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2017 Journal Article Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosisLee, John D., Kumar, Vinod, Fung, Jenny N. T., Ruitenberg, Marc J., Noakes, Peter G. and Woodruff, Trent M. (2017). Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. British Journal of Pharmacology, 173 (8), 689-699. doi: 10.1111/bph.13730 |
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2016 Journal Article T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cellsArbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 (6292) aad1210, 1424+-U95. doi: 10.1126/science.aad1210 |
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2014 Journal Article Role for terminal complement activation in amyotrophic lateral sclerosis disease progressionWoodruff, Trent M., Lee, John D. and Noakes, Peter G. (2014). Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proceeding of the National Academy of Sciences of the United States of America, 111 (1), E3-E4. doi: 10.1073/pnas.1321248111 |
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2013 Journal Article The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilizationWu, Mike C. L., Brennan, Faith H., Lynch, Jason P. L., Mantovani, Susanna, Phipps, Simon, Wetsel, Rick A., Ruitenberg, Marc J., Taylor, Stephen M. and Woodruff, Trent M. (2013). The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proceedings of the National Academy of Sciences of the United States of America, 110 (23), 9439-9444. doi: 10.1073/pnas.1218815110 |
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2026 Journal Article Molecular basis of diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptor C3aRMishra, Sudha, Yadav, Manish K., Dalal, Annu, Ganguly, Manisankar, Yadav, Ravi, Sawada, Kazuhiro, Tiwari, Divyanshu, Roy, Nabarun, Banerjee, Nilanjana, Fung, Jenny N., Marallag, Jianina, Cui, Cedric S., Li, Xaria X., Lee, John D., Dsouza, Calvin A., Sarma, Parishmita, Rawat, Ganita, Zhu, Houming, Khant, Htet A., Clark, Richard J., Sano, Fumiya K., Banerjee, Ramanuj, Woodruff, Trent M., Nureki, Osamu, Gati, Cornelius and Shukla, Arun K. (2026). Molecular basis of diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptor C3aR. Nature Communications. doi: 10.1038/s41467-026-76518-z |
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2026 Journal Article Inflammation-associated serum amyloid A amplifies amyloid-β-driven oxidative stress and microglial activationJiang, Yuhao, Albornoz, Eduardo A., Zheng, Huiwen, Munir, Muhammad Usman, McLean, Catriona, Mar, Jessica C., Woodruff, Trent M., Davis, Thomas P., Javed, Ibrahim and Kakinen, Aleksandr (2026). Inflammation-associated serum amyloid A amplifies amyloid-β-driven oxidative stress and microglial activation. Journal of Neuroinflammation. doi: 10.1186/s12974-026-04003-x |
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2026 Journal Article Gut-bacterial amyloids can prime microglia against endogenous Amyloid-β and mediate neuroinflammation in Alzheimer’s diseaseForgham, Helen, Albornoz, Eduardo A., Pietrogrande, Giovanni, Munir, Muhammad Usman, Zhu, Jiayuan, Anjum, Muhammad Awais, Chung, Ka Hang Karen, Tahir, Muhammad S., Ali, Syed Aoun, Kakinen, Aleksandr, Wolvetang, Ernst J., Woodruff, Trent M., Aguado, Julio, Otzen, Daniel E., Davis, Thomas P. and Javed, Ibrahim (2026). Gut-bacterial amyloids can prime microglia against endogenous Amyloid-β and mediate neuroinflammation in Alzheimer’s disease. npj Dementia, 2 (1) 59. doi: 10.1038/s44400-026-00122-7 |
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2026 Journal Article Structural basis of complement anaphylatoxin receptor activation by an immunostimulant lead candidateDalal, Annu, Yadav, Manish K., Ganguly, Manisankar, Mishra, Sudha, Yadav, Ravi, Sinha, Shachie, Roy, Nabarun, Tiwari, Divyanshu, Mukherjee, Debdatta, Reyaz, Ashna, Dsouza, Calvin A., Nigam, Ameesha, Banerjee, Nilanjana, Li, Xaria X., Clark, Richard J., Woodruff, Trent M., Banerjee, Ramanuj, Gati, Cornelius and Shukla, Arun K. (2026). Structural basis of complement anaphylatoxin receptor activation by an immunostimulant lead candidate. Proceedings of the National Academy of Sciences, 123 (28) e2614459123, e2614459123-e2614459123. doi: 10.1073/pnas.2614459123 |
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2026 Journal Article Molecular mechanisms of naturally encoded signaling bias at the complement anaphylatoxin receptorsTiwari, Divyanshu, Sawada, Kazuhiro, Dalal, Annu, Mishra, Sudha, Li, Xaria X., Dent, Joshua C., Kim, Kiae, Yadav, Manish K., Roy, Nabarun, Ganguly, Manisankar, Banerjee, Nilanjana, Stepniewski, Tomasz Maciej, Ahn, Donghoon, Yamaguchi, Kohei, Oshima, Hidetaka S., Hashimoto, Kana, Fung, Jenny N., Lerskiatiphanich, Titaya, Cui, Cedric S., Lee, John D., Selent, Jana, Inoue, Asuka, Clark, Richard J., Chung, Ka Young, Banerjee, Ramanuj, Sano, Fumiya K., Woodruff, Trent M., Nureki, Osamu and Shukla, Arun K. (2026). Molecular mechanisms of naturally encoded signaling bias at the complement anaphylatoxin receptors. Molecular Cell, 86 (13), 2586-2604. doi: 10.1016/j.molcel.2026.06.002 |
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2026 Journal Article Complement dysregulation in multiple sclerosis: emerging mechanisms and translational therapeutic opportunitiesKhan, Nemat, Zakriya, Zikra M., McCombe, Pamela and Woodruff, Trent M. (2026). Complement dysregulation in multiple sclerosis: emerging mechanisms and translational therapeutic opportunities. Trends in Pharmacological Sciences, 47 (4), 355-368. doi: 10.1016/j.tips.2026.02.006 |
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2026 Journal Article PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease modelsAlbornoz, Eduardo A., Mardon, Karine, Bhalla, Rajiv, Kumar, Vinod, Stimson, Damion H. R., Cowin, Gary, Cui, Cedric S., Butler, Mark S., Pelingon, Ruby, Gordon, Richard, Coll, Rebecca C., Schroder, Kate, Halai, Reena, MacLeod, Angus M., Matthews, Kim, Robertson, Avril A. B., Cooper, Matthew A. and Woodruff, Trent M. (2026). PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models. Brain, 149 (4) awaf372, 1289-1301. doi: 10.1093/brain/awaf372 |
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2026 Journal Article C5aR1 inhibition alleviates cranial radiation-induced cognitive declineKrattli, Robert P., Do, An H., El-Khatib, Sanad M., Alikhani, Leila, Markarian, Mineh, Vagadia, Arya R., Usmani, Manal T., Madan, Shreya, Baulch, Janet E., Clark, Richard J., Woodruff, Trent M., Tenner, Andrea J. and Acharya, Munjal M. (2026). C5aR1 inhibition alleviates cranial radiation-induced cognitive decline. Cancer Research, 86 (1), OF1-OF18. doi: 10.1158/0008-5472.can-24-4869 |
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2026 Journal Article Complement-mediated and direct activation of human neutrophils induced by Premolis semirufa caterpillar toxinsGabrili, Joel J. M., Megale, Ângela A. A., Pidde, Giselle, Woodruff, Trent M. and Tambourgi, Denise V. (2026). Complement-mediated and direct activation of human neutrophils induced by Premolis semirufa caterpillar toxins. Frontiers in Immunology, 16 1706235, 1-14. doi: 10.3389/fimmu.2025.1706235 |
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2025 Journal Article The temporal gene expression landscape of rhabdomyolysis-induced acute kidney injury reveals the timing of complement activationGrunenwald, Anne, Boudhabhay, Idris, Revel, Margot, Poillerat, Victoria, Voilin, Elodie, Majdi, Amine, Chaibi, Khalil, Gaudry, Stephane, Woodruff, Trent M., Crambert, Gilles, Guihaire, Julien, Zaidan, Mohamad, Oniszczuk, Julie, Frimat, Marie, Gnemmi, Viviane, Aletti, Marc, Nielly, Hubert, Gilardin, Laurent and Roumenina, Lubka T. (2025). The temporal gene expression landscape of rhabdomyolysis-induced acute kidney injury reveals the timing of complement activation. Communications Biology, 9 (1) 171, 1-13. doi: 10.1038/s42003-025-09449-y |
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2025 Journal Article The concise guide to PHARMACOLOGY 2025/26: G protein‐coupled receptorsAlexander, Stephen P. H., Davenport, Anthony P., Kelly, Eamonn, Gibb, Alasdair J., Mathie, Alistair A., Peach, Chloe J., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Southan, Christopher, Davies, Jamie A., Abbracchio, Maria Pia, Abraham, George R., Agoulnik, Alexander, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Baker, Jillian G., Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean‐Martin, Beck‐Sickinger, Annette G., Behrens, Maik, Bennett, Kirstie A., Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J. M., Blaho, Victoria A. ... Zaidman, Nathan (2025). The concise guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors. British Journal of Pharmacology, 182 (S1), S24-S151. doi: 10.1111/bph.70230 |
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2025 Journal Article IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microgliaRisby-Jones, Grace, Marallag, Jianina, Jagaraj, Cyril Jones, Atkin, Julie D., Walker, Adam K., Woodruff, Trent M., Lee, John D. and Fung, Jenny N. (2025). IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microglia. Brain, Behavior, and Immunity, 129, 296-304. doi: 10.1016/j.bbi.2025.06.021 |
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2025 Journal Article Complement peptide receptors in GtoPdb v.2025.3Cianciulli, Antonia, Shukla, Arun K., Panaro, Maria A., Monk, Peter, Mitolo, Vincenzo, Li, Xaria X., Lee, John D., Hawksworth, Owen, Coulthard, Liam and Woodruff, Trent M. (2025). Complement peptide receptors in GtoPdb v.2025.3. IUPHAR/BPS Guide to Pharmacology CITE, 2025 (3). doi: 10.2218/gtopdb/f5/2025.3 |
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2025 Journal Article Complement membrane attack complex alters the proliferation of neural progenitor cells during late embryonic murine neurogenesisRead, Austin, Lee, John, Fung, Jenny and Woodruff, Trent (2025). Complement membrane attack complex alters the proliferation of neural progenitor cells during late embryonic murine neurogenesis. Immunobiology, 230 (4) 153063, 61-61. doi: 10.1016/j.imbio.2025.153063 |
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2025 Journal Article Targeting C5a inflammation in ALS: Ex vivo findings from PMX205 phase Ib trialFung, Jenny, Lee, John and Woodruff, Trent (2025). Targeting C5a inflammation in ALS: Ex vivo findings from PMX205 phase Ib trial. Immunobiology, 230 (4) 153003, 35-35. doi: 10.1016/j.imbio.2025.153003 |
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2025 Journal Article Complement C9-mediated RBC hemolysis drives microvascular obstruction via endothelial necroptosis and hemolyzed RBC aggregation in COVID-19Lun (Mike) Wu, Chia, Ju, Lining Arnold, Italiano, Ethan, Jarvis-Child, Rocko, Alwis, Imala, Smythe, Rhyll, Albornoz, Eduardo A., Noonan, Jonathan, Portelli, Marie, Baptista, Marrisa, Maclean, Jessica, Norri, Pashtana, Yang, Jinglu, Lee, John, McFadyen, James D., Sharland, Alexandra, Woodruff, Trent M., Samson, Andre, Rapkiewicz, Amy, Barrett, Tessa, Pham, Alan, Schoenwaelder, Simone, Yuan, Yuping and Jackson, Shaun P. (2025). Complement C9-mediated RBC hemolysis drives microvascular obstruction via endothelial necroptosis and hemolyzed RBC aggregation in COVID-19. Immunobiology, 230 (4) 153045, 53-53. doi: 10.1016/j.imbio.2025.153045 |
