How basal progenitors shape mammalian brain development and diversification (2026-2028)
Abstract
This project investigates how basal progenitors, a specialised subtype of neuron-producing cells, impact brain development and diversification. While placental mammals (e.g. humans) have these cells, marsupial mammals do not. By ectopically inducing basal progenitors in marsupials, this study expects to recreate placental-like brain features and will generate new knowledge on the molecular mechanisms behind basal progenitor generation and their impact on brain shape and function. Expected outcomes include insights into the evolution of complex mammalian traits. By unveiling how developmental dynamics diversify among mammals, this project has the benefit of offering new perspectives on the plasticity of these processes in health and disease.
