Molecular basis of effector-triggered immunity in plants (2026-2030)

Plants detect pathogen effector (avirulence) proteins by immune receptors called plant NLRs, in a process termed effector-triggered immunity. The applicants¿TM) laboratories have identified key signalling events in this process: NLR oligomerization into ¿resistosomes¿, and NAD+ (nicotinamide adenine dinucleotide) and nucleic acid binding and cleavage by NLR TIR (Toll/interleukin-1 receptor) domains. The current project aims to fill gaps in understanding the structural architecture of resistosomes and NLR:nucleic acid complexes, and the nature and functions of signalling molecules produced. This new knowledge aims to help develop strategies the long-term objective of protecting crops from pathogens.