
Overview
Background
NAME Professor Elizabeth Ellen POWELL
POSITION TITLE Professor, School of Medicine, The University of Queensland; Hepatologist, Princess Alexandra Hospital
Email e.powell@uq.edu.au
EDUCATION/TRAINING
Bachelor of Medicine and Bachelor of Surgery with First Class Honours (M.B.,B.S.Hons1), The University of Queensland
Fellow of the Royal Australasian College of Physicians
Doctor of Philosophy (PhD), The University of Queensland
Fellow of the Royal College of Physicians, London
Fellow, American Association for the Study of Liver Diseases
Elizabeth Powell is a Hepatologist and Senior Staff Specialist in the Department of Gastroenterology and Hepatology, Princess Alexandra Hospital. She is also Professor, School of Medicine, The University of Queensland, Director of the network Centre for Liver Disease Research in The University of Queensland and a Research Fellow with the American Association for the Study of Liver Diseases. She is also a recent past member of the Executive of the Australian Liver Association.
Professor Powell has a very productive research group, bridging basic science and clinical research. Her main research interests include:
(i) developing strategies to improve the assessment of non-alcoholic fatty liver disease by primary care clinicians and non-hepatology specialists.
(ii) examining ways to improve education and medication management for people with decompensated cirrhosis (advanced liver disease)
(iii) examining the role of injury-stratifying biomarkers for non-alcoholic fatty liver disease
Availability
- Professor Elizabeth Powell is:
- Available for supervision
Fields of research
Research impacts
Contributions to the field: Include shaping two new paradigms in hepatology research: the importance of metabolic risk factors in the progression of chronic liver diseases, and more recently proposing altered hepatic regeneration and the ductular reaction as a potential driver of hepatic fibrosis. This innovative research on the association between the hepatic stem cell niche and fibrosis has led to increasing recognition internationally that fibrogenesis and carcinogenesis may be intrinsically associated with activation of this niche. A significant contribution has been to foster a multidisciplinary, collaborative approach to the field, involving hepatopathology together with molecular and clinical hepatology research. More recently she has established new interdisciplinary partnerships to undertake research in areas related to chronic liver disease management.
Collaborations: Nationally, collaborations include those with researchers from QIMR Berghofer Medical Research Institute, Translational Research Institute and Institute for Molecular Bioscience, the University of Queensland; she also collaborates with clinicians from Inala Primary Care and the Princess Alexandra Hospital. Internationally, she contributes to the Drug-induced liver injury network (DILIN) and International Serious Adverse Events Consortium (iSAEC) (based in the UK) and the International Liver Disease Genetics Consortium. More recently she has partnered with Siemens Healthineers to study prevalence and severity of non-alcoholic fatty liver disease in diabetes clinics and primary care.
Community Engagement: Prof Powell is regularly involved in speaking to General Practitioners and community groups and reviews resources for the Ethnic Communities Council of QLD. She has organized and chaired numerous multidisciplinary networking workshops with the purpose of bringing together clinicians/researchers, showcase what is going on in the field, and open opportunities for communication and collaboration.
Professional Involvement and Peer Review: Prof Powell is a past member of the Editorial Board of Hepatology, the Clinical Research Committee of the American Association for the Study of Liver Diseases and a recent past member of the Executive of the Australian Liver Association. She convened the research workshop for the Asian Pacific Association for the Study of the Liver and was consulted by QLD Government to prepare a report on models of care for liver disease. As a member of Executive, Australian Liver Association, she helped write and review documents on treatment, education and technology pertinent to liver disease. Prof Powell has been a panel member for NHMRC (Career Development Fellowship). She has reviewed project grants for the NHMRC, Wellcome Trust (Health Innovation Challenge Fund) and INSERM, and frequently reviews manuscripts for leading international journals.
International Standing: Prof Powell has international recognition in liver disease research and has been an invited speaker at >15 major international meetings. These include invitations as a faculty member of the American Association for the Study of Liver Disease Postgraduate Course, the International Association for the Study of the Liver Postgraduate Course, the Asia-Pacific Association for the Study of the Liver Postgraduate Course and the International Symposium on Viral Hepatitis and Liver Disease Postgraduate Course. She has also presented at the Siemens Scientific Symposium, Berlin and the International Federation of Clinical Chemistry and Laboratory Medicine, Athens on serum biomarkers for risk stratification in non-alcoholic fatty liver disease.
Supervision and Mentoring: Elizabeth has supervised 8 PhD/MD, 3 Honours and 3 Masters students. She has supervised 4 international scholars from the UK and 1 from the USA.
Works
Search Professor Elizabeth Powell’s works on UQ eSpace
2012
Journal Article
Triage of referrals to outpatient hepatology services: an ineffective tool to prioritise patients?
Horsfall, Leigh, Skoien, Richard, Moss, Cathy, Scott, Ian, Macdonald, Graeme A. and Powell, Elizabeth E. (2012). Triage of referrals to outpatient hepatology services: an ineffective tool to prioritise patients?. Australian Health Review, 36 (4), 443-447. doi: 10.1071/AH11111
2012
Conference Publication
A simple scoring system accurately excludes portal fibrosis in non-alcoholic fatty liver disease
Skoien, R., Rich, G. G., Horsfall, L., Jonsson, J. R., Clouston, A. D., George, J. and Powell, E. E. (2012). A simple scoring system accurately excludes portal fibrosis in non-alcoholic fatty liver disease. 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Barcelona, Spain, 18-22 April 2012. Amsterdam, Netherlands: Elsevier. doi: 10.1016/S0168-8278(12)61081-2
2012
Conference Publication
Attitudes towards non-alcoholic fatty liver disease amongst non-hepatology specialists in two major Australian hospitals
Bergqvist, C. J., Skoien, R., Horsfall, L., Jonsson, J. R. and Powell, E. E. (2012). Attitudes towards non-alcoholic fatty liver disease amongst non-hepatology specialists in two major Australian hospitals. 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Barcelona, Spain, 18-22 April 2012. Amsterdam, Netherlands: Elsevier. doi: 10.1016/S0168-8278(12)61333-6
2012
Conference Publication
CDT as a biomarker of alcohol excess in patients with chronic liver disease: BMI affects diagnostic sensitivity
Fagan, Kevin, McWhinney, Brett, Horsfall, Leigh, Ungerer, Jacobus P., Pretorius, Carel J., Johnson, Lambro A., Clouston, Andrew, Fletcher, Linda M., Jonsson, Julie, O'Rourke, Peter and Powell, Elizabeth (2012). CDT as a biomarker of alcohol excess in patients with chronic liver disease: BMI affects diagnostic sensitivity. Australian Gastroenterology Week 2012, Adelaide, SA Australia, 16-19 October 2012. Richmond, VIC Australia: Wiley-Blackwell. doi: 10.1111/j.1440-1746.2011.07251_5.x
2011
Journal Article
IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European cohort: A cross-sectional study
Suppiah, Vijayaprakash, Gaudieri, Silvana, Armstrong, Nicola J., O'Connor, Kate S., Berg, Thomas, Weltman, Martin, Abate, Maria Lorena, Spengler, Ulrich, Bassendine, Margaret, Dore, Gregory J., Irving, William L., Powell, Elizabeth, Hellard, Margaret, Riordan, Stephen, Matthews, Gail, Sheridan, David, Nattermann, Jacob, Smedile, Antonina, Muller, Tobias, Hammond, Emma, Dunn, David, Negro, Francesco, Bochud, Pierre-Yves, Mallal, Simon, Ahlenstiel, Golo, Stewart, Graeme J., George, Jacob, Booth, David R. and for the International Hepatitis C Genetics Consortium (IHCGC) (2011). IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European cohort: A cross-sectional study. PLoS Medicine, 8 (9) e1001092, e1001092.1-e1001092.8. doi: 10.1371/journal.pmed.1001092
2011
Journal Article
Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort
Smith, Katherine R., Suppiah, Vijayaprakash, O'Connor, Kate, Berg, Thomas, Weltman, Martin, Abate, Maria Lorena, Spengler, Ulrich, Bassendine, Margaret, Matthews, Gail, Irving, William L., Powell, Elizabeth, Riordan, Stephen, Ahlenstiel, Golo, Stewart, Graeme J., Bahlo, Melanie, George, Jacob and Booth, David R. (2011). Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort. Genome Medicine, 3 (8) 57. doi: 10.1186/gm273
2011
Journal Article
Interleukin-32: A new proinflammatory cytokine involved in hepatitis C virus-related liver inflammation and fibrosis
Moschen, Alexander R., Fritz, Teresa Fritz, Clouston, Andrew D., Rebhan, Ilka, Bauhofer, Oliver, Barrie, Helen D., Powell, Elizabeth E., Kim, Soo-Hyun, Dinarello, Charles A., Bartenschlager, Ralf, Jonsson, Julie R. and Tilg, Herbert (2011). Interleukin-32: A new proinflammatory cytokine involved in hepatitis C virus-related liver inflammation and fibrosis. Hepatology, 53 (6), 1819-1829. doi: 10.1002/hep.24285
2011
Journal Article
No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection
McPherson, Stuart, Powell, Elizabeth E., Barrie, Helen D., Clouston, Andrew D., McGuckin, Michael and Jonsson, Julie R. (2011). No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection. Journal of Gastroenterology and Hepatalogy, 26 (2), 319-327. doi: 10.1111/j.1440-1746.2010.06368.x
2011
Conference Publication
Characterisation of liver macrophages in chronic hepatitis C: role in an alternate pathway of liver regeneration and fibrosis
Gadd, V.L., Roy, S., Clouston, A. D., Melino, M., Jonsson, J. R. and Powell, E. E. (2011). Characterisation of liver macrophages in chronic hepatitis C: role in an alternate pathway of liver regeneration and fibrosis. Australian Gastroenterology Week 2011, Brisbane, Australia, 12-15 September 2011. MALDEN: WILEY-BLACKWELL.
2011
Journal Article
Not every cell is as it seems: A role for ductular epithelial cells in fibrosis?
Powell, Elizabeth E., Jonsson, Julie R. and Clouston, Andrew D. (2011). Not every cell is as it seems: A role for ductular epithelial cells in fibrosis?. Gut, 60 (1), 1-2. doi: 10.1136/gut.2010.226365
2011
Journal Article
GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism
Barclay, JL, Nelson, CN, Ishikawa, M, Murray, LA, Kerr, LM, McPhee, TR, Powell, EE and Waters, MJ (2011). GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism. Endocrinology, 152 (1), 181-192. doi: 10.1210/en.2010-0537
2011
Conference Publication
Macrophage secretory products induce an inflammatory phenotype in hepatocytes
Melino, Michelle, Gadd, Victoria L., Thomas, G. P., Walker, Gene V., Skoien, Richard, Clouston, Andrew D., Jonsson, Julie R. and Powell, Elizabeth E. (2011). Macrophage secretory products induce an inflammatory phenotype in hepatocytes. Australian Gastroenterology Week 2011, Brisbane, Australia, 12-15 September 2011. MALDEN: WILEY-BLACKWELL.
2010
Conference Publication
Macrophage-secreted products induce a phenotypic change in hepatocytes: Implications for fibrogenesis
Melino, M., Powell, E. E., Gadd, V. L., Skoien, R., Walker, G., Clouston, A. D. and Jonsson, J. R. (2010). Macrophage-secreted products induce a phenotypic change in hepatocytes: Implications for fibrogenesis. AGW2010: Australian Gastroenterology Week 2010, Gold Coast, QLD, Australia, 20-23 October, 2010. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2010.06450.x
2010
Conference Publication
Heterogeneity of fibrosis patterns in non-alcoholic fatty liver disease supports the presence of multiple fibrogenic pathways
Skoien, R., Richardson, M. M., Jonsson, J. R., Powell, E. E. and Clouston, A. D. (2010). Heterogeneity of fibrosis patterns in non-alcoholic fatty liver disease supports the presence of multiple fibrogenic pathways. Australian Gastroenterology Week 2010, Broadbeach, Qld., Australia, 20-23 October 2010. Richmond, Vic., Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2010.06457.x
2010
Conference Publication
Fatty acids induce hepatocyte senescence in vitro: implications for pathogenesis in non-alcoholic steatohepatitis
Skoien, R., Powell, E. E., Melino, M., Clouston, A. D., Gabrielli, B. G. and Jonsson, J. R. (2010). Fatty acids induce hepatocyte senescence in vitro: implications for pathogenesis in non-alcoholic steatohepatitis. Australian Gastroenterology Week 2010, Gold Coast, QLD, Australia, 20-23 October 2010. Richmond, VIC, Australia: Wiley-Blackwell Publishing. doi: 10.1111/j.1440-1746.2010.06450.x
2010
Conference Publication
Metabolic factors and non-alcoholic fatty liver disease as co-factors in other liver diseases
Powell, Elizabeth E., Jonsson, Julie R. and Clouston, Andrew D. (2010). Metabolic factors and non-alcoholic fatty liver disease as co-factors in other liver diseases. Falk Symposium 171 on Liver and Metabolic Syndrome, Hannover, Germany, 15-18 October 2009. Basel, Switzerland: S. Karger AG. doi: 10.1159/000282084
2009
Journal Article
Combined approach for non-invasive measurement of liver pathology by MR
Cowin, Gary J., Jonsson, Julie R., McPherson, Stuart, Clouston, Andrew D., Benson, Mark, Powell, Elizabeth E. and Galloway, Graham J. (2009). Combined approach for non-invasive measurement of liver pathology by MR. Journal of Hepatology, 51 (6), 1083-1084. doi: 10.1016/j.jhep.2009.09.005
2009
Journal Article
IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
Suppiah, Vijayaprakash, Moldovan, Max, Ahlenstiel, Golo, Berg, Thomas, Weltman, Martin, Abate, Maria Lorena, Bassendine, Margaret, Spengler, Ulrich, Dore, Gregory J., Powell, Elizabeth, Riordan, Stephen, Sheridan, David, Smedile, Antonnia, Fragomeli, Vincenzo, Muller, Tobias, Bahlo, Melanie, Stewart, Graeme J., Booth, David R., George, Jacob and Hepatitis C Study (2009). IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nature Genetics, 41 (10), 1100-1104. doi: 10.1038/ng.447
2009
Journal Article
Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered
McPherson, S., Jonsson, J. R., Cowin, GJ, O'Rourke, P., Clouston, A. D., Volp, A., Horsfall, L., Jothimani, D., Fawcett, J., Galloway, G. J., Benson, M. and Powell, E. E. (2009). Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered. Journal of Hepatology, 51 (2), 389-397. doi: 10.1016/j.jhep.2009.04.012
2009
Journal Article
Kupffer cells and hepatocyte metabolism: A two-way street?
Powell, Elizabeth E., Waters, Michael J. and Jonsson, Julie R. (2009). Kupffer cells and hepatocyte metabolism: A two-way street?. Hepatology, 49 (2), 690-692. doi: 10.1002/hep.22801
Funding
Supervision
Availability
- Professor Elizabeth Powell is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Diabetes and non-alcoholic fatty liver disease: implementing the right care, in the right place, at the right time (NAFLD-RRR study)
Principal Advisor
-
Doctor Philosophy
Diabetes and non-alcoholic fatty liver disease: implementing the right care, in the right place, at the right time (NAFLD-RRR study)
Principal Advisor
Completed supervision
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2019
Doctor Philosophy
Medication-related problems in people with chronic liver disease: the effect of a patient-oriented medication management intervention delivered by a clinical pharmacist
Principal Advisor
Other advisors: Dr Katharine Irvine
-
2015
Doctor Philosophy
Characterisation of Infiltrating Inflammatory Cells in the Development of Liver Injury and Progressive Fibrosis
Principal Advisor
Other advisors: Dr Katharine Irvine, Professor Andrew Clouston
-
2004
Doctor Philosophy
THE ROLE OF OBESITY IN THE DEVELOPMENT AND PROGRESSION OF CHRONIC LIVER DISEASES
Principal Advisor
-
2012
Master Philosophy
Characterisation of polarised macrophages and their influence on hepatocyte phenotype and function
Joint Principal Advisor
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2022
Master Philosophy
Targeting peritoneal immunity to improve outcomes of patients with decompensated cirrhosis
Associate Advisor
Other advisors: Dr Katharine Irvine
-
2013
Doctor Philosophy
The pathogenesis of non-alcoholic fatty liver disease: From parenchymal injury to portal fibrosis
Associate Advisor
Other advisors: Professor Andrew Clouston
-
2012
Master Philosophy
Does Whole Liver Determination of Liver Steatosis Improve Accuracy?
Associate Advisor
Other advisors: Dr Gary Cowin
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2008
Doctor Philosophy
Investigation of the role of hepatic progenitor cells and the ductular reaction in chronic liver injury in adults, children, and post transplantation
Associate Advisor
-
2008
Doctor Philosophy
The Role of Host Factors in Liver Injury and Non-Response to Antiviral Therapy in Patients With Chronic HCV
Associate Advisor
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2002
Doctor Philosophy
AN EVALUATION OF STEATOSIS INDUCED FIBROSIS IN CHRONIC HEPATITIS C
Associate Advisor
Media
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