Properties of nanomaterials determine their disposal by liver cells (2017-2020)
Abstract
Nanomaterials are now widely used in industrial, environmental, consumer and drug products, but how they impact on human health is poorly understood. It is critical to understand how nanomaterials in the body are handled by their main disposition organ, the liver, and impact the liver functions. We aim to characterise the spatiotemporal distribution of a set of nanomaterials with defined attributes in naïve and modified livers using state-of-the-art chemistry, imaging and biological methods. A key outcome will be to determine how the attributes of nanomaterials direct pathways for liver cell disposal. This work will build a novel paradigm that describes nanomaterial¿liver interactions at the cellular level.
