Overview
Availability
- Ms Weixi Gu is:
- Available for supervision
Qualifications
- Masters (Coursework), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Weixi Gu’s works on UQ eSpace
2025
Conference Publication
Development of 3DED/MicroED Facility at the University of Queensland
Arachchige, Kasun. S. Athukorala, Koifman, Na’ama, Floetenmeyer, Matthias, Clegg, Jack K., Gu, Weixi, Kobe, Bostjan, Xu, Hongyi and Wepf, Roger (2025). Development of 3DED/MicroED Facility at the University of Queensland. 13th Asia Pacific Microscopy Congress 2025 (APMC13), Brisbane, QLD Australia, 2-7 Febuary 2025. Lexington, MA United States: ScienceOpen. doi: 10.14293/apmc13-2025-0350
2024
Journal Article
Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly
Li, Y., Pacoste, L. C., Gu, W., Thygesen, S. J., Stacey, K. J., Ve, T., Kobe, B., Xu, H. and Nanson, J. D. (2024). Microcrystal electron diffraction structure of Toll-like receptor 2 TIR-domain-nucleated MyD88 TIR-domain higher-order assembly. Acta Crystallographica Section D Structural Biology, 80 (9), 699-712. doi: 10.1107/s2059798324008210
2024
Journal Article
Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches
Bhatt, Akansha, Mishra, Biswa P., Gu, Weixi, Sorbello, Mitchell, Xu, Hongyi, Ve, Thomas and Kobe, Bostjan (2024). Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches. IUCrJ, 11 (5), 695-707. doi: 10.1107/s2052252524007693
2024
Journal Article
SARM1-dependent axon degeneration: nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities
McGuinness, Helen Y., Gu, Weixi, Shi, Yun, Kobe, Bostjan and Ve, Thomas (2024). SARM1-dependent axon degeneration: nucleotide signaling, neurodegenerative disorders, toxicity, and therapeutic opportunities. The Neuroscientist, 30 (4), 473-492. doi: 10.1177/10738584231162508
2024
Journal Article
Structural characterization of macro domain–containing Thoeris antiphage defense systems
Shi, Yun, Masic, Veronika, Mosaiab, Tamim, Rajaratman, Premraj, Hartley-Tassell, Lauren, Sorbello, Mitchell, Goulart, Cassia C., Vasquez, Eduardo, Mishra, Biswa P., Holt, Stephanie, Gu, Weixi, Kobe, Bostjan and Ve, Thomas (2024). Structural characterization of macro domain–containing Thoeris antiphage defense systems. Science Advances, 10 (26) eadn3310, eadn3310. doi: 10.1126/sciadv.adn3310
2023
Conference Publication
Allosteric regulation of SARM1, the executioner of axon degeneration
Gu, W., Luo, Z., Nanson, J. D., Ve, T. and Kobe, B. (2023). Allosteric regulation of SARM1, the executioner of axon degeneration. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323089398
2023
Conference Publication
Structural basis for activation and inhibition of the pro-neurodegenerative NADase SARM1
Shi, Y., Nanson, J., Gu, W., Masic, V., Mosaiab, T., Landsberg, M., Kobe, B. and Ve, T. (2023). Structural basis for activation and inhibition of the pro-neurodegenerative NADase SARM1. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323087776
2023
Conference Publication
Structural evolution of TIR-domain signalosomes in mammalian, plant and bacterial immunity characterized by integrative structural biology
Kobe, Bostjan, Nanson, Jeffrey D., Manik, Mohammad K., Li, Sulin, Gu, Weixi, Pan, Mengqi, Li, Yan, Muusse, Timothy W., Vajjhala, Parimala R, Stacey, Katryn J., Holmes, Susannah, Darmanin, Connie, Clabbers, Max T. B., Xu, Hongyi, Shi, Yun and Ve, Thomas (2023). Structural evolution of TIR-domain signalosomes in mammalian, plant and bacterial immunity characterized by integrative structural biology. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323093658
2023
Conference Publication
Characterisation of Axundead, a novel downstream regulator of Wallerian degeneration
McGuinness, Helen Ying, Rosell, Arnau Llobert, Gu, Weixi, Nanson, Jeffrey, Ve, Thomas and Kobe, Bostjan (2023). Characterisation of Axundead, a novel downstream regulator of Wallerian degeneration. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323087661
2023
Conference Publication
Structural basis of an anti-cancer biological warhead bound to its target CDCP1 for the diagnosis and treatment of epithelial cancers
Kwah, Kayden, Gu, Weixi, Arachchige, Kasun S. A., He, Yaowu, Landsberg, Michael, Kobe, Bostjan and Hooper, John (2023). Structural basis of an anti-cancer biological warhead bound to its target CDCP1 for the diagnosis and treatment of epithelial cancers. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323084449
2023
Conference Publication
Development of 3D-ED/MicroED facility at the University of Queensland
Arachchige, K. S. A., Koifman, N., Gu, W., Kobe, B., Clegg, J. K., Xu, H. and Wepf, R. (2023). Development of 3D-ED/MicroED facility at the University of Queensland. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086461
2022
Journal Article
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling
Manik, Mohammad K., Shi, Yun, Li, Sulin, Zaydman, Mark A., Damaraju, Neha, Eastman, Samuel, Smith, Thomas G., Gu, Weixi, Masic, Veronika, Mosaiab, Tamim, Weagley, James S., Hancock, Steven J., Vasquez, Eduardo, Hartley-Tassell, Lauren, Kargios, Nestoras, Maruta, Natsumi, Lim, Bryan Y. J., Burdett, Hayden, Landsberg, Michael J., Schembri, Mark A., Prokes, Ivan, Song, Lijiang, Grant, Murray, DiAntonio, Aaron, Nanson, Jeffrey D., Guo, Ming, Milbrandt, Jeffrey, Ve, Thomas and Kobe, Bostjan (2022). Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. Science, 377 (6614) eadc8969, 1-11. doi: 10.1126/science.adc8969
2022
Journal Article
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules
Shi, Yun, Kerry, Philip S., Nanson, Jeffrey D., Bosanac, Todd, Sasaki, Yo, Krauss, Raul, Saikot, Forhad K., Adams, Sarah E., Mosaiab, Tamim, Masic, Veronika, Mao, Xianrong, Rose, Faith, Vasquez, Eduardo, Furrer, Marieke, Cunnea, Katie, Brearley, Andrew, Gu, Weixi, Luo, Zhenyao, Brillault, Lou, Landsberg, Michael J., DiAntonio, Aaron, Kobe, Bostjan, Milbrandt, Jeffrey, Hughes, Robert O. and Ve, Thomas (2022). Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Molecular Cell, 82 (9), 1643-1659.e10. doi: 10.1016/j.molcel.2022.03.007
2022
Journal Article
Crystal structure of the Toll/interleukin‐1 receptor (TIR) domain of IL‐1R10 provides structural insights into TIR domain signaling
Nimma, Surekha, Gu, Weixi, Manik, Mohammad K., Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2022). Crystal structure of the Toll/interleukin‐1 receptor (TIR) domain of IL‐1R10 provides structural insights into TIR domain signaling. FEBS Letters, 596 (7), 886-897. doi: 10.1002/1873-3468.14288
2021
Journal Article
Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1
Loreto, Andrea, Angeletti, Carlo, Gu, Weixi, Osborne, Andrew, Nieuwenhuis, Bart, Gilley, Jonathan, Arthur-Farraj, Peter, Merlini, Elisa, Amici, Adolfo, Luo, Zhenyao, Hartley-Tassell, Lauren, Ve, Thomas, Desrochers, Laura M, Wang, Qi, Kobe, Bostjan, Orsomando, Giuseppe and Coleman, Michael P (2021). Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1. eLife, 10 e72823. doi: 10.7554/elife.72823
2021
Journal Article
Structural evolution of TIR-domain signalosomes
Nimma, Surekha, Gu, Weixi, Maruta, Natsumi, Li, Yan, Pan, Mengqi, Saikot, Forhad Karim, Lim, Bryan Y. J., McGuinness, Helen Ying, Zaoti, Zannati Ferdous, Li, Sulin, Desa, Sneha, Manik, Mohammad Kawsar, Nanson, Jeffrey D. and Kobe, Bostjan (2021). Structural evolution of TIR-domain signalosomes. Frontiers in Immunology, 12 784484, 1-10. doi: 10.3389/fimmu.2021.784484
2021
Journal Article
Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection
Sasaki, Yo, Zhu, Jian, Shi, Yun, Gu, Weixi, Kobe, Bostjan, Ve, Thomas, DiAntonio, Aaron and Milbrandt, Jeffrey (2021). Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Experimental Neurology, 345 113842, 113842. doi: 10.1016/j.expneurol.2021.113842
2021
Journal Article
Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing
Gu, Weixi, Luo, Zhenyao, Vonrhein, Clemens, Jia, Xinying, Ve, Thomas, Nanson, Jeffrey D. and Kobe, Bostjan (2021). Crystal structure determination of the armadillo repeat domain of Drosophila SARM1 using MIRAS phasing. Acta Crystallographica. Section F: Structural Biology Communications, 77 (10), 364-373. doi: 10.1107/s2053230x21006786
2021
Journal Article
A novel NAD signaling mechanism in axon degeneration and its relationship to innate immunity
Hopkins, Eleanor L., Gu, Weixi, Kobe, Bostjan and Coleman, Michael P. (2021). A novel NAD signaling mechanism in axon degeneration and its relationship to innate immunity. Frontiers in Molecular Biosciences, 8 703532, 1-16. doi: 10.3389/fmolb.2021.703532
2021
Journal Article
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration
Figley, Matthew D., Gu, Weixi, Nanson, Jeffrey D., Shi, Yun, Sasaki, Yo, Cunnea, Katie, Malde, Alpeshkumar K., Jia, Xinying, Luo, Zhenyao, Saikot, Forhad K., Mosaiab, Tamim, Masic, Veronika, Holt, Stephanie, Hartley-Tassell, Lauren, McGuinness, Helen Y., Manik, Mohammad K., Bosanac, Todd, Landsberg, Michael J., Kerry, Philip S., Mobli, Mehdi, Hughes, Robert O., Milbrandt, Jeffrey, Kobe, Bostjan, DiAntonio, Aaron and Ve, Thomas (2021). SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration. Neuron, 109 (7), 1-19. doi: 10.1016/j.neuron.2021.02.009
Supervision
Availability
- Ms Weixi Gu is:
- Available for supervision
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