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Honorary Professor

Luregn Schlapbach

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Overview

Availability

Honorary Professor Luregn Schlapbach is:
Available for supervision

Works

Search Professor Luregn Schlapbach’s works on UQ eSpace

325 works between 2002 and 2025

141 - 160 of 325 works

2021

Journal Article

Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis

Boeddha, Navin P., Driessen, Gertjan J., Hagedoorn, Nienke N., Kohlfuerst, Daniela S., Hoggart, Clive J., van Rijswijk, Angelique L., Ekinci, Ebru, Priem, Debby, Schlapbach, Luregn J., Herberg, Jethro A., de Groot, Ronald, Anderson, Suzanne T., Fink, Colin G., Carrol, Enitan D., van der Flier, Michiel, Martinón-Torres, Federico, Levin, Michael, Leebeek, Frank W., Zenz, Werner, de Maat, Moniek P. M., Hazelzet, Jan A., Emonts, Marieke and Dik, Willem A. (2021). Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis. Critical Care Explorations, 3 (11) e0569, e0569. doi: 10.1097/CCE.0000000000000569

Detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 in serum is associated with adverse outcome in pediatric sepsis

2021

Journal Article

Knowledge translation following the implementation of a state-wide Paediatric Sepsis Pathway in the emergency department- a multi-centre survey study

Harley, Amanda, Schlapbach, Luregn J., Lister, Paula, Massey, Debbie, Gilholm, Patricia and Johnston, Amy N. B. (2021). Knowledge translation following the implementation of a state-wide Paediatric Sepsis Pathway in the emergency department- a multi-centre survey study. BMC Health Services Research, 21 (1) 1161, 1161. doi: 10.1186/s12913-021-07128-2

Knowledge translation following the implementation of a state-wide Paediatric Sepsis Pathway in the emergency department- a multi-centre survey study

2021

Journal Article

Long-term functional outcomes after sepsis for adult and pediatric critical care patients—protocol for a systematic review

Simpson, Adam, Long, Deborah, Fleischmann-Struzek, Carolin, Minogue, Jessicah, Venkatesh, Balasubramanian, Hammond, Naomi E., Tian, David H. and Schlapbach, Luregn J. (2021). Long-term functional outcomes after sepsis for adult and pediatric critical care patients—protocol for a systematic review. Frontiers in Pediatrics, 9 734205, 734205. doi: 10.3389/fped.2021.734205

Long-term functional outcomes after sepsis for adult and pediatric critical care patients—protocol for a systematic review

2021

Journal Article

Metabolic resuscitation in pediatric sepsis: a narrative review

Schlapbach, Luregn J., de Oliveira, Claudio Flauzinho, Raman, Sainath and de Souza, Daniela (2021). Metabolic resuscitation in pediatric sepsis: a narrative review. Translational Pediatrics, 10 (10), 2678-2688. doi: 10.21037/tp-21-1

Metabolic resuscitation in pediatric sepsis: a narrative review

2021

Journal Article

Parental and healthcare professional concern in the diagnosis of paediatric sepsis: a protocol for a prospective multicentre observational study

Sever, Zoe, Schlapbach, Luregn J, Jessup, Melanie, George, Shane and Harley, Amanda (2021). Parental and healthcare professional concern in the diagnosis of paediatric sepsis: a protocol for a prospective multicentre observational study. BMJ Open, 11 (9) e045910, e045910. doi: 10.1136/bmjopen-2020-045910

Parental and healthcare professional concern in the diagnosis of paediatric sepsis: a protocol for a prospective multicentre observational study

2021

Journal Article

A pediatric perspective on World Sepsis Day in 2021: leveraging lessons from the pandemic to reduce the global pediatric sepsis burden?

Schlapbach, Luregn J., Reinhart, Konrad, Kissoon, Niranjan and On behalf of the Pediatric Sepsis Data CoLaboratory (Sepsis CoLab) and the Global Sepsis Alliance (GSA) (2021). A pediatric perspective on World Sepsis Day in 2021: leveraging lessons from the pandemic to reduce the global pediatric sepsis burden?. American Journal of Physiology-Lung Cellular and Molecular Physiology, 321 (3), L608-L613. doi: 10.1152/ajplung.00331.2021

A pediatric perspective on World Sepsis Day in 2021: leveraging lessons from the pandemic to reduce the global pediatric sepsis burden?

2021

Journal Article

A novel framework for phenotyping children with suspected or confirmed infection for future biomarker studies

Nijman, Ruud G., Oostenbrink, Rianne, Moll, Henriette A., Casals-Pascual, Climent, von Both, Ulrich, Cunnington, Aubrey, De, Tisham, Eleftheriou, Irini, Emonts, Marieke, Fink, Colin, van der Flier, Michiel, de Groot, Ronald, Kaforou, Myrsini, Kohlmaier, Benno, Kuijpers, Taco W., Lim, Emma, Maconochie, Ian K., Paulus, Stephane, Martinon-Torres, Federico, Pokorn, Marko, Romaine, Sam T., Calle, Irene Rivero, Schlapbach, Luregn J., Smit, Frank J., Tsolia, Maria, Usuf, Effua, Wright, Victoria J., Yeung, Shunmay, Zavadska, Dace ... Carrol, Enitan D. (2021). A novel framework for phenotyping children with suspected or confirmed infection for future biomarker studies. Frontiers in Pediatrics, 9 688272, 1-18. doi: 10.3389/fped.2021.688272

A novel framework for phenotyping children with suspected or confirmed infection for future biomarker studies

2021

Journal Article

Individualized precision dosing approaches to optimize antimicrobial therapy in pediatric populations

Tu, Quyen, Cotta, Menino, Raman, Sainath, Graham, Nicolette, Schlapbach, Luregn and Roberts, Jason A (2021). Individualized precision dosing approaches to optimize antimicrobial therapy in pediatric populations. Expert Review of Clinical Pharmacology, 14 (11), 1-17. doi: 10.1080/17512433.2021.1961578

Individualized precision dosing approaches to optimize antimicrobial therapy in pediatric populations

2021

Journal Article

0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate solution in children admitted to PICU—a randomized controlled trial (SPLYT-P): study protocol for an intravenous fluid therapy trial

Raman, Sainath, Schibler, Andreas, Le Marsney, Renate, Trnka, Peter, Kennedy, Melanie, Mattke, Adrian, Gibbons, Kristen and Schlapbach, Luregn J. (2021). 0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate solution in children admitted to PICU—a randomized controlled trial (SPLYT-P): study protocol for an intravenous fluid therapy trial. Trials, 22 (1) 427. doi: 10.1186/s13063-021-05376-5

0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate solution in children admitted to PICU—a randomized controlled trial (SPLYT-P): study protocol for an intravenous fluid therapy trial

2021

Journal Article

Treatment of Multisystem Inflammatory Syndrome in Children

McArdle, Andrew J., Vito, Ortensia, Patel, Harsita, Seaby, Eleanor G., Shah, Priyen, Wilson, Clare, Broderick, Claire, Nijman, Ruud, Tremoulet, Adriana H., Munblit, Daniel, Ulloa-Gutierrez, Rolando, Carter, Michael J., De, Tisham, Hoggart, Clive, Whittaker, Elizabeth, Herberg, Jethro A., Kaforou, Myrsini, Cunnington, Aubrey J., Levin, Michael, Vazquez, Jorge Agrimbau, Carmona, Rodrigo, Perez, Laura, Rubinos, Mayra, Veliz, Natalia, Yori, Silvana, Haerynck, Filomeen, Hoste, Levi, Leal, Izabel Alves, Da Silva, Andre Ricardo Araujo ... Kandawasvika, Gwendoline (2021). Treatment of Multisystem Inflammatory Syndrome in Children. New England Journal of Medicine, 385 (1) NEJMoa2102968, 11-22. doi: 10.1056/NEJMoa2102968

Treatment of Multisystem Inflammatory Syndrome in Children

2021

Journal Article

Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT)

Irwin, Adam D., Coin, Lachlan J. M., Harris, Patrick N. A., Cotta, Menino Osbert, Bauer, Michelle J., Buckley, Cameron, Balch, Ross, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Beatson, Scott A., Forde, Brian M., Paterson, David, Clark, Julia, Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Schlapbach, Luregn J. and Roberts, Jason A. (2021). Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT). Frontiers in Cellular and Infection Microbiology, 11 667680, 1-8. doi: 10.3389/fcimb.2021.667680

Optimising treatment outcomes for children and adults through rapid genome sequencing of sepsis pathogens. A study protocol for a prospective, multi-centre trial (DIRECT)

2021

Journal Article

Priorities for paediatric critical care research: a modified Delphi study by the Australian and New Zealand Intensive Care Society Paediatric Study Group

Raman, Sainath, Brown, Georgia, Long, Debbie, Gelbart, Ben, Delzoppo, Carmel, Millar, Johnny, Erickson, Simon, Festa, Marino, Schlapbach, Luregn J., For the Australian and New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG) and Gibbons, Kristen (2021). Priorities for paediatric critical care research: a modified Delphi study by the Australian and New Zealand Intensive Care Society Paediatric Study Group. Critical Care and Resuscitation, 23 (2), 194-201. doi: 10.51893/2021.2.oa6

Priorities for paediatric critical care research: a modified Delphi study by the Australian and New Zealand Intensive Care Society Paediatric Study Group

2021

Journal Article

Early resuscitation in paediatric sepsis using inotropes – a randomised controlled pilot study in the emergency department (RESPOND ED): study protocol and analysis plan

Harley, Amanda, George, Shane, King, Megan, Phillips, Natalie, Keijzers, Gerben, Long, Debbie, Gibbons, Kristen, Bellomo, Rinaldo and Schlapbach, Luregn J. (2021). Early resuscitation in paediatric sepsis using inotropes – a randomised controlled pilot study in the emergency department (RESPOND ED): study protocol and analysis plan. Frontiers in Pediatrics, 9 663028, 663028. doi: 10.3389/fped.2021.663028

Early resuscitation in paediatric sepsis using inotropes – a randomised controlled pilot study in the emergency department (RESPOND ED): study protocol and analysis plan

2021

Journal Article

Best practice recommendations for the diagnosis and management of children with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS; multisystem inflammatory syndrome in children, MIS-C) in Switzerland

Schlapbach, Luregn J., Andre, Maya C., Grazioli, Serge, Schöbi, Nina, Ritz, Nicole, Aebi, Christoph, Agyeman, Philipp, Albisetti, Manuela, Bailey, Douggl G. N., Berger, Christoph, Blanchard-Rohner, Géraldine, Bressieux-Degueldre, Sabrina, Hofer, Michael, L'Huillier, Arnaud G., Marston, Mark, Meyer Sauteur, Patrick M., Pachlopnik Schmid, Jana, Perez, Marie-Helene, Rogdo, Bjarte, Trück, Johannes, Woerner, Andreas, Wütz, Daniela, Zimmermann, Petra, Levin, Michael, Whittaker, Elizabeth and Rimensberger, Peter C. (2021). Best practice recommendations for the diagnosis and management of children with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS; multisystem inflammatory syndrome in children, MIS-C) in Switzerland. Frontiers in Pediatrics, 9 667507, 667507. doi: 10.3389/fped.2021.667507

Best practice recommendations for the diagnosis and management of children with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS; multisystem inflammatory syndrome in children, MIS-C) in Switzerland

2021

Journal Article

Performance of seven different paediatric early warning scores to predict critical care admission in febrile children presenting to the emergency department: a retrospective cohort study

Romaine, Sam T., Sefton, Gerri, Lim, Emma, Nijman, Ruud G., Bernatoniene, Jolanta, Clark, Simon, Schlapbach, Luregn J., Pallmann, Philip and Carrol, Enitan D. (2021). Performance of seven different paediatric early warning scores to predict critical care admission in febrile children presenting to the emergency department: a retrospective cohort study. BMJ Open, 11 (5) e044091, e044091. doi: 10.1136/bmjopen-2020-044091

Performance of seven different paediatric early warning scores to predict critical care admission in febrile children presenting to the emergency department: a retrospective cohort study

2021

Journal Article

Resuscitation in Paediatric Sepsis Using Metabolic Resuscitation–A Randomized Controlled Pilot Study in the Paediatric Intensive Care Unit (RESPOND PICU): Study Protocol and Analysis Plan

Schlapbach, Luregn J., Gibbons, Kristen, Ridolfi, Roberta, Harley, Amanda, Cree, Michele, Long, Debbie, Buckley, David, Erickson, Simon, Festa, Marino, George, Shane, King, Megan, Singh, Puneet, Raman, Sainath, Bellomo, Rinaldo and The RESPOND PICU study investigators and the Australian New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG) (2021). Resuscitation in Paediatric Sepsis Using Metabolic Resuscitation–A Randomized Controlled Pilot Study in the Paediatric Intensive Care Unit (RESPOND PICU): Study Protocol and Analysis Plan. Frontiers in Pediatrics, 9 663435, 1-10. doi: 10.3389/fped.2021.663435

Resuscitation in Paediatric Sepsis Using Metabolic Resuscitation–A Randomized Controlled Pilot Study in the Paediatric Intensive Care Unit (RESPOND PICU): Study Protocol and Analysis Plan

2021

Journal Article

Challenges in the recognition and management of paediatric sepsis — the journey

Harley, Amanda, Schlapbach, Luregn J., Johnston, Amy N. B. and Massey, Debbie (2021). Challenges in the recognition and management of paediatric sepsis — the journey. Australasian Emergency Care, 25 (1), 23-29. doi: 10.1016/j.auec.2021.03.006

Challenges in the recognition and management of paediatric sepsis — the journey

2021

Other Outputs

0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate Solution in children admitted to PICU – a randomised controlled trial – SPLYT-P: study protocol for an intravenous fluid therapy trial

Raman, Sainath, Schibler, Andreas, Marsney, Renate Le, Trnka, Peter, Kennedy, Melanie, Mattke, Adrian, Gibbons, Kristen and Schlapbach, Luregn (2021). 0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate Solution in children admitted to PICU – a randomised controlled trial – SPLYT-P: study protocol for an intravenous fluid therapy trial. doi: 10.21203/rs.3.rs-390577/v1

0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate Solution in children admitted to PICU – a randomised controlled trial – SPLYT-P: study protocol for an intravenous fluid therapy trial

2021

Journal Article

Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial

Gibbons, Kristen S., Schlapbach, Luregn J., Johnson, Kerry, Horton, Stephen B., Long, Debbie A., Beca, John, Erickson, Simon, Festa, Marino, d’Udekem, Yves, Alphonso, Nelson, Winlaw, David, Delzoppo, Carmel, van Loon, Kim, Gannon, Brenda, Fooken, Jonas, Blumenthal, Antje, Young, Paul J., Butt, Warwick and Schibler, Andreas (2021). Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial. Critical Care and Resuscitation, 23 (1), 47-58. doi: 10.51893/2021.1.oa4

Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial

2021

Journal Article

The challenge of infrequency

Long, Elliot, Schlapbach, Luregn J. and Babl, Franz E. (2021). The challenge of infrequency. Acta Paediatrica, 110 (3), 1075-1075. doi: 10.1111/apa.15647

The challenge of infrequency

Funding

Current funding

  • 2025 - 2030
    Comparison of Beta-Lactam Antibiotic Infusions in Septic Critically Ill Children: The BUILD Trial
    NHMRC MRFF CTA - Clinical Trials Activity
    Open grant
  • 2025 - 2030
    Comparison of Continuous and Extended vs Intermittent Beta-Lactam Infusions in Critically Ill Children with Sepsis ¿ the BUILD Multicentre Binational Randomised Controlled Trial
    NHMRC MRFF CTA - Clinical Trials Activity
    Open grant
  • 2022 - 2027
    Resuscitation in Paediatric Septic Shock using Mega-Dose Vitamin C and Hydrocortisone - A Randomised Controlled Multicentre Trial (RESPOND study)
    NHMRC Clinical Trials and Cohort Studies Grants
    Open grant
  • 2022 - 2025
    Machine learning for precision medicine in paediatric critical care
    Ramaciotti Health Investment Grants
    Open grant
  • 2021 - 2025
    Pharmacokinetics of antimicrobials in paediatric patients on extracorporeal therapies (APET-PK)
    Children's Health Queensland Hospital and Health Service
    Open grant
  • 2020 - 2025
    Validating a new Gene Expression Signature test to diagnose sepsis in children
    Immunexpress
    Open grant
  • 2020 - 2025
    Gene Expression to Predict Long-Term Outcome in Infants After Heart Surgery
    MRFF Accelerated Research - Congenital Heart Disease administered by AusIndustry
    Open grant
  • 2020 - 2025
    Host Gene Expression Signatures to Diagnose Sepsis in Children
    MRFF Genomics Health Futures Mission, Project Grant administered by AusIndustry
    Open grant

Past funding

  • 2021 - 2023
    Rapid diagnosis of Sepsis in children using host RNA signatures
    The Children's Hospital Foundation
    Open grant
  • 2021 - 2022
    PIMS Study: An investigation of the utility of Microsampling versus traditional blood sampling for antibiotic pharmacokinetics in Children (SCHS Wishlist Foundation grant administered by SCHHS
    Sunshine Coast Hospital and Health Service
    Open grant
  • 2021 - 2023
    Restrictive Fluid Strategy vs Standard Care in Mechanically Ventilated Children - a Feasibility Pilot Randomised Controlled Trial
    Preclinical and Clinical Early Career Research
    Open grant
  • 2020 - 2021
    Early Resuscitation in Paediatric Sepsis Using Inotropes and Metabolic Support - A Randomized Controlled Pilot Study Platform
    Gold Coast Hospital and Health Services
    Open grant
  • 2020 - 2023
    Machine learning to predict future educational outcomes in critically ill children
    The Children's Hospital Foundation
    Open grant
  • 2020 - 2021
    Understanding the clinical and molecular epidemiology of Gram-negative bloodstream infections to improve outcomes in Australian children
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2023
    Acute Resuscitation In Paediatric SEpsis (ARISE-KIDS) - a randomised controlled trial to reduce morbidity and mortality due to sepsis in children
    Financial Markets Foundation for Children
    Open grant
  • 2019 - 2022
    Paediatric Neurodevelopmental Outcomes following a randomised controlled trial of nitric oxide bypass in infants undergoing cardiac surgery
    Intensive Care Foundation
    Open grant
  • 2019 - 2022
    Nitric Oxide to improve recovery and survival in neonates and children on Extracorporeal Life Support - a pilot randomized controlled trial (the NECTAR trial)
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2021
    Early Resuscitation in Paediatric Sepsis Using Inotropes and Metabolic Support: A randomised controlled 2x2 pilot study
    Emergency Medicine Foundation Ltd
    Open grant
  • 2019 - 2022
    Acute Resuscitation In Paediatric Sepsis (ARISE-KIDS) - a randomised controlled trail to reduce morbidity and mortality due to sepsis in children
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2020
    Implementation of a statewide paediatric sepsis quality improvement initiative
    The Children's Hospital Foundation
    Open grant
  • 2019 - 2024
    Nasal High Flow Apnoeic Oxygenation during Pediatric Emergency Intubation: A Randomised Controlled Trial
    NHMRC Project Grant
    Open grant
  • 2019 - 2021
    Sepsis, Infection and Inflammation in Critically Ill Children
    NHMRC Practitioner Fellowships
    Open grant
  • 2018 - 2020
    RAPIDS TRIAL: Rapid Acute Paediatric Infection Diagnosis in Suspected Sepsis
    Gold Coast Hospital and Health Services
    Open grant
  • 2018 - 2020
    Impact of life-threatening illness on education outcomes in Queensland children: A population-based study to identify risk factors and pathways to intervention
    Education Horizon
    Open grant
  • 2018 - 2020
    Rapid diagnosis of sepsis in acutely ill children
    Emergency Medicine Foundation Ltd
    Open grant
  • 2018 - 2022
    Nasal Highflow for Paediatric Acute Hypoxic Respiratory Failure
    NHMRC Project Grant
    Open grant
  • 2017 - 2018
    Saturation Accuracy in Paediatrics Study (SAPS)
    Intensive Care Foundation
    Open grant
  • 2017 - 2018
    Use of nitric oxide to reduce cardiopulmonary bypass-induced inflammation after cardiac surgery in young children - a multicentre randomized controlled trial: pilot study
    Heart Kids Australia Inc
    Open grant
  • 2017 - 2020
    High flow nasal cannula treatment for infants and children with acute respiratory failure
    Thrasher Research Fund
    Open grant
  • 2017 - 2019
    Reducing morbidity and mortality in infants and children after cardiopulmonary bypass - a multicenter randomized controlled trial
    The Children's Hospital Foundation
    Open grant
  • 2015 - 2017
    High Flow Cannula Therapy in Bronchiolitis, a Randomised Controlled Trial
    NHMRC Project Grant
    Open grant
  • 2015 - 2016
    Identifying the Genetic Cause of Fatal Pseudomonas
    Intensive Care Foundation
    Open grant

Supervision

Availability

Honorary Professor Luregn Schlapbach is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Improving drug therapy for children with sepsis and life-threatening infections

    Associate Advisor

    Other advisors: Dr Sainath Raman, Professor Jason Roberts

  • Doctor Philosophy

    Establishing effective antibiotic and sedative dosing in paediatrics with extracorporeal therapies (including extracorporeal membrane oxygenation and renal replacement therapies)

    Associate Advisor

    Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts

Completed supervision

Media

Enquiries

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