Overview
Background
Dr Nchafatso G. Obonyo (BSc Hons, MB.ChB, DTM&H, MD/PhD, FCRcert)
Post-doctoral Research Fellow at the Critical Care Research Group-The Prince Charles Hospital, Institute of Molecular Bioscience-The University of Queensland. Main research focus is cardiac critical care and sepsis research.
Visiting Fellow in the Academic Division, Medical Engineering Research Facility, Queenlsand University of Technology. Fellow of the Initiative to Develop African Research Leaders (IDeAL) at the KEMRI-Wellcome Trust Research Programme, Kenya; Global Health Fellow, Wellcome Trust Centre for Global Health Research at Imperial College London,UK.
Recipient of the 2023 Africa Top-40 Under-40 Science Award and the 2023 African Professional in Australia of the Year Award.
Availability
- Dr Nchafatso Obonyo is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Open University (UK)
Research interests
-
Sepsis and Septic Shock Resuscitation
Research on the effects of resuscitation on the microcirculation in sepsis and septic shock
-
Cardiac and microvascular dysfunction in sepsis
Research on non-invasive imaging of cardiac and microvascular function in sepsis and septic shock states
-
Cardiac critical care
Research on cardiac emergency and intensive care
Research impacts
Dr Obonyo's research work on septic shock and haemodynamic resuscitation highlights the global impact of sepsis and the importance of investigating resuscitation-associated dysfunction of the heart and vascular endothelium:
1. World Sepsis Day (13 September): https://youtu.be/VkAxQ0BD2QU
2. Aggressive fluid resucitation worsens endotoxaemic shock: Am J Respir Crit Care Med. 2018 Oct 15;198(8):1043-1054: https://pubmed.ncbi.nlm.nih.gov/29882682/
3. Resuscitation-associated endotheliopathy: https://www.ccrg.org.au/all-publications/rase
Dr Obonyo has also received awards for his research work including:
a. Postdoctoral Research Fellowship and Innovations Research Grant awarded by The Prince Charles Hospital Foundation (https://www.thecommongood.org.au/news/meet-doctor-nchafatso-obonyo/)
b. Continental recognition winning the 2023 Africa Top-40 Under-40 Award in Science and the Africa (https://www.ccrg.org.au/news/fortyunder40)
c. African Professional in Australia award in 2023 awarded across all professionals by the African Professionals of Australia (https://www.ccrg.org.au/news/obonyo-wins-national-apa-accolade)
Works
Search Professor Nchafatso Obonyo’s works on UQ eSpace
2023
Journal Article
Hemorrhage, disseminated intravascular coagulopathy, and thrombosis complications among critically ill patients with COVID-19: an international COVID-19 critical care consortium study
Fanning, Jonathon P., Weaver, Natasha, Fanning, Robert B., Griffee, Matthew J., Cho, Sung-Min, Panigada, Mauro, Obonyo, Nchafatso G., Zaaqoq, Akram M., Rando, Hannah, Chia, Yew Woon, Fan, Bingwen Eugene, Sela, Declan, Chiumello, Davide, Coppola, Silvia, Labib, Ahmed, Whitman, Glenn J. R., Arora, Rakesh C., Kim, Bo S., Motos, Anna, Torres, Antoni, Barbé, Ferran, Grasselli, Giacomo, Zanella, Alberto, Etchill, Eric, Usman, Asad Ali, Feth, Maximilian, White, Nicole M., Suen, Jacky Y., Li Bassi, Gianluigi ... on behalf of the COVID-19 Critical Care Consortium (2023). Hemorrhage, disseminated intravascular coagulopathy, and thrombosis complications among critically ill patients with COVID-19: an international COVID-19 critical care consortium study. Critical Care Medicine, 51 (5), 619-631. doi: 10.1097/ccm.0000000000005798
2023
Journal Article
Resuscitation Associated Endotheliopathy (PubMed)
Obonyo, Nchafatso G., Sela, Declan P., Raman, Sainath, Rachakonda, Reema, Schneider, Bailey, Hoe, Louise E. See, Fanning, Jonathon P., Bassi, Gianluigi Li, Maitland, Kathryn, Suen, Jacky Y. and Fraser, John F. (2023). Resuscitation Associated Endotheliopathy (PubMed). searchRxiv, 2023. doi: 10.1079/searchrxiv.2023.00206
2022
Journal Article
A clinical and physiological prospective observational study on the management of pediatric shock in the post-fluid expansion as supportive therapy trial era
Obonyo, Nchafatso G., Olupot-Olupot, Peter, Mpoya, Ayub, Nteziyaremye, Julius, Chebet, Martin, Uyoga, Sophie, Muhindo, Rita, Fanning, Jonathon P., Shiino, Kenji, Chan, Jonathan, Fraser, John F. and Maitland, Kathryn (2022). A clinical and physiological prospective observational study on the management of pediatric shock in the post-fluid expansion as supportive therapy trial era. Pediatric Critical Care Medicine, 23 (7), 502-513. doi: 10.1097/pcc.0000000000002968
2022
Journal Article
Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis
Li Bassi, Gianluigi, Gibbons, Kristen, Suen, Jacky Y., Dalton, Heidi J., White, Nicole, Corley, Amanda, Shrapnel, Sally, Hinton, Samuel, Forsyth, Simon, Laffey, John G., Fan, Eddy, Fanning, Jonathon P., Panigada, Mauro, Bartlett, Robert, Brodie, Daniel, Burrell, Aidan, Chiumello, Davide, Elhazmi, Alyaa, Esperatti, Mariano, Grasselli, Giacomo, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Marwali, Eva, Merson, Laura, Murthy, Srinivas, Nichol, Alistair, Ogino, Mark, Pelosi, Paolo ... The COVID-19 Critical Care Consortium (2022). Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis. Critical Care, 26 (1) 141, 141. doi: 10.1186/s13054-022-03983-5
2022
Journal Article
Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study
Urner, Martin, Barnett, Adrian G., Bassi, Gianluigi Li, Brodie, Daniel, Dalton, Heidi J., Ferguson, Niall D., Heinsar, Silver, Hodgson, Carol L., Peek, Giles, Shekar, Kiran, Suen, Jacky Y., Fraser, John F., Fan, Eddy, COVID-19 Critical Care Consortium Investigators and Obonyo, Nchafatso (2022). Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study. BMJ, 377 e068723, e068723. doi: 10.1136/bmj-2021-068723
2022
Conference Publication
Hypothermic ex vivo perfusion of donor hearts can safely preserve post-transplant cardiac function in sheep for 8 hours
See Hoe, Louise E., Bouquet, Mahe, Hyslop, Kieran, Passmore, Margaret R., Wells, Matthew A., Sato, Kei, Wilson, Emily, Wildi, Karin, Skeggs, Kris, Palmeri, Chiara, Reid, Janice, O'Neill, Hollier, Bartnikowski, Nicole, Jung, Jae-Seung, Ainola, Carmen, Abbate, Gabriella, Colombo, Sebastiano M., Obonyo, Nchafatso G., McDonald, Charles, Shuker, Tristan, Heinsar, Silver, Haymet, Andrew, Pedersen, Sanne, Molenaar, Peter, Li Bassi, Gianluigi, Suen, Jacky Y., McGiffin, David C. and Fraser, John F. (2022). Hypothermic ex vivo perfusion of donor hearts can safely preserve post-transplant cardiac function in sheep for 8 hours. Experimental Biology 2022 Meeting, Philadelphia, PA United States, 2-5 April 2022. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.2022.36.S1.R3270
2022
Journal Article
Exploration of the utility of speckle-tracking echocardiography during mechanical ventilation and mechanical circulatory support
Sato, Kei, Chan, Jonathan, Appadurai, Vinesh, Obonyo, Nchafatso, See Hoe, Louise, Suen, Jacky Y. and Fraser, John F. (2022). Exploration of the utility of speckle-tracking echocardiography during mechanical ventilation and mechanical circulatory support. Critical Care Explorations, 4 (4) e0666, 1-10. doi: 10.1097/CCE.0000000000000666
2022
Journal Article
Impact of renin-angiotensin-aldosterone system inhibition on mortality in critically ill COVID-19 patients with pre-existing hypertension: a prospective cohort study
Sato, Kei, White, Nicole, Fanning, Jonathon P., Obonyo, Nchafatso, Yamashita, Michael H., Appadurai, Vinesh, Ciullo, Anna, May, Meryta, Worku, Elliott T., Helms, Leticia, Ohshimo, Shinichiro, Juzar, Dafsah A., Suen, Jacky Y., Bassi, Gianluigi Li, Fraser, John F., Arora, Rakesh C. and on behalf of COVID-19 Critical Care Consortium Investigators (2022). Impact of renin-angiotensin-aldosterone system inhibition on mortality in critically ill COVID-19 patients with pre-existing hypertension: a prospective cohort study. BMC Cardiovascular Disorders, 22 (1) 123, 123. doi: 10.1186/s12872-022-02565-1
2022
Conference Publication
Post-transplant cardiac contractility and mitochondrial function is preserved following 8 hours hypothermic ex vivo perfusion in sheep
See Hoe, L., Bouquet, M., Hyslop, K., Passmore, M., Wells, M., Sato, K., Wilson, E., Wildi, K., Skeggs, K., Palmeri, C., Reid, J., O'Neill, H., Bartnikowski, N., Jung, J., Ainola, C., Abbate, G., Colombo, S., Obonyo, N., McDonald, C., Shuker, T., Heinsar, S., Haymet, A., Engkilde-Pedersen, S., Peart, J., Molenaar, P., Li Bassi, G., Suen, J., McGiffin, D. and Fraser, J. (2022). Post-transplant cardiac contractility and mitochondrial function is preserved following 8 hours hypothermic ex vivo perfusion in sheep. 70th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Gold Coast, QLD, Australia, 11-14 August 2022. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2022.06.547
2021
Journal Article
A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death
See Hoe, Louise E., Wildi, Karin, Obonyo, Nchafatso G., Bartnikowski, Nicole, McDonald, Charles, Sato, Kei, Heinsar, Silver, Engkilde-Pedersen, Sanne, Diab, Sara, Passmore, Margaret R., Wells, Matthew A., Boon, Ai-Ching, Esguerra, Arlanna, Platts, David G., James, Lynnette, Bouquet, Mahe, Hyslop, Kieran, Shuker, Tristan, Ainola, Carmen, Colombo, Sebastiano M., Wilson, Emily S., Millar, Jonathan E., Malfertheiner, Maximillian V., Reid, Janice D., O’Neill, Hollier, Livingstone, Samantha, Abbate, Gabriella, Sato, Noriko, He, Ting ... Fraser, John F. (2021). A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death. Intensive Care Medicine Experimental, 9 (1) 60, 1-24. doi: 10.1186/s40635-021-00425-4
2021
Journal Article
Assessment of 28-day in-hospital mortality in mechanically ventilated patients with coronavirus disease 2019: an international cohort study
Li Bassi, Gianluigi, Suen, Jacky Y., White, Nicole, Dalton, Heidi J., Fanning, Jonathon, Corley, Amanda, Shrapnel, Sally, Hinton, Samuel, Forsyth, Simon, Parsons, Rex, Laffey, John G., Fan, Eddy, Bartlett, Robert, Brodie, Daniel, Burrell, Aidan, Chiumello, Davide, Elhazmi, Alyaa, Grasselli, Giacomo, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Marwali, Eva, Merson, Laura, Murthy, Srinivas, Nichol, Alistair, Panigada, Mauro, Pelosi, Paolo, Torres, Antoni, Ng, Pauline Yeung ... Obonyo, Nchafatso (2021). Assessment of 28-day in-hospital mortality in mechanically ventilated patients with coronavirus disease 2019: an international cohort study. Critical Care Explorations, 3 (11) e0567, e0567. doi: 10.1097/cce.0000000000000567
2021
Journal Article
Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model
Walweel, K., Boon, A. C., See Hoe, L. E., Obonyo, N. G., Pedersen, S. E., Diab, S. D., Passmore, M. R., Hyslop, K., Colombo, S. M., Bartnikowski, N. J., Bouquet, M., Wells, M. A., Black, D. M., Pimenta, L. P., Stevenson, A. K., Bisht, K., Skeggs, K., Marshall, L., Prabhu, A., James, L. N., Platts, D. G., Macdonald, P. S., McGiffin, D. C., Suen, J. Y. and Fraser, J. F. (2021). Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model. Biomedical Journal, 45 (5), 776-787. doi: 10.1016/j.bj.2021.10.007
2021
Journal Article
Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: an experimental ovine study
Millar, Jonathan E., Wildi, Karin, Bartnikowski, Nicole, Bouquet, Mahe, Hyslop, Kieran, Passmore, Margaret R., Ki, Katrina K., See Hoe, Louise E., Obonyo, Nchafatso G., Neyton, Lucile, Pedersen, Sanne, Rozencwajg, Sacha, Baillie, J. Kenneth, Li Bassi, Gianluigi, Suen, Jacky Y., McAuley, Daniel F. and Fraser, John F. (2021). Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: an experimental ovine study. Physiological Reports, 9 (19) e15048, e15048. doi: 10.14814/phy2.15048
2021
Journal Article
Global infectious disease research collaborations in crises: building capacity and inclusivity through cooperation
Fanning, Jonathon P., Murthy, Srinivas, Obonyo, Nchafatso G., Baillie, J. Kenneth, Webb, Steve, Dalton, Heidi J. and Fraser, John F. (2021). Global infectious disease research collaborations in crises: building capacity and inclusivity through cooperation. Globalization and Health, 17 (1) 84, 1-6. doi: 10.1186/s12992-021-00731-2
2021
Other Outputs
Myocardial and microvascular physiology in septic shock and response to volume expansion treatment
Obonyo, Nchafatso Gikenyi (2021). Myocardial and microvascular physiology in septic shock and response to volume expansion treatment. PhD Thesis, Life, Health and Chemical Sciences; Faculty of Science Technology, Engineering and Mathematics, The Open University of London, United Kingdom. doi: 10.21954/ou.ro.00011dde
2021
Journal Article
Compromised right ventricular contractility in an ovine model of heart transplantation following 24 h donor brain stem death
Wells, Matthew A., See Hoe, Louise E., Molenaar, Peter, Pedersen, Sanne, Obonyo, Nchafatso G., McDonald, Charles I., Mo, Weilan, Bouquet, Mahè, Hyslop, Kieran, Passmore, Margaret R., Bartnikowski, Nicole, Suen, Jacky Y., Peart, Jason N., McGiffin, David C., Fraser, John F. and on behalf of the Dead Heart Project (2021). Compromised right ventricular contractility in an ovine model of heart transplantation following 24 h donor brain stem death. Pharmacological Research, 169 105631, 1-12. doi: 10.1016/j.phrs.2021.105631
2021
Journal Article
An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients
Li Bassi, Gianluigi, Suen, Jacky Y, Dalton, Heidi J, White, Nicole, Shrapnel, Sally, Fanning, Jonathon P, Liquet, Benoit, Hinton, Samuel, Vuorinen, Aapeli, Booth, Gareth, Millar, Jonathan E, Forsyth, Simon, Panigada, Mauro, Laffey, John, Brodie, Daniel, Fan, Eddy, Torres, Antoni, Chiumello, Davide, Corley, Amanda, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Murthy, Srinivas, Nichol, Alistair, Ng, Pauline Yeung, Ogino, Mark, Pesenti, Antonio, Trieu, Huynh Trung ... Obonyo, Gikenyi N. (2021). An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients. Critical Care, 25 (1) 199, 1-22. doi: 10.1186/s13054-021-03518-4
2021
Conference Publication
Donor heart preservation by hypothermic ex vivo perfusion - improved recipient survival and successful prolongation of ischemic time
Hoe, L. E. See, Wildi, K., Skeggs, K., Bouquet, M., Sato, K., Jung, J., Ainola, C., Hyslop, K., Heinsar, S., Abbate, G., Colombo, S. M., Passmore, M., Wood, E. S., Wells, M., Bartnikowski, N., O'Neill, H., Reid, J., Shuker, T., Haymet, A., Livingstone, S., Sato, N., Obonyo, N., James, L., He, T., McDonald, C., Mullins, D., Engkilde-Pedersen, S., Diab, S., Millar, J. E. ... Fraser, J. F. (2021). Donor heart preservation by hypothermic ex vivo perfusion - improved recipient survival and successful prolongation of ischemic time. ISHLT 41st Annual Meeting, Virtual, 24-28 April 2021. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2021.01.1864
2021
Journal Article
Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): a phase II randomised controlled trial: trial protocol
Maitland, Kathryn, Olupot-Olupot, Peter, Aloroker, Florence, Mpoya, Ayub, Mnjalla, Hellen, Passi, George, Nakuya, Margaret, Houston, Kirsty, Obonyo, Nchafatso, Hamaluba, Mainga, Evans, Jennifer A, Connon, Roisin, George, Elizabeth C and Gibb, Diana M (2021). Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): a phase II randomised controlled trial: trial protocol. Wellcome Open Research, 6 160, 160. doi: 10.12688/wellcomeopenres.16885.1
2020
Journal Article
Characterising pre-clinical sub-phenotypic models of Acute Respiratory Distress Syndrome: an experimental ovine study
Millar, Jonathan E., Wildi, Karin, Bartnikowski, Nicole, Bouquet, Mahe, Hyslop, Kieran, Passmore, Margaret R., Ki, Katrina K., See Hoe, Louise E., Obonyo, Nchafatso G., Neyton, Lucile, Pedersen, Sanne, Rozencwajg, Sacha, Baillie, J. Kenneth, Li Bassi, Gianluigi, Suen, Jacky Y, McAuley, Daniel F. and Fraser, John F. (2020). Characterising pre-clinical sub-phenotypic models of Acute Respiratory Distress Syndrome: an experimental ovine study.
Supervision
Availability
- Dr Nchafatso Obonyo is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Pre-clinical models of cardiac critical illness
Resuscitation-associated endotheliopathy in shock states
https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-023-02385-0
Media
Enquiries
For media enquiries about Dr Nchafatso Obonyo's areas of expertise, story ideas and help finding experts, contact our Media team: