Overview
Background
Research interests in Artificial Heart and Lung therapies.
Charted Engineering (Biomedical) with Engineers Australia and BPEQ. Industry experience in nonclinical device testing and regulatory submissions of total artificial heart.
Engineering Lead at Innovative Cardiovascular Engineering and Technology Laboratory (ICETLab), Critical Care Research Group, The Prince Charles Hospital
Availability
- Dr Eric Wu is:
- Available for supervision
Research impacts
Verification and validation activities of total artificial heart therapy that has been approved for clinical investigation
Nonclinical test platforms for evaluation of mechanical circulatory and respiratory support devices.
Works
Search Professor Eric Wu’s works on UQ eSpace
2025
Journal Article
Evaluation of Cardiac Output Estimation with Veno-Venous Extracorporeal membrane Oxygenation Support: in vitro study
Garbutt, Michael, Grant, Oriane, Nonaka, Hideaki, Bosch, Johannes, Benitez, Jessica, Fraser, John F. and Wu, Eric L. (2025). Evaluation of Cardiac Output Estimation with Veno-Venous Extracorporeal membrane Oxygenation Support: in vitro study. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2025, 1-4. doi: 10.1109/EMBC58623.2025.11251892
2025
Book Chapter
Ventricular assist devices: volume displacement pumps
Wu, Eric L. and Stevens, Michael C. (2025). Ventricular assist devices: volume displacement pumps. Mechanical Circulatory and Respiratory Support. (pp. 123-144) London, United Kingdom: Academic Press. doi: 10.1016/b978-0-443-22148-4.00004-6
2025
Book Chapter
Pulsatile versus continuous flow
Heinsar, Silver, Wu, Eric L., Ajamu, Samuel and Ündar, Akif (2025). Pulsatile versus continuous flow. Mechanical Circulatory and Respiratory Support. (pp. 517-551) London, United Kingdom: Academic Press. doi: 10.1016/b978-0-443-22148-4.00017-4
2025
Journal Article
In Vitro Hemocompatibility of the BiVACOR Total Artificial Heart Near the Boundaries of Clinical Operation
Mcna Mee, Antony P., Timms, Daniel, Nestler, Frank, Bartnikowski, Nicole, Tansley, Geoff D., Wu, Eric and Simmonds, Michael J. (2025). In Vitro Hemocompatibility of the BiVACOR Total Artificial Heart Near the Boundaries of Clinical Operation. ASAIO Journal 10.1097/MAT.0000000000002536. doi: 10.1097/MAT.0000000000002536
2023
Journal Article
Estimation of left ventricular stroke work for rotary left ventricular assist devices
Wu, Eric L., Maw, Martin, Stephens, Andrew F., Stevens, Michael C., Fraser, John F., Tansley, Geoffrey, Moscato, Francesco and Gregory, Shaun D. (2023). Estimation of left ventricular stroke work for rotary left ventricular assist devices. ASAIO Journal, 69 (9), 817-826. doi: 10.1097/MAT.0000000000001972
2023
Conference Publication
CARD5: chronic In-vivo evaluation of the BiVACOR rotary total artificial heart
Timms, Daniel, Greatrex, Nicholas, Nestler, Frank, Wu, Eric, Kleinheyer, Matthias, Gluck, Trenton, Elgalad, Abdelmotagaly, Costas, Gil, Shafii, Alexis E., Dowling, Robert, Cohn, William and Frazier, O.H. (2023). CARD5: chronic In-vivo evaluation of the BiVACOR rotary total artificial heart. ASAIO 2023 Annual Meeting, San Francisco, CA USA, 14-17 June 2023. Philadelphia, PA USA: Lippincott Williams & Wilkins. doi: 10.1097/01.mat.0000943544.23409.60
2023
Conference Publication
(127) Preclinical evaluation of the bivacor total artificial heart
Timms, D. L., Greatrex, N., Nestler, F., Wu, E., Kleinheyer, M., Cohn, W. and Frazier, O. (2023). (127) Preclinical evaluation of the bivacor total artificial heart. ISHLT 43rd Annual Meeting and Scientific Sessions, Denver, CO USA, 19-22 April 2023. Philadelphia, PA USA: Elsevier. doi: 10.1016/j.healun.2023.02.143
2023
Journal Article
A comprehensive evaluation of hemodynamic energy production and circuit loss using four different ECMO arterial cannulae
Heinsar, Silver, Bartnikowski, Nicole, Hartel, Gunter, Farah, Samia M., Seah, E‐Peng, Wu, Eric, Colombo, Sebastiano Maria, Semenzin, Clayton, Haymet, Andrew, Rätsep, Indrek, Pauls, Jo, Fraser, John F. and Suen, Jacky Y. (2023). A comprehensive evaluation of hemodynamic energy production and circuit loss using four different ECMO arterial cannulae. Artificial Organs, 47 (7), 1122-1132. doi: 10.1111/aor.14523
2020
Journal Article
Open-source automated centrifugal pump test rig
Semenzin, Clayton S, Mapley, Martin, Wu, Eric, Pauls, Jo P, Simpson, Benjamin, Gregory, Shaun D and Tansley, Geoff (2020). Open-source automated centrifugal pump test rig. HardwareX, 8 e00140, e00140. doi: 10.1016/j.ohx.2020.e00140
2020
Journal Article
HeartWare HVAD flow estimator accuracy for left and right ventricular support
Stephens, Andrew F., Mapley, Martin, Wu, Eric L., Fraser, John F., Steinseifer, Ulrich, Bartnikowski, Nicole and Gregory, Shaun D. (2020). HeartWare HVAD flow estimator accuracy for left and right ventricular support. ASAIO Journal, 67 (4), 416-422. doi: 10.1097/MAT.0000000000001247
2020
Journal Article
Haemodynamic effect of left atrial and left ventricular cannulation with a rapid speed modulated rotary blood pump during rest and exercise: investigation in a numerical cardiorespiratory model
Wu, Eric L., Fresiello, Libera, Kleinhyer, Matthias, Meyns, Bart, Fraser, John F., Tansley, Geoff and Gregory, Shaun D. (2020). Haemodynamic effect of left atrial and left ventricular cannulation with a rapid speed modulated rotary blood pump during rest and exercise: investigation in a numerical cardiorespiratory model. Cardiovascular engineering and technology, 11 (4), 350-361. doi: 10.1007/s13239-020-00471-1
2020
Journal Article
An advanced mock circulation loop for in vitro cardiovascular device evaluation
Gregory, Shaun D., Pauls, Jo P., Wu, Eric L., Stephens, Andrew, Steinseifer, Ulrich, Tansley, Geoff and Fraser, John F. (2020). An advanced mock circulation loop for in vitro cardiovascular device evaluation. Artificial Organs, 44 (6) aor.13636, E238-E250. doi: 10.1111/aor.13636
2020
Journal Article
A Starling-like total work controller for rotary blood pumps: an in vitro evaluation
Wu, Eric L., Stevens, Michael C., Nestler, Frank, Pauls, Jo P., Bradley, Andrew P., Tansley, Geoff, Fraser, John F. and Gregory, Shaun D. (2020). A Starling-like total work controller for rotary blood pumps: an in vitro evaluation. Artificial Organs, 44 (3), E40-E53. doi: 10.1111/aor.13570
2019
Journal Article
In Vitro Hemocompatibility Evaluation of Modified Rotary Left to Right Ventricular Assist Devices in Pulmonary Flow Conditions
Chan, Chris Hoi Houng, Nandakumar, Deepika, Balletti, Nicoletta, Horobin, Jarod, Wu, Eric Lee-Jan, Bouquet, Mahe, Stephens, Andrew, Pauls, Jo P., Tansley, Geoff, Fraser, John F., Simmonds, Michael J. and Gregory, Shaun D. (2019). In Vitro Hemocompatibility Evaluation of Modified Rotary Left to Right Ventricular Assist Devices in Pulmonary Flow Conditions. ASAIO Journal, 66 (6), 1-8. doi: 10.1097/mat.0000000000001049
2019
Journal Article
Evaluation of an intraventricular balloon pump for short‐term support of patients with heart failure
Boone, Alice C., Gregory, Shaun D., Wu, Eric L., Stephens, Andrew, Liao, Sam, Pauls, Jo P., Salamonsen, Robert, Fraser, John and Tansley, Geoff D. (2019). Evaluation of an intraventricular balloon pump for short‐term support of patients with heart failure. Artificial Organs, 43 (9) aor.13454, 860-869. doi: 10.1111/aor.13454
2018
Journal Article
The influence of rotary blood pump speed modulation on the risk of intraventricular thrombosis
Liao, Sam, Wu, Eric L., Neidlin, Michael, Li, Zhiyong, Simpson, Benjamin and Gregory, Shaun D. (2018). The influence of rotary blood pump speed modulation on the risk of intraventricular thrombosis. Artificial Organs, 42 (10), 943-953. doi: 10.1111/aor.13330
2018
Journal Article
Pulmonary valve opening with two rotary left ventricular assist devices for biventricular support
Wu, Eric L., Nestler, Frank, Kleinheyer, Matthias, Stevens, Michael C., Pauls, Jo P., Fraser, John F. and Gregory, Shaun D. (2018). Pulmonary valve opening with two rotary left ventricular assist devices for biventricular support. Artificial Organs, 42 (1), 31-40. doi: 10.1111/aor.12967
2018
Book Chapter
Pulsatile vs. continuous flow
Wu, Eric L., Kleinheyer, Matthias and Undar, Akif (2018). Pulsatile vs. continuous flow. Mechanical circulatory and respiratory support. (pp. 379-406) edited by Shaun D. Gregory, Michael C. Stevens and John F. Fraser. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-810491-0.00012-6
2018
Conference Publication
In-vitro evaluation of cardiac energetics and coronary flow with volume displacement and rotary blood pumps
Wu, Eric L., Tansley, Geoff, Fraser, John F. and Gregory, Shaun D. (2018). In-vitro evaluation of cardiac energetics and coronary flow with volume displacement and rotary blood pumps. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, Honolulu, Hawaii, 18-21 July 2018. NEW YORK: IEEE. doi: 10.1109/EMBC.2018.8513158
2018
Book Chapter
First-generation ventricular assist devices
Wu, Eric L., Stevens, Michael C., Pauls, Jo P. and Steinseifer, Ulrich (2018). First-generation ventricular assist devices. Mechanical circulatory and respiratory support. (pp. 93-115) edited by Shaun D. Gregory, Michael C. Stevens and John F. Fraser. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-810491-0.00003-5
Funding
Current funding
Supervision
Availability
- Dr Eric Wu is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
-
Algorithm Development for Haemodynamic Monitoring in the ICU
Background and Aim: Circulatory shock is a devastating condition resulting in patient mortality and morbidity. Intensive care clinicians currently do not have adequate diagnostic tools to continuously monitor patient heart function to identify shock conditions. The project aims to develop and validated algorithms to estimate how well the heart fills (left ventricular end-diastolic volume) and pumps (left ventricular end-systolic elastance) in real time, using nonclinical and human observation data.
Methods:
- Use a mechanical representation of the cardiovascular system to generate a data set and develop estimation algorithms (mechanistic- and data-driven methods)
- Verify performance in acute animal studies and with human observation data
- Collaborate with clinicians to identify suitable alerts and alarms
Potential outcomes
- Provide clinicians with a tool to improve patient monitoring in the intensive care unit for better patient outcomes
- Contribute to intellectual property development and journal publications
Funding: Currently unfunded. Prospective students will be supported for scholarship applications (through UQ and The Prince Charles Hospital Foundation)
About us: Work at The Prince Charles Hospital with clinicians and engineers with industry expertise. Opportunities to complete visiting research / industry internships at international institutes / companies.
About you: Experience in biomedical signal processing (essential). Experience with haemodynamic modelling (desirable) and interacting with clinicians (desirable).
-
Artificial Lung Development - Circulatory Connections
Background and Aim: For patients with end-stage lung disease, donor transplantation is considered the gold-standard therapy. However, limited donors increase risk of patient dying on the waitlist, whilst many others are not eligible for transplantation. An Artificial Lung is under development, and circulatory connections are needed to facilitate blood transfer between the cardiovascular system and device.
Methods:
- Design and develop circulatory connections in collaboration with surgeons.
- Verify performance of circulatory connections in numerical model (computational fluid dynamics) and bench top (particle image velocimetry)
- Investigate and select hemocompatible materials and evaluate with blood studies
Potential outcomes
- Provide surgical team with user friendly circulatory connection for device implantation
- Improved patient outcomes with reduced risk of blood trauma
- Contribute to intellectual property development and journal publications
Funding: Currently unfunded. Prospective students will be supported for scholarship applications (through UQ and The Prince Charles Hospital Foundation)
About us: Work at The Prince Charles Hospital with clinicians and engineers with industry expertise. Opportunities to complete visiting research / industry internships at international institutes / companies.
About you: Experience in flow visualization techniques (essential). Experience with biocompatibility evaluation (desirable) and interacting with clinicians (desirable).
Media
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