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2016 Journal Article Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peakWinkler, Ingrid G., Wiercinska, Eliza, Barbier, Valerie, Nowlan, Bianca, Bonig, Halvard and Levesque, Jean-Pierre (2016). Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peak. Experimental Hematology, 44 (4), 303-314.e1. doi: 10.1016/j.exphem.2016.01.001 |
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2016 Journal Article Fms-like tyrosine kinase 3 (Flt3) ligand depletes erythroid island macrophages and blocks medullar erythropoiesis in the mouseJacobsen, Rebecca N., Nowlan, Bianca, Brunck, Marion E., Barbier, Valerie, Winkler, Ingrid G. and Levesque, Jean-Pierre (2016). Fms-like tyrosine kinase 3 (Flt3) ligand depletes erythroid island macrophages and blocks medullar erythropoiesis in the mouse. Experimental Hematology, 44 (3), 207-212.e4. doi: 10.1016/j.exphem.2015.11.004 |
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2015 Journal Article Tissue engineered humanized bone supports human hematopoiesis in vivoHolzapfel, Boris M., Hutmacher, Dietmar W., Nowlan, Bianca, Barbier, Valerie, Thibaudeau, Laure, Theodoropoulos, Christina, Hooper, John D., Loessner, Daniela, Clements, Judith A., Russell, Pamela J., Pettit, Allison R., Winkler, Ingrid G. and Levesque, Jean-Pierre (2015). Tissue engineered humanized bone supports human hematopoiesis in vivo. Biomaterials, 61, 103-114. doi: 10.1016/j.biomaterials.2015.04.057 |
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2015 Journal Article Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscleGenet, Francois, Kulina, Irina, Vaquette, Cedryck, Torossian, Frederic, Millard, Susan, Pettit, Allison R., Sims, Natalie A., Anginot, Adrienne, Guerton, Bernadette, Winkler, Ingrid G., Barbier, Valerie, Lataillade, Jean-Jacques, Le Bousse-Kerdiles, Marie-Caroline, Hutmacher, Dietmar W. and Levesque, Jean-Pierre (2015). Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle. Journal of Pathology, 236 (2), 229-240. doi: 10.1002/path.4519 |
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2015 Journal Article Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AMLForristal, C. E., Brown, A. L., Helwani, F. M., Winkler, I. G., Nowlan, B., Barbier, V., Powell, R. J., Engler, G. A., Diakiw, S. M., Zannettino, A. C. W., Martin, S., Pattabiraman, D., D'Andrea, R. J., Lewis, I. D. and Levesque, J. P. (2015). Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia, 29 (10), 2075-2085. doi: 10.1038/leu.2015.102 |
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2015 Journal Article HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1αForristal, C. E., Nowlan, B., Jacobsen, R. N., Barbier, V., Walkinshaw, G., Walkley, C. R., Winkler, I. G. and Levesque, J. P. (2015). HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α. Leukemia, 29 (6), 1366-1378. doi: 10.1038/leu.2015.8 |
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2014 Journal Article Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages in the mouseJacobsen, Rebecca N., Forristal, Catherine E., Raggatt, Liza J., Nowlan, Bianca, Barbier, Valerie, Kaur, Simranpreet, van Rooijen, Nico, Winkler, Ingrid G., Pettit, Allison R. and Levesque, Jean-Pierre (2014). Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages in the mouse. Experimental Hematology, 42 (7), 547-561. doi: 10.1016/j.exphem.2014.03.009 |
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2014 Journal Article Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenesPattabiraman, Diwakar R., McGirr, Crystal, Shakhbazov, Konstantin, Barbier, Valerie, Krishnan, Keerthana, Mukhopadhyay, Pamela, Hawthorne, Paula, Trezise, Ann, Ding, Jianmin, Grimmond, Sean M., Papathanasiou, Peter, Alexander, Warren S., Perkins, Andrew C., Levesque, Jean-Pierre, Winkler, Ingrid G. and Gonda, Thomas J. (2014). Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes. Blood, 123 (17), 2682-2690. doi: 10.1182/blood-2012-02-413187 |
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2013 Journal Article A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicityOancea, Iulia, Png, Chin Wen, Das, Indrajit, Lourie, Rohan, Winkler, Ingrid G., Eri, Rajaraman, Subramaniam, Nathan, Jinnah, H. A., McWhinney, Brett C., Levesque, Jean-Pierre, McGuckin, Michael A., Duley, John A. and Florin, Timothy H. J. (2013). A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity. Gut, 62 (4), 594-605. doi: 10.1136/gutjnl-2012-302274 |
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2013 Journal Article Nichotherapy for stem cells: there goes the neighborhoodLevesque, Jean-Pierre, Winkler, Ingrid G. and Rasko, John E. J. (2013). Nichotherapy for stem cells: there goes the neighborhood. BioEssays, 35 (3), 183-190. doi: 10.1002/bies.201200111 |
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2013 Journal Article B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2Winkler, Ingrid G., Bendall, Linda J., Forristal, Catherine E., Helwani, Falak, Nowlan, Bianca, Barbier, Valerie, Shen, Yi, Cisterne, Adam, Sedger, Lisa M. and Levesque, Jean-Pierre (2013). B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2. Haematologica, 98 (3), 325-333. doi: 10.3324/haematol.2012.069260 |
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2013 Journal Article Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiationForristal, Catherine E., Winkler, Ingrid G., Nowlan, Bianca, Barbier, Valerie, Walkinshaw, Gail and Levesque, Jean-Pierre (2013). Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation. Blood, 121 (5), 759-769. doi: 10.1182/blood-2012-02-408419 |
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2013 Journal Article E-selectin, a key regulator of the division of hematopoietic stem cells and their resistance to chemotherapyLevesque, Jean-Pierre and Winkler, Ingrid G. (2013). E-selectin, a key regulator of the division of hematopoietic stem cells and their resistance to chemotherapy. Medecine/Sciences, 29 (3), 249-251. doi: 10.1051/medsci/2013293007 |
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2012 Journal Article Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistanceWinkler, Ingrid G., Barbier, Valerie, Nowlan, Bianca, Jacobsen, Rebecca N., Forristal, Catherine E., Patton, John T., Magnani, John L. and Levesque, Jean-Pierre (2012). Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nature Medicine, 18 (11), 1651-1657. doi: 10.1038/nm.2969 |
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2012 Journal Article Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formationWinkler, I. G., Pettit, A. R., Raggatt, L. J., Jacobsen, R. N., Forristal, C. E., Barbier, V., Nowlan, B., Cisterne, A., Bendall, L. J., Sims, N. A. and Levesque, J-P. (2012). Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation. Leukemia, 26 (7), 1594-1601. doi: 10.1038/leu.2012.17 |
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2011 Journal Article Mobilisation strategies for normal and malignant cellsTo, L. Bik, Levesque, Jean-Pierre, Herbert, Kirsten E., Winkler, Ingrid G., Bendall, Linda J., Hiwase, Devendra K., Antonenas, Vicki, Rice, Alison M., Gottlieb, David, Mills, Anthony K., Rasko, John E. J., Larsen, Stephen, Beligaswatte, Ashanka, Nilsson, Susan K., Cooney, Julian P., Cambareri, Antony C. and Lewis, Ian D. (2011). Mobilisation strategies for normal and malignant cells. Pathology, 43 (6), 547-565. doi: 10.1097/PAT.0b013e32834a9eb8 |
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2011 Journal Article Hierarchy of immature hematopoietic cells related to blood flow and nicheLevesque, Jean-Pierre and Winkler, Ingrid G. (2011). Hierarchy of immature hematopoietic cells related to blood flow and niche. Current Opinion in Hematology, 18 (4), 220-225. doi: 10.1097/MOH.0b013e3283475fe7 |
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2010 Journal Article Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCsWinkler, Ingrid G., Sims, Natalie A., Pettit, Allison R., Barbier, Valérie, Nowlan, Bianca, Helwani, Falak, Poulton, Ingrid J., van Rooijen, Nico van, Alexander, Kylie A., Raggatt, Liza J. and Levesque, Jean-Pierre (2010). Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood, 116 (23), 4815-4828. doi: 10.1182/blood-2009-11-253534 |
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2010 Journal Article Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivoShen, Yi, Winkler, Ingrid G., Barbier, Valerie, Sims, Natalie A., Hendy, Jean and Lévesque, Jean-Pierre (2010). Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo. PLoS One, 5 (9) e13086, e13086-1-e13086-13. doi: 10.1371/journal.pone.0013086 |
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2010 Journal Article Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: Serially reconstituting hematopoietic stem cells reside in distinct nonperfused nichesWinkler, Ingrid G., Barbier, Valérie, Wadley, Robert, Zannettino, Andrew C. W., Williams, Sharon and Lévesque, Jean-Pierre (2010). Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: Serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches. Blood, 116 (3), 375-385. doi: 10.1182/blood-2009-07-233437 |
