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2016 Journal Article Cell adhesion molecules in normal and malignant hematopoiesis: from bench to bedsideLevesque, Jean-Pierre and Winkler, Ingrid G. (2016). Cell adhesion molecules in normal and malignant hematopoiesis: from bench to bedside. Current Stem Cell Reports, 2 (4), 356-367. doi: 10.1007/s40778-016-0066-0 |
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2016 Conference Publication Therapeutic blockade of macrophage colony stimulating factor (CSF-1) delays leukaemia progression of AMLin mice in vivoGoh, Sal Lee, Levesque, Jean-Pierre, Pettit, Allison, Barbier, Valerie, Jeanclos, Cecile and Winkler, Ingrid (2016). Therapeutic blockade of macrophage colony stimulating factor (CSF-1) delays leukaemia progression of AMLin mice in vivo. 45th Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH), San Diego, CA, United States, 25-28 August 2016. Philadelphia, PA, United States: Elsevier. |
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2016 Conference Publication Prostaglandin I2 is produced in the endosteal region of the bone marrow and protects haematopoietic stem cell from irradiation stressTay, Joshua, Levesque, Jean-Pierre, Helwani, Falak, Price, Gareth, Barbier, Valerie, Nowlan, Bianca and Winkler, Ingrid (2016). Prostaglandin I2 is produced in the endosteal region of the bone marrow and protects haematopoietic stem cell from irradiation stress. 45th Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH), San Diego, CA, United States, 25-28 August 2016. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2016.06.224 |
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2016 Journal Article Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow nichesKaur, Simranpreet, Raggatt, Liza Jane, Batoon, Lena, Hume, David Arthur, Levesque, Jean-Pierre and Pettit, Allison Robyn (2016). Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches. Seminars in Cell and Developmental Biology, 61, 12-21. doi: 10.1016/j.semcdb.2016.08.009 |
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2016 Journal Article A validated preclinical animal model for primary bone tumor researchWagner, Ferdinand, Holzapfel, Boris M., Thibaudeau, Laure, Straub, Melanie, Ling, Ming-Tat, Grifka, Joachim, Loessner, Daniela, Levesque, Jean-Pierre and Hutmacher, Dietmar W. (2016). A validated preclinical animal model for primary bone tumor research. The Journal of Bone and Joint Surgery, 98 (11), 916-925. doi: 10.2106/JBJS.15.00920 |
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2016 Journal Article CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancerWu, Andy C., He, Yaowu, Broomfield, Amy, Paatan, Nicoll J., Harrington, Brittney S., Tseng, Hsu-Wen, Beaven, Elizabeth A., Kiernan, Deirdre M., Swindle, Peter, Clubb, Adrian B., Levesque, Jean-Pierre, Winkler, Ingrid G., Ling, Ming-Tat, Srinivasan, Bhuvana, Hooper, John D. and Pettit, Allison R. (2016). CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer. Journal of Pathology, 239 (2), 218-230. doi: 10.1002/path.4718 |
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2016 Journal Article Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peakWinkler, Ingrid G., Wiercinska, Eliza, Barbier, Valerie, Nowlan, Bianca, Bonig, Halvard and Levesque, Jean-Pierre (2016). Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peak. Experimental Hematology, 44 (4), 303-314.e1. doi: 10.1016/j.exphem.2016.01.001 |
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2016 Journal Article Fms-like tyrosine kinase 3 (Flt3) ligand depletes erythroid island macrophages and blocks medullar erythropoiesis in the mouseJacobsen, Rebecca N., Nowlan, Bianca, Brunck, Marion E., Barbier, Valerie, Winkler, Ingrid G. and Levesque, Jean-Pierre (2016). Fms-like tyrosine kinase 3 (Flt3) ligand depletes erythroid island macrophages and blocks medullar erythropoiesis in the mouse. Experimental Hematology, 44 (3), 207-212.e4. doi: 10.1016/j.exphem.2015.11.004 |
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2016 Conference Publication Vascular E-Selectin Protects Leukemia Cells from Chemotherapy By Directly Activating Pro-Survival NF-Kb Signalling - Therapeutic Blockade of E-Selectin Dampens NF-Kb ActivationWinkler, Ingrid G., Barbier, Valerie, Ward, Micheal, Tallack, Michael, Lowe, Jessica, Davies, Julie, Erbani, Johanna, Magnani, John L. and Levesque, Jean-Pierre (2016). Vascular E-Selectin Protects Leukemia Cells from Chemotherapy By Directly Activating Pro-Survival NF-Kb Signalling - Therapeutic Blockade of E-Selectin Dampens NF-Kb Activation. 58th Annual Meeting and Exposition of the American Society of Hematology (ASH), San Diego, CA, United States, 3-6 December 2016. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.v128.22.2823.2823 |
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2016 Conference Publication Radio-resistant recipient bone marrow (BM) macrophages (Macs) are necessary for hematopoietic stem cell (HSC) engraftment post transplantationLevesque, Jean-Pierre, Kaur, Simranpreet, Jacobsen, Rebecca, Millard, Susan, Batoon, Lena, Winkler, Ingrid, Macdonald, Kelli, Perkins, Andrew, Hume, David, Raggatt, Liza and Pettit, Allison (2016). Radio-resistant recipient bone marrow (BM) macrophages (Macs) are necessary for hematopoietic stem cell (HSC) engraftment post transplantation. 45th Annual Scientific Meeting of the ISEH – International Society for Experimental Hematology, San Diego, CA, United States, 25-28 August, 2016. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2016.06.049 |
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2016 Conference Publication Suppression of medullar erythropoiesis in response to bacterial lipopolysaccharides (LPS) involves two distinct TLR4-dependent mechanisms with contrasted requirements for G-CSF receptorsBisht, Kavita, Jacobsen, Rebecca, Nowlan, Bianca, McGirr, Crystal, Brunck, Marion, Keech, Thomas, Winkler, Ingrid G. and Levesque, Jean-Pierre (2016). Suppression of medullar erythropoiesis in response to bacterial lipopolysaccharides (LPS) involves two distinct TLR4-dependent mechanisms with contrasted requirements for G-CSF receptors. 58th Annual Meeting and Exposition of the American Society of Hematology (ASH), San Diego, CA, United States, 3-6 December 2016. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V128.22.546.546 |
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2016 Conference Publication Hematopoietic Stem Cell Mobilization and Erythropoiesis Suppression in Response to Lipopolysaccharides Involve Two Distinct Tlr4-Depedent Mechanisms with Different Requirement for G-Csf ReceptorsBisht, Kavita, Jacobsen, Rebecca, Brunck, Marion, Keech, Thomas, McGirr, Crystal, Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid and Levesque, Jean-Pierre (2016). Hematopoietic Stem Cell Mobilization and Erythropoiesis Suppression in Response to Lipopolysaccharides Involve Two Distinct Tlr4-Depedent Mechanisms with Different Requirement for G-Csf Receptors. 45th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), San Diego, CA, United States, 25-28 August 2016. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2016.06.096 |
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2016 Conference Publication Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantationKaur, S., Raggatt, L. J., Jacobsen, R. N., Millard, S., Batoon, L., Winkler, I. G., Macdonald, K. P. A., Perkins, A. C., Hume, D. A., Levesque, J. P. and Pettit, A. R. (2016). Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200 |
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2015 Journal Article Filling the void: allogeneic myeloid cells for transplantationSchwaber, Jessica L., Brunck, Marion E., Levesque, Jean-Pierre and Nielsen, Lars K. (2015). Filling the void: allogeneic myeloid cells for transplantation. Current Opinion in Hematology, 23 (1), 72-77. doi: 10.1097/MOH.0000000000000205 |
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2015 Journal Article Tissue engineered humanized bone supports human hematopoiesis in vivoHolzapfel, Boris M., Hutmacher, Dietmar W., Nowlan, Bianca, Barbier, Valerie, Thibaudeau, Laure, Theodoropoulos, Christina, Hooper, John D., Loessner, Daniela, Clements, Judith A., Russell, Pamela J., Pettit, Allison R., Winkler, Ingrid G. and Levesque, Jean-Pierre (2015). Tissue engineered humanized bone supports human hematopoiesis in vivo. Biomaterials, 61, 103-114. doi: 10.1016/j.biomaterials.2015.04.057 |
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2015 Journal Article Concise review: Humanized models of tumor immunology in the 21st century: Convergence of cancer research and tissue engineeringHolzapfel, Boris Michael, Wagner, Ferdinand, Thibaudeau, Laure, Levesque, Jean-Pierre and Hutmacher, Dietmar Werner (2015). Concise review: Humanized models of tumor immunology in the 21st century: Convergence of cancer research and tissue engineering. Stem Cells, 33 (6), 1696-1704. doi: 10.1002/stem.1978 |
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2015 Journal Article Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscleGenet, Francois, Kulina, Irina, Vaquette, Cedryck, Torossian, Frederic, Millard, Susan, Pettit, Allison R., Sims, Natalie A., Anginot, Adrienne, Guerton, Bernadette, Winkler, Ingrid G., Barbier, Valerie, Lataillade, Jean-Jacques, Le Bousse-Kerdiles, Marie-Caroline, Hutmacher, Dietmar W. and Levesque, Jean-Pierre (2015). Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle. Journal of Pathology, 236 (2), 229-240. doi: 10.1002/path.4519 |
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2015 Journal Article Macrophages and regulation of erythropoiesisJacobsen, Rebecca N., Perkins, Andrew C. and Levesque, Jean-Pierre (2015). Macrophages and regulation of erythropoiesis. Current Opinion in Hematology, 22 (3), 212-219. doi: 10.1097/MOH.0000000000000131 |
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2015 Journal Article Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AMLForristal, C. E., Brown, A. L., Helwani, F. M., Winkler, I. G., Nowlan, B., Barbier, V., Powell, R. J., Engler, G. A., Diakiw, S. M., Zannettino, A. C. W., Martin, S., Pattabiraman, D., D'Andrea, R. J., Lewis, I. D. and Levesque, J. P. (2015). Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia, 29 (10), 2075-2085. doi: 10.1038/leu.2015.102 |
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2015 Journal Article HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1αForristal, C. E., Nowlan, B., Jacobsen, R. N., Barbier, V., Walkinshaw, G., Walkley, C. R., Winkler, I. G. and Levesque, J. P. (2015). HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α. Leukemia, 29 (6), 1366-1378. doi: 10.1038/leu.2015.8 |
