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2025 Journal Article PEG-free lipid nanoparticles for mRNA delivery: superhydrophilic sulfoxide polymer coatingsChoy, On Ting, Fletcher, Nicholas L., Fu, Changkui, Vu, Mai N., Ediriweera, Gayathri R., Humphries, James, Hu, Mingdi, Kent, Stephen J., Cai, Rong, Chen, Chunying and Whittaker, Andrew K. (2025). PEG-free lipid nanoparticles for mRNA delivery: superhydrophilic sulfoxide polymer coatings. Biomacromolecules acs.biomac.5c01899. doi: 10.1021/acs.biomac.5c01899 |
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2025 Journal Article Evaluating mRNA Delivery Using Nuclear MedicineHumphries, James, Witjaksono, Andrea, Poudel, Abishek, Mardon, Karine, Migotto, Mary-anne, Cheetham, Seth, Howard, Christopher and Thurecht, Kristofer (2025). Evaluating mRNA Delivery Using Nuclear Medicine. Nuclear Medicine and Biology, 150-151 109117, 109117. doi: 10.1016/j.nucmedbio.2025.109117 |
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2025 Conference Publication Development of novel 18F-PET imaging probes for mTOR signaling in Focal cortical Dysplasia type IIAlmass, Adrian, Paterson, Brett, Humphries, James, Grieve, Melyssa, Stimson, Damion, Migotto, Mary-anne, Cowin, Gary and Reutens, David (2025). Development of novel 18F-PET imaging probes for mTOR signaling in Focal cortical Dysplasia type II. International Symposium on Radiopharmaceutical Sciences iSRS 2025, Gold Coast, QLD, Australia, 11-15 May 2025. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.nucmedbio.2025.109196 |
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2025 Journal Article Optimising VHH-Based Radiopharmaceuticals: Addressing Pharmacokinetics and Renal Clearance ChallengesHuda, Pie, Owen, David, Bell, Craig, Wood, James, Humphries, James and Thurecht, Kristofer (2025). Optimising VHH-Based Radiopharmaceuticals: Addressing Pharmacokinetics and Renal Clearance Challenges. Nuclear Medicine and Biology, 150-151 109460, 109460. doi: 10.1016/j.nucmedbio.2025.109460 |
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2025 Journal Article Pre-targeting of PEG-based nanomedicines: precise delivery of potent payloadsFletcher, Nicholas, Thurecht, Kristofer, Chu, Weijing, Huda, Pie, Humphries, James and Wood, James (2025). Pre-targeting of PEG-based nanomedicines: precise delivery of potent payloads. Nuclear Medicine and Biology, 150-151 109150, 109150. doi: 10.1016/j.nucmedbio.2025.109150 |
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2025 Journal Article D2 – Enabling a theranostic approach with 89Zr/177Lu in a single trifunctional ligand scaffoldWood, James, Ghosh, Saikat, Houston, Zachary, Fletcher, Nicholas, Humphries, James, Mardon, Karine, Akhter, Dewan, Tieu, William, Ivashkevich, Alesia, Wheatcroft, Michael, Thurecht, Kristofer and Codd, Rachel (2025). D2 – Enabling a theranostic approach with 89Zr/177Lu in a single trifunctional ligand scaffold. Nuclear Medicine and Biology, 150-151 109244, 109244. doi: 10.1016/j.nucmedbio.2025.109244 |
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2025 Journal Article Targeted mRNA delivery with bispecific antibodies that tether LNPs to cell-surface markersDietmair, Bettina, Humphries, James, Mercer, Timothy R., Thurecht, Kristofer J., Howard, Christopher B. and Cheetham, Seth W. (2025). Targeted mRNA delivery with bispecific antibodies that tether LNPs to cell-surface markers. Molecular Therapy Nucleic Acids, 36 (2) 102520, 1-7. doi: 10.1016/j.omtn.2025.102520 |
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2025 Journal Article Nanobody-mediated cellular uptake maximizes the potency of polylysine dendrimers while preserving solid tumor penetrationYuen, Daniel, Feeney, Orlagh M., Noi, Leo, Shengule, Sudhir, McLeod, Victoria M., Reitano, Pauline, Tsegay, Sammi, Hufton, Richard, Houston, Zachary H., Fletcher, Nicholas L., Humphries, James, Thurecht, Kristofer J., Cullinane, Carleen, Owen, David J., Porter, Christopher J.H. and Johnston, Angus P.R. (2025). Nanobody-mediated cellular uptake maximizes the potency of polylysine dendrimers while preserving solid tumor penetration. ACS Nano, 19 (6), 6044-6057. doi: 10.1021/acsnano.4c10851 |
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2025 Journal Article Multiplexing label-free polymeric nanocarriers via antipolymer antibodiesHumphries, James, Hobson-Peters, Jody, Ghosh, Saikat, Howard, Christopher B., Huda, Pie, Bell, Craig A., Fletcher, Nicholas L., Kempe, Kristian and Thurecht, Kristofer J. (2025). Multiplexing label-free polymeric nanocarriers via antipolymer antibodies. ACS Sensors, 10 (2), 1280-1288. doi: 10.1021/acssensors.4c03184 |
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2024 Journal Article A first-in-class dual-chelator theranostic agent designed for use with imaging-therapy radiometal pairs of different elementsWood, James Liam, Ghosh, Saikat, Houston, Zachary, Fletcher, Nicholas, Humphries, James, Mardon, Karine, Akhter, Dewan T., Tieu, William, Ivashkevich, Alesia, Wheatcroft, Michael P., Thurecht, Kristofer J. and Codd, Rachel (2024). A first-in-class dual-chelator theranostic agent designed for use with imaging-therapy radiometal pairs of different elements. Chemical Science, 15 (30), 11748-11760. doi: 10.1039/d4sc02851a |
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2024 Journal Article Mitigating the effects of persistent antipolymer immune reactions in nanomedicine: Evaluating materials-based approaches using molecular imagingHumphries, James, Fletcher, Nicholas L., Sonderegger, Stefan E., Bell, Craig A., Kempe, Kristian and Thurecht, Kristofer J. (2024). Mitigating the effects of persistent antipolymer immune reactions in nanomedicine: Evaluating materials-based approaches using molecular imaging. ACS Nano, 18 (30), 19890-19904. doi: 10.1021/acsnano.4c07317 |
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2024 Journal Article Multifunctional fluoropolymer‐engineered magnetic nanoparticles to facilitate blood‐brain barrier penetration and effective gene silencing in medulloblastomaForgham, Helen, Zhu, Jiayuan, Huang, Xumin, Zhang, Cheng, Biggs, Heather, Liu, Liwei, Wang, Yi Cheng, Fletcher, Nicholas, Humphries, James, Cowin, Gary, Mardon, Karine, Kavallaris, Maria, Thurecht, Kristofer, Davis, Thomas P. and Qiao, Ruirui (2024). Multifunctional fluoropolymer‐engineered magnetic nanoparticles to facilitate blood‐brain barrier penetration and effective gene silencing in medulloblastoma. Advanced Science, 11 (25) 2401340, 1-20. doi: 10.1002/advs.202401340 |
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2024 Journal Article Influence of chirality on protein corona formation of low-fouling chiral poly(2-oxazoline) coated nanoparticlesPizzi, David, Nandakumar, Aparna, Morrow, Joshua P., Humphries, James, Siddiqui, Ghizal, Creek, Darren J., Quinn, John.F., Yin, Jialiang, Shi, Qianqian, Cheng, Wenlong, Thurecht, Kristofer J. and Kempe, Kristian (2024). Influence of chirality on protein corona formation of low-fouling chiral poly(2-oxazoline) coated nanoparticles. European Polymer Journal, 210 112964, 1-12. doi: 10.1016/j.eurpolymj.2024.112964 |
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2023 Conference Publication A HER2 targeted polylysine dendrimer nanoparticle radiotheranostic demonstrates excellent tumor accumulation, rapid clearance from circulation, and promising performance in PET-CT imagingJohnstone, Cameron N., Heery, Graham P., Kelly, Brian D, Humphries, James, Akhter, Dewan T., Thurecht, Kristofer J., Yuen, Daniel, Giannis, Michael, Yong, Ken, Chadwick, Gareth, Barker, Helena, Cargill, Anne, Eglezos, Anthony, Castellarnau, Alex, Paull, Jeremy R. A. and Hufton, Richard (2023). A HER2 targeted polylysine dendrimer nanoparticle radiotheranostic demonstrates excellent tumor accumulation, rapid clearance from circulation, and promising performance in PET-CT imaging. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, MA United States, 11-15 October 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1535-7163.targ-23-a147 |
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2023 Other Outputs Understanding immunogenicity in nanomedicineHumphries, James (2023). Understanding immunogenicity in nanomedicine. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/28b468b |
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2023 Journal Article Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporationHuda, Pie, Humphries, James, Fletcher, Nicholas L., Howard, Christopher B., Thurecht, Kristofer J. and Bell, Craig A. (2023). Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation. Chemistry–Methods, 4 (2) e202300036. doi: 10.1002/cmtd.202300036 |
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2022 Journal Article Probing the biocompatibility and immune cell association of chiral, water-soluble, bottlebrush poly(2-oxazoline)sPizzi, David, Humphries, James, Morrow, Joshua P., Mahmoud, Ayaat M., Fletcher, Nicholas L., Sonderegger, Stefan E., Bell, Craig A., Thurecht, Kristofer J. and Kempe, Kristian (2022). Probing the biocompatibility and immune cell association of chiral, water-soluble, bottlebrush poly(2-oxazoline)s. Biomacromolecules, 24 (1), 246-257. doi: 10.1021/acs.biomac.2c01105 |
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2022 Journal Article Modulating macrophage clearance of nanoparticles: comparison of small-molecule and biologic drugs as pharmacokinetic modifiers of soft nanomaterialsMills, Jessica A., Humphries, James, Simpson, Joshua D., Sonderegger, Stefan E., Thurecht, Kristofer J. and Fletcher, Nicholas L. (2022). Modulating macrophage clearance of nanoparticles: comparison of small-molecule and biologic drugs as pharmacokinetic modifiers of soft nanomaterials. Molecular Pharmaceutics, 19 (11), 4080-4097. doi: 10.1021/acs.molpharmaceut.2c00528 |
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2022 Journal Article Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearanceFletcher, N. L., Prior, A., Choy, O., Humphries, J., Huda, P., Ghosh, S., Houston, Z. H., Bell, C. A. and Thurecht, K. J. (2022). Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance. Chemical Communications, 58 (57), 7912-7915. doi: 10.1039/d2cc02443h |
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2022 Journal Article Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruptionJanowicz, Phillip W., Houston, Zachary H., Bunt, Jens, Fletcher, Nicholas L., Bell, Craig A., Cowin, Gary, Howard, Christopher B., Taslima, Dewan, Westra van Holthe, Nicholas, Prior, Amber, Soh, Vanessa, Ghosh, Saikat, Humphries, James, Huda, Pie, Mahler, Stephen M., Richards, Linda J. and Thurecht, Kristofer J. (2022). Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption. Biomaterials, 283 121416, 121416. doi: 10.1016/j.biomaterials.2022.121416 |
