
Overview
Background
NAME Professor Elizabeth Ellen POWELL
POSITION TITLE Professor, School of Medicine, The University of Queensland; Hepatologist, Princess Alexandra Hospital
Email e.powell@uq.edu.au
EDUCATION/TRAINING
Bachelor of Medicine and Bachelor of Surgery with First Class Honours (M.B.,B.S.Hons1), The University of Queensland
Fellow of the Royal Australasian College of Physicians
Doctor of Philosophy (PhD), The University of Queensland
Fellow of the Royal College of Physicians, London
Fellow, American Association for the Study of Liver Diseases
Elizabeth Powell is a Hepatologist and Senior Staff Specialist in the Department of Gastroenterology and Hepatology, Princess Alexandra Hospital. She is also Professor, School of Medicine, The University of Queensland, Director of the network Centre for Liver Disease Research in The University of Queensland and a Research Fellow with the American Association for the Study of Liver Diseases. She is also a recent past member of the Executive of the Australian Liver Association.
Professor Powell has a very productive research group, bridging basic science and clinical research. Her main research interests include:
(i) developing strategies to improve the assessment of non-alcoholic fatty liver disease by primary care clinicians and non-hepatology specialists.
(ii) examining ways to improve education and medication management for people with decompensated cirrhosis (advanced liver disease)
(iii) examining the role of injury-stratifying biomarkers for non-alcoholic fatty liver disease
Availability
- Professor Elizabeth Powell is:
- Available for supervision
Fields of research
Research impacts
Contributions to the field: Include shaping two new paradigms in hepatology research: the importance of metabolic risk factors in the progression of chronic liver diseases, and more recently proposing altered hepatic regeneration and the ductular reaction as a potential driver of hepatic fibrosis. This innovative research on the association between the hepatic stem cell niche and fibrosis has led to increasing recognition internationally that fibrogenesis and carcinogenesis may be intrinsically associated with activation of this niche. A significant contribution has been to foster a multidisciplinary, collaborative approach to the field, involving hepatopathology together with molecular and clinical hepatology research. More recently she has established new interdisciplinary partnerships to undertake research in areas related to chronic liver disease management.
Collaborations: Nationally, collaborations include those with researchers from QIMR Berghofer Medical Research Institute, Translational Research Institute and Institute for Molecular Bioscience, the University of Queensland; she also collaborates with clinicians from Inala Primary Care and the Princess Alexandra Hospital. Internationally, she contributes to the Drug-induced liver injury network (DILIN) and International Serious Adverse Events Consortium (iSAEC) (based in the UK) and the International Liver Disease Genetics Consortium. More recently she has partnered with Siemens Healthineers to study prevalence and severity of non-alcoholic fatty liver disease in diabetes clinics and primary care.
Community Engagement: Prof Powell is regularly involved in speaking to General Practitioners and community groups and reviews resources for the Ethnic Communities Council of QLD. She has organized and chaired numerous multidisciplinary networking workshops with the purpose of bringing together clinicians/researchers, showcase what is going on in the field, and open opportunities for communication and collaboration.
Professional Involvement and Peer Review: Prof Powell is a past member of the Editorial Board of Hepatology, the Clinical Research Committee of the American Association for the Study of Liver Diseases and a recent past member of the Executive of the Australian Liver Association. She convened the research workshop for the Asian Pacific Association for the Study of the Liver and was consulted by QLD Government to prepare a report on models of care for liver disease. As a member of Executive, Australian Liver Association, she helped write and review documents on treatment, education and technology pertinent to liver disease. Prof Powell has been a panel member for NHMRC (Career Development Fellowship). She has reviewed project grants for the NHMRC, Wellcome Trust (Health Innovation Challenge Fund) and INSERM, and frequently reviews manuscripts for leading international journals.
International Standing: Prof Powell has international recognition in liver disease research and has been an invited speaker at >15 major international meetings. These include invitations as a faculty member of the American Association for the Study of Liver Disease Postgraduate Course, the International Association for the Study of the Liver Postgraduate Course, the Asia-Pacific Association for the Study of the Liver Postgraduate Course and the International Symposium on Viral Hepatitis and Liver Disease Postgraduate Course. She has also presented at the Siemens Scientific Symposium, Berlin and the International Federation of Clinical Chemistry and Laboratory Medicine, Athens on serum biomarkers for risk stratification in non-alcoholic fatty liver disease.
Supervision and Mentoring: Elizabeth has supervised 8 PhD/MD, 3 Honours and 3 Masters students. She has supervised 4 international scholars from the UK and 1 from the USA.
Works
Search Professor Elizabeth Powell’s works on UQ eSpace
2009
Journal Article
Hepatic progenitor cell–mediated regeneration and fibrosis: chicken or egg?
Clouston, A. D., Jonsson, J. R. and Powell, E. E. (2009). Hepatic progenitor cell–mediated regeneration and fibrosis: chicken or egg?. Hepatology, 49 (5), 1424-1426. doi: 10.1002/hep.22893
2009
Conference Publication
Quantitation of Steatosis by Magnetic Resonance Imaging (Mri) and Spectroscopy (Mrs) in Liver Disease: Effect of Hepatic Fibrosis
McPherson, S., Cowin, G., O'Rourke, P., Volp, A., Horsfall, L., Burke, L., Jonsson, J., Clouston, A., Fawcett, J., Galloway, G., Benson, M. and Powell, E. (2009). Quantitation of Steatosis by Magnetic Resonance Imaging (Mri) and Spectroscopy (Mrs) in Liver Disease: Effect of Hepatic Fibrosis. 44th Annual Meeting of the European-Association-for-the-Study-of-the-Liver, Copenhagen Denmark, Apr 22-26, 2009. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/S0168-8278(09)61011-4
2009
Conference Publication
IL:32: A new pro-inflammatory cytokine involved in HCV-related liver inflammation and fibrosis
Fritz, Teresa, Moschen, Alexander R., Jonsson, Julie R., Woerz, Ilka, Clouston, Andrew D., Kim, SooHyun, Dinarello, Charles A., Bartenschlager, Ralf, Powell, Elizabeth E. and Tilg, Herbert (2009). IL:32: A new pro-inflammatory cytokine involved in HCV-related liver inflammation and fibrosis. 60th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA, U.S.A., 30 October - 3 November 2009. Hoboken, NJ, U.S.A.: John Wiley & Sons. doi: 10.1002/hep.23300
2009
Conference Publication
Quantitation of steatosis by magnetic resonance imaging (MRI) and spectroscopy (MRS) in liver disease: effect of hepatic fibrosis and iron
McPherson, S., Cowin, G., O'Rourke, P., Volp, A., Horsfall, L., Burke, L., Jonsson, J.R., Clouston, A., Fawcett, J., Galloway, G., Benson, M. and Powell, E. (2009). Quantitation of steatosis by magnetic resonance imaging (MRI) and spectroscopy (MRS) in liver disease: effect of hepatic fibrosis and iron. Annual Meeting of the British Society of Gastroenterology, Glasgow, Scotland, 23-26 March 2009. London, United Kingdom: B M J Group.
2008
Journal Article
Recognition of genetic factors influencing the progression of Hepatitis C
Jonsson, Julie R., Purdie, David M., Clouston, Andrew D. and Powell, Elizabeth E. (2008). Recognition of genetic factors influencing the progression of Hepatitis C. Molecular Diagnosis and Therapy, 12 (4), 209-218. doi: 10.2165/1250444-200812040-00002
2008
Journal Article
Obesity and steatosis influence serum and hepatic inflammatory in chronic Hepatitis C
Jonsson, J. R., Barrie, H. D., O'Rourke, P., Clouston, A. D. and Powell, E. E. (2008). Obesity and steatosis influence serum and hepatic inflammatory in chronic Hepatitis C. Hepatology, 48 (1), 80-87. doi: 10.1002/hep.22311
2008
Journal Article
Magnetic resonance imaging and spectroscopy for monitoring liver steatosis
Cowin, Gary J., Jonsson, Julie R., Bauer, Judith D., Ash, Susan, Ali, Azmat, Osland, Emma J., Purdie, David M., Clouston, Andrew D., Powell, Elizabeth E. and Galloway, Graham J. (2008). Magnetic resonance imaging and spectroscopy for monitoring liver steatosis. Journal of Magnetic Resonance Imaging, 28 (4), 937-945. doi: 10.1002/jmri.21542
2008
Journal Article
Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosis
McPherson, S., Jonsson, J. R., Barrie, H. D., O'Rourke, P., Clouston, A. D. and Powell, E. (2008). Investigation of the role of SREBP-1c in the pathogenesis of HCV-related steatosis. Journal of Hepatology, 49 (6), 1046-1054. doi: 10.1016/j.jhep.2008.06.022
2007
Book Chapter
Does NASH or NAFLD Contribute to Comorbidity of Other Liver Diseases?
Clouston, Andrew D. and Powell, Elizabeth E. (2007). Does NASH or NAFLD Contribute to Comorbidity of Other Liver Diseases?. Fatty Liver Disease: NASH and Related Disorders. (pp. 276-288) Oxford, UK: wiley. doi: 10.1002/9780470987438.ch23
2007
Journal Article
Obesity management in liver clinics: Translation of research into clinical practice
Osland, Emma J., Powell, Elizabeth E., Banks, Merrilyn, Jonsson, Julie R. and Hickman, Ingrid J. (2007). Obesity management in liver clinics: Translation of research into clinical practice. Journal of Gastroenterology And Hepatology, 22 (4), 504-509. doi: 10.1111/j.1440-1746.2006.04830.x
2007
Journal Article
Steatosis as a cofactor in other liver diseases: hepatitis C virus, alcohol, hemochromatosis, and others
Clouston, Andrew D., Jonsson, Julie R. and Powell, Elizabeth E. (2007). Steatosis as a cofactor in other liver diseases: hepatitis C virus, alcohol, hemochromatosis, and others. Clinics in Liver Disease, 11 (1), 173-189. doi: 10.1016/j.cld.2007.02.007
2007
Journal Article
An assessment of the role of SREBP 1 C in the pathogenesis of HCV-related steatosis
McPhersonS, Jonsson, JR, BarrieHD, CloustonAD and PowellEE (2007). An assessment of the role of SREBP 1 C in the pathogenesis of HCV-related steatosis. Hepatology, 46 (4), 438A-438A.
2007
Journal Article
Progressive fibrosis in nonalcoholic steato hepatitis: Association with altered regeneration and a ductular reaction
Richardson M. M., Jonsson, J. R., Powell, E. E., Brunt, EM, Neuschwander-Tetri, BA, Bhathal, PS, Dixon, JB, Weltman, MD, Tilg, H, Moschen, AR, Purdie, DM, Demetris, AJ and Clouston, A. D. (2007). Progressive fibrosis in nonalcoholic steato hepatitis: Association with altered regeneration and a ductular reaction. Gastroenterology, 133 (1), 80-90. doi: 10.1053/j.gastro.2007.05.012
2007
Journal Article
Progressive fibrosis in non-alcoholic steatohepatitis - Association with altered regeneration and a ductular reaction
RichardsonMM, Jonsson, JR, PowellEE, BruntEM, Neuschwander-TetriBA, BhathalPS, DixonJB, WeltmanMD, TilgH, MoschenAR, PurdieDM, DemetrisAJ and CloustonAD (2007). Progressive fibrosis in non-alcoholic steatohepatitis - Association with altered regeneration and a ductular reaction. Journal of Hepatology, 46, S49-S50. doi: 10.1016/S0168-8278(07)61711-5
2007
Journal Article
An assessment of the role of endoplasmic reticulum (ER) stress in the pathogenesis of HCV
McPhersonS, PowellEE, BarrieHD, CloustonAD and Jonsson, JR (2007). An assessment of the role of endoplasmic reticulum (ER) stress in the pathogenesis of HCV. Hepatology, 46 (4), 444A-444A.
2007
Book Chapter
Fatty liver as a cofactor for other liver diseases
McPherson, S., Clouston, A.D., Jonsson, J.R. and Powell, E. (2007). Fatty liver as a cofactor for other liver diseases. International Hepatology Updates: Nonalcoholic steatohepatitis (NASH). (pp. 161-174) edited by Bataller, R. and Caballeria, J.. Spain: Permanyer Publications.
2006
Journal Article
Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: A meta-analysis of individual patient data
Leandro, G, Mangia, A, Hui, J, Fabris, P, Rubbia-Brandt, L, Colloredo, G, Adinolfi, LE, Asselah, T, Jonsson, JR, Smedile, A, Terrault, N, Pazienza, V, Giordani, MT, Giostra, E, Sonzogni, A, Ruggiero, G, Marcellin, P, Powell, EE, George, J and Negro, F (2006). Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: A meta-analysis of individual patient data. Gastroenterology, 130 (6), 1636-1642. doi: 10.1053/j.gastro.2006.03.014
2006
Journal Article
Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1
Walsh, MJ, Jonsson, JR, Richardson, MM, Lipka, GM, Purdie, DM, Clouston, D and Powell, EE (2006). Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1. Gut, 55 (4), 529-535. doi: 10.1136/gut.2005.069674
2005
Journal Article
Steatosis is a cofactor in liver injury in hemochromatosis
Powell, Elizabeth E., Ali, Azmat, Clouston, Andrew D., Dixon, Jeannette L., Lincoln, Douglas J., Purdie, David M., Fletcher, Linda M., Powell, Lawrie W. and Jonsson, Julie R. (2005). Steatosis is a cofactor in liver injury in hemochromatosis. Gastroenterology, 129 (6), 1937-1943. doi: 10.1053/j.gastro.2005.09.015
2005
Journal Article
Fibrosis correlates with a ductular reaction in hepatitis C: Roles of impaired replication, progenitor cells and steatosis
Clouston, Andrew D., Powell, Elizabeth E., Walsh, Meagan J., Richardson, Michelle M., Demetris, A. Jake and Jonsson, Julie R. (2005). Fibrosis correlates with a ductular reaction in hepatitis C: Roles of impaired replication, progenitor cells and steatosis. Hepatology, 41 (4), 809-818. doi: 10.1002/hep.20650
Funding
Supervision
Availability
- Professor Elizabeth Powell is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Diabetes and non-alcoholic fatty liver disease: implementing the right care, in the right place, at the right time (NAFLD-RRR study)
Principal Advisor
-
Doctor Philosophy
Diabetes and non-alcoholic fatty liver disease: implementing the right care, in the right place, at the right time (NAFLD-RRR study)
Principal Advisor
Completed supervision
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2019
Doctor Philosophy
Medication-related problems in people with chronic liver disease: the effect of a patient-oriented medication management intervention delivered by a clinical pharmacist
Principal Advisor
Other advisors: Dr Katharine Irvine
-
2015
Doctor Philosophy
Characterisation of Infiltrating Inflammatory Cells in the Development of Liver Injury and Progressive Fibrosis
Principal Advisor
Other advisors: Dr Katharine Irvine, Professor Andrew Clouston
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2004
Doctor Philosophy
THE ROLE OF OBESITY IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC LIVER DISEASES
Principal Advisor
-
2012
Master Philosophy
Characterisation of polarised macrophages and their influence on hepatocyte phenotype and function
Joint Principal Advisor
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2022
Master Philosophy
Targeting peritoneal immunity to improve outcomes of patients with decompensated cirrhosis
Associate Advisor
Other advisors: Dr Katharine Irvine
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2013
Doctor Philosophy
The pathogenesis of non-alcoholic fatty liver disease: From parenchymal injury to portal fibrosis
Associate Advisor
Other advisors: Professor Andrew Clouston
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2012
Master Philosophy
Does Whole Liver Determination of Liver Steatosis Improve Accuracy?
Associate Advisor
Other advisors: Dr Gary Cowin
-
2008
Doctor Philosophy
Investigation of the role of hepatic progenitor cells and the ductular reaction in chronic liver injury in adults, children, and post transplantation
Associate Advisor
-
2008
Doctor Philosophy
The Role of Host Factors in Liver Injury and Non-Response to Antiviral Therapy in Patients With Chronic HCV
Associate Advisor
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2002
Doctor Philosophy
AN EVALUATION OF STEATOSIS INDUCED FIBROSIS IN CHRONIC HEPATITIS C
Associate Advisor
Media
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