Understanding neuronal fusion in nervous system development and remodelling (2025-2027)

Neuronal self-fusion, that is, the merging of separate sections of an individual neuron, is a poorly understood biological process. Yet, self-fusion is known to occur in multiple animal species during the development, remodelling, and repair of the nervous system. This project aims to define how developmentally regulated self-fusion occurs in the nervous system, the molecules that mediate this process, and its importance for neuronal function. Expected outcomes include new knowledge on the process of neuronal self-fusion. These findings should provide significant benefits by offering novel insights into nervous system function, and thereby positioning Australia at the intellectual forefront of this innovative and fervent area of research.