Overview
Background
Dr Joseph Yunis obtained his PhD from the University of Queensland under the mentorship of Associate Professor Philip Stevenson at the School of Chemistry and Molecular Biosciences on understanding the role of CD4+ T cells in herpesvirus immunity. He uncovered the immune evasion mechanisms of CD4+ T cells by cytomegaloviruses and demonstrated a novel vaccine design that specifically licences CD4+ T cells to control herpesvirus infection. Dr Yunis trained in Immunology under Professor Di Yu, first at the John Curtin School of Medical Research of Australian National University (Canberra), UQ Frazer Institute and now at the Child Health Research Centre. Dr Yunis employs preclinial models of infection (acute, chronic and latent), murine cancer models (melanoma, colorectal, glioma, osteosarcoma) and xenograft models of patient-derived tumour cells ((pediatric) to evaulate function and immune modulation of CD8+ T cells through immunisation and infection in immunity. His research has been recognised by a number of awards including, the Frazer Institute publication of the month award, The Gretel and Gordon Bootes Medical Research and Education Foundation Award, Eureka Research Fund for Immunology and Virology and UQ postdoctoral Fellowship and the Australian and New Zealand Sarcoma Association award.
Availability
- Dr Joseph Yunis is:
- Available for supervision
Qualifications
- Bachelor (Honours) of Science, The University of Queensland
Research interests
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Role of T cells in immunity and disease.
I) Immunopathology: T cells are critical in eliminating infection. However, they can also cause severe disease by driving excessive inflammatory response. The balance between anti-viral, bystander T cells and regulatory T cells shape immunity. My goal is to understand how T cells can be pathologic. II) Cytotoxic CD8+ T cell function: Cytotoxic CD8+ T cells are fundamental in eliminating infection. However, viruses like human immunodeficiency virus (HIV), Epstein Barr Virus (EBV) and Human cytomegaloviruses take advantage of immune privileged sites such as the germinal centre, and the salivary glands and the nasopharynx to evade immune control. Understanding how we can harness CD8+ T cell trafficking to these immune privileged sites is critical in eliminating infection in hard to reach areas. To achieve this, our lab uses genetic engineering of CD8+ T cells in a mouse model of HIV and EBV using LCMV and MuHV-4 respectively.
Research impacts
Overall goals:
To understand how to harness the power of T cells to shape immunity to viruses and cancer.
Research Interest:
- Immunity and Immunopathology- how to determine pathologic T cells in infection (LCMV infection model).
- ImmunoTherapy- Adoptive T cell therapy, Cancer vaccines and Immune Checkpoint Blockade Therapy (Solid cancers- skin, colorectal, osteosarcoma, glioma).
- Targeting latent reservoires in chronic infection- chemokine signalling and cell trafficking (CMV and EBV).
- 3D Cultures in Cancer- A Preclinical Model for Vaccine validation (Pediatric Cancers).
- Neoantigens- Shaping the T cell landscape (Pediatric Cancers).
Key Techniques:
- Multiparameter flow cytometry.
- Histology.
- 3D confocal microscopy.
- Whole mount microscopy.
- ELISA and ELISpot assays
- Real-time PCR
- Virological assays
- TIssue culture (2D and 3D).
Works
Search Professor Joseph Yunis’s works on UQ eSpace
2016
Conference Publication
A murine cytomegalovirus vaccine vector protects against murine gamma herpesvirus 68
Stevenson, P. G. and Yunis, J. (2016). A murine cytomegalovirus vaccine vector protects against murine gamma herpesvirus 68. International Congress of Immunology (ICI), Melbourne Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley.
Supervision
Availability
- Dr Joseph Yunis is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
mRNA-based T cell guided cancer vaccine to treat solid cancers.
Principal Advisor
Other advisors: Professor Di Yu, Dr Zhian Chen
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Doctor Philosophy
A new therapy for paediatric brain tumours.
Associate Advisor
Other advisors: Professor Brandon Wainwright
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Doctor Philosophy
Personalised cancer vaccine for brain tumors
Associate Advisor
Other advisors: Associate Professor Wayne Nicholls, Professor Di Yu
Completed supervision
-
2025
Doctor Philosophy
Ferroptosis: A Novel Layer of Regulation for T Cell Homeostasis and Function
Associate Advisor
Other advisors: Dr Zhian Chen, Professor Di Yu
Media
Enquiries
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