and function of novel macrophage proteins using high throughput crystallography
    ARC Discovery Projects
    Open grant
  • 2004
    The Australian Protease Network
    ARC Seed Funding for Research Networks
    Open grant
  • 2003
    Application for Support for Access to Major Research Facilities Program - Project title: Structural Studies on PNMT, Mouse Latexin, Insect Ferritin
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2003
    Dynamic Light Scattering Instrument
    NHMRC Equipment Grant
    Open grant
  • 2003 - 2005
    Investigating the structure, function and inhibition of the adrenaline-synthesizing enzyme PNMT
    ARC Discovery Projects
    Open grant
  • 2003 - 2004
    Structural studies on carbohydrate modifying enzymes
    ARC Linkage Projects
    Open grant
  • 2003
    Structural Studies on the Regulation of SNARE Proteins by Munc18c
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003 - 2005
    Structure, Function And Regulation Of Human Cytosolic Sulfotransferases
    NHMRC Project Grant
    Open grant
  • 2002
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for access to the Advanced Photon Source to visit BIOCARS
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2000
    Chromatography system for structural biology
    Ramaciotti Foundation
    Open grant
  • 2000 - 2002
    Design and development of inhibitors of the dengue virus protease as antiviral agents
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Structural studies on SNARE proteins involved in insulin action
    NHMRC Project Grant
    Open grant
  • 2000 - 2002
    Structural studies on the adrenaline-synthesising enzyme, PNMT
    ARC Australian Research Council (Large grants)
    Open grant
  • 1999 - 2000
    Structural determination of the protein folding factor CycY
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 1999 - 2003
    Applications of Protein Crystallography in Drug Design
    ARC Australian Senior Research Fellowships
    Open grant
  • 1999
    Expression and crystallization of SNARE proteins from adipocytes
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999 - 2001
    Protein Disulfide Exchange and Protein Folding in vivo: Structural Studies of Disulfide Oxidoreductases
    ARC Australian Research Council (Large grants)
    Open grant
  • 1999 - 2001
    Structural, Functional and Genetic Characterisation of Human Sulfotransferases
    NHMRC Project Grant
    Open grant
  • 1998
    Plant pyruvate phosphate dikinase and human aryl sulfotransferase 3
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 1997
    Structure-function studies on human phenylethanolamine N-methyltransferase
    UQ External Support Enabling Grant
    Open grant
  • 1996 - 1998
    Structural studies on purine phosphoribosyltransferases (PRTases)
    ARC Australian Research Council (Large grants)
    Open grant
  • 1996
    Structure determination by NMR of the disulfide-dithiol exchange protein TcpG
    ARC Australian Research Council (Small grants)
    Open grant
  • 1995 - 1997
    Structural studies on reduced DsbA and DsbA analogues
    ARC Australian Research Council (Large grants)
    Open grant
  • 1994 - 2006
    Design of inhibitors of epinephrine biosynthesis.
    University of Kansas
    Open grant

Availability

Emerita Professor Jenny Martin is:
Not available for supervision

Supervision history

Completed supervision

Enquiries

Contact Emerita Professor Jenny Martin directly for media enquiries about:

  • antibacterials
  • Antibiotic discovery
  • antibiotics
  • bacteria
  • bacterial infection
  • Crystallography - protein
  • diabetes
  • drug discovery
  • Enzyme inhibition
  • infection
  • inflammation
  • insulin
  • Protein crystallography
  • Protein function
  • Protein structure
  • Proteins
  • science policy
  • scientific leadership
  • superbugs
  • women in science

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