Overview
Background
Dr Nchafatso G. Obonyo (BSc Hons, MB.ChB, DTM&H, MD/PhD, FCRcert)
Post-doctoral Research Fellow at the Critical Care Research Group-The Prince Charles Hospital, Institute of Molecular Bioscience-The University of Queensland. Main research focus is cardiac critical care and sepsis research.
Visiting Fellow in the Academic Division, Medical Engineering Research Facility, Queenlsand University of Technology. Fellow of the Initiative to Develop African Research Leaders (IDeAL) at the KEMRI-Wellcome Trust Research Programme, Kenya; Global Health Fellow, Wellcome Trust Centre for Global Health Research at Imperial College London,UK.
Recipient of the 2023 Africa Top-40 Under-40 Science Award and the 2023 African Professional in Australia of the Year Award.
Availability
- Dr Nchafatso Obonyo is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Open University (UK)
Research interests
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Sepsis and Septic Shock Resuscitation
Research on the effects of resuscitation on the microcirculation in sepsis and septic shock
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Cardiac and microvascular dysfunction in sepsis
Research on non-invasive imaging of cardiac and microvascular function in sepsis and septic shock states
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Cardiac critical care
Research on cardiac emergency and intensive care
Research impacts
Dr Obonyo's research work on septic shock and haemodynamic resuscitation highlights the global impact of sepsis and the importance of investigating resuscitation-associated dysfunction of the heart and vascular endothelium:
1. World Sepsis Day (13 September): https://youtu.be/VkAxQ0BD2QU
2. Aggressive fluid resucitation worsens endotoxaemic shock: Am J Respir Crit Care Med. 2018 Oct 15;198(8):1043-1054: https://pubmed.ncbi.nlm.nih.gov/29882682/
3. Resuscitation-associated endotheliopathy: https://www.ccrg.org.au/all-publications/rase
Dr Obonyo has also received awards for his research work including:
a. Postdoctoral Research Fellowship and Innovations Research Grant awarded by The Prince Charles Hospital Foundation (https://www.thecommongood.org.au/news/meet-doctor-nchafatso-obonyo/)
b. Continental recognition winning the 2023 Africa Top-40 Under-40 Award in Science and the Africa (https://www.ccrg.org.au/news/fortyunder40)
c. African Professional in Australia award in 2023 awarded across all professionals by the African Professionals of Australia (https://www.ccrg.org.au/news/obonyo-wins-national-apa-accolade)
Works
Search Professor Nchafatso Obonyo’s works on UQ eSpace
2023
Journal Article
Cardiovascular Health Priorities in Sub-Saharan Africa
Obonyo, Nchafatso G. and Etyang, Anthony O. (2023). Cardiovascular Health Priorities in Sub-Saharan Africa. SN Comprehensive Clinical Medicine, 5 (1) 262. doi: 10.1007/s42399-023-01605-x
2023
Journal Article
The effects of nitric oxide on coagulation and inflammation in ex‐vivo models of extracorporeal membrane oxygenation and cardiopulmonary bypass
Malfertheiner, Maximilian V., Ashlen, Garrett, Margaret, Passmore, Haymet, Andrew B., Richard, Webb I., von Bahr, Viktor, Millar, Jonathan E., Schneider, Bailey A., Obonyo, Nchafatso G., Debra, Black, Mahe, Bouquet, Nicole, Bartnikowski, Suen, Jacky Y. and Fraser, John F. (2023). The effects of nitric oxide on coagulation and inflammation in ex‐vivo models of extracorporeal membrane oxygenation and cardiopulmonary bypass. Artificial Organs, 47 (10), 1581-1591. doi: 10.1111/aor.14608
2023
Journal Article
SEVUparin as a potential Adjunctive Treatment in children with severe malaria: A phase I trial safety and dose finding trial (SEVUSMAART)
Maitland, Kathryn, Hamaluba, Mainga, Obonyo, Nchafatso, Oguda, Emmanuel, Mogoka, Christabel, Williams, Thomas N., Chaponda, Mike, Miti, Sam, Kamavu, Luc Kambale, Connon, Roisin, Gibb, Diana M., Dondorp, Arjen, Day, Nick, White, Nick, Walker, A. Sarah, George, Elizabeth C. and Severe Malaria in African Children A Research and Trials (SMAART) consortium (2023). SEVUparin as a potential Adjunctive Treatment in children with severe malaria: A phase I trial safety and dose finding trial (SEVUSMAART). Wellcome Open Research, 8, 484. doi: 10.12688/wellcomeopenres.20111.1
2023
Journal Article
Donor heart ischemic time can be extended to 8 hours using hypothermic machine perfusion in sheep
See Hoe, Louise E., Bassi, Gianluigi Li, Wildi, Karin, Passmore, Margaret R., Bouquet, Mahe, Sato, Kei, Heinsar, Silver, Ainola, Carmen, Bartnikowski, Nicole, Wilson, Emily S., Hyslop, Kieran, Skeggs, Kris, Obonyo, Nchafatso G., Shuker, Tristan, Bradbury, Lucy, Palmieri, Chiara, Pedersen, Sanne-Engkilde, McDonald, Charles, Colombo, Sebastiano M., Wells, Matthew A., Reid, Janice D., O'Neill, Hollier, Livingstone, Samantha, Abbate, Gabriella, Haymet, Andrew, Jung, Jae-Seung, Sato, Noriko, James, Lynnette, He, Ting ... Fraser, John F. (2023). Donor heart ischemic time can be extended to 8 hours using hypothermic machine perfusion in sheep. The Journal of Heart and Lung Transplantation, 42 (8), 1015-1029. doi: 10.1016/j.healun.2023.03.020
2023
Journal Article
Effects of transfusing older red blood cells and platelets on obstetric patient outcomes: a retrospective cohort study
Obonyo, Nchafatso G., Lu, Lawrence Y., White, Nicole M., Sela, Declan P., Rachakonda, Reema H., Teo, Derek, Tunbridge, Matthew, Sim, Beatrice, See Hoe, Louise E., Fanning, Jonathon P., Tung, John‐Paul, McKnoulty, Matthew, Bassi, Gianluigi Li, Suen, Jacky Y. and Fraser, John F. (2023). Effects of transfusing older red blood cells and platelets on obstetric patient outcomes: a retrospective cohort study. International Journal of Gynecology and Obstetrics, 164 (1), 184-191. doi: 10.1002/ijgo.14997
2023
Conference Publication
Effects of Red Blood Cell Transfusion on Patients Undergoing Cardiac Surgery in Queensland—A Retrospective Cohort Study
Dhanapathy, V., Obonyo, N., White, N., Sela, D., Rachakonda, R., Tunbridge, M., Sim, B., Teo, D., Hoe, L. See, Fanning, J., Tung, J., Suen, J. and Fraser, J. (2023). Effects of Red Blood Cell Transfusion on Patients Undergoing Cardiac Surgery in Queensland—A Retrospective Cohort Study. 71st Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Adelaide, SA Australia, 3-6 August 2023. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2023.06.458
2023
Conference Publication
A novel speckle-tracking echocardiographic parameter assessing left ventricular loading during VA ECMO in a pre-clinical model of cardiogenic shock
Sato, K., Heinsar, S., Obonyo, N., Wildi, K., Liu, K., Farah, S., Ainola, C., Sato, N., Ijuin, S., Ro, S. Kyun, Fior, G., Gandini, L., Bouquet, M., Wilson, E., Passmore, M., Hyslop, K., Chan, J., Platts, D., Scalia, G., Suen, J., Bassi, G. Li and Fraser, J. (2023). A novel speckle-tracking echocardiographic parameter assessing left ventricular loading during VA ECMO in a pre-clinical model of cardiogenic shock. 71st Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Adelaide, SA Australia, 3-6 August 2023. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2023.06.562
2023
Journal Article
Assessment and diagnosis of right ventricular failure—retrospection and future directions
Ro, Sun Kyun, Sato, Kei, Ijuin, Shinichi, Sela, Declan, Fior, Gabriele, Heinsar, Silver, Kim, Ji Young, Chan, Jonathan, Nonaka, Hideaki, Lin, Aaron C. W., Bassi, Gianluigi Li, Platts, David G., Obonyo, Nchafatso G., Suen, Jacky Y. and Fraser, John F. (2023). Assessment and diagnosis of right ventricular failure—retrospection and future directions. Frontiers in Cardiovascular Medicine, 10 1030864, 1-17. doi: 10.3389/fcvm.2023.1030864
2023
Journal Article
Interleukin-6 inhibitors in non-COVID-19 ARDS: analyzing the past to step into the post-COVID-19 era
Gandini, Lucia, Fior, Gabriele, Schibler, Andreas, Obonyo, Nchafatso G., Li Bassi, Gianluigi, Suen, Jacky Y. and Fraser, John F. (2023). Interleukin-6 inhibitors in non-COVID-19 ARDS: analyzing the past to step into the post-COVID-19 era. Critical Care, 27 (1) 124, 124. doi: 10.1186/s13054-023-04394-w
2023
Conference Publication
A novel speckle-tracking echocardiographic parameter considering left ventricular loading condition in cardiogenic shock during VA ECMO
Sato, Kei, Heinsar, Silver, Wildi, Karin Susanne, Obonyo, Nchafatso, Liu, Keibun, Farah, Samia, Ainola, Carmen, Sato, Noriko, Fior, Gabriele, Ro, Sun Kyun, Gandini, Lucia, Ijuin, Shinichi, Bouquet, Mahe, Wilson, Emily, Passmore, Margaret, Hyslop, Kieran, Chan, Jonathan H., Platts, David, Suen, Jacky, Li Bassi, Gianluigi and Fraser, John (2023). A novel speckle-tracking echocardiographic parameter considering left ventricular loading condition in cardiogenic shock during VA ECMO. 72nd Annual Scientific Session (ACC), New Orleans, LA, United States, 4-6 March 2023. San Diego, CA, United States: Elsevier.
2023
Journal Article
A novel speckle-tracking echocardiographic parameter considering left ventricular loading condition in cardiogenic shock during VA ECMO
Sato, Kei, Heinsar, Silver, Wildi, Karin Susanne, Obonyo, Nchafatso, LIU, KEIBUN, Farah, Samia, Ainola, Carmen, Sato, Noriko, Fior, Gabriele, Ro, Sun Kyun, Gandini, Lucia, Ijuin, Shinichi, Bouquet, Mahe, Wilson, Emily, Passmore, Margaret, Hyslop, Kieran, Chan, Jonathan H., Platts, David, Suen, Jacky, Bassi, Gianluigi Li and Fraser, John (2023). A novel speckle-tracking echocardiographic parameter considering left ventricular loading condition in cardiogenic shock during VA ECMO. Journal of the American College of Cardiology, 81 (8) 1396, 1-1. doi: 10.1016/s0735-1097(23)01840-5
2023
Journal Article
Hemorrhage, disseminated intravascular coagulopathy, and thrombosis complications among critically ill patients with COVID-19: an international COVID-19 critical care consortium study
Fanning, Jonathon P., Weaver, Natasha, Fanning, Robert B., Griffee, Matthew J., Cho, Sung-Min, Panigada, Mauro, Obonyo, Nchafatso G., Zaaqoq, Akram M., Rando, Hannah, Chia, Yew Woon, Fan, Bingwen Eugene, Sela, Declan, Chiumello, Davide, Coppola, Silvia, Labib, Ahmed, Whitman, Glenn J. R., Arora, Rakesh C., Kim, Bo S., Motos, Anna, Torres, Antoni, Barbé, Ferran, Grasselli, Giacomo, Zanella, Alberto, Etchill, Eric, Usman, Asad Ali, Feth, Maximilian, White, Nicole M., Suen, Jacky Y., Li Bassi, Gianluigi ... on behalf of the COVID-19 Critical Care Consortium (2023). Hemorrhage, disseminated intravascular coagulopathy, and thrombosis complications among critically ill patients with COVID-19: an international COVID-19 critical care consortium study. Critical Care Medicine, 51 (5), 619-631. doi: 10.1097/ccm.0000000000005798
2023
Journal Article
Resuscitation Associated Endotheliopathy (PubMed)
Obonyo, Nchafatso G., Sela, Declan P., Raman, Sainath, Rachakonda, Reema, Schneider, Bailey, Hoe, Louise E. See, Fanning, Jonathon P., Bassi, Gianluigi Li, Maitland, Kathryn, Suen, Jacky Y. and Fraser, John F. (2023). Resuscitation Associated Endotheliopathy (PubMed). searchRxiv, 2023. doi: 10.1079/searchrxiv.2023.00206
2022
Journal Article
A clinical and physiological prospective observational study on the management of pediatric shock in the post-fluid expansion as supportive therapy trial era
Obonyo, Nchafatso G., Olupot-Olupot, Peter, Mpoya, Ayub, Nteziyaremye, Julius, Chebet, Martin, Uyoga, Sophie, Muhindo, Rita, Fanning, Jonathon P., Shiino, Kenji, Chan, Jonathan, Fraser, John F. and Maitland, Kathryn (2022). A clinical and physiological prospective observational study on the management of pediatric shock in the post-fluid expansion as supportive therapy trial era. Pediatric Critical Care Medicine, 23 (7), 502-513. doi: 10.1097/pcc.0000000000002968
2022
Journal Article
Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis
Li Bassi, Gianluigi, Gibbons, Kristen, Suen, Jacky Y., Dalton, Heidi J., White, Nicole, Corley, Amanda, Shrapnel, Sally, Hinton, Samuel, Forsyth, Simon, Laffey, John G., Fan, Eddy, Fanning, Jonathon P., Panigada, Mauro, Bartlett, Robert, Brodie, Daniel, Burrell, Aidan, Chiumello, Davide, Elhazmi, Alyaa, Esperatti, Mariano, Grasselli, Giacomo, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Marwali, Eva, Merson, Laura, Murthy, Srinivas, Nichol, Alistair, Ogino, Mark, Pelosi, Paolo ... The COVID-19 Critical Care Consortium (2022). Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis. Critical Care, 26 (1) 141, 141. doi: 10.1186/s13054-022-03983-5
2022
Journal Article
Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study
Urner, Martin, Barnett, Adrian G., Bassi, Gianluigi Li, Brodie, Daniel, Dalton, Heidi J., Ferguson, Niall D., Heinsar, Silver, Hodgson, Carol L., Peek, Giles, Shekar, Kiran, Suen, Jacky Y., Fraser, John F., Fan, Eddy, COVID-19 Critical Care Consortium Investigators and Obonyo, Nchafatso (2022). Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study. BMJ, 377 e068723, e068723. doi: 10.1136/bmj-2021-068723
2022
Conference Publication
Hypothermic ex vivo perfusion of donor hearts can safely preserve post-transplant cardiac function in sheep for 8 hours
See Hoe, Louise E., Bouquet, Mahe, Hyslop, Kieran, Passmore, Margaret R., Wells, Matthew A., Sato, Kei, Wilson, Emily, Wildi, Karin, Skeggs, Kris, Palmeri, Chiara, Reid, Janice, O'Neill, Hollier, Bartnikowski, Nicole, Jung, Jae-Seung, Ainola, Carmen, Abbate, Gabriella, Colombo, Sebastiano M., Obonyo, Nchafatso G., McDonald, Charles, Shuker, Tristan, Heinsar, Silver, Haymet, Andrew, Pedersen, Sanne, Molenaar, Peter, Li Bassi, Gianluigi, Suen, Jacky Y., McGiffin, David C. and Fraser, John F. (2022). Hypothermic ex vivo perfusion of donor hearts can safely preserve post-transplant cardiac function in sheep for 8 hours. Experimental Biology 2022 Meeting, Philadelphia, PA United States, 2-5 April 2022. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.2022.36.S1.R3270
2022
Journal Article
Exploration of the utility of speckle-tracking echocardiography during mechanical ventilation and mechanical circulatory support
Sato, Kei, Chan, Jonathan, Appadurai, Vinesh, Obonyo, Nchafatso, See Hoe, Louise, Suen, Jacky Y. and Fraser, John F. (2022). Exploration of the utility of speckle-tracking echocardiography during mechanical ventilation and mechanical circulatory support. Critical Care Explorations, 4 (4) e0666, 1-10. doi: 10.1097/CCE.0000000000000666
2022
Journal Article
Impact of renin-angiotensin-aldosterone system inhibition on mortality in critically ill COVID-19 patients with pre-existing hypertension: a prospective cohort study
Sato, Kei, White, Nicole, Fanning, Jonathon P., Obonyo, Nchafatso, Yamashita, Michael H., Appadurai, Vinesh, Ciullo, Anna, May, Meryta, Worku, Elliott T., Helms, Leticia, Ohshimo, Shinichiro, Juzar, Dafsah A., Suen, Jacky Y., Bassi, Gianluigi Li, Fraser, John F., Arora, Rakesh C. and on behalf of COVID-19 Critical Care Consortium Investigators (2022). Impact of renin-angiotensin-aldosterone system inhibition on mortality in critically ill COVID-19 patients with pre-existing hypertension: a prospective cohort study. BMC Cardiovascular Disorders, 22 (1) 123, 123. doi: 10.1186/s12872-022-02565-1
2022
Conference Publication
Post-transplant cardiac contractility and mitochondrial function is preserved following 8 hours hypothermic ex vivo perfusion in sheep
See Hoe, L., Bouquet, M., Hyslop, K., Passmore, M., Wells, M., Sato, K., Wilson, E., Wildi, K., Skeggs, K., Palmeri, C., Reid, J., O'Neill, H., Bartnikowski, N., Jung, J., Ainola, C., Abbate, G., Colombo, S., Obonyo, N., McDonald, C., Shuker, T., Heinsar, S., Haymet, A., Engkilde-Pedersen, S., Peart, J., Molenaar, P., Li Bassi, G., Suen, J., McGiffin, D. and Fraser, J. (2022). Post-transplant cardiac contractility and mitochondrial function is preserved following 8 hours hypothermic ex vivo perfusion in sheep. 70th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Gold Coast, QLD, Australia, 11-14 August 2022. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2022.06.547
Supervision
Availability
- Dr Nchafatso Obonyo is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Pre-clinical models of cardiac critical illness
Resuscitation-associated endotheliopathy in shock states
https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-023-02385-0
Media
Enquiries
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