
Overview
Background
David Evans is an NHMRC Leadership Fellow and Professor of Statistical Genetics at the University of Queensland Institute for Molecular Bioscience. He is a winner of the NHMRC Marshall and Warren Award.
He completed his PhD in Statistical Genetics at the University of Queensland in 2003, before undertaking a four-year post-doctoral fellowship at the Wellcome Trust Centre for Human Genetics, University of Oxford where he worked as part of the The International HapMap Consortium and co-led the analysis of four diseases within the first Wellcome Trust Case Control Consortium. In 2007 he moved to take up a Senior Lecturer position at the University of Bristol where he led much of the genome-wide association studies work in the Avon Longitudinal Study of Parents and Children (ALSPAC). In 2013 he returned to take up a chair at the University of Queensland whilst continuing to lead an MRC Programme in statistical genetics at the University of Bristol.
His research interests include the genetic mapping of complex traits and diseases (including birthweight and other perinatal traits, osteoporosis, ankylosing spondylitis, sepsis, laterality) and the development of statistical methodologies in genetic epidemiology including approaches for gene mapping, individual risk prediction, causal modelling and dissecting the genetic architecture of complex traits. He has a particular interest in Mendelian randomization and has used it and other causal methods to investigate the Developmental Origins of Health and Disease (DOHaD)- the idea that adverse intrauterine exposures lead to increased risk of disease in later life.
He is Academic Codirector at the NIH funded International Workshop on Statistical Genetics Methods and is faculty on the European Programme in Educational Epidemiology.
He is Associate Editor at the International Journal of Epidemiology and Behavior Genetics journals.
Availability
- Professor David Evans is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Mendelian randomization
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Genome-wide association studies
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Causal Modeling
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Developmental Origins of Health and Disease (DOHaD)
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Laterality
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Sepsis
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Osteoporosis
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Ankylosing Spondylitis
Works
Search Professor David Evans’s works on UQ eSpace
2010
Journal Article
Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control
Ferreira, Mar, Mangino, M, Brumme, CJ, Zhao, ZZ, Medland, SE, Wright, MJ, Nyholt, DR, Gordon, S, Campbell, M, McEvoy, BP, Henders, A, Evans, DM, Lanchbury, JS, Pereyra, F, Walker, BD, Haas, DW, Soranzo, N, Spector, TD, de Bakker, PIW, Frazer, IH, Montgomery, GW, Martin, NG and Int HIV Controllers Study (2010). Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. American Journal of Human Genetics, 86 (1), 88-92. doi: 10.1016/j.ajhg.2009.12.008
2010
Journal Article
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
Freathy, Rachel M., Mook-Kanamor, Dennis O., Sovio, Ulla, Prokopenko, Inga, Timpson, Nicholas J., Berry, Diane J., Warrington, Nicole M., Widen, Elisabeth, Hottenga, Jouke Jan, Kaakinen, Marika, Lange, Leslie A., Bradfield, Jonathan P., Kerkhof, Marjan, Marsh, Julie A., Magi, Reedik, Chen, Chih-Mei, Lyon, Helen N., Kirin, Mirna, Adair, Linda S., Aulchenko, Yurii S., Bennett, Amanda J., Borja, Judith B., Bouatia-Naji, Nabila, Charoen, Pimphen, Coin, Lachlan ..J. M., Cousminer, Diana L., De Geus, Eco J. C., Deloukas, Panos, Elliott, Paul ... McCarthy, Mark I. (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42 (5), 430-435. doi: 10.1038/ng.567
2010
Journal Article
OPG and RANK polymorphisms are both associated with cortical bone mineral density: Findings from a metaanalysis of the avon longitudinal study of parents and children and Gothenburg osteoporosis and obesity determinants cohorts
Paternoster, L., Ohlsson, C., Sayers, A., Vandenput, L., Lorentzon, M., Evans, D. M. and Tobias, J. H. (2010). OPG and RANK polymorphisms are both associated with cortical bone mineral density: Findings from a metaanalysis of the avon longitudinal study of parents and children and Gothenburg osteoporosis and obesity determinants cohorts. Journal of Clinical Endocrinology and Metabolism, 95 (8), 3940-3948. doi: 10.1210/jc.2010-0025
2010
Journal Article
Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential Pleiotropic effects on bone
Paternoster, Lavinia, Lorentzon, Mattias, Vandenput, Liesbeth, Karlsson, Magnus K., Ljunggren, Osten, Kindmark, Andreas, Mellstrom, Dan, Kemp, John P., Jarett, Caroline E., Holly, Jeff M. P., Sayers, Adrian, St. Pourcain, Beate, Timpson, Nicholas J., Deloukas, Panos, Smith, George Davey, Ring, Ssusan M., Evans, David M., Tobias, Jon H. and Ohlsson, Claes (2010). Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential Pleiotropic effects on bone. PLoS Genetics, 6 (11) e1001217, e1001217.1-e1001217.12. doi: 10.1371/journal.pgen.1001217
2010
Journal Article
Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy
Bouzigon, Emmanuelle, Forabosco, Paola, Koppelman, Gerard H., Cookson, William O. C. M., Dizier, Marie-Helene, Duffy, David L., Evans, David M., Ferreira, Manuel A. R., Kere, Juha, Laitinen, Tarja, Malerba, Giovanni, Meyers, Deborah A., Moffatt, Miriam, Martin, Nicholas G, Ng, Mandy Y., Pignatti, Pier Franco, Wjst, Mathias, Kauffmann, Francine, Demenais, Florence and Lewis, Cathryn M. (2010). Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy. European Journal of Human Genetics, 18 (6), 700-706. doi: 10.1038/ejhg.2009.224
2010
Journal Article
Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals
Heid, Iris M., Henneman, Peter, Hicks, Andrew, Coassin, Stefan, Winkler, Thomas, Aulchenko, Yurii S., Fuchsberger, Christian, Song, Kijoung, Hivert, Marie-France, Waterworth, Dawn M., Timpson, Nicholas J., Richards, J. Brent, Perry, John R. B., Tanaka, Toshiko, Amin, Najaf, Kollerits, Barbara, Pichler, Irene, Oostra, Ben A., Thorand, Barbara, Frants, Rune R., Illig, Thomas, Dupuis, Josée, Glaser, Beate, Spector, Tim, Guralnik, Jack, Egan, Josephine M., Florez, Jose C., Evans, David M., Soranzo, Nicole ... van Duijn, Cornelia M. (2010). Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis, 208 (2), 412-420. doi: 10.1016/j.atherosclerosis.2009.11.035
2010
Journal Article
Triglyceride-mediated pathways and coronary disease: Collaborative analysis of 101 studies
Sarwar, N., Sandhu, M. S., Ricketts, S. L., Butterworth, Adam S., Di Angelantonio, Emanuele, Matthijs Boekholdt, S., Ouwehand, W., Watkins, H., Samani, N. J., Saleheen, D., Lawlor, Debbie, Reilly, Muredach P., Hingorani, A. D., Talmud, P. J., Danesh, J., Braund, P. S., Hall, A. S., Thompson, J., Marz, W., Trip, M., Lawlor, D. A., Casas, J. P., Ebrahim, S., Arsenault, B. J., Boekholdt, S. M., Khaw, K. T., Wareham, N. J., Grallert, H., Illig, T. ... Wood, A. M. (2010). Triglyceride-mediated pathways and coronary disease: Collaborative analysis of 101 studies. The Lancet, 375 (9726), 1634-1639. doi: 10.1016/S0140-6736(10)60545-4
2010
Journal Article
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy
Pillas, Demetris, Hoggart, Clive J., Evans, David M., O'Reilly, Paul F., Sipila, Kirsi, Lahdesmaki, Raija, Millwood, Iona Y., Kaakinen, Marika., Netuveli, Gopalakrishnan, Blane, David, Charoen, Pimphen, Sovio, Ulla, Pouta, Anneli, Freimer, Nelson, Hartikainen, Anna-Lisa., Laitinen, Jaana, Vaara, Sarianna, Glaser, Beate, Crawford, Peter, Timpson, Nicholas J., Ring, Susan M., Deng, Guohong, Zhang, Weihua, McCarthy, Mark I., Deloukas, Panos, Peltonen, Leena, Elliott, Paul, Coin, Lachlan J. M., Smith, George D. and Jarvelin, Marjo-Riita (2010). Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. PLoS Genetics, 6 (2) e1000856, e1000856.1-e1000856.7. doi: 10.1371/journal.pgen.1000856
2009
Journal Article
Leveraging therapeutic potential of multi-targeted siRNA inhibitors
Ge, Qing, Xu, John J., Evans, David M., Mixson, A. James, Yang, Harry Y. and Lu, Patrick Y. (2009). Leveraging therapeutic potential of multi-targeted siRNA inhibitors. Future Medicinal Chemistry, 1 (9), 1671-1681. doi: 10.4155/fmc.09.131
2009
Journal Article
Genome-wide association study identifies five loci associated with lung function
Repapi, E., Sayers, I., Wain, L. V., Burton, P. R., Johnson, T., Obeidat, M., Zhao, J. H., Ramasamy, A., Evans, David M., Wellcome Trust Case Control Consortium, Brown, Matthew A. and Bradbury, Linda (2009). Genome-wide association study identifies five loci associated with lung function. Nature Genetics, 42 (1), 36-45. doi: 10.1038/ng.501
2009
Journal Article
Investigating the genetic association between ERAP1 and ankylosing spondylitis
Harvey, David, Pointon, Jennifer J., Evans, David M., Karaderi, Tugce, Farrar, Claire, Appleton, Louise H., Sturrock, Roger D., Stone, Millicent A., Oppermann, Udo, Brown, Matthew A. and Wordsworth, B. Paul (2009). Investigating the genetic association between ERAP1 and ankylosing spondylitis. Human Molecular Genetics, 18 (21), 4204-4212. doi: 10.1093/hmg/ddp371
2009
Journal Article
Genetic Variant m <i>HK1</i> Is Associated With a Proanemic State and A1C but Not Other Glycemic Control-Related Traits
Bonnefond, Amelie, Vaxillaire, Martine, Labrune, Yann, Lecoeur, Cecile, Chevre, Jean-Claude, Bouatia-Naji, Nabila, Cauchi, Stephane, Balkau, Beverley, Marre, Michel, Tichet, Jean, Riveline, Jean-Pierre, Hadjadj, Samy, Gallois, Yves, Czernichow, Sebastien, Hercberg, Serge, Kaakinen, Marika, Wiesner, Susanne, Charpentier, Guillaume, Levy-Marchal, Claire, Elliott, Paul, Jarvelin, Marjo-Riitta, Horber, Fritz, Dina, Christian, Pedersen, Oluf, Sladek, Robert, Meyre, David and Froguel, Philippe (2009). Genetic Variant m HK1 Is Associated With a Proanemic State and A1C but Not Other Glycemic Control-Related Traits. Diabetes, 58 (11), 2687-2697. doi: 10.2337/db09-0652
2009
Journal Article
Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume
Ferreira, MAR, Hottenga, JJ, Warrington, NM, Medland, SE, Willemsen, G, Lawrence, RW, Gordon, S, de Geus, EJC, Henders, AK, Smit, JH, Campbell, MJ, Wallace, L, Evans, DM, Wright, MJ, Nyholt, DR, James, AL, Beilby, JP, Penninx, BW, Palmer, LJ, Frazer, IH, Montgomery, GW, Martin, NG and Boomsma, DI (2009). Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume. AMERICAN JOURNAL OF HUMAN GENETICS, 85 (5), 745-749. doi: 10.1016/j.ajhg.2009.10.005
2009
Journal Article
Association and interaction analyses of eight genes under asthma linkage peaks
Ferreira, M. A. R., Zhao, Z. Z., Thomsen, S. F., James, M., Evans, D. M., Postmus, P. E., Kyvik, K. O., Backer, V., Boomsma, D. I., Martin, N. G., Montgomery, G. W. and Duffy, D. L. (2009). Association and interaction analyses of eight genes under asthma linkage peaks. Allergy, 64 (11), 1623-1628. doi: 10.1111/j.1398-9995.2009.02091.x
2009
Journal Article
Genetic variant near <i>IRS1</i> is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
Rung, Johan, Cauchi, Stephane, Albrechtsen, Anders, Shen, Lishuang, Rocheleau, Ghislain, Cavalcanti-Proenca, Christine, Bacot, Francois, Balkau, Beverley, Belisle, Alexandre, Borch-Johnsen, Knut, Charpentier, Guillaume, Dina, Christian, Durand, Emmanuelle, Elliott, Paul, Hadjadj, Samy, Jaervelin, Marjo-Riitta, Laitinen, Jaana, Lauritzen, Torsten, Marre, Michel, Mazur, Alexander, Meyre, David, Montpetit, Alexandre, Pisinger, Charlotta, Posner, Barry, Poulsen, Pernille, Pouta, Anneli, Prentki, Marc, Ribel-Madsen, Rasmus, Ruokonen, Aimo ... Sladek, Robert (2009). Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nature Genetics, 41 (10), 1110-U89. doi: 10.1038/ng.443
2009
Journal Article
Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population
Pimentel-Santos, F. M., Ligeiro, D., Matos, M., Mourao, A. F., Sousa, E., Pinto, P., Ribeiro, A., Sousa, M., Barcelos, A., Godinho, F., Cruz, M., Fonseca, J. E., Guedes-Pinto, H., Trindade, H., Evans, D. M., Brown, M. A. and Branco, J. C. (2009). Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population. Clinical And Experimental Rheumatology, 27 (5), 800-806.
2009
Journal Article
Genome-wide association study identifies eight loci associated with blood pressure.
Newton-Chen, C., Johnson, T., Gateva, V., Tobin, M. D., Bochud, M., Coin, L., Najjar, S. S., Zhao, J. H., et al, Wellcome Trust Case Control Consortium, Brown, Matthew A., Bradbury, Linda and Evans, David (2009). Genome-wide association study identifies eight loci associated with blood pressure.. Nature Genetics, 41 (6), 666-676. doi: 10.1038/ng.361
2009
Journal Article
Combined effects of <i>MC4R</i> and <i>FTO</i> common genetic variants on obesity in European general populations
Cauchi, Stephane, Stutzmann, Fanny, Cavalcanti-Proenca, Christine, Durand, Emmanuelle, Pouta, Anneli, Hartikainen, Anna-Liisa, Marre, Michel, Vol, Sylviane, Tammelin, Tuija, Laitinen, Jaana, Gonzalez-Izquierdo, Arturo, Blakemore, Alexandra I. F., Elliott, Paul, Meyre, David, Balkau, Beverley, Jaervelin, Marjo-Riitta and Froguel, Philippe (2009). Combined effects of MC4R and FTO common genetic variants on obesity in European general populations. Journal of Molecular Medicine-Jmm, 87 (5), 537-546. doi: 10.1007/s00109-009-0451-6
2009
Journal Article
Common variants in the region around Osterix are associated with bone mineral density and growth in childhood
Timpson, Nicholas J., Tobias, Jon H., Richards, J. Brent, Soranzo, Nicole, Duncan, Emma L., Sims, Anne-Maree, Whittaker, Pamela, Kumanduri, Vasudev, Zhai, Guangju, Glaser, Beate, Eisman, John, Jones, Graeme, Nicholson, Geoff, Prince, Richard, Seeman, Ego, Spector, Tim D., Brown, Matthew A., Peltonen, Leena, Smith, George Davey, Deloukas, Panos and Evans, David M. (2009). Common variants in the region around Osterix are associated with bone mineral density and growth in childhood. Human Molecular Genetics, 18 (8), 1510-1517. doi: 10.1093/hmg/ddp052
2009
Journal Article
Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk
Evans, David M., Visscher, Peter M. and Wray, Naomi R. (2009). Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk. Human Molecular Genetics, 18 (18), 3525-3531. doi: 10.1093/hmg/ddp295
Funding
Current funding
Supervision
Availability
- Professor David Evans is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Sometimes Correlation does Equal Causation: Developing Statistical Methods to Determine Causality Using Genetic Data
There is a well-known mantra that correlation does not necessarily equal causation. This is why randomized controlled trials in which participants are physically randomized into treatment and placebo groups are the gold standard for assessing causality in epidemiological investigations. However, what is less appreciated is that strong evidence for causality can sometimes be obtained using observational data only. In particular, genotypes are randomly transmitted from parents to their offspring independent of the environment and other confounding factors, meaning that genotypes associated with particular traits can be used like natural “randomized controlled trials” to examine whether these traits causally affect risk of disease.
The aim of this PhD project is to develop statistical methods to assess causality using observational data alone. The successful candidate will gain experience across a wide range of advanced statistical genetics methodologies including Mendelian randomization (a way of using genetic variants to investigate putatively causal relationships), structural equation modelling, genome-wide association analysis (GWAS), genetic restricted maximum likelihood (G-REML) analysis of genome-wide data which can be used to partition variation in phenotypes into genetic and environmental sources of variation, and instrumental variables analysis (using natural “experiments” to obtain information on causality from observational data). The candidate will apply the new statistical methods that they develop to large genetically informative datasets like the UK Biobank (500,000 individuals with genome-wide SNP data).
Supervision history
Current supervision
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Doctor Philosophy
Developing and Applying Statistical Genetics Methods to Elucidate the Developmental Origins of Health and Disease
Principal Advisor
Other advisors: Dr Nicole Warrington
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Doctor Philosophy
Investigating the association between maternal and fetal HLA-KIR genotypes and offspring birth weight
Principal Advisor
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Doctor Philosophy
Understanding the genetic epidemiology of women's reproductive health
Principal Advisor
Other advisors: Dr Gunn-Helen Moen
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Doctor Philosophy
Using genetics to predict drug efficacy and on-target side effects of pharmacological agents
Principal Advisor
Other advisors: Professor Glenn King, Associate Professor Sonia Shah
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Doctor Philosophy
Harnessing Genetically Informative Within-Family Research Designs for Deeper Insights into the Intrauterine Developmental Period and Downstream Effects on Offspring Neurodevelopmental Outcomes
Principal Advisor
Other advisors: Dr Daniel Hwang, Dr Gunn-Helen Moen
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Doctor Philosophy
Multi-omic Approaches to Understanding Septic Shock
Principal Advisor
Other advisors: Dr Daniel Hwang
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Doctor Philosophy
Multi-omic Approaches to Understanding Septic Shock
Principal Advisor
Other advisors: Dr Daniel Hwang
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Doctor Philosophy
Using multi-omics approaches to characterise determinants of early growth trajectories and their consequences on later life health
Associate Advisor
Other advisors: Honorary Professor Jake Gratten, Dr Nicole Warrington
Completed supervision
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2024
Doctor Philosophy
Using genetics to investigate the interplay of maternal and fetal factors in pregnancy outcomes
Principal Advisor
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2024
Doctor Philosophy
Harnessing Genetically Informative Within-Family Research Designs for Deeper Insights into the Intrauterine Developmental Period and Downstream Effects on Offspring Neurodevelopmental Outcomes
Principal Advisor
Other advisors: Dr Daniel Hwang, Dr Gunn-Helen Moen
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2023
Doctor Philosophy
Using Genetics to Understand the Relationship Between the Intrauterine Environment and Future Offspring Cardiometabolic Risk
Principal Advisor
Other advisors: Dr Nicole Warrington
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2019
Doctor Philosophy
Detecting and Quantifying the Effect of Assortative mating and Maternal Effects on Statistical Genetics Analyses
Principal Advisor
Other advisors: Dr Nicole Warrington
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Media
Enquiries
Contact Professor David Evans directly for media enquiries about:
- Genetics
- Genome-wide association
- Mendelian randomization
- Twin Studies
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