
Overview
Background
NAME Professor Elizabeth Ellen POWELL
POSITION TITLE Professor, School of Medicine, The University of Queensland; Hepatologist, Princess Alexandra Hospital
Email e.powell@uq.edu.au
EDUCATION/TRAINING
Bachelor of Medicine and Bachelor of Surgery with First Class Honours (M.B.,B.S.Hons1), The University of Queensland
Fellow of the Royal Australasian College of Physicians
Doctor of Philosophy (PhD), The University of Queensland
Fellow of the Royal College of Physicians, London
Fellow, American Association for the Study of Liver Diseases
Elizabeth Powell is a Hepatologist and Senior Staff Specialist in the Department of Gastroenterology and Hepatology, Princess Alexandra Hospital. She is also Professor, School of Medicine, The University of Queensland, Director of the network Centre for Liver Disease Research in The University of Queensland and a Research Fellow with the American Association for the Study of Liver Diseases. She is also a recent past member of the Executive of the Australian Liver Association.
Professor Powell has a very productive research group, bridging basic science and clinical research. Her main research interests include:
(i) developing strategies to improve the assessment of non-alcoholic fatty liver disease by primary care clinicians and non-hepatology specialists.
(ii) examining ways to improve education and medication management for people with decompensated cirrhosis (advanced liver disease)
(iii) examining the role of injury-stratifying biomarkers for non-alcoholic fatty liver disease
Availability
- Professor Elizabeth Powell is:
- Available for supervision
Fields of research
Research impacts
Contributions to the field: Include shaping two new paradigms in hepatology research: the importance of metabolic risk factors in the progression of chronic liver diseases, and more recently proposing altered hepatic regeneration and the ductular reaction as a potential driver of hepatic fibrosis. This innovative research on the association between the hepatic stem cell niche and fibrosis has led to increasing recognition internationally that fibrogenesis and carcinogenesis may be intrinsically associated with activation of this niche. A significant contribution has been to foster a multidisciplinary, collaborative approach to the field, involving hepatopathology together with molecular and clinical hepatology research. More recently she has established new interdisciplinary partnerships to undertake research in areas related to chronic liver disease management.
Collaborations: Nationally, collaborations include those with researchers from QIMR Berghofer Medical Research Institute, Translational Research Institute and Institute for Molecular Bioscience, the University of Queensland; she also collaborates with clinicians from Inala Primary Care and the Princess Alexandra Hospital. Internationally, she contributes to the Drug-induced liver injury network (DILIN) and International Serious Adverse Events Consortium (iSAEC) (based in the UK) and the International Liver Disease Genetics Consortium. More recently she has partnered with Siemens Healthineers to study prevalence and severity of non-alcoholic fatty liver disease in diabetes clinics and primary care.
Community Engagement: Prof Powell is regularly involved in speaking to General Practitioners and community groups and reviews resources for the Ethnic Communities Council of QLD. She has organized and chaired numerous multidisciplinary networking workshops with the purpose of bringing together clinicians/researchers, showcase what is going on in the field, and open opportunities for communication and collaboration.
Professional Involvement and Peer Review: Prof Powell is a past member of the Editorial Board of Hepatology, the Clinical Research Committee of the American Association for the Study of Liver Diseases and a recent past member of the Executive of the Australian Liver Association. She convened the research workshop for the Asian Pacific Association for the Study of the Liver and was consulted by QLD Government to prepare a report on models of care for liver disease. As a member of Executive, Australian Liver Association, she helped write and review documents on treatment, education and technology pertinent to liver disease. Prof Powell has been a panel member for NHMRC (Career Development Fellowship). She has reviewed project grants for the NHMRC, Wellcome Trust (Health Innovation Challenge Fund) and INSERM, and frequently reviews manuscripts for leading international journals.
International Standing: Prof Powell has international recognition in liver disease research and has been an invited speaker at >15 major international meetings. These include invitations as a faculty member of the American Association for the Study of Liver Disease Postgraduate Course, the International Association for the Study of the Liver Postgraduate Course, the Asia-Pacific Association for the Study of the Liver Postgraduate Course and the International Symposium on Viral Hepatitis and Liver Disease Postgraduate Course. She has also presented at the Siemens Scientific Symposium, Berlin and the International Federation of Clinical Chemistry and Laboratory Medicine, Athens on serum biomarkers for risk stratification in non-alcoholic fatty liver disease.
Supervision and Mentoring: Elizabeth has supervised 8 PhD/MD, 3 Honours and 3 Masters students. She has supervised 4 international scholars from the UK and 1 from the USA.
Works
Search Professor Elizabeth Powell’s works on UQ eSpace
2005
Journal Article
Adiponectin and its receptors in patients with chronic hepatitis C
Jonsson, JR, Moschen, AR, Hickman, IJ, Richardson, MM, Kaser, S, Clouston, AD, Powell, EE and Tilg, H (2005). Adiponectin and its receptors in patients with chronic hepatitis C. Journal of Hepatology, 43 (6), 929-936. doi: 10.1016/j.jhep.2005.05.030
2005
Conference Publication
Hepatic progenitor cell expansion and a periportal ductular reaction in NAFLD - Relationship with impaired hepatocyte proliferation and fibrosis, and reversal with treatment
Richardson, M., Jonsson, J., Powell, E., Brunt, E. M., Bhathal, P., Dixon, J. and Clouston, A. (2005). Hepatic progenitor cell expansion and a periportal ductular reaction in NAFLD - Relationship with impaired hepatocyte proliferation and fibrosis, and reversal with treatment. 56th Annual Meeting of the American Association for the Study of Liver Diseases, San Francisco, CA, United States, 11-15 November 2005. HOBOKEN: JOHN WILEY & SONS INC.
2005
Book Chapter
Does NASH or NAFLD contribute to comorbidity of other liver diseases?
Powell, Elizabeth E. (2005). Does NASH or NAFLD contribute to comorbidity of other liver diseases?. Fatty liver disease: NASH and related disorders. (pp. 276-288) edited by Geoffrey C. Farrell, Jacob George, Pauline de la M. Hall and Arthur J. McCullough. Oxford, United Kingdom: Blackwell.
2005
Conference Publication
Obesity is associated with non-response to antiviral therapy and increased hepatic expression of SOCS-3 in chronic hepatitis C
Walsh, M.J., Jonsson, J.R., Richardson, M.M., Lipka, G.M., Purdie, D.M., Clouston, A.D. and Powell, E.E. (2005). Obesity is associated with non-response to antiviral therapy and increased hepatic expression of SOCS-3 in chronic hepatitis C. 40th Annual Meeting of the European Association for the Study of the Liver, Paris, France, 13-17 April 2005. Amsterdam , Netherlands: Elsevier.
2005
Journal Article
A combination of genetic polymorphisms increases the risk of progressive disease in chronic hepatitis C
Richardson, M. M., Powell, E. E., Barrie, H. D., Clouston, A. D., Purdie, D. M. and Jonsson, J. R. (2005). A combination of genetic polymorphisms increases the risk of progressive disease in chronic hepatitis C. Journal of Medical Genetics, 42 (7), 1-6. doi: 10.1136/jmg.2005.032557
2005
Journal Article
Steatosis: Co-factor in other liver diseases
Powell, EE, Jonsson, JR and Clouston, AD (2005). Steatosis: Co-factor in other liver diseases. Hepatology, 42 (1), 5-13. doi: 10.1002/hep.20750
2005
Journal Article
Dangerous liaisons: The metabolic syndrome and nonalcoholic fatty liver disease
Powell, EE, Jonsson, JR and Clouston, AD (2005). Dangerous liaisons: The metabolic syndrome and nonalcoholic fatty liver disease. Annals of Internal Medicine, 143 (10), 753-754. doi: 10.7326/0003-4819-143-10-200511150-00015
2004
Journal Article
Nonalcoholic fatty liver disease: is all the fat bad?
Clouston, A. D. and Powell, E. E. (2004). Nonalcoholic fatty liver disease: is all the fat bad?. Internal Medicine Journal, 34 (4), 187-191. doi: 10.1111/j.1444-0903.2004.00574.x
2004
Journal Article
Increased mononuclear cell activation and apoptosis early after human liver transplantation is associated with a reduced frequency of acute rejection
Jonsson, Julie R., Gu, Wenyi, Vanags, Daina M., Bishop, G. Alex, McCaughan, Geoffrey W., Fawcett, Jonathon, Lynch, Stephen V., Balderson, Glenda A., Powell, Elizabeth E. and Clouston, Andrew D. (2004). Increased mononuclear cell activation and apoptosis early after human liver transplantation is associated with a reduced frequency of acute rejection. Liver Transplantation, 10 (3), 397-403. doi: 10.1002/lt.20084
2004
Journal Article
Bone mineral density in Australian children, adolescents and adults with cystic fibrosis: a controlled cross sectional study
Buntain, HM, Greer, RM, Schluter, PJ, Wong, JCH, Batch, JA, Potter, JM, Lewindon, PJ, Powell, E, Wainwright, CE and Bell, SC (2004). Bone mineral density in Australian children, adolescents and adults with cystic fibrosis: a controlled cross sectional study. Thorax, 59 (2), 149-155. doi: 10.1136/thorax.2003.006726
2004
Journal Article
Association between apolipoprotein E epsilon 4 and neuropsychiatric symptoms during interferon alpha treatment for chronic hepatitis C
Gochee, Peter A., Powell, Elizabeth E., Purdie, David M., Pandeya, Nirmala, Kelemen, Livia, Shorthouse, Claudia, Jonsson, Julie R. and Kelly, Brian (2004). Association between apolipoprotein E epsilon 4 and neuropsychiatric symptoms during interferon alpha treatment for chronic hepatitis C. Psychosomatics, 45 (1), 49-57. doi: 10.1176/appi.psy.45.1.49
2004
Journal Article
Chronic hepatitis C and steatosis
Clouston, A. D., Jonsson, J. R. and Powell, E. (2004). Chronic hepatitis C and steatosis. Current Hepatitis Reports, 3 (4), 123-128.
2004
Conference Publication
Factors affecting the gene expression of hepcidin in chronic viral hepatitis C
Bridle, K. R., Fletcher, L. M., Jonsson, J. R., Richardson, M. M., Clouston, A. D., Powell, E. E. and Crawford, D. H. G. (2004). Factors affecting the gene expression of hepcidin in chronic viral hepatitis C. Australian Gastroenterology Week 2004, Brisbane Convention Centre, Brisbane, Qld Australia, 4-8 October, 2004. Carlton South, Vic. Australia: Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2004.3615_3..x
2004
Journal Article
Steatosis and liver cell apoptosis in chronic hepatitis C: A mechanism for increased liver injury
Walsh, MJ, Vanags, DM, Clouston, AD, Richardson, MM, Purdie, DM, Jonsson, JR and Powell, EE (2004). Steatosis and liver cell apoptosis in chronic hepatitis C: A mechanism for increased liver injury. Hepatology, 39 (5), 1230-1238. doi: 10.1002/hep.20179
2004
Journal Article
CCR5-Delta 32 mutation is strongly associated with primary sclerosing cholangitis
Eri, R, Jonsson, JR, Pandeya, N, Purdie, DM, Clouston, AD, Martin, N, Duffy, D, Powell, EE, Fawcett, J, Florin, THJ and Radford-Smith, GL (2004). CCR5-Delta 32 mutation is strongly associated with primary sclerosing cholangitis. Genes And Immunity, 5 (6), 444-450. doi: 10.1038/sj.gene.6364113
2004
Journal Article
Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life
Hickman, IJ, Jonsson, JR, Prins, JB, Ash, S, Purdie, DM, Clouston, AD and Powell, EE (2004). Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life. Gut, 53 (3), 413-419. doi: 10.1136/gut.2003.027581
2004
Journal Article
Virus-specific CD8+ T lymphocytes within the normal human liver
Ward, S. M., Jonsson, J. R., Sierro, S., Clouston, A. D., Lucas, M., Vargas, A. L., Powell, E. E. and Klenerman, P. (2004). Virus-specific CD8+ T lymphocytes within the normal human liver. European Journal of Immunology, 34 (6), 1526-1531. doi: 10.1002/eji.200324275
2003
Journal Article
In overweight patients with chronic hepatitis C, circulating insulin is associated with hepatic fibrosis: implications for therapy
Hickman, I. J., Powell, E. E., Prins, J. B., Clouston, A. D., Ash, S., Purdie, D. M. and Jonsson, J. R. (2003). In overweight patients with chronic hepatitis C, circulating insulin is associated with hepatic fibrosis: implications for therapy. Journal of Hepatology, 39 (6), 1042-1048. doi: 10.1016/S0168-8278(03)00463-X
2003
Journal Article
Fatty liver disease: The next epidemic?
Hickman, Ingrid and Powell, Elizabeth (2003). Fatty liver disease: The next epidemic?. Medicine Today, 4 (2), 40-47.
2003
Journal Article
Modelling hepatitis C virus incidence, prevalence and long-term sequelae in Australia, 2001
Law M.G., Dore G.J., Bath N., Thompson S., Crofts N., Dolan K., Giles W., Gow P., Kaldor J., Loveday S., Powell E., Spencer J. and Wodak A. (2003). Modelling hepatitis C virus incidence, prevalence and long-term sequelae in Australia, 2001. International Journal of Epidemiology, 32 (5), 717-724. doi: 10.1093/ije/dyg101
Funding
Supervision
Availability
- Professor Elizabeth Powell is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Diabetes and non-alcoholic fatty liver disease: implementing the right care, in the right place, at the right time (NAFLD-RRR study)
Principal Advisor
-
Doctor Philosophy
Diabetes and non-alcoholic fatty liver disease: implementing the right care, in the right place, at the right time (NAFLD-RRR study)
Principal Advisor
Completed supervision
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2019
Doctor Philosophy
Medication-related problems in people with chronic liver disease: the effect of a patient-oriented medication management intervention delivered by a clinical pharmacist
Principal Advisor
Other advisors: Dr Katharine Irvine
-
2015
Doctor Philosophy
Characterisation of Infiltrating Inflammatory Cells in the Development of Liver Injury and Progressive Fibrosis
Principal Advisor
Other advisors: Dr Katharine Irvine, Professor Andrew Clouston
-
2004
Doctor Philosophy
THE ROLE OF OBESITY IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC LIVER DISEASES
Principal Advisor
-
2012
Master Philosophy
Characterisation of polarised macrophages and their influence on hepatocyte phenotype and function
Joint Principal Advisor
-
2022
Master Philosophy
Targeting peritoneal immunity to improve outcomes of patients with decompensated cirrhosis
Associate Advisor
Other advisors: Dr Katharine Irvine
-
2013
Doctor Philosophy
The pathogenesis of non-alcoholic fatty liver disease: From parenchymal injury to portal fibrosis
Associate Advisor
Other advisors: Professor Andrew Clouston
-
2012
Master Philosophy
Does Whole Liver Determination of Liver Steatosis Improve Accuracy?
Associate Advisor
Other advisors: Dr Gary Cowin
-
2008
Doctor Philosophy
Investigation of the role of hepatic progenitor cells and the ductular reaction in chronic liver injury in adults, children, and post transplantation
Associate Advisor
-
2008
Doctor Philosophy
The Role of Host Factors in Liver Injury and Non-Response to Antiviral Therapy in Patients With Chronic HCV
Associate Advisor
-
2002
Doctor Philosophy
AN EVALUATION OF STEATOSIS INDUCED FIBROSIS IN CHRONIC HEPATITIS C
Associate Advisor
Media
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