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2015 Journal Article Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.Shannon, A. E, Chappell, K. J., Stoermer, M. J., Chow, S. Y., Kok, W. M., Fairlie, D. P. and Young, P. R. (2015). Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.. Protein Expression and Purification, 119, 124-129. doi: 10.1016/j.pep.2015.11.022 |
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2015 Journal Article Viral bacterial co-infection of the respiratory tract during early childhoodBrealey, Jaelle C., Sly, Peter D., Young, Paul R. and Chappell, Keith J. (2015). Viral bacterial co-infection of the respiratory tract during early childhood. FEMS Microbiology Letters, 362 (10) fnv062. doi: 10.1093/femsle/fnv062 |
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2014 Book Chapter The nonstructural proteins of dengue virusChappell, Keith J. and Young, Paul R. (2014). The nonstructural proteins of dengue virus. Dengue and Dengue Hemorrhagic Fever: Second Edition. (pp. 377-405) edited by D. J. Gubler, Eng Eong Ooi, Subhash Vasudevan and Jeremy Farrar. Oxfordshire, United Kingdom: CABI International. doi: 10.1079/9781845939649.0377 |
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2013 Conference Publication Novel inhibitors of DENV NS2B/NS3pro proteaseChow, Shiao Yun, Stoermer, Martin J., Chappell, Keith J., Young, Paul R. and Fairlie, David P. (2013). Novel inhibitors of DENV NS2B/NS3pro protease. 246th National Meeting of the American-Chemical-Society (ACS), Indianapolis in, Sep 08-12, 2013. WASHINGTON: AMER CHEMICAL SOC. |
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2013 Journal Article Respiratory syncytial virus infection is associated with increased bacterial load in the upper respiratory tract in young childrenChappell, K.J., Brealey, J.C., Mackay, I.M., Bletchly, C., Hugenholtz, P., Sloots, T.P., Sly, P.D. and Young, P.R. (2013). Respiratory syncytial virus infection is associated with increased bacterial load in the upper respiratory tract in young children. Journal of Medical Microbiology & Diagnosis, S (1), 1-9. doi: 10.4172/2161-0703.S1-005 |
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2012 Journal Article Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical interventionMagro, Margarita, Mas, Vicente, Chappell, Keith, Vázquez, Mónica, Cano, Olga, Luque, Daniel, Terrón, María C., Melero, José A. and Palomo, Concepción (2012). Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical intervention. Proceedings of the National Academy of Sciences of USA, 109 (8), 3089-3094. doi: 10.1073/pnas.1115941109 |
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2010 Conference Publication Sneaking up on West Nile Virus NS2B/NS3 protease subcellular activity utilising dye-quenched substratesLiebscher, Susan, Chappell, K. J., Stoermer, Martin J., Watterson, Daniel, Webb, Richard I., Khromykh, Alexander A., Fairlie, David P. and Young, Paul R. (2010). Sneaking up on West Nile Virus NS2B/NS3 protease subcellular activity utilising dye-quenched substrates. PlusStrand 2010: The Ninth International Symposium on Positive-Strand RNA Viruses, Atlanta, GA, U.S.A., 17-21 May 2010. |
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2010 Conference Publication Potent inhibitors of West Nile Virus NS2B/NS3 proteaseChappell, K. J., Fairlie, D. P., Gan, C. H., Gupta, P. K., Hu, S., Jensen, C. M., Liebscher, S., Martin, J. L., Robin, G., Stoermer M. J., Xu, W. and Young, P. R. (2010). Potent inhibitors of West Nile Virus NS2B/NS3 protease. 6th General Meeting of the International Proteolysis Society, Gold Coast, QLD, Australia, 26-30 October 2009. Berlin, Germany: Walter De Gruyter. |
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2009 Journal Article Structure of West Nile virus NS3 protease: Ligand stabilization of the catalytic conformationRobin, Gautier, Chappell, Keith, Stoermer, Martin J., Hu, Shu-Hong, Young, Paul R., Fairlie, David P. and Martin, Jennifer L. (2009). Structure of West Nile virus NS3 protease: Ligand stabilization of the catalytic conformation. Journal of Molecular Biology, 385 (5), 1568-1577. doi: 10.1016/j.jmb.2008.11.026 |
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2009 Conference Publication Antiviral activity in cell culture of potent inhibitors targeting the West Nile Virus NS2B/NS3 proteaseLiebscher, S., Chappell, K.J., Stoermer, M.J., Fairlie, D.P. and Young, P.R (2009). Antiviral activity in cell culture of potent inhibitors targeting the West Nile Virus NS2B/NS3 protease. 6th General Meeting of the International Proteolysis Society, Gold Coast , QLD, Australia, 26-30 October, 2009. |
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2008 Journal Article West Nile Virus NS2B/NS3 protease as an antiviral targetChappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2008). West Nile Virus NS2B/NS3 protease as an antiviral target. Current Medicinal Chemistry, 15 (27), 2771-2784. doi: 10.2174/092986708786242804 |
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2008 Journal Article Potent cationic inhibitors of West Nile Virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activityStoermer, Martin J., Chappell, Keith J., Liebscher, Susann, Jensen, Christina M., Gan, Chun H., Gupta, Praveer K., Xu, Wei-Jun, Young, Paul R. and Fairlie, David P. (2008). Potent cationic inhibitors of West Nile Virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity. Journal of Medicinal Chemistry, 51 (18), 5714-5721. doi: 10.1021/jm800503y |
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2008 Journal Article Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activityChappell, Keith J., Stoermer, Martin J., Fairlie, David P. and Young, Paul R. (2008). Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity. Journal of General Virology, 89 (4), 1010-1014. doi: 10.1099/vir.0.83447-0 |
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2008 Journal Article A dual-purpose synthetic colloidal platform for protease mapping: substrate profiling for Dengue and West Nile virus proteasesMarcon, L., Kozak, D., Battersby, B.J., Chappell, K., Fairlie, D., Young, P.R. and Trau, M. (2008). A dual-purpose synthetic colloidal platform for protease mapping: substrate profiling for Dengue and West Nile virus proteases. Analytical Biochemistry, 2008 (376), 151-153. doi: 10.1016/j.ab.2008.01.034 |
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2007 Journal Article Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3Chappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2007). Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3. Protein Expression and Purification, 53 (1), 87-96. doi: 10.1016/j.pep.2006.10.022 |
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2007 Other Outputs Structure-function relationships of the West Nile Virus protease NS3 and its cofactor NS2BChappell, Keith Joseph (2007). Structure-function relationships of the West Nile Virus protease NS3 and its cofactor NS2B. PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland. doi: 10.14264/158576 |
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2006 Conference Publication Multiple targets for antiviral inhibitorsYoung, P. R., Chappell, K. J., Stoermer, M. J., Fairlie, D., Kampmann, T. and Kobe, B. (2006). Multiple targets for antiviral inhibitors. 7th Asia Pacific Congress of Virology, New Delhi, 13-15 Nov, 2006. |
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2006 Conference Publication Investigation of the West Nile virus NS3 protease by tandem use of site-directed mutagenesis and substrate modificationChappell, K. J., Stoermer, M J, Fairlie, D and Young, P R (2006). Investigation of the West Nile virus NS3 protease by tandem use of site-directed mutagenesis and substrate modification. Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, Qld, 2-6 July, 2006. |
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2006 Journal Article Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studiesChappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2006). Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies. Journal of Biological Chemistry, 281 (50), 38448-38458. doi: 10.1074/jbc.M607641200 |
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2005 Journal Article Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactionsChappell, Keith J., Nall, Tessa A., Stoermer, Martin J., Fang, Ning-Xia, Tyndall, Joel D. A., Fairlie, David P. and Young, Paul R. (2005). Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactions. Journal of Biological Chemistry, 280 (4), 2896-2903. doi: 10.1074/jbc.M409931200 |
