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2024 Conference Publication Interplay of the proteotoxic CEL-MODY protein and oncogenic Kras in pancreatic cancer developmentFjeld, Karianne, Alam, Jahedul, López, Diego Iglesias, Kuznetsova, Ksenia, Seierstad, Renate V., Verbeke, Caroline, Vaudel, Marc, Regel, Ivonne, Halberg, Nils and Molven, Anders (2024). Interplay of the proteotoxic CEL-MODY protein and oncogenic Kras in pancreatic cancer development. 56th European Pancreatic Club Meeting 2024, Santiago de Compostela, Spain, 26 - 29 June 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.pan.2024.05.010 |
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2024 Conference Publication Detection of epigenetic priming in acinar cells after recovering from pancreatitis or metabolic stressWolff, Julia, Zhou, Quan, Schreiner, Nicole, Fahr, Lisa, Straub, Tobias, Mahajan, Ujjwal M., Holt, Eric, Bozdag, Beyza, Imhof, Axel, Mayerle, Julia, Halberg, Nils and Regel, Ivonne (2024). Detection of epigenetic priming in acinar cells after recovering from pancreatitis or metabolic stress. 56th European Pancreatic Club Meeting 2024, Santiago de Compostela, Spain, 26 - 29 June 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.pan.2024.05.309 |
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2024 Journal Article PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levelsZhu, Qingzhang, Chen, Shiuhwei, Funcke, Jan-Bernd, Straub, Leon G., Lin, Qian, Zhao, Shangang, Joung, Chanmin, Zhang, Zhuzhen, Kim, Dae-Seok, Li, Na, Gliniak, Christy M., Lee, Charlotte, Cebrian-Serrano, Alberto, Pedersen, Line, Halberg, Nils, Gordillo, Ruth, Kusminski, Christine M. and Scherer, Philipp E. (2024). PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels. Nature Metabolism, 6 (7), 1347-1366. doi: 10.1038/s42255-024-01078-9 |
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2023 Journal Article Correction: The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer (Molecular Cancer, (2023), 22, 1, (86), 10.1186/s12943-023-01788-w)Entrialgo‑Cadierno, Rodrigo, Cueto‑Ureña, Cristina, Welch, Connor, Feliu, Iker, Macaya, Irati, Vera, Laura, Morales, Xabier, Michelina, Sandra Vietti, Scaparone, Pietro, Lopez, Ines, Darbo, Elodie, Erice, Oihane, Vallejo, Adrian, Moreno, Haritz, Goñi‑Salaverri, Ainhoa, Lara‑Astiaso, David, Halberg, Nils, Cortes‑Dominguez, Ivan, Guruceaga, Elizabeth, Ambrogio, Chiara, Lecanda, Fernando and Vicent, Silve (2023). Correction: The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer (Molecular Cancer, (2023), 22, 1, (86), 10.1186/s12943-023-01788-w). Molecular Cancer, 22 (1) 97. doi: 10.1186/s12943-023-01795-x |
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2023 Journal Article Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastasesParida, Pravat Kumar, Marquez-Palencia, Mauricio, Ghosh, Suvranil, Khandelwal, Nitin, Kim, Kangsan, Nair, Vidhya, Liu, Xiao-Zheng, Vu, Hieu S., Zacharias, Lauren G., Gonzalez-Ericsson, Paula I., Sanders, Melinda E., Mobley, Bret C., McDonald, Jeffrey G., Lemoff, Andrew, Peng, Yan, Lewis, Cheryl, Vale, Gonçalo, Halberg, Nils, Arteaga, Carlos L., Hanker, Ariella B., DeBerardinis, Ralph J. and Malladi, Srinivas (2023). Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases. Nature Cancer, 4 (6), 893-907. doi: 10.1038/s43018-023-00563-6 |
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2022 Journal Article C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancerLiu, Xiao-Zheng, Rulina, Anastasiia, Choi, Man Hung, Pedersen, Line, Lepland, Johanna, Takle, Sina T., Madeleine, Noelly, Peters, Stacey D’mello, Wogsland, Cara Ellen, Grøndal, Sturla Magnus, Lorens, James B., Goodarzi, Hani, Lønning, Per E., Knappskog, Stian, Molven, Anders and Halberg, Nils (2022). C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer. Nature Communications, 13 (1) 69, 69. doi: 10.1038/s41467-021-27734-2 |
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2022 Journal Article Carbon dot therapeutic platforms: administration, distribution, metabolism, excretion, toxicity, and therapeutic potentialTruskewycz, Adam, Yin, Hong, Halberg, Nils, Lai, Daniel T. H., Ball, Andrew S., Truong, Vi Khanh, Rybicka, Agata Marta and Cole, Ivan (2022). Carbon dot therapeutic platforms: administration, distribution, metabolism, excretion, toxicity, and therapeutic potential. Small, 18 (16) 2106342, 16. doi: 10.1002/smll.202106342 |
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2021 Journal Article High-dimensional immunotyping of tumors grown in obese and non-obese miceWogsland, Cara E., Lien, Hilde E., Pedersen, Line, Hanjra, Pahul, Grondal, Sturla M., Brekken, Rolf A., Lorens, James B. and Halberg, Nils (2021). High-dimensional immunotyping of tumors grown in obese and non-obese mice. DMM Disease Models and Mechanisms, 14 (4) dmm.048977, 1-18. doi: 10.1242/dmm.048977 |
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2021 Journal Article Cellular mechanisms linking cancers to obesityLiu, Xiao-Zheng, Pedersen, Line and Halberg, Nils (2021). Cellular mechanisms linking cancers to obesity. Cell Stress, 5 (5), 55-72. doi: 10.15698/CST2021.05.248 |
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2020 Journal Article AXL Is a driver of stemness in normal mammary gland and breast cancerEngelsen, Agnete S. T., Wnuk-Lipinska, Katarzyna, Bougnaud, Sebastien, Pelissier Vatter, Fanny A., Tiron, Crina, Villadsen, René, Miyano, Masaru, Lotsberg, Maria L., Madeleine, Noëlly, Panahandeh, Pouda, Dhakal, Sushil, Tan, Tuan Zea, Peters, Stacey D'mello, Grøndal, Sturla, Aziz, Sura M., Nord, Silje, Herfindal, Lars, Stampfer, Martha R., Sørlie, Therese, Brekken, Rolf A., Straume, Oddbjørn, Halberg, Nils, Gausdal, Gro, Thiery, Jean Paul, Akslen, Lars A., Petersen, Ole W., LaBarge, Mark A. and Lorens, James B. (2020). AXL Is a driver of stemness in normal mammary gland and breast cancer. iScience, 23 (11) 101649, 1-19. doi: 10.1016/j.isci.2020.101649 |
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2020 Journal Article Golgi-localized PAQR4 mediates antiapoptotic ceramidase activity in breast cancerPedersen, Line, Panahandeh, Pouda, Siraji, Muntequa I., Knappskog, Stian, Lønning, Per Eystein, Gordillo, Ruth, Scherer, Philipp E., Molven, Anders, Teigen, Knut and Halberg, Nils (2020). Golgi-localized PAQR4 mediates antiapoptotic ceramidase activity in breast cancer. Cancer Research, 80 (11), 2163-2174. doi: 10.1158/0008-5472.CAN-19-3177 |
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2019 Journal Article Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidationPettersen, Ina Katrine Nitschke, Tusubira, Deusdedit, Ashrafi, Hanan, Dyrstad, Sissel Elisabeth, Hansen, Lena, Liu, Xiao-Zheng, Nilsson, Linn Iren Hodneland, Løvsletten, Nils Gunnar, Berge, Kjetil, Wergedahl, Hege, Bjørndal, Bodil, Fluge, Øystein, Bruland, Ove, Rustan, Arild Christian, Halberg, Nils, Røsland, Gro Vatne, Berge, Rolf Kristian and Tronstad, Karl Johan (2019). Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation. Mitochondrion, 49, 97-110. doi: 10.1016/j.mito.2019.07.009 |
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2019 Journal Article Human endotrophin as a driver of malignant tumor growthBu, Dawei, Crewe, Clair, Kusminski, Christine M., Gordillo, Ruth, Ghaben, Alexandra L., Kim, Min, Park, Jiyoung, Deng, Hui, Xiong, Wei, Liu, Xiao-Zheng, Lønning, Per Eystein, Halberg, Nils, Rios, Adan, Chang, Yujun, Gonzalez, Anneliese, Zhang, Ningyan, An, Zhiqiang and Scherer, Philipp E. (2019). Human endotrophin as a driver of malignant tumor growth. JCI Insight, 4 (9) e125094, 9. doi: 10.1172/jci.insight.125094 |
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2017 Journal Article Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesisJun, Jonathan C., Devera, Ronald, Unnikrishnan, Dileep, Shin, Mi-Kyung, Bevans-Fonti, Shannon, Yao, Qiaoling, Rathore, Aman, Younas, Haris, Halberg, Nils, Scherer, Philipp E. and Polotsky, Vsevolod Y. (2017). Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis. Journal of Molecular Medicine, 95 (3), 287-297. doi: 10.1007/s00109-016-1480-6 |
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2016 Journal Article PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant SecretionHalberg, Nils, Sengelaub, Caitlin A., Navrazhina, Kristina, Molina, Henrik, Uryu, Kunihiro and Tavazoie, Sohail F. (2016). PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion. Cancer Cell, 29 (3), 339-353. doi: 10.1016/j.ccell.2016.02.013 |
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2016 Journal Article PTPRN2 and PLCβ1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodelingSengelaub, Caitlin A., Navrazhina, Kristina, Ross, Jason B., Halberg, Nils and Tavazoie, Sohail F. (2016). PTPRN2 and PLCβ1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling. EMBO Journal, 35 (1), 62-76. doi: 10.15252/embj.201591973 |
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2013 Journal Article Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4Drager, Luciano F., Yao, Qiaoling, Hernandez, Karen L., Shin, Mi-Kyung, Bevans-Fonti, Shannon, Gay, Jason, Sussan, Thomas E., Jun, Jonathan C., Myers, Allen C., Olivecrona, Gunilla, Schwartz, Alan R., Halberg, Nils, Scherer, Philipp E., Semenza, Gregg L., Powell, David R. and Polotsky, Vsevolod Y. (2013). Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4. American Journal of Respiratory and Critical Care Medicine, 188 (2), 240-248. doi: 10.1164/rccm.201209-1688OC |
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2013 Journal Article Selective inhibition of Hypoxia-inducible factor 1α ameliorates adipose tissue dysfunctionSun, Kai, Halberg, Nils, Khan, Mahmood, Magalang, Ulysses J. and Scherer, Philipp E. (2013). Selective inhibition of Hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction. Molecular and Cellular Biology, 33 (5), 904-917. doi: 10.1128/MCB.00951-12 |
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2012 Journal Article MicroRNA regulation of cancer-endothelial interactions: Vesicular microRNAs on the moveHalberg, Nils, Alarcón, Claudio and Tavazoie, Sohail F. (2012). MicroRNA regulation of cancer-endothelial interactions: Vesicular microRNAs on the move. EMBO Journal, 31 (17), 3509-3510. doi: 10.1038/emboj.2012.198 |
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2009 Journal Article Hypoxia-inducible factor 1α induces fibrosis and insulin resistance in white adipose tissueHalberg, Nils, Khan, Tayeba, Trujillo, Maria E., Wernstedt-Asterholm, Ingrid, Attie, Alan D., Sherwani, Shariq, Wang, Zhao V., Landskroner-Eiger, Shira, Dineen, Sean, Magalang, Ulysses J., Brekken, Rolf A. and Scherer, Philipp E. (2009). Hypoxia-inducible factor 1α induces fibrosis and insulin resistance in white adipose tissue. Molecular and Cellular Biology, 29 (16), 4467-4483. doi: 10.1128/MCB.00192-09 |
