Reversible shielding to enhance mRNA manufacture and delivery (2026-2029)
Abstract
The manufacture of mRNA is a global priority, and rapid expansion of the mRNA industry has been enabled by advances in high-quality mRNA manufacture. However, current manufacturing methods produce mRNA that has low stability and poor delivery performance. This project aims to address these limitations by developing a new class of ultra-stable ¿cloaked¿ mRNAs (cmRNAs). Expected outcomes include cmRNAs with an improved synthetic workflow and precision control of cloaking. This synthetic strategy has the potential to transform the manufacture of mRNAs, increasing performance, stability and decreasing costs. The targeted delivery capability of the developed cmRNAs will also significantly expand the scope of applications of mRNA products.
