Overview
Background
Dr Nchafatso G. Obonyo (BSc Hons, MB.ChB, DTM&H, MD/PhD, FCRcert)
Post-doctoral Research Fellow at the Critical Care Research Group-The Prince Charles Hospital, Institute of Molecular Bioscience-The University of Queensland. Main research focus is cardiac critical care and sepsis research.
Visiting Fellow in the Academic Division, Medical Engineering Research Facility, Queenlsand University of Technology. Fellow of the Initiative to Develop African Research Leaders (IDeAL) at the KEMRI-Wellcome Trust Research Programme, Kenya; Global Health Fellow, Wellcome Trust Centre for Global Health Research at Imperial College London,UK.
Recipient of the 2023 Africa Top-40 Under-40 Science Award and the 2023 African Professional in Australia of the Year Award.
Availability
- Dr Nchafatso Obonyo is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Open University (UK)
Research interests
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Sepsis and Septic Shock Resuscitation
Research on the effects of resuscitation on the microcirculation in sepsis and septic shock
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Cardiac and microvascular dysfunction in sepsis
Research on non-invasive imaging of cardiac and microvascular function in sepsis and septic shock states
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Cardiac critical care
Research on cardiac emergency and intensive care
Research impacts
Dr Obonyo's research work on septic shock and haemodynamic resuscitation highlights the global impact of sepsis and the importance of investigating resuscitation-associated dysfunction of the heart and vascular endothelium:
1. World Sepsis Day (13 September): https://youtu.be/VkAxQ0BD2QU
2. Aggressive fluid resucitation worsens endotoxaemic shock: Am J Respir Crit Care Med. 2018 Oct 15;198(8):1043-1054: https://pubmed.ncbi.nlm.nih.gov/29882682/
3. Resuscitation-associated endotheliopathy: https://www.ccrg.org.au/all-publications/rase
Dr Obonyo has also received awards for his research work including:
a. Postdoctoral Research Fellowship and Innovations Research Grant awarded by The Prince Charles Hospital Foundation (https://www.thecommongood.org.au/news/meet-doctor-nchafatso-obonyo/)
b. Continental recognition winning the 2023 Africa Top-40 Under-40 Award in Science and the Africa (https://www.ccrg.org.au/news/fortyunder40)
c. African Professional in Australia award in 2023 awarded across all professionals by the African Professionals of Australia (https://www.ccrg.org.au/news/obonyo-wins-national-apa-accolade)
Works
Search Professor Nchafatso Obonyo’s works on UQ eSpace
2021
Journal Article
A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death
See Hoe, Louise E., Wildi, Karin, Obonyo, Nchafatso G., Bartnikowski, Nicole, McDonald, Charles, Sato, Kei, Heinsar, Silver, Engkilde-Pedersen, Sanne, Diab, Sara, Passmore, Margaret R., Wells, Matthew A., Boon, Ai-Ching, Esguerra, Arlanna, Platts, David G., James, Lynnette, Bouquet, Mahe, Hyslop, Kieran, Shuker, Tristan, Ainola, Carmen, Colombo, Sebastiano M., Wilson, Emily S., Millar, Jonathan E., Malfertheiner, Maximillian V., Reid, Janice D., O’Neill, Hollier, Livingstone, Samantha, Abbate, Gabriella, Sato, Noriko, He, Ting ... Fraser, John F. (2021). A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death. Intensive Care Medicine Experimental, 9 (1) 60, 1-24. doi: 10.1186/s40635-021-00425-4
2021
Journal Article
Abstract 10482: Renin-Angiotensin-Aldosterone System Inhibition is Associated with Reduced In-Hospital Mortality in Critically Ill Covid-19 Patients with Pre-Existing Hypertension
Sato, Kei, White, Nicole, Fanning, Jonathon P, Obonyo, Nchafatso, Appadurai, Vinesh, Ciullo, Anna, May, Meryta, Worku, Elliott, Helms, Leticia, Ohshimo, Shinichiro, Yamashita, Michael, Suen, Jacky Y, Bassi, Gianluigi Li, Fraser, John F and ARORA, Rakesh C (2021). Abstract 10482: Renin-Angiotensin-Aldosterone System Inhibition is Associated with Reduced In-Hospital Mortality in Critically Ill Covid-19 Patients with Pre-Existing Hypertension. Circulation, 144 (Suppl_1). doi: 10.1161/circ.144.suppl_1.10482
2021
Journal Article
Assessment of 28-day in-hospital mortality in mechanically ventilated patients with coronavirus disease 2019: an international cohort study
Li Bassi, Gianluigi, Suen, Jacky Y., White, Nicole, Dalton, Heidi J., Fanning, Jonathon, Corley, Amanda, Shrapnel, Sally, Hinton, Samuel, Forsyth, Simon, Parsons, Rex, Laffey, John G., Fan, Eddy, Bartlett, Robert, Brodie, Daniel, Burrell, Aidan, Chiumello, Davide, Elhazmi, Alyaa, Grasselli, Giacomo, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Marwali, Eva, Merson, Laura, Murthy, Srinivas, Nichol, Alistair, Panigada, Mauro, Pelosi, Paolo, Torres, Antoni, Ng, Pauline Yeung ... Obonyo, Nchafatso (2021). Assessment of 28-day in-hospital mortality in mechanically ventilated patients with coronavirus disease 2019: an international cohort study. Critical Care Explorations, 3 (11) e0567, e0567. doi: 10.1097/cce.0000000000000567
2021
Journal Article
Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model
Walweel, K., Boon, A. C., See Hoe, L. E., Obonyo, N. G., Pedersen, S. E., Diab, S. D., Passmore, M. R., Hyslop, K., Colombo, S. M., Bartnikowski, N. J., Bouquet, M., Wells, M. A., Black, D. M., Pimenta, L. P., Stevenson, A. K., Bisht, K., Skeggs, K., Marshall, L., Prabhu, A., James, L. N., Platts, D. G., Macdonald, P. S., McGiffin, D. C., Suen, J. Y. and Fraser, J. F. (2021). Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model. Biomedical Journal, 45 (5), 776-787. doi: 10.1016/j.bj.2021.10.007
2021
Journal Article
Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: an experimental ovine study
Millar, Jonathan E., Wildi, Karin, Bartnikowski, Nicole, Bouquet, Mahe, Hyslop, Kieran, Passmore, Margaret R., Ki, Katrina K., See Hoe, Louise E., Obonyo, Nchafatso G., Neyton, Lucile, Pedersen, Sanne, Rozencwajg, Sacha, Baillie, J. Kenneth, Li Bassi, Gianluigi, Suen, Jacky Y., McAuley, Daniel F. and Fraser, John F. (2021). Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: an experimental ovine study. Physiological Reports, 9 (19) e15048, e15048. doi: 10.14814/phy2.15048
2021
Journal Article
Global infectious disease research collaborations in crises: building capacity and inclusivity through cooperation
Fanning, Jonathon P., Murthy, Srinivas, Obonyo, Nchafatso G., Baillie, J. Kenneth, Webb, Steve, Dalton, Heidi J. and Fraser, John F. (2021). Global infectious disease research collaborations in crises: building capacity and inclusivity through cooperation. Globalization and Health, 17 (1) 84, 1-6. doi: 10.1186/s12992-021-00731-2
2021
Other Outputs
Myocardial and microvascular physiology in septic shock and response to volume expansion treatment
Obonyo, Nchafatso Gikenyi (2021). Myocardial and microvascular physiology in septic shock and response to volume expansion treatment. PhD Thesis, Life, Health and Chemical Sciences; Faculty of Science Technology, Engineering and Mathematics, The Open University of London, United Kingdom. doi: 10.21954/ou.ro.00011dde
2021
Journal Article
Compromised right ventricular contractility in an ovine model of heart transplantation following 24 h donor brain stem death
Wells, Matthew A., See Hoe, Louise E., Molenaar, Peter, Pedersen, Sanne, Obonyo, Nchafatso G., McDonald, Charles I., Mo, Weilan, Bouquet, Mahè, Hyslop, Kieran, Passmore, Margaret R., Bartnikowski, Nicole, Suen, Jacky Y., Peart, Jason N., McGiffin, David C., Fraser, John F. and on behalf of the Dead Heart Project (2021). Compromised right ventricular contractility in an ovine model of heart transplantation following 24 h donor brain stem death. Pharmacological Research, 169 105631, 1-12. doi: 10.1016/j.phrs.2021.105631
2021
Journal Article
An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients
Li Bassi, Gianluigi, Suen, Jacky Y, Dalton, Heidi J, White, Nicole, Shrapnel, Sally, Fanning, Jonathon P, Liquet, Benoit, Hinton, Samuel, Vuorinen, Aapeli, Booth, Gareth, Millar, Jonathan E, Forsyth, Simon, Panigada, Mauro, Laffey, John, Brodie, Daniel, Fan, Eddy, Torres, Antoni, Chiumello, Davide, Corley, Amanda, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Murthy, Srinivas, Nichol, Alistair, Ng, Pauline Yeung, Ogino, Mark, Pesenti, Antonio, Trieu, Huynh Trung ... Obonyo, Gikenyi N. (2021). An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients. Critical Care, 25 (1) 199, 1-22. doi: 10.1186/s13054-021-03518-4
2021
Conference Publication
Donor heart preservation by hypothermic ex vivo perfusion - improved recipient survival and successful prolongation of ischemic time
Hoe, L. E. See, Wildi, K., Skeggs, K., Bouquet, M., Sato, K., Jung, J., Ainola, C., Hyslop, K., Heinsar, S., Abbate, G., Colombo, S. M., Passmore, M., Wood, E. S., Wells, M., Bartnikowski, N., O'Neill, H., Reid, J., Shuker, T., Haymet, A., Livingstone, S., Sato, N., Obonyo, N., James, L., He, T., McDonald, C., Mullins, D., Engkilde-Pedersen, S., Diab, S., Millar, J. E. ... Fraser, J. F. (2021). Donor heart preservation by hypothermic ex vivo perfusion - improved recipient survival and successful prolongation of ischemic time. ISHLT 41st Annual Meeting, Virtual, 24-28 April 2021. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2021.01.1864
2021
Journal Article
Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): a phase II randomised controlled trial: trial protocol
Maitland, Kathryn, Olupot-Olupot, Peter, Aloroker, Florence, Mpoya, Ayub, Mnjalla, Hellen, Passi, George, Nakuya, Margaret, Houston, Kirsty, Obonyo, Nchafatso, Hamaluba, Mainga, Evans, Jennifer A, Connon, Roisin, George, Elizabeth C and Gibb, Diana M (2021). Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): a phase II randomised controlled trial: trial protocol. Wellcome Open Research, 6 160, 160. doi: 10.12688/wellcomeopenres.16885.1
2020
Journal Article
Characterising pre-clinical sub-phenotypic models of Acute Respiratory Distress Syndrome: an experimental ovine study
Millar, Jonathan E., Wildi, Karin, Bartnikowski, Nicole, Bouquet, Mahe, Hyslop, Kieran, Passmore, Margaret R., Ki, Katrina K., See Hoe, Louise E., Obonyo, Nchafatso G., Neyton, Lucile, Pedersen, Sanne, Rozencwajg, Sacha, Baillie, J. Kenneth, Li Bassi, Gianluigi, Suen, Jacky Y, McAuley, Daniel F. and Fraser, John F. (2020). Characterising pre-clinical sub-phenotypic models of Acute Respiratory Distress Syndrome: an experimental ovine study.
2020
Journal Article
Microvascular dysfunction in septic and dengue shock: pathophysiology and implications for clinical management
McBride, Angela, Chanh, Ho Q., Fraser, John F., Yacoub, Sophie and Obonyo, Nchafatso G. (2020). Microvascular dysfunction in septic and dengue shock: pathophysiology and implications for clinical management. Global Cardiology Science and Practice, 2020 (2) e202029, e202029. doi: 10.21542/gcsp.2020.29
2020
Journal Article
Heart transplantation from brain dead donors: a systematic review of animal models
See Hoe, Louise E., Wells, Matthew A., Bartnikowski, Nicole, Obonyo, Nchafatso G., Millar, Jonathan E., Khoo, Aimee, Ki, Katrina K., Shuker, Tristan, Ferraioli, Alessandro, Colombo, Sebastiano M., Chan, Wandy, McGiffin, David C., Suen, Jacky Y. and Fraser, John F. (2020). Heart transplantation from brain dead donors: a systematic review of animal models. Transplantation, 104 (11), 2272-2289. doi: 10.1097/tp.0000000000003217
2020
Journal Article
Endothelin receptor antagonist improves donor lung function in an ex vivo perfusion system
Walweel, K., Skeggs, K., Boon, A. C., See Hoe, L. E., Bouquet, M., Obonyo, N. G., Pedersen, S. E., Diab, S. D., Passmore, M. R., Hyslop, K., Wood, E. S., Reid, J., Colombo, S. M., Bartnikowski, N. J., Wells, M. A., Black, D., Pimenta, L. P., Stevenson, A. K., Bisht, K., Marshall, L., Prabhu, D. A., James, L., Platts, D. G., MacDonald, P. S., McGiffin, D. C., Suen, J. Y. and Fraser, J. F. (2020). Endothelin receptor antagonist improves donor lung function in an ex vivo perfusion system. Journal of Biomedical Science, 27 (1) 96, 96. doi: 10.1186/s12929-020-00690-7
2020
Journal Article
Combined mesenchymal stromal cell therapy and ECMO in ARDS: a controlled experimental study in sheep
Millar, Jonathan E., Bartnikowski, Nicole, Passmore, Margaret R., Obonyo, Nchafatso G, Malfertheiner, Maximillian V., von Bahr, Viktor, Redd, Meredith A., See Hoe, Louise, Ki, Katrina K., Pedersen, Sanne, Boyle, Andrew J., Baillie, J Kenneth, Shekar, Kiran, Palpant, Nathan, Suen, Jacky Y., Matthay, Michael A., McAuley, Daniel F., Fraser, John F. and Combining Extracorporeal Life Support and Cell Therapy in Critical Illness (CELTIC) investigators (2020). Combined mesenchymal stromal cell therapy and ECMO in ARDS: a controlled experimental study in sheep. American Journal of Respiratory and Critical Care Medicine, 202 (3) rccm.201911-2143OC, 383-392. doi: 10.1164/rccm.201911-2143oc
2020
Journal Article
Corrigendum: Sepsis: changing definitions, unchanging treatment (vol 6, 425, 2019)
Obonyo, Nchafatso Gikenyi, Schlapbach, Luregn Jan and Fraser, John Francis (2020). Corrigendum: Sepsis: changing definitions, unchanging treatment (vol 6, 425, 2019). Frontiers in Pediatrics, 7 538, 538. doi: 10.3389/fped.2019.00538
2020
Conference Publication
Metabolic and mitochondrial alterations following brain death and heart transplantation
Hoe, L. E. See, Wells, M. A., Bouquet, M., Hyslop, K., Passmore, M. R., Bartnikowski, N., Obonyo, N. G., Reid, J., O'Neill, H., Shuker, T., McDonald, C., Engkilde-Pedersen, S., Wildi, K., Ainola, C., Skeggs, K., Jung, J., Colombo, S., Sato, K., James, L., He, P., Wood, E. S., Heinser, S., Wang, X., Abbate, G., Livingstone, S., Haymet, A., Walweel, K., Mullins, D., Marasco, S. ... Fraser, J. F. (2020). Metabolic and mitochondrial alterations following brain death and heart transplantation. 40th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Montreal, Canada, 22-25 April 2020. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2020.01.419
2020
Conference Publication
(-)-Noradrenaline sensitivity, contractility and mitochondrial function in an ovine model of brain stem death and transplantation
Wells, Matthew, Molenaar, Peter, Hoe, Louise See, Obonyo, Nchafatso, James, Lynette, Bouquet, Mahe, Bartnikowski, Nicole, Passmore, Margaret, Boone, Connie, Wilde, Karin, Weilan, Mo, Hyslop, Kieran, McDonald, Charles, Pedersen, Sanne, Suen, Jacky, Peart, Jason, McGiffin, David and Fraser, John (2020). (-)-Noradrenaline sensitivity, contractility and mitochondrial function in an ovine model of brain stem death and transplantation. 2019 ISHR World Congress, Beijing, China, 3-6 June 2019. London, United Kingdom: Academic Press. doi: 10.1016/j.yjmcc.2019.11.114
2020
Conference Publication
Donor brain stem death and cardiac transplantation causes mitochondrial dyscoupling and oxidative stress
Wells, Matthew, Seehoe, Louise, Zechovic, Olivia, Nchafatso, Obonyo, Bouquet, Mahe, Hyslop, Keiran, Black, Deborah, McDonald, Charles, Pedersen, Sanne, Suen, Jacky, Peart, Jason, McGiffin, David, Fraser, John and Lye, India (2020). Donor brain stem death and cardiac transplantation causes mitochondrial dyscoupling and oxidative stress. World Congress of Intensive Care, Melbourne, VIC Australia, 14-18 October 2019. Philadelphia, PA USA: Elsevier. doi: 10.1016/j.aucc.2020.04.098
Supervision
Availability
- Dr Nchafatso Obonyo is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Pre-clinical models of cardiac critical illness
Resuscitation-associated endotheliopathy in shock states
https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-023-02385-0
Media
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