Overview
Background
Dr Nchafatso G. Obonyo (BSc Hons, MB.ChB, DTM&H, MD/PhD, FCRcert)
Post-doctoral Research Fellow at the Critical Care Research Group-The Prince Charles Hospital, Institute of Molecular Bioscience-The University of Queensland. Main research focus is cardiac critical care and sepsis research.
Visiting Fellow in the Academic Division, Medical Engineering Research Facility, Queenlsand University of Technology. Fellow of the Initiative to Develop African Research Leaders (IDeAL) at the KEMRI-Wellcome Trust Research Programme, Kenya; Global Health Fellow, Wellcome Trust Centre for Global Health Research at Imperial College London,UK.
Recipient of the 2023 Africa Top-40 Under-40 Science Award and the 2023 African Professional in Australia of the Year Award.
Availability
- Dr Nchafatso Obonyo is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Open University (UK)
Research interests
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Sepsis and Septic Shock Resuscitation
Research on the effects of resuscitation on the microcirculation in sepsis and septic shock
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Cardiac and microvascular dysfunction in sepsis
Research on non-invasive imaging of cardiac and microvascular function in sepsis and septic shock states
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Cardiac critical care
Research on cardiac emergency and intensive care
Research impacts
Dr Obonyo's research work on septic shock and haemodynamic resuscitation highlights the global impact of sepsis and the importance of investigating resuscitation-associated dysfunction of the heart and vascular endothelium:
1. World Sepsis Day (13 September): https://youtu.be/VkAxQ0BD2QU
2. Aggressive fluid resucitation worsens endotoxaemic shock: Am J Respir Crit Care Med. 2018 Oct 15;198(8):1043-1054: https://pubmed.ncbi.nlm.nih.gov/29882682/
3. Resuscitation-associated endotheliopathy: https://www.ccrg.org.au/all-publications/rase
Dr Obonyo has also received awards for his research work including:
a. Postdoctoral Research Fellowship and Innovations Research Grant awarded by The Prince Charles Hospital Foundation (https://www.thecommongood.org.au/news/meet-doctor-nchafatso-obonyo/)
b. Continental recognition winning the 2023 Africa Top-40 Under-40 Award in Science and the Africa (https://www.ccrg.org.au/news/fortyunder40)
c. African Professional in Australia award in 2023 awarded across all professionals by the African Professionals of Australia (https://www.ccrg.org.au/news/obonyo-wins-national-apa-accolade)
Works
Search Professor Nchafatso Obonyo’s works on UQ eSpace
2018
Journal Article
Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia
Byrne, Liam, Obonyo, Nchafatso G., Diab, Sara D., Dunster, Kimble R., Passmore, Margaret R., Boon, Ai-Ching, See Hoe, Louise, Pedersen, Sanne, Hashairi Fauzi, Mohd, Pretti Pimenta, Leticia, Van Haren, Frank, Anstey, Christopher M., Cullen, Louise, Tung, John-Paul, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2018). Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia. American Journal of Respiratory and Critical Care Medicine, 198 (8), 1043-1054. doi: 10.1164/rccm.201801-0064OC
2018
Conference Publication
Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxemic shock
Obonyo, N., Byrne, L., Shiino, K., Diab, S., Dunster, K., Passmore, M., Boon, A.C., See Hoe, L., Pedersen, S., Fauzi, M., Pimenta, L., Van Haren, F., Shekar, K., Anstey, C., Tung, J.P., Cullen, L., Platts, D., Chan, J., Maitland, K. and Fraser, J. (2018). Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxemic shock. 9th Congress of the World Federation of Pediatric Intensive & Critical Care Societies (WFPICCS 2018), Singapore, 9-13 June 2018. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.pcc.0000538016.15507.8c
2018
Conference Publication
G265(P) Gastroenteritis aggressive versus slow treatment for rehydration (gastro study): a descriptive analysis
Houston, K., Gibb, J., Mpoya, A., Obonyo, N., Olupot-Olupot, P., George, E., Gibb, D. and Maitland, K. (2018). G265(P) Gastroenteritis aggressive versus slow treatment for rehydration (gastro study): a descriptive analysis. Annual Conference of Royal College of Paediatrics and Child Health, Glasgow, United Kingdom, 13-15 March 2018. London, United Kingdom: BMJ Publishing Group. doi: 10.1136/archdischild-2018-rcpch.258
2018
Conference Publication
Development of an ovine model of dilated cardiomyopathy to facilitate clinically translational research
Bartnikowski, N., Obonyo, N., Pedersen, S., Wells, M., Millar, J., Raffel, O., Suen, J., Gregory, S., Haqqani, H. and Fraser, J. (2018). Development of an ovine model of dilated cardiomyopathy to facilitate clinically translational research. 66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting, Brisbane, QLD Australia, 2 - 5 August 2018. Chatswood, NSW Australia: Elsevier . doi: 10.1016/j.hlc.2018.06.110
2018
Conference Publication
Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxaemic shock
See Hoe, L., Obonyo, N., Byrne, L., Shiino, K., Diab, S., Dunster, K., Passmore, M., Boon, C., Engkilde-Pedersen, S., Esguerra, A., Fauzi, M., Pretti Pimenta, L., Simonova, G., Van Haren, F., Shekar, K., Anstey, C., Tung, J., Cullen, L., Platts, D., Chan, J., Maitland, K. and Fraser, J. (2018). Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxaemic shock. 66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting, Brisbane, Australia, 2-5 August 2018. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2018.06.129
2018
Conference Publication
Packed red cell age associated with adverse cardiovascular changes in an ovine model of septic shock resuscitation
Fanning, Jonathon P., Obonyo, Nchafatso G., Tung, John-Paul, Byrne, Liam, Simonova, Gabriela, Diab, Sara, Dunster, Kimble, Passmore, Margaret, Boon, Ai-Ching, Hoe, See Louise, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Fauzi, Hashairi Mohd, Pretti, Pimenta Leticia, Millar, Jonathan, Anstey, Christopher, van Haren, Frank, Cullen, Louise, Suen, Jacky, Shekar, Kiran, Maitland, Kathryn and Fraser, John (2018). Packed red cell age associated with adverse cardiovascular changes in an ovine model of septic shock resuscitation. -, -, 2018. Philadelphia, PA United States: Lippincott Williams & Wilkins.
2018
Conference Publication
Neuron specific enolase and matrix metaloproteinase 9 signal silent brain infarction associated with TAVI
Fanning, Jonathon P., Hoe, See Louise E., Passmore, Margaret R., Barnett, Adrian G., Obonyo, Nchafatso G., Millar, Jonathan E., Suen, Jacky Y. and Fraser, John F. (2018). Neuron specific enolase and matrix metaloproteinase 9 signal silent brain infarction associated with TAVI. Philadelphia, PA, United States: Lippincott Williams & Wilkins.
2018
Journal Article
An ovine model of hyperdynamic endotoxemia and vital organ metabolism
Byrne, Liam, Obonyo, Nchafatso G., Diab, Sara, Dunster, Kimble, Passmore, Margaret, Boon, Ai Ching, Hoe, Louise See, Hay, Karen, Van Haren, Frank, Tung, John-Paul, Cullen, Louise, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2018). An ovine model of hyperdynamic endotoxemia and vital organ metabolism. Shock, 49 (1), 99-107. doi: 10.1097/SHK.0000000000000904
2018
Conference Publication
Pre-transplant microcirculatory profile in an ovine model of brain stem death
Tsui, Michelle, Obonyo, Nchafatso G., Boon, Ai Ching, Hoe, Louise See, Bartnikowski, Nicole J., Passmore, Margaret R., Pedersen, Sanne Engkilde S. P., Diab, Sara D., McGiffin, David C. and Fraser, John F. (2018). Pre-transplant microcirculatory profile in an ovine model of brain stem death. Owen Wangensteen Scientific Forum / Annual Clinical Congress of the American-College-of-Surgeons (ACS), Boston, MA, United States, 21-25 October 2018. New York, United States: Elsevier. doi: 10.1016/j.jamcollsurg.2018.08.608
2018
Conference Publication
Inflammatory cytokine profiles in 24-hour brain stem death model
Boon, A. C., Hoe, L. E. See, Pederson, S. E., Obonyo, N. G., Wells, M. A., Bartnikowski, N. J., Passmore, M. R., Marshall, L., James, L., Tung, J., Suen, J. Y., Macdonald, P. S., McGiffin, D. C. and Fraser, J. F. (2018). Inflammatory cytokine profiles in 24-hour brain stem death model. 38th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation (ISHLT), Nice, France, 11-14 April 2018. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.healun.2018.01.506
2018
Book Chapter
Optimizing the patient and timing of the introduction of mechanical circulatory and extracorporeal respiratory support
Shekar, Kiran, Obonyo, Nchafatso and Fraser, John F. (2018). Optimizing the patient and timing of the introduction of mechanical circulatory and extracorporeal respiratory support. Mechanical circulatory and respiratory support. (pp. 441-468) edited by Shaun D. Gregory, Michael C. Stevens and John F. Fraser. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-810491-0.00014-X
2018
Conference Publication
Development of an ovine model of heart transplantation following 24-hour brain stem death
See Hoe, L., Engkilde-Pedersen, S., Obonyo, N., Wells, M., Boon, C., Bartnikowski, N., Passmore, M., McDonald, C., Black, D., Molenaar, P., Diab, S., Suen, J., Marasco, S., McGiffin, D. and Fraser, J. (2018). Development of an ovine model of heart transplantation following 24-hour brain stem death. 66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting, Brisbane, Australia, 2-5 August 2018. Chatswood, NSW, Australia: Elsevier . doi: 10.1016/j.hlc.2018.06.111
2017
Journal Article
Acquired von willebrand syndrome in respiratory extracorporeal life support: A systematic review of the literature
Malfertheiner, M. V., Pimenta, L. P., Von Bahr, V., Millar, J. E., Obonyo, N. G., Suen, J. Y., Pellegrino, V. and Fraser, J. F. (2017). Acquired von willebrand syndrome in respiratory extracorporeal life support: A systematic review of the literature. Critical Care and Resuscitation, 19, 45-52.
2017
Journal Article
Gastroenteritis Aggressive Versus Slow Treatment For Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO plan C versus slower rehydration
Houston, Kirsty A., Gibb, Jack G., Mpoya, Ayub, Obonyo, Nchafatso, Olupot-Olupot, Peter, Nakuya, Margeret, Evans, Jennifer A., George, Elizabeth C., Gibb, Diana M. and Maitland, Kathryn (2017). Gastroenteritis Aggressive Versus Slow Treatment For Rehydration (GASTRO). A pilot rehydration study for severe dehydration: WHO plan C versus slower rehydration. Wellcome Open Research, 2 62, 62. doi: 10.12688/wellcomeopenres.12261.1
2017
Journal Article
Left Ventricular Global Strain Analysis by Two-Dimensional Speckle-Tracking Echocardiography: The Learning Curve
Chan, Jonathan, Shiino, Kenji, Obonyo, Nchafatso G., Hanna, Joseph, Chamberlain, Robert, Small, Andrew, Scalia, Isabel G., Scalia, William, Yamada, Akira, Hamilton-Craig, Christian R., Scalia, Gregory M. and Zamorano, Jose Luis (2017). Left Ventricular Global Strain Analysis by Two-Dimensional Speckle-Tracking Echocardiography: The Learning Curve. Journal of the American Society of Echocardiography, 30 (11), 1081-1090. doi: 10.1016/j.echo.2017.06.010
2017
Journal Article
Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study)
Obonyo, Nchafatso, Brent, Bernadette, Olupot-Olupot, Peter, van Hensbroek, Michael Boele, Kuipers, Irene, Wong, Sidney, Shiino, Kenji, Chan, Jonathan, Fraser, John, van Woensel, Job B. M. and Maitland, Kathryn (2017). Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study). Critical Care, 21. doi: 10.1186/s13054-017-1679-0
2017
Conference Publication
Point-of-care testing in an ovine model of transfusion-related acute lung injury (TRALI)
Tung, John-Paul, Simonova, Gabriela, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Sultana, Annette, Hewlett, Elise, Obonyo, Nchafatso, Millar, Jonathan, Flower, Robert and Fraser, John (2017). Point-of-care testing in an ovine model of transfusion-related acute lung injury (TRALI). Pathology Update 2017, Sydney, NSW Australia, 24-26 February 2017. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2016.12.309
2017
Conference Publication
Heart failure pre-clinical model development: echocardiography and cardiac strain evaluation
Obonyo, N., Bartnikowski, N., Haqqani, H., Pedersen, S., Millar, J., He, C., Shiino, K., Chan, J., Platts, D., Raffel, O., Gregory, S. and Fraser, J. (2017). Heart failure pre-clinical model development: echocardiography and cardiac strain evaluation. 65th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Perth, WA Australia, 10-13 August 2017. Chatswood, NSW Australia: Elsevier Australia. doi: 10.1016/j.hlc.2017.06.212
2016
Journal Article
Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review
Obonyo, Nchafatso G., Fanning, Jonathon P., Ng, Angela S. Y., Pimenta, Leticia P., Shekar, Kiran, Platts, David G., Maitland, Kathryn and Fraser, John F. (2016). Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review. Intensive Care Medicine Experimental, 4 (1) 38, 1-16. doi: 10.1186/s40635-016-0112-3
2016
Journal Article
Career preferences of final year medical students at a medical school in Kenya-a cross sectional study
Dossajee, Hussein, Obonyo, Nchafatso and Ahmed, Syed Masud (2016). Career preferences of final year medical students at a medical school in Kenya-a cross sectional study. BMC Medical Education, 16 (1) 5. doi: 10.1186/s12909-016-0528-1
Supervision
Availability
- Dr Nchafatso Obonyo is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Pre-clinical models of cardiac critical illness
Resuscitation-associated endotheliopathy in shock states
https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-023-02385-0
Media
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