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2025 Journal Article Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapyEdiriweera, Gayathri R., Sivaram, Amal J., Cowin, Gary, Brown, Mikayla L., McAlary, Luke, Lum, Jeremy S., Fletcher, Nicholas L., Robinson, Liam, Simpson, Joshua D., Chen, Liyu, Wasielewska, Joanna M., Byrne, Ella, Finnie, John W., Manavis, Jim, White, Anthony R., Yerbury, Justin J., Thurecht, Kristofer J. and Vine, Kara L. (2025). Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy. Journal of Controlled Release, 378, 221-235. doi: 10.1016/j.jconrel.2024.11.074 |
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2024 Journal Article Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binderChen, Liyu, Song, Jae, Richter-Stretton, Gina, Lee, Wendy, Padmanabhan, Pranesh and Götz, Jürgen (2024). Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder. Nanotheranostics, 8 (4), 427-441. doi: 10.7150/ntno.95146 |
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2022 Journal Article Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasoundChen, Liyu, Cruz, Esteban, Oikari, Lotta E., Padmanabhan, Pranesh, Song, Jae and Götz, Jürgen (2022). Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound. Advanced Drug Delivery Reviews, 189 114517, 1-18. doi: 10.1016/j.addr.2022.114517 |
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2022 Journal Article A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodiesWasielewska, Joanna M., Chaves, Juliana C.S., Johnston, Rebecca L., Milton, Laura A., Hernández, Damián, Chen, Liyu, Song, Jae, Lee, Wendy, Leinenga, Gerhard, Nisbet, Rebecca M., Pébay, Alice, Götz, Jürgen, White, Anthony R. and Oikari, Lotta E. (2022). A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies. Theranostics, 12 (16), 6826-6847. doi: 10.7150/thno.72685 |
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2022 Journal Article Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier modelChen, Liyu, Sutharsan, Ratneswary, Lee, Jonathan L. F., Cruz, Esteban, Asnicar, Blaise, Palliyaguru, Tishila, Wasielewska, Joanna M., Gaudin, Arnaud, Song, Jae, Leinenga, Gerhard and Götz, Jürgen (2022). Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics, 12 (5), 1952-1970. doi: 10.7150/thno.65539 |
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2021 Journal Article Non-viral vector-mediated gene therapy for ALS: challenges and future perspectivesEdiriweera, Gayathri R., Chen, Liyu, Yerbury, Justin J., Thurecht, Kristofer J. and Vine, Kara L. (2021). Non-viral vector-mediated gene therapy for ALS: challenges and future perspectives. Molecular Pharmaceutics, 18 (6), 2142-2160. doi: 10.1021/acs.molpharmaceut.1c00297 |
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2019 Journal Article The blood-brain barrier: physiology and strategies for drug deliveryPandit, Rucha, Chen, Liyu and Götz, Jürgen (2019). The blood-brain barrier: physiology and strategies for drug delivery. Advanced Drug Delivery Reviews, 165-166, 1-14. doi: 10.1016/j.addr.2019.11.009 |
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2018 Journal Article Influence of Charge on Hemocompatibility and Immunoreactivity of Polymeric NanoparticlesChen, Liyu, Glass, Joshua J., De Rose, Robert, Sperling, Claudia, Kent, Stephen J., Houston, Zachary H., Fletcher, Nicholas L., Rolfe, Barbara E. and Thurecht, Kristofer J. (2018). Influence of Charge on Hemocompatibility and Immunoreactivity of Polymeric Nanoparticles. ACS Applied Bio Materials, 1 (3) acsabm.8b00220, 756-767. doi: 10.1021/acsabm.8b00220 |
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2017 Journal Article Effects of Surface Charge of Hyperbranched Polymers on Cytotoxicity, Dynamic Cellular Uptake and Localization, Hemotoxicity, and Pharmacokinetics in MiceChen, Liyu, Simpson, Joshua D, Fuchs, Adrian V, Rolfe, Barbara E and Thurecht, Kristofer J (2017). Effects of Surface Charge of Hyperbranched Polymers on Cytotoxicity, Dynamic Cellular Uptake and Localization, Hemotoxicity, and Pharmacokinetics in Mice. Molecular pharmaceutics, 14 (12), 4485-4497. doi: 10.1021/acs.molpharmaceut.7b00611 |
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2017 Journal Article Using peptide aptamer targeted polymers as a model nanomedicine for investigating drug distribution in cancer nanotheranosticsZhao, Yongmei, Houston, Zachary H., Simpson, Joshua D., Chen, Liyu, Fletcher, Nicholas L., Fuchs, Adrian V., Blakey, Idriss and Thurecht, Kristofer J. (2017). Using peptide aptamer targeted polymers as a model nanomedicine for investigating drug distribution in cancer nanotheranostics. Molecular Pharmaceutics, 14 (10), 3539-3549. doi: 10.1021/acs.molpharmaceut.7b00560 |
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2017 Journal Article Improving the delivery of SOD1 antisense oligonucleotides to motor neurons using calcium phosphate-lipid nanoparticleChen, Liyu, Watson, Clare, Morsch, Marco, Cole, Nicholas J., Chung, Roger S., Saunders, Darren N., Yerbury, Justin J. and Vine, Kara L. (2017). Improving the delivery of SOD1 antisense oligonucleotides to motor neurons using calcium phosphate-lipid nanoparticle. Frontiers in Neuroscience, 11 (AUG) 476, 476. doi: 10.3389/fnins.2017.00476 |
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2017 Journal Article Charge has a marked influence on hyperbranched polymer nanoparticle association in whole human bloodGlass, Joshua J., Chen, Liyu, Alcantara, Sheilajen, Crampin, Edmund J., Thurecht, Kristofer J., De Rose, Robert and Kent, Stephen J. (2017). Charge has a marked influence on hyperbranched polymer nanoparticle association in whole human blood. ACS Macro Letters, 6 (6), 586-592. doi: 10.1021/acsmacrolett.7b00229 |
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2016 Other Outputs Physiological response to polymeric materials in nanomedicineChen, Liyu (2016). Physiological response to polymeric materials in nanomedicine. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/uql.2016.994 |
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2013 Journal Article Vesicular phospholipid gels using low concentrations of phospholipids for the sustained release of thymopentin: Pharmacokinetics and pharmacodynamicsZhong, Ying, Chen, Liyu, Zhang, Yu, Li, Wenhao, Sun, Xun, Gong, Tao and Zhang, Zhirong (2013). Vesicular phospholipid gels using low concentrations of phospholipids for the sustained release of thymopentin: Pharmacokinetics and pharmacodynamics. Pharmazie, 68 (10), 811-815. doi: 10.1691/ph.2013.3008 |
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2012 Journal Article Novel brain targeting prodrugs of naproxen based on dimethylamino group with various linkagesZhang, Q., Liang, Z., Chen, L. Y., Sun, X., Gong, T. and Zhang, Z. R. (2012). Novel brain targeting prodrugs of naproxen based on dimethylamino group with various linkages. Arzneimittel-Forschung/Drug Research, 62 (6), 261-266. doi: 10.1055/s-0032-1306273 |
