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2017 Journal Article Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosisLee, John D., Kumar, Vinod, Fung, Jenny N. T., Ruitenberg, Marc J., Noakes, Peter G. and Woodruff, Trent M. (2017). Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. British Journal of Pharmacology, 173 (8), 689-699. doi: 10.1111/bph.13730 |
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2016 Journal Article T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cellsArbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Koehl, Jorg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D. and Kemper, Claudia (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells. Science, 352 (6292) aad1210, 1424+-U95. doi: 10.1126/science.aad1210 |
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2014 Journal Article Role for terminal complement activation in amyotrophic lateral sclerosis disease progressionWoodruff, Trent M., Lee, John D. and Noakes, Peter G. (2014). Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proceeding of the National Academy of Sciences of the United States of America, 111 (1), E3-E4. doi: 10.1073/pnas.1321248111 |
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2013 Journal Article The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilizationWu, Mike C. L., Brennan, Faith H., Lynch, Jason P. L., Mantovani, Susanna, Phipps, Simon, Wetsel, Rick A., Ruitenberg, Marc J., Taylor, Stephen M. and Woodruff, Trent M. (2013). The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proceedings of the National Academy of Sciences of the United States of America, 110 (23), 9439-9444. doi: 10.1073/pnas.1218815110 |
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2025 Journal Article PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease modelsAlbornoz, Eduardo A., Mardon, Karine, Bhalla, Rajiv, Kumar, Vinod, Stimson, Damion H. R., Cowin, Gary, Cui, Cedric S., Butler, Mark S., Pelingon, Ruby, Gordon, Richard, Coll, Rebecca C., Schroder, Kate, Halai, Reena, MacLeod, Angus M., Matthews, Kim, Robertson, Avril A. B., Cooper, Matthew A. and Woodruff, Trent M. (2025). PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models. Brain awaf372. doi: 10.1093/brain/awaf372 |
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2025 Journal Article IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microgliaRisby-Jones, Grace, Marallag, Jianina, Jagaraj, Cyril Jones, Atkin, Julie D., Walker, Adam K., Woodruff, Trent M., Lee, John D. and Fung, Jenny N. (2025). IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microglia. Brain, Behavior, and Immunity, 129, 296-304. doi: 10.1016/j.bbi.2025.06.021 |
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2025 Journal Article Complement peptide receptors in GtoPdb v.2025.3Cianciulli, Antonia, Shukla, Arun K., Panaro, Maria A., Monk, Peter, Mitolo, Vincenzo, Li, Xaria X., Lee, John D., Hawksworth, Owen, Coulthard, Liam and Woodruff, Trent M. (2025). Complement peptide receptors in GtoPdb v.2025.3. IUPHAR/BPS Guide to Pharmacology CITE, 2025 (3). doi: 10.2218/gtopdb/f5/2025.3 |
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2025 Journal Article Complement membrane attack complex alters the proliferation of neural progenitor cells during late embryonic murine neurogenesisRead, Austin, Lee, John, Fung, Jenny and Woodruff, Trent (2025). Complement membrane attack complex alters the proliferation of neural progenitor cells during late embryonic murine neurogenesis. Immunobiology, 230 (4) 153063, 61-61. doi: 10.1016/j.imbio.2025.153063 |
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2025 Journal Article Targeting C5a inflammation in ALS: Ex vivo findings from PMX205 phase Ib trialFung, Jenny, Lee, John and Woodruff, Trent (2025). Targeting C5a inflammation in ALS: Ex vivo findings from PMX205 phase Ib trial. Immunobiology, 230 (4) 153003, 35-35. doi: 10.1016/j.imbio.2025.153003 |
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2025 Journal Article Complement C9-mediated RBC hemolysis drives microvascular obstruction via endothelial necroptosis and hemolyzed RBC aggregation in COVID-19Lun (Mike) Wu, Chia, Ju, Lining Arnold, Italiano, Ethan, Jarvis-Child, Rocko, Alwis, Imala, Smythe, Rhyll, Albornoz, Eduardo A., Noonan, Jonathan, Portelli, Marie, Baptista, Marrisa, Maclean, Jessica, Norri, Pashtana, Yang, Jinglu, Lee, John, McFadyen, James D., Sharland, Alexandra, Woodruff, Trent M., Samson, Andre, Rapkiewicz, Amy, Barrett, Tessa, Pham, Alan, Schoenwaelder, Simone, Yuan, Yuping and Jackson, Shaun P. (2025). Complement C9-mediated RBC hemolysis drives microvascular obstruction via endothelial necroptosis and hemolyzed RBC aggregation in COVID-19. Immunobiology, 230 (4) 153045, 53-53. doi: 10.1016/j.imbio.2025.153045 |
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2025 Journal Article The Complement System: Biology, Pathology and Therapeutic InterventionsLi, Xaria X. and Woodruff, Trent M. (2025). The Complement System: Biology, Pathology and Therapeutic Interventions. Pharmacological Reviews, 77 (5) 100079, 100079. doi: 10.1016/j.pharmr.2025.100079 |
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2025 Journal Article Inhibition of terminal complement complex formation alleviates murine antibody-mediated TRALIChen, Dawei, Liang, Huaqin, Xu, Xiuzhang, Xia, Wenjie, Ye, Xin, Luo, Yalin, He, Jiansen, Xu, Yaori, Liu, Jing, Ren, Hui, Luo, Shengxue, Woodruff, Trent M., Zelek, Wioleta M., Morgan, Bryan Paul, Kapur, Rick, Santoso, Sentot and Fu, Yongshui (2025). Inhibition of terminal complement complex formation alleviates murine antibody-mediated TRALI. Blood Journal, 146 (6) 2024028012, 1-16. doi: 10.1182/blood.2024028012 |
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2025 Journal Article The C5a/C5aR1 axis promotes migration of tolerogenic dendritic cells to lymph nodes, impairing the anticancer immune responseSenent, Yaiza, Remírez, Ana, Repáraz, David, Llopiz, Diana, Celias, Daiana P., Sainz, Cristina, Entrialgo-Cadierno, Rodrigo, Suarez, Lucia, Rouzaut, Ana, Alignani, Diego, Tavira, Beatriz, Lambris, John D., Woodruff, Trent M., de Andrea, Carlos E., Ruffell, Brian, Sarobe, Pablo, Ajona, Daniel and Pio, Ruben (2025). The C5a/C5aR1 axis promotes migration of tolerogenic dendritic cells to lymph nodes, impairing the anticancer immune response. Cancer Immunology Research, 13 (3), 384-399. doi: 10.1158/2326-6066.cir-24-0250 |
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2024 Journal Article Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitmentSnelson, Matthew, Deliyanti, Devy, Tan, Sih Min, Drake, Anna M., de Pasquale, Cassandra, Kumar, Vinod, Woodruff, Trent M., Wilkinson-Berka, Jennifer L. and Coughlan, Melinda T. (2024). Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment. Nutrition and Diabetes, 14 (1) 46, 1-9. doi: 10.1038/s41387-024-00305-2 |
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2024 Journal Article The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathologyStables, Jennifer, Pal, Reiss, Bradford, Barry M., Carter-Cusack, Dylan, Taylor, Isis, Pridans, Clare, Khan, Nemat, Woodruff, Trent M., Irvine, Katharine M., Summers, Kim M., Mabbott, Neil A. and Hume, David A. (2024). The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology. Neurobiology of Disease, 203 106743, 106743. doi: 10.1016/j.nbd.2024.106743 |
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2024 Journal Article Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1Beach, Callum, MacLean, David, Majorova, Dominika, Melemenidis, Stavros, Nambiar, Dhanya K., Kim, Ryan K., Valbuena, Gabriel N., Guglietta, Silvia, Krieg, Carsten, Darvish-Damavandi, Mahnaz, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Domingo, Enric, Moon, Eui Jung, Jiang, Dadi, Jiang, Yanyan, Zhang, Qingyang, Koong, Albert C., Woodruff, Trent M., Graves, Edward E., Maughan, Tim, Buczacki, Simon J.A. ... Olcina, Monica M. (2024). Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 134 (16), 16. doi: 10.1172/jci185067 |
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2024 Journal Article Sex differences in Huntington's disease from a neuroinflammation perspectiveRisby-Jones, Grace, Lee, John D., Woodruff, Trent M. and Fung, Jenny N. (2024). Sex differences in Huntington's disease from a neuroinflammation perspective. Frontiers in Neurology, 15 1384480, 1-7. doi: 10.3389/fneur.2024.1384480 |
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2024 Journal Article Complement(ing) long-COVID thromboinflammation and pathogenesisLee, John D. and Woodruff, Trent M. (2024). Complement(ing) long-COVID thromboinflammation and pathogenesis. Trends in Immunology, 45 (6), 397-399. doi: 10.1016/j.it.2024.04.001 |
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2024 Journal Article Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposureChen, Hsiao-Jou Cortina, Spiers, Jereme G., Lerskiatiphanich, Titaya, Parker, Sandra E., Lavidis, Nickolas A., Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2024). Complement C5a receptor signaling alters stress responsiveness and modulates microglia following chronic stress exposure. Biological Psychiatry: Global Open Science, 4 (3) 100306, 100306. doi: 10.1016/j.bpsgos.2024.100306 |
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2024 Journal Article C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosisPerrino, Melissa R., Ahmari, Niousha, Hall, Ashley, Jackson, Mark, Na, Youjin, Pundavela, Jay, Szabo, Sara, Woodruff, Trent M., Dombi, Eva, Kim, Mi-Ok, Köhl, Jörg, Wu, Jianqiang and Ratner, Nancy (2024). C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis. Life Science Alliance, 7 (5) e202302229, 1-16. doi: 10.26508/lsa.202302229 |
