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Dr Moe Thuzar
Dr

Moe Thuzar

Email: 
Phone: 
+61 7 3176 2111

Overview

Background

Moe Thuzar (MBBS, FRCP UK, FRACP, PhD) is an Endocrinologist at the Princess Alexandra Hospital and a Research Fellow at the University of Queensland Diamantina Institute, Faculty of Medicine, University of Queensland, Brisbane. She has a strong research interest in the Neuroendocrine Regulation of Metabolism and Cardiovascular Health in Humans. After completing her specialist training and receiving FRACP (Fellowship of the Royal Australasian College of Physicians) in early 2014, she undertook her PhD study (2014-2018, UQ) investigating the role of adrenal neuroendocrine system in the regulation of human brown adipose tissue and energy metabolism under the primary supervision of Professor Ken Ho. Moe then joined the Endocrine Hypertension Unit of Professor Michael Stowasser at the UQDI, pursuing further research in Cardiovascular Endocrinology, in particular, elucidating the role of the mineralocorticoid system in the regulation of cardiometabolic health and its interplay with other systems in humans, and investigating optimal diagnostic and management strategies for primary aldosteronism.

She has received numerous awards for her work including US Endocrine Society’s Outstanding Abstract Award (2016) and Presidential Awards for Excellence in Cardiovascular Endocrinology Research (2017) and in Adipocyte Biology Research (2017), Early Career Researcher Award from the Australian & New Zealand Obesity Society (2016), Australasian Women in Endocrinology Young Investigator Award (2017), Queensland Health & Medical Research Award (Previously “Premier’s award”, finalist, 2017), Young Investigator Award, International Aldosterone Conference (runner-up, 2019). She is a Principal Investigator (PI) or Chief Investigator (CI) of a number of successful competitive grants, totalling ~4 millions to date, which include Royal Australasian College of Physicians-Australian Diabetes Society Research Establishment Fellowship (2023), MRFF Clinician Researchers Project Grant (CI, 2022-2025), Metro South Research Support Scheme Program Grant (PI, 2021-2023), Diabetes Australia Project Grant (PI, 2019-2021), Metro South Research Support Scheme Early Career Researcher Grant (PI, 2019-2022), High Blood Pressure Research Council of Australia International Travel Grant (2021), Endocrine Society of Australia Postdoctoral Fellowship (2019). She has served as an expert reviewer for Grant review panels including NHMRC Project Grants Scheme and for top journals in the field, and held editorial roles for a number of journals including the Frontiers in Endocrinology, Metabolites.

Availability

Dr Moe Thuzar is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Works

Search Professor Moe Thuzar’s works on UQ eSpace

24 works between 2014 and 2024

21 - 24 of 24 works

2016

Journal Article

MECHANISMS IN ENDOCRINOLOGY: brown adipose tissue in humans: regulation and metabolic significance

Thuzar, Moe and Ho, Ken K. Y. (2016). MECHANISMS IN ENDOCRINOLOGY: brown adipose tissue in humans: regulation and metabolic significance. European Journal of Endocrinology, 175 (1), R11-R25. doi: 10.1530/EJE-15-1217

MECHANISMS IN ENDOCRINOLOGY: brown adipose tissue in humans: regulation and metabolic significance

2014

Journal Article

Extreme hypertriglyceridemia managed with insulin

Thuzar, Moe, Shenoy, Vasant V., Malabu, Usman H., Schrale, Ryan and Sangla, Kunwarjit S. (2014). Extreme hypertriglyceridemia managed with insulin. Journal of Clinical Lipidology, 8 (6), 630-634. doi: 10.1016/j.jacl.2014.09.004

Extreme hypertriglyceridemia managed with insulin

2014

Journal Article

Infrared thermography in the detection of brown adipose tissue in humans

Jang, Christina, Jalapu, Sandya, Thuzar, Moe, Law, Phillip W., Jeavons, Susanne, Barclay, Johanna L. and Ho, Ken K. Y. (2014). Infrared thermography in the detection of brown adipose tissue in humans. Physiological Reports, 2 (11) e12167, e12167.1-e12167.7. doi: 10.14814/phy2.12167

Infrared thermography in the detection of brown adipose tissue in humans

2014

Journal Article

Use of a standardised diabetic ketoacidosis management protocol improved clinical outcomes

Thuzar, Moe, Malabu, Usman H., Tisdell, Ben and Sangla, Kunwarjit S. (2014). Use of a standardised diabetic ketoacidosis management protocol improved clinical outcomes. Diabetes Research and Clinical Practice, 104 (1), E8-E11. doi: 10.1016/j.diabres.2014.01.016

Use of a standardised diabetic ketoacidosis management protocol improved clinical outcomes

Funding

Past funding

  • 2019 - 2021
    Defining the Novel Effects of Mineralocorticoid Receptor Antagonism on Adiposity and Glucose Homeostatis - A Randomised Controlled Trial
    Diabetes Australia Research Program
    Open grant

Supervision

Availability

Dr Moe Thuzar is:
Available for supervision

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Available projects

  • Defining the Novel Effects of Mineralocorticoid Receptor Antagonism on Metabolism in Humans

    This project involves a randomised clinical trial designed to investigate the potential novel metabolic benefits of Mineralocorticoid receptor (MR) antagonism and to elucidate the mechanistic changes underlying the metabolic benefits conferred by MR antagonism in humans.

    MRs are hormone receptors present in high abundance on fat cells of obese subjects. Metabolic syndrome is commonly found with mineralocorticoid hormone excess (primary hyperaldosteronism) and in the general population, mineralocorticoid level is predictive of obesity and metabolic diseases. There is strong evidence in animals that blocking MRs (MR antagonism) protects against obesity and metabolic complications. It is not known if similar mechanisms operate in humans.

    This project will help define the novel therapeutic potential of MR antagonists for management of obesity and metabolic diseases in overweight/obese humans. The results may also offer unique physiological insights into the underlying mechanisms modulating metabolic health for future research and development.

  • Mineralocorticoid Receptor Antagonist To Counteract Cardiometabolic Adverse Effects of Steroids/Glucocorticoids

    Metabolic syndrome and cardiovascular diseases are common side effects of steroids/glucocorticoids such as prednisolone, widely used for inflammatory diseases; there is no specific agent to counteract these adverse effects. There is evidence that these side effects are likely mediated by closely-related hormone receptors called mineralocorticoid receptors (MRs), present in fat and cardiac tissues and immune cells. We have previously discovered in healthy humans that MR antagonists exert opposing effects to those of glucocorticoids on adipose tissue metabolism.

    This project will examine if blocking the MRs by spironolactone can counteract metabolic and cardiac side effects without compromising beneficial antiinflammatory effects in people requiring prednisolone.

Supervision history

Current supervision

  • Doctor Philosophy

    Defining The Role Of Mineralocorticoid Receptor In Cardiometabolic Health & Inflammation & Optimising The Diagnostic Approach For Aldosterone-producing Adenoma

    Associate Advisor

    Other advisors: Professor Michael Stowasser

Media

Enquiries

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