Associate Professor Seth Cheetham
Associate Professor

Seth Cheetham

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Background

A/Prof. Seth Cheetham is an ARC Discovery Early Career Award Fellow and Group Leader at the Australian Institute for Bioengineering and Nanotechnology. He is also the Deputy Director of the BASE facility, Australia's leading mRNA manufacturing hub. He completed his PhD at the University of Cambridge, supported by the Herchel Smith Research Studentship. Seth is a molecular biologist and geneticist with a focus on mRNA drugs, synthetic biology and epigenetics. He has authored 25 publications, in some of the most influential molecular biology journals including Science, Molecular Cell, Nature Reviews Genetics , Genome Biology and Nature Structural and Molecular Biology. His work has attracted > $15M including back-to-back NHMRC and ARC Fellowships. In 2021 Seth was awarded the Genetics Society of Australasia Alan Wilton ECR awarded for his research in the field of RNA and epigenetics.

Availability

Associate Professor Seth Cheetham is:
Available for supervision
Media expert

Fields of research

Biochemistry and cell biology Bioinformatics and computational biology Biological Sciences Epigenetics (incl. genome methylation and epigenomics) Gene expression (incl. microarray and other genome-wide approaches) Genetics Genomics

Search Professor Seth Cheetham’s works on UQ eSpace

28 works between 2012 and 2025
All (28) Journal Article (27) Book Chapter (1)

21 - 28 of 28 works

2018

Journal Article

Targeted DamID reveals differential binding of mammalian pluripotency factors

Cheetham, Seth W., Gruhn, Wolfram H., van den Ameele, Jelle, Krautz, Robert, Southall, Tony D., Kobayashi, Toshihiro, Surani, M. Azim and Brand, Andrea H. (2018). Targeted DamID reveals differential binding of mammalian pluripotency factors. Development, 145 (20) dev170209, dev.170209. doi: 10.1242/dev.170209

Targeted DamID reveals differential binding of mammalian pluripotency factors

2017

Journal Article

High resolution temporal transcriptomics of mouse embryoid body development reveals complex expression dynamics of coding and noncoding loci

Gloss, Brian S., Signal, Bethany, Cheetham, Seth W., Gruhl, Franziska, Kaczorowski, Dominik C., Perkins, Andrew C. and Dinger, Marcel E. (2017). High resolution temporal transcriptomics of mouse embryoid body development reveals complex expression dynamics of coding and noncoding loci. Scientific Reports, 7 (1) 6731, 6731. doi: 10.1038/s41598-017-06110-5

High resolution temporal transcriptomics of mouse embryoid body development reveals complex expression dynamics of coding and noncoding loci

2016

Journal Article

Cell-type-specific profiling of protein-DNA interactions without cell isolation using targeted DamID with next-generation sequencing

Marshall, Owen J., Southall, Tony D., Cheetham, Seth W. and Brand, Andrea H. (2016). Cell-type-specific profiling of protein-DNA interactions without cell isolation using targeted DamID with next-generation sequencing. Nature Protocols, 11 (9), 1586-1598. doi: 10.1038/nprot.2016.084

Cell-type-specific profiling of protein-DNA interactions without cell isolation using targeted DamID with next-generation sequencing

2016

Journal Article

The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation

Bell, Charles C., Amaral, Paulo P., Kalsbeek, Anton, Magor, Graham W., Gillinder, Kevin R., Tangermann, Pierre, di Lisio, Lorena, Cheetham, Seth W., Gruhl, Franziska, Frith, Jessica, Tallack, Michael R., Ru, Ke-Lin, Crawford, Joanna, Mattick, John S., Dinger, Marcel E. and Perkins, Andrew C. (2016). The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation. Scientific Reports, 6 (1) 26657, 26657. doi: 10.1038/srep26657

The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation

2014

Journal Article

Freedom of expression: cell-type-specific gene profiling

Otsuki, Leo, Cheetham, Seth W. and Brand, Andrea H. (2014). Freedom of expression: cell-type-specific gene profiling. Wiley Interdisciplinary Reviews: Developmental Biology, 3 (6), 429-443. doi: 10.1002/wdev.149

Freedom of expression: cell-type-specific gene profiling

2013

Journal Article

Long noncoding RNAs and the genetics of cancer

Cheetham, S. W., Gruhl, F., Mattick, J. S. and Dinger, M. E. (2013). Long noncoding RNAs and the genetics of cancer. British Journal of Cancer, 108 (12), 2419-2425. doi: 10.1038/bjc.2013.233

Long noncoding RNAs and the genetics of cancer

2013

Journal Article

Insulin finds its niche

Cheetham, Seth W. and Brand, Andrea H. (2013). Insulin finds its niche. Science, 340 (6134), 817-818. doi: 10.1126/science.1238525

Insulin finds its niche

2012

Journal Article

Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes

Gascoigne, Dennis K., Cheetham, Seth W., Cattenoz, Pierre B., Clark, Michael B., Amaral, Paulo P., Taft, Ryan J., Wilhelm, Dagmar, Dinger, Marcel E. and Mattick, John S. (2012). Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes. Bioinformatics, 28 (23), 3042-3050. doi: 10.1093/bioinformatics/bts582

Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes

Current funding

  • 2025 - 2028
    Improving Quality Control of mRNA Manufacture with Nanopore Sequencing
    ARC Linkage Projects
    Open grant
  • 2025
    Hepatic delivery of Colony Stimulating Factor 1mRNA to promote liver repair
    Gastroenterological Society of Australia
    Open grant
  • 2025 - 2027
    Personalized immunotherapy for the treatment of light chain amyloidosis
    Snowdome Haematology Fellowship
    Open grant
  • 2024 - 2025
    Evaluating vaccine efficacy in a preclinical humanised mouse model for paediatric sarcoma
    ANZ Sarcoma Research Grant
    Open grant
  • 2024 - 2025
    Proof-of-concept study of mRNA-based gene therapy for Mitochondrial Neuro-Gastro-lntestinal Encephalomyopathy (The Lily Foundation Research Grant administered by the University of Cambridge)
    University of Cambridge
    Open grant
  • 2024 - 2029
    Building mRNA Cancer Vaccines for Australia.
    MRFF - National Critical Infrastructure Initiative
    Open grant
  • 2023 - 2028
    Building the next mRNA vaccines and therapies
    MRFF - National Critical Infrastructure Initiative
    Open grant
  • 2023 - 2026
    Personalising Innate-immunotherapy for Superior Treatment Outcomes with Large anticancer applicability (PISTOL)
    NHMRC MRFF EMCR - Early to Mid-Career Researchers
    Open grant
  • 2023 - 2025
    Tracing the epigenetic life-history of cells
    ARC Discovery Early Career Researcher Award
    Open grant

Past funding

  • 2024
    Drugging the undruggable with mRNA technology: A new treatment for liver cancer
    UQ Foundation Research Excellence Awards
    Open grant
  • 2024
    Targeting liver cancer with mRNA therapies
    TdC Mid Career Grant
    Open grant
  • 2023 - 2024
    Optimisation of mRNA production and purification using the AMBR15 and AMBRCF
    Innovation Connections
    Open grant
  • 2021 - 2024
    Long-read genetic and epigenetic profiling in lung cancer for precision medicine
    Priority-driven Collaborative Cancer Research Scheme
    Open grant
  • 2019
    Are inhibitory pseudogenes key players in cancer?
    UQ Early Career Researcher
    Open grant
  • 2019 - 2022
    Deciphering global and locus-specific regulation of LINE-1 retrotransposons in cancer
    NHMRC Early Career Fellowships
    Open grant

Availability

Associate Professor Seth Cheetham is:
Available for supervision

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Available projects

  • Next generation mRNA vaccines and therapeutics

    mRNA vaccines and therapeutics are rapidly emerging technologies with enormous potential to improve human health. The mRNA COVID-19 vaccines are credited with saving millions of lives throughout the pandemic and mRNA vaccine candidates have demonstrated the capacity to protect against various infectious diseases and cancer. mRNA-based gene therapies have the potential to alleviate a myriad of chronic diseases. This project will develop novel technologies to improve mRNA vaccines and therapeutics to achieve cell-type specific expression and enhance stability.

  • mRNA cancer vaccines

    Involves designing and testing of personalised mRNA cancer vaccines that can provoke robust and durable immune responses.

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Associate Professor Seth Cheetham directly for media enquiries about:

  • mRNA
  • RNA
  • therapies
  • vaccines

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