
Overview
Background
Professor Mark Schembri is a prominent microbiologist with experience in combating the global health crisis presented by multi-drug resistant pathogens. Professor Schembri’s expertise on the virulence of bacterial pathogens and his innovative analysis of biofilm formation aims to improve the outcomes of the >400 million individuals that suffer from urinary tract infections each year across the globe.
Through the application of genetic, genomic and functional studies on uropathogenic E. coli, Professor Schembri has identified targets to reduce the virulence of this pathogen, and will pursue the development of life-saving therapeutic and preventative advances with the assistance of NHMRC, MRFF and ARC grants. Professor Schembri has tracked the rapid emergence and global spread of a virulent, drug-resistant E. coli clone and used genome sequencing to understand its evolution and virulence.
Links: Professor Schembri collaborates with national and international research leaders, including in Denmark, where he was a lecturer. Professor Schembri has strong links with other international experts in his field, including at the Pasteur Institute and the Wellcome Trust Sanger Institute in Cambridge. His research collaborations also span lead groups at UQ and other top Australian institutes, including Griffith and La Trobe Universities.
Membership, Funding and patents: Since 2014, Professor Schembri has been awarded over $15 million in funding from competitive national research funding bodies. He holds provisional patents for the development of novel therapeutic agents and vaccine antigens. He is a Fellow of the American Academy of Microbiology, and is regularly invited to speak at international conferences in his field.
Awards and Communication: Professor Schembri was the recipient of the Frank Fenner Award (2010) and the ASM BacPath Oration Award (2019) for his outstanding original research contribution to the study of Infectious Disease. He was an Australian Research Council Future Fellow (2011-2015) a National Health and Medical Research Council Senior Research Fellow (2016-2020). Professor Schembri is the author of >240 peer-reviewed research manuscripts. He is President of the Australian Society for Microbiology (2022-2026).
Availability
- Professor Mark Schembri is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Monash University
Research impacts
Professor Schembri’s outstanding original work in the field of infectious disease and multi-drug resistant pathogens has led to several key advances in the fight to reduce the prevalence and improve outcomes of urinary tract infections.
Key research outputs: The genomic epidemiology of the most widespread antibiotic resistant uropathogenic E. coli clone allowed its origin and dissemination to be mapped on a global scale. Recent work in Professor Schembri’s group has defined the virulence of this pathogen using advanced genetic, transcriptomic and proteomic methods in conjunction with mouse models of infection. He has also led the use of new treatments to prevent infection by this antibiotic resistant pathogen.
Key capabilities: Professor Schembri has deep expertise in microbiology, with particular capability in the study of antibiotic resistant Gram-negative bacterial pathogens and high-throughput modelling of drug-resistant biofilms, as well as the application of forefront technologies to examine virulence, genomic epidemiology, host-pathogen interactions and novel strategies for the treatment/prevention of infectious diseases.
Works
Search Professor Mark Schembri’s works on UQ eSpace
2009
Journal Article
Virulence properties of asymptomatic bacteriuria Escherichia coli
Mabbett, Amanda N., Ulett, Glen C., Watts, Rebecca E., Tree, Jai J., Totsika, Makrina, Ong, Cheryl-Lynn, Wood, Jacqueline M., Monaghan, Wayne, Looke, David F., Nimmo, Graeme R., Svanborg, Catharina and Schembri, Mark A. (2009). Virulence properties of asymptomatic bacteriuria Escherichia coli. International Journal of Medical Microbiology, 299 (1), 53-63. doi: 10.1016/j.ijmm.2008.06.003
2009
Journal Article
Colonisation dynamics and virulence of two clonal groups of multidrug-resistant Escherichia coli isolated from dogs
Sidjabat, Hanna E., Chin, James J.-C., Chapman, Toni, Wu, Kent, Ulett, Glen C., Cheryl-Lynn Ong, Schembri, Mark A., Johnson, James R. and Trott, Darren J. (2009). Colonisation dynamics and virulence of two clonal groups of multidrug-resistant Escherichia coli isolated from dogs. Microbes and Infection, 11 (1), 100-107. doi: 10.1016/j.micinf.2008.10.014
2008
Journal Article
Trade-off between iron uptake and protection against oxidative stress: Deletion of cueO promotes uropathogenic Escherichia coli virulence in a mouse model of urinary tract infection
Tree, Jai J., Ulett, Glen C., Ong, Cheryl-Lynn Y., Trott, Darren J., McEwan, Alastair G. and Schembri, Mark A. (2008). Trade-off between iron uptake and protection against oxidative stress: Deletion of cueO promotes uropathogenic Escherichia coli virulence in a mouse model of urinary tract infection. Journal of Bacteriology, 190 (20), 6909-6912. doi: 10.1128/JB.00451-08
2008
Journal Article
UpaG, a new member of the trimeric autotransporter family of adhesins in uropathogenic Escherichia coli
Valle, Jaione, Mabbett, Amanda N., Ulett, Glen C., Toledo-Arana, Alejandro, Wecker, Karine, Totsika. Makrina, Schembri, Mark A., Ghigo, Jean-Marc and Beloin, Christophe (2008). UpaG, a new member of the trimeric autotransporter family of adhesins in uropathogenic Escherichia coli. Journal of Bacteriology, 190 (12), 4147-4161. doi: 10.1128/JB.00122-08
2008
Journal Article
EhaA is a novel autotransporter protein of enterohemorrhagic Escherichia coli O157:H7 that contributes to adhesion and biofilm formation
Wells, T.J., Sherlock, O., Rivas, L., Mahajan, A., Beatson, S.A., Torpdahl, M., Webb, R.I., Allsopp, L., Gobius, K., Gally, D.L. and Schembri, M.A. (2008). EhaA is a novel autotransporter protein of enterohemorrhagic Escherichia coli O157:H7 that contributes to adhesion and biofilm formation. Environmental Microbiology, 10 (3), 589-604. doi: 10.1111/j.1462-2920.2007.01479.x
2008
Journal Article
Identification of Type 3 Fimbriae in Uropathogenic Escherichia coli Reveals a Role in Biofilm Formation
Ong, C., Ulett, G., Mabbett, A., Beatson, S., Webb, R., Monaghan, W., Nimmo, G., Looke, D., McEwan, A. and Schembri, M. (2008). Identification of Type 3 Fimbriae in Uropathogenic Escherichia coli Reveals a Role in Biofilm Formation. Journal of Bacteriology, 190 (3), 1054-1063. doi: 10.1128/JB.01523-07
2007
Journal Article
Candidate targets for new antivirulence drugs: selected cases of bacterial adhesion and biofilm formation
Klemm, P., Hancock, V., Kvist, M. and Schembri, M. (2007). Candidate targets for new antivirulence drugs: selected cases of bacterial adhesion and biofilm formation. Future Microbiology, 2 (6), 643-653. doi: 10.2217/17460913.2.6.643
2007
Journal Article
Autotransporter proteins: novel targets at the bacterial cell surface
Wells, T. J., Tree, J. J., Ulett, G. C. and Schembri, M. A. (2007). Autotransporter proteins: novel targets at the bacterial cell surface. Fems Microbiology Letters, 274 (2), 163-172. doi: 10.1111/j.1574-6968.2007.00833.x
2007
Journal Article
The cysteine bond in the Escherichia coli FimH adhesin is critical for adhesion under flow conditions
Nilsson, LM, Yakovenko, O, Tchesnokova, V, Thomas, WE, Schembri, MA, Vogel, V, Klemm, P and Sokurenko, EV (2007). The cysteine bond in the Escherichia coli FimH adhesin is critical for adhesion under flow conditions. Molecular Microbiology, 65 (5), 1158-1169. doi: 10.1111/j.1365-2958.2007.05858.x
2007
Journal Article
Mellowing out: Adaptation to commensalism by Escherichia coli asymptomatic bacteriuria strain 83972
Klemm, Per, Hancock, Viktoria and Schembri, Mark A. (2007). Mellowing out: Adaptation to commensalism by Escherichia coli asymptomatic bacteriuria strain 83972. Infection and Immunity, 75 (8), 3688-3695. doi: 10.1128/IAI.01730-06
2007
Journal Article
Functional analysis of antigen 43 in uropathogenic Escherichia coli reveals a role in long-term persistence in the urinary tract
Ulett, Glen C., Valle, Jaione, Beloin, Christophe, Sherlock, Orla, Ghigo, Jean-Marc and Schembri, Mark A. (2007). Functional analysis of antigen 43 in uropathogenic Escherichia coli reveals a role in long-term persistence in the urinary tract. Infection and Immunity, 75 (7), 3233-3244. doi: 10.1128/IAI.01952-06
2007
Journal Article
The multicopper oxidase (CueO) and cell aggregation in Escherichia coli
Tree, JJ, Ulett, GC, Hobman, JL, Constantinidou, C, Brown, NL, Kershaw, C, Schembri, MA, Jennings, MP and McEwan, AG (2007). The multicopper oxidase (CueO) and cell aggregation in Escherichia coli. Environmental Microbiology, 9 (8), 2110-2116. doi: 10.1111/j.1462-2920.2007.01320.x
2007
Journal Article
Do type 1 fimbriae promote inflammation in the human urinary tract?
Bergsten, G, Wullt, B, Schembri, MA, Leijonhufvud, I and Svanborg, C (2007). Do type 1 fimbriae promote inflammation in the human urinary tract?. Cellular Microbiology, 9 (7), 1766-1781. doi: 10.1111/j.1462-5822.2007.00912.x
2007
Journal Article
The role of F9 fimbriae of uropathogenic Escherichia coli in biofilm formation
Ulett, GC, Mabbett, AN, Fung, KC, Webb, RI and Schembri, MA (2007). The role of F9 fimbriae of uropathogenic Escherichia coli in biofilm formation. Microbiology-sgm, 153 (7), 2321-2331. doi: 10.1099/mic.0.2006/004648-0
2007
Conference Publication
E. coli virulence factors; The role of the type 1 fimbriae for host response induction in the human urinary tract
Wullt, B., Bergsten, G., Schembri, M. A., Leijonhufvud, I. and Svanborg, C. (2007). E. coli virulence factors; The role of the type 1 fimbriae for host response induction in the human urinary tract. 22nd Annual Congress of the European Association of Urology, Berlin, Germany, 21-24 March 2007. Amsterdam, Netherlands: Elsevier Science. doi: 10.1016/S1569-9056(07)60003-7
2006
Journal Article
Antigen-43-mediated autoaggregation impairs motility in Escherichia coli
Ulett, G. C., Webb, R. I. and Schembri, M. A. (2006). Antigen-43-mediated autoaggregation impairs motility in Escherichia coli. Microbiology-sgm, 152 (9), 2101-2110. doi: 10.1099/mic.0.28607-0
2006
Journal Article
Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin
Bouckaert, J., Berglund, J., Schembri, M., De Genst, E., Cools, L., Wuhrer, M., Hung, C. S., Pinkner, J., Slattegard, R., Zavialov, A., Choudhury, D., Langermann, S., Hultgren, S. J., Wyns, L., Klemm, P., Oscarson, S., Knight, S. D. and De Greve, H. (2006). Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin. Journal of Urology, 175 (4), 1570-1570. doi: 10.1016/S0022-5347(05)00871-2
2006
Journal Article
The asymptomatic bacteriuria Escherichia coli strain 83972 outcompetes uropathogenic E-coli strains in human urine
Roos, Viktoria, Ulett, Glen C., Schembri, Mark A. and Klemm, Per (2006). The asymptomatic bacteriuria Escherichia coli strain 83972 outcompetes uropathogenic E-coli strains in human urine. Infection and Immunity, 74 (1), 615-624. doi: 10.1128/IAI.74.1.615-624.2006
2006
Journal Article
Asymptomatic bacteriuria Escherichia coli strain 83972 carries mutations in the foc locus and is unable to express F1C fimbriae
Roos, Viktoria, Schembri, Mark A., Ulett, Glen C. and Klemm, Per (2006). Asymptomatic bacteriuria Escherichia coli strain 83972 carries mutations in the foc locus and is unable to express F1C fimbriae. Microbiology, 152 (Part 6), 1799-1806. doi: 10.1099/mic.0.28711-0
2006
Journal Article
Active genetic elements present in the locus of enterocyte effacement in Escherichia coli O26 and their role in mobility
Muniesa, Maite, Schembri, Mark A., Hauf, Nadja and Chakraborty, Trinad (2006). Active genetic elements present in the locus of enterocyte effacement in Escherichia coli O26 and their role in mobility. Infection and Immunity, 74 (7), 4190-4199. doi: 10.1128/IAI.00926-05
Funding
Current funding
Past funding
Supervision
Availability
- Professor Mark Schembri is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Diversity, regulation and function of the uropathogenic Escherichia coli capsule
Principal Advisor
Other advisors: Professor Matt Sweet, Dr Duy Phan
-
Doctor Philosophy
Understanding virulence factors and their regulation in uropathogenic Escherichia coli (UPEC)
Principal Advisor
Other advisors: Dr Nhu Nguyen
-
Doctor Philosophy
How bacteria form antibiotic resistant biofilms
Principal Advisor
Other advisors: Dr Nhu Nguyen, Dr Duy Phan
-
Doctor Philosophy
Microbial effects on host mitochondrial DNA
Associate Advisor
Other advisors: Associate Professor Steven Zuryn
-
Doctor Philosophy
Application of Transposon Directed Insertion Site Sequencing to Enhance Understanding of Essential Genes in Escherichia coli
Associate Advisor
Other advisors: Professor Ian Henderson
-
Doctor Philosophy
Identifying new targets for treatment of antimicrobial resistant infections
Associate Advisor
Other advisors: Professor Ian Henderson
-
Doctor Philosophy
Boosting innate immune defence to combat antibiotic-resistant bacterial infections
Associate Advisor
Other advisors: Dr Divya Ramnath, Professor Matt Sweet
-
Doctor Philosophy
Application of Transposon Directed Insertion Site Sequencing to Enhance Understanding of Essential Genes in Escherichia coli
Associate Advisor
Other advisors: Professor Ian Henderson
-
Doctor Philosophy
Genomic and molecular characterisation of antibiotic resistance mechanisms
Associate Advisor
Other advisors: Dr Brian Forde
Completed supervision
-
2024
Doctor Philosophy
Understanding virulence factors and their regulation in uropathogenic Escherichia coli (UPEC)
Principal Advisor
Other advisors: Dr Nhu Nguyen
-
2024
Doctor Philosophy
Understanding antibiotic resistance and virulence in uropathogenic Escherichia coli
Principal Advisor
Other advisors: Dr Duy Phan
-
2023
Doctor Philosophy
Understanding the regulation of biofilm matrix components in uropathogenic Escherichia coli virulence
Principal Advisor
Other advisors: Dr Nhu Nguyen
-
2023
Doctor Philosophy
Virulence and Resistance Plasmids of Extra-intestinal Pathogenic Escherichia coli
Principal Advisor
Other advisors: Dr Duy Phan
-
2022
Doctor Philosophy
Characterisation of Escherichia coli fimbrial and autotransporter adhesins
Principal Advisor
Other advisors: Dr Duy Phan
-
2019
Doctor Philosophy
Molecular characterisation of A/C plasmids
Principal Advisor
Other advisors: Dr Duy Phan
-
2018
Doctor Philosophy
Molecular and genomic analysis of multidrug resistant Uropathogenic Escherichia coli
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2017
Doctor Philosophy
Characterisation of flagella and resistance to oxidative stress in Escherichia coli ST131 virulence
Principal Advisor
-
2017
Doctor Philosophy
Characterisation of Factors Involved in Escherichia coli Virulence: Type Ve Inverse Autotransporter Proteins and the K1 Capsule
Principal Advisor
-
2016
Doctor Philosophy
Uropathogenic Escherichia coli: Towards a Better Understanding through the Characterisation of a Vaccine Antigen and Virulence Factor
Principal Advisor
-
2016
Master Philosophy
Autotransporter Proteins of Uropathogenic Escherichia coli: Regulation, Characterisation and the Role of Periplasmic Proteins in their Expression
Principal Advisor
-
2014
Doctor Philosophy
Evolutionary Phylogeny and Molecular Characterisation of Chaperone-Usher Fimbriae from Uropathogenic Escherichia coli
Principal Advisor
-
2014
Doctor Philosophy
Investigating the Virulence Potential of the Multidrug Resistant Uropathogenic Escherichia coli ST131 clone
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2012
Doctor Philosophy
Molecular analysis of Acinetobacter baumannii isolates from an intensive care unit
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2011
Doctor Philosophy
Identification and Characterisation of New Adhesins in Uropathogenic Escherichia coli
Principal Advisor
-
2011
Doctor Philosophy
Molecular characterisation of asymptomatic bacteriuria Escherichia coli
Principal Advisor
-
2011
Doctor Philosophy
Identification and characterisation of novel surface proteins of the urinary tract pathogen Staphylococcus saprophyticus
Principal Advisor
Other advisors: Associate Professor Scott Beatson
-
2009
Doctor Philosophy
Identification and Characterisation of Novel Autotransporters of Enterohaemorrhagic Escherichia coli O157:H7
Principal Advisor
-
2009
Doctor Philosophy
Bacterial Aggregation and Biofilm Formation by Uropathogenic Escherichia coli
Principal Advisor
-
2024
Master Philosophy
Theoretical investigations of integron evolution in bacteria
Associate Advisor
Other advisors: Associate Professor Jan Engelstaedter
-
2024
Doctor Philosophy
Application of Transposon Directed Insertion Site Sequencing to Enhance Understanding of Essential Genes in Escherichia coli
Associate Advisor
Other advisors: Professor Ian Henderson
-
2023
Doctor Philosophy
Characterisation of the macrophage zinc toxicity response as an antimicrobial weapon
Associate Advisor
Other advisors: Professor Matt Sweet
-
2022
Doctor Philosophy
A bitter taste in your heart: the role of T2Rs in cardiovascular physiology and pathophysiology
Associate Advisor
Other advisors: Professor Mark Walker, Professor Wally Thomas
-
2022
Doctor Philosophy
Understanding Roles of Commonly Prescribed Antidepressants in the Dissemination of Antibiotic Resistance
Associate Advisor
Other advisors: Professor Jianhua Guo
-
2021
Doctor Philosophy
Characterising B1 Metallo-ß-Lactamases (MBLs)
Joint Principal Advisor
Other advisors: Professor Gary Schenk
-
2019
Doctor Philosophy
Investigation of innate immune antimicrobial zinc toxicity
Associate Advisor
Other advisors: Professor Matt Sweet
-
2019
Doctor Philosophy
Characterization of interactions between uropathogenic Escherichia coli and the innate immune system
Associate Advisor
Other advisors: Professor Matt Sweet
-
2019
Doctor Philosophy
Application of whole genome sequencing to characterise clinically significant multidrug resistant bacteria
Associate Advisor
Other advisors: Associate Professor Scott Beatson
-
2017
Doctor Philosophy
Bacterial ketol-acid reductoisomerase: structure, catalytic mechanism and thermal stability
Associate Advisor
Other advisors: Professor Bostjan Kobe, Professor Luke Guddat
-
2016
Doctor Philosophy
Preventing canine urinary tract infection (UTI) using an asymptomatic bacteriuria (ASB) Escherichia coli strain
Associate Advisor
Other advisors: Professor Paul Mills
-
2015
Doctor Philosophy
Investigating the host and bacterial factors in cystic fibrosis that promote persistence of infection in the lung.
Associate Advisor
-
2014
Doctor Philosophy
Structural and functional studies of TcpB, a protein involved in Brucella pathogenesis
Associate Advisor
Other advisors: Professor Matt Sweet, Professor Bostjan Kobe
-
2014
Doctor Philosophy
Structural & Functional Characterization of Bacterial TRX-fold proteins
Associate Advisor
Other advisors: Emerita Professor Jenny Martin
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2013
Doctor Philosophy
Identification and characterization of anti-microbial pathways in human macrophages
Associate Advisor
Other advisors: Professor Kate Stacey, Professor Matt Sweet
-
2007
Doctor Philosophy
FUNCTIONAL CHARACTERISATION OF THE MULTICOPPER OXIDASE FROM Escherichia coli and Salmonella typhimurium
Associate Advisor
Media
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