Overview
Background
Dr Nchafatso G. Obonyo (BSc Hons, MB.ChB, DTM&H, MD/PhD, FCRcert)
Post-doctoral Research Fellow at the Critical Care Research Group-The Prince Charles Hospital, Institute of Molecular Bioscience-The University of Queensland. Main research focus is cardiac critical care and sepsis research.
Visiting Fellow in the Academic Division, Medical Engineering Research Facility, Queenlsand University of Technology. Fellow of the Initiative to Develop African Research Leaders (IDeAL) at the KEMRI-Wellcome Trust Research Programme, Kenya; Global Health Fellow, Wellcome Trust Centre for Global Health Research at Imperial College London,UK.
Recipient of the 2023 Africa Top-40 Under-40 Science Award and the 2023 African Professional in Australia of the Year Award.
Availability
- Dr Nchafatso Obonyo is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Open University (UK)
Research interests
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Sepsis and Septic Shock Resuscitation
Research on the effects of resuscitation on the microcirculation in sepsis and septic shock
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Cardiac and microvascular dysfunction in sepsis
Research on non-invasive imaging of cardiac and microvascular function in sepsis and septic shock states
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Cardiac critical care
Research on cardiac emergency and intensive care
Research impacts
Dr Obonyo's research work on septic shock and haemodynamic resuscitation highlights the global impact of sepsis and the importance of investigating resuscitation-associated dysfunction of the heart and vascular endothelium:
1. World Sepsis Day (13 September): https://youtu.be/VkAxQ0BD2QU
2. Aggressive fluid resucitation worsens endotoxaemic shock: Am J Respir Crit Care Med. 2018 Oct 15;198(8):1043-1054: https://pubmed.ncbi.nlm.nih.gov/29882682/
3. Resuscitation-associated endotheliopathy: https://www.ccrg.org.au/all-publications/rase
Dr Obonyo has also received awards for his research work including:
a. Postdoctoral Research Fellowship and Innovations Research Grant awarded by The Prince Charles Hospital Foundation (https://www.thecommongood.org.au/news/meet-doctor-nchafatso-obonyo/)
b. Continental recognition winning the 2023 Africa Top-40 Under-40 Award in Science and the Africa (https://www.ccrg.org.au/news/fortyunder40)
c. African Professional in Australia award in 2023 awarded across all professionals by the African Professionals of Australia (https://www.ccrg.org.au/news/obonyo-wins-national-apa-accolade)
Works
Search Professor Nchafatso Obonyo’s works on UQ eSpace
2025
Journal Article
Effects of transfusing older red blood cells on patient outcomes in critical illness: A retrospective cohort study
Obonyo, Nchafatso G., Sela, Declan P., White, Nicole, Tunbridge, Matthew, Sim, Beatrice, Rachakonda, Reema H., See Hoe, Louise E., Li Bassi, Gianluigi, Fanning, Jonathon P., Tung, John‐Paul, Suen, Jacky Y. and Fraser, John F. (2025). Effects of transfusing older red blood cells on patient outcomes in critical illness: A retrospective cohort study. Vox Sanguinis. doi: 10.1111/vox.70007
2025
Book Chapter
Role of cTnT Versus Echocardiography in Diagnosing the Early Myocardial Injury in Children on Doxorubicin for Cancer Chemotherapy: A Cross-sectional Study in a Tertiary Referral Centre in Kenya
Kariuki, Nyambura, Kimani, Esther, Jowi, Christine, Wamalwa, Dalton, Suen, Jacky Y., Fraser, John F. and Obonyo, Nchafatso G. (2025). Role of cTnT Versus Echocardiography in Diagnosing the Early Myocardial Injury in Children on Doxorubicin for Cancer Chemotherapy: A Cross-sectional Study in a Tertiary Referral Centre in Kenya. Medical Science: Trends and Innovations Vol. 6. (pp. 155-173) BP International. doi: 10.9734/bpi/msti/v6/2838
2024
Journal Article
Early myocardial injury in children on doxorubicin for cancer chemotherapy: a cross-sectional study in a tertiary referral centre in Kenya
Kariuki, Nyambura, Kimani, Esther, Jowi, Christine, Wamalwa, Dalton, Suen, Jacky Y., Fraser, John F. and Obonyo, Nchafatso G. (2024). Early myocardial injury in children on doxorubicin for cancer chemotherapy: a cross-sectional study in a tertiary referral centre in Kenya. BMC Cardiovascular Disorders, 24 (1) 260, 1-9. doi: 10.1186/s12872-024-03922-y
2024
Journal Article
Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation
Karnik, Varun, Colombo, Sebastiano Maria, Rickards, Leah, Heinsar, Silver, See Hoe, Louise E., Wildi, Karin, Passmore, Margaret R., Bouquet, Mahe, Sato, Kei, Ainola, Carmen, Bartnikowski, Nicole, Wilson, Emily S., Hyslop, Kieran, Skeggs, Kris, Obonyo, Nchafatso G., McDonald, Charles, Livingstone, Samantha, Abbate, Gabriella, Haymet, Andrew, Jung, Jae-Seung, Sato, Noriko, James, Lynnette, Lloyd, Benjamin, White, Nicole, Palmieri, Chiara, Buckland, Mark, Suen, Jacky Y., McGiffin, David C., Fraser, John F. and Li Bassi, Gianluigi (2024). Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation. Intensive Care Medicine Experimental, 12 (1) 109. doi: 10.1186/s40635-024-00669-w
2024
Journal Article
An ovine septic shock model of live bacterial infusion
Obonyo, Nchafatso G., Raman, Sainath, Suen, Jacky Y., Peters, Kate M., Phan, Minh-Duy, Passmore, Margaret R., Bouquet, Mahe, Wilson, Emily S., Hyslop, Kieran, Palmieri, Chiara, White, Nicole, Sato, Kei, Farah, Samia M., Gandini, Lucia, Liu, Keibun, Fior, Gabriele, Heinsar, Silver, Ijuin, Shinichi, Kyun Ro, Sun, Abbate, Gabriella, Ainola, Carmen, Sato, Noriko, Lundon, Brooke, Portatadino, Sofia, Rachakonda, Reema H., Schneider, Bailey, Harley, Amanda, See Hoe, Louise E., Schembri, Mark A. ... Fraser, John F. (2024). An ovine septic shock model of live bacterial infusion. Intensive Care Medicine Experimental, 12 (1) 94, 1-20. doi: 10.1186/s40635-024-00684-x
2024
Journal Article
A novel echocardiographic parameter considering left ventricular afterload during V‐A ECMO support
Sato, Kei, Heinsar, Silver, Chan, Jonathan, Farah, Samia M., Wildi, Karin, Obonyo, Nchafatso G., Liu, Keibun, Ainola, Carmen, Sato, Noriko, Abbate, Gabriella, Wilson, Emily S., Bouquet, Mahé, Hyslop, Kieran, Passmore, Margaret R., Ijuin, Shinichi, Ro, Sun Kyun, Fior, Gabriele, Gandini, Lucia, Lundon, Brooke, Platts, David G., Suen, Jacky Y., Li Bassi, Gianluigi and Fraser, John F. (2024). A novel echocardiographic parameter considering left ventricular afterload during V‐A ECMO support. European Journal of Clinical Investigation, 54 (10) e14263, 1-11. doi: 10.1111/eci.14263
2024
Journal Article
Echocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors
Sato, Kei, See Hoe, Louise, Chan, Jonathan, Obonyo, Nchafatso G., Wildi, Karin, Heinsar, Silver, Colombo, Sebastiano M., Ainola, Carmen, Abbate, Gabriella, Sato, Noriko, Passmore, Margaret R., Bouquet, Mahe, Wilson, Emily S., Hyslop, Kieran, Livingstone, Samantha, Haymet, Andrew, Jung, Jae‐Seung, Skeggs, Kris, Palmieri, Chiara, White, Nicole, Platts, David, Suen, Jacky Y., McGiffin, David C., Li Bassi, Gianluigi and Fraser, John F. (2024). Echocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors. European Journal of Clinical Investigation, 54 (10) e14259, 1-11. doi: 10.1111/eci.14259
2024
Conference Publication
In vivo isolated lung perfusion: an innovative platform for assessing lung injury propagation in ARDS
Fior, Gabriele, Lloyd, Benjamin, Liu, Keibun, Milani, Angelo, Obonyo, Nchafatso, Hoshino, Kota, Nonaka, Hideaki, Abbate, Gabriella, Portatadino, Sofia, Panduru, Rachana, Hyslop, Kieran, Passmore, Margaret, Meechan-Brown, Carolyn, Redmond, Kendal, Slaughter, Richard, Garlick, Bruce, Mcgiffin, David, Suen, Jacky, Fraser, John and Li Bassi, Gianluigi (2024). In vivo isolated lung perfusion: an innovative platform for assessing lung injury propagation in ARDS. European Respiratory Society Congress (ERS), Vienna, Austria, 7-11 September 2024. Sheffield, United Kingdom: European Respiratory Society. doi: 10.1183/13993003.congress-2024.pa845
2024
Conference Publication
Development of Right Ventricular Dysfunction Induced by Respiratory Failure: Insights from an Ovine Model of Acute Respiratory Distress Syndrome and Veno-Venous Extracorporeal Membrane Oxygenation
Nonaka, Hideaki, Liu, Keibun, Milani, Angelo, Fior, Gabriele, Hoshino, Kota, Obonyo, Nchafatso, Portatadino, Sofia, Abbate, Gabriella, Panduru, Rachana, McInerney, Molly-Rose, Passmore, Margaret, Li Bassi, Gianluigi, Suen, Jacky and Fraser, John F. (2024). Development of Right Ventricular Dysfunction Induced by Respiratory Failure: Insights from an Ovine Model of Acute Respiratory Distress Syndrome and Veno-Venous Extracorporeal Membrane Oxygenation. 35th Annual ELSO Conference, Detroit, MI United States, 28 September - 1 October 2024. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.mat.0001070112.10477.fa
2024
Journal Article
SEVUparin as a potential Adjunctive Treatment in children with severe malaria: A phase I trial safety and dose finding trial (SEVUSMAART)
Maitland, Kathryn, Hamaluba, Mainga, Obonyo, Nchafatso, Oguda, Emmanuel, Mogoka, Christabel, Williams, Thomas N., Chaponda, Mike, Miti, Sam, Kamavu, Luc Kambale, Jonathan Gwasupika, Jonathan, Connon, Roisin, Gibb, Diana M., Dondorp, Arjen, Day, Nick, White, Nick, Walker, A. Sarah, George, Elizabeth C. and Severe Malaria in African Children A Research and Trials (SMAART) consortium (2024). SEVUparin as a potential Adjunctive Treatment in children with severe malaria: A phase I trial safety and dose finding trial (SEVUSMAART). Wellcome Open Research, 8 484, 484. doi: 10.12688/wellcomeopenres.20111.2
2024
Journal Article
Effects of red blood cell transfusion on patients undergoing cardiac surgery in Queensland – a retrospective cohort study
Obonyo, Nchafatso. G., Dhanapathy, Vikash, White, Nicole, Sela, Declan P., Rachakonda, Reema H., Tunbridge, Matthew, Sim, Beatrice, Teo, Derek, Nadeem, Zohaib, See Hoe, Louise E., Bassi, Gianluigi Li, Fanning, Jonathon P., Tung, John-Paul, Suen, Jacky Y. and Fraser, John F. (2024). Effects of red blood cell transfusion on patients undergoing cardiac surgery in Queensland – a retrospective cohort study. Journal of Cardiothoracic Surgery, 19 (1) 475. doi: 10.1186/s13019-024-02974-7
2024
Journal Article
Current trends and latest developments in echocardiographic assessment of right ventricular function: load dependency perspective
Nonaka, Hideaki, Rätsep, Indrek, Obonyo, Nchafatso G., Suen, Jacky Y., Fraser, John F. and Chan, Jonathan (2024). Current trends and latest developments in echocardiographic assessment of right ventricular function: load dependency perspective. Frontiers in Cardiovascular Medicine, 11 1365798, 1-15. doi: 10.3389/fcvm.2024.1365798
2024
Journal Article
Joint EASPS-AAPS Conference in Tanzania 2023: a beginning of the pragmatic efforts to promote physiology education, research and practice in East Africa
Alagbonsi, Abdullateef Isiaka, Essop, Faadiel, Njelekela, Marina, Leminie, Abebaye Aragaw, Ojiambo, Robert, Malindisa, Evangelista Kenan, Alkizim, Faraj Omar, Ninsiima, Herbert Izo, Kediso, Teketel Eristu, Mashili, Fredirick L., Chillo, Omary, Ebrahim, Ashabilan A., Dionis, Ikunda, Ruhighira, Jacktan Josephat and Obonyo, Nchafatso Gikenyi (2024). Joint EASPS-AAPS Conference in Tanzania 2023: a beginning of the pragmatic efforts to promote physiology education, research and practice in East Africa. Advances in Physiology Education, 48 (3), 573-577. doi: 10.1152/advan.00091.2024
2024
Journal Article
A Phase I trial of Non-invasive Ventilation and seizure prophylaxis with levetiracetam In Children with Cerebral Malaria Trial (NOVICE-M Trial)
Maitland, Kathryn, Obonyo, Nchafasto, Hamaluba, Mainga, Ogoda, Emmanuel, Mogaka, Christabel, Williams, Thomas N., Newton, Charles, Kariuki, Symon M., Gibb, Diana M., Walker, A. Sarah, Connon, Roisin and George, Elizabeth C. (2024). A Phase I trial of Non-invasive Ventilation and seizure prophylaxis with levetiracetam In Children with Cerebral Malaria Trial (NOVICE-M Trial). Wellcome Open Research, 9 281. doi: 10.12688/wellcomeopenres.21403.1
2024
Journal Article
Comparative analysis of novel esophageal pressure monitoring catheters versus commercially available alternatives in a biomechanical model of the thoracic cavity
Abbate, Gabriella, Colombo, Sebastiano Maria, Semenzin, Clayton, Sato, Noriko, Liu, Keibun, Ainola, Carmen, Milani, Angelo, Fior, Gabriele, Obonyo, Nchafatso, White, Nicole, Chiumello, Davide, Pauls, Jo, Suen, Jacky Y., Fraser, John F. and Li Bassi, Gianluigi (2024). Comparative analysis of novel esophageal pressure monitoring catheters versus commercially available alternatives in a biomechanical model of the thoracic cavity. Scientific Reports, 14 (1) 9771, 1-12. doi: 10.1038/s41598-024-59790-1
2024
Journal Article
Improved microcirculation with pulsatile veno-arterial ECMO: an ovine model of cardiogenic shock
Heinsar, Silver, Sato, Kei, Obonyo, Nchafatso, Farah, Samia M, Bouquet, Mahe, Passmore, Margaret R, Liu, Keibun, Ijunin, Shinichi, Ainola, Carmen, Li Bassi, Gianluigi, Suen, Jacky Y and Fraser, John F. (2024). Improved microcirculation with pulsatile veno-arterial ECMO: an ovine model of cardiogenic shock. American Journal of Respiratory and Critical Care Medicine, 209 (11), 1396-1399. doi: 10.1164/rccm.202402-0419le
2024
Journal Article
Catalysing global surgery: a meta-research study on factors affecting surgical research collaborations with Africa
Kirengo, Thomas O., Dossajee, Hussein, Onyango, Evans M., Rachakonda, Reema H., Schneider, Bailey, Sela, Declan P., Hosseinzadeh, Zahra, Nadeem, Zohaib and Obonyo, Nchafatso G. (2024). Catalysing global surgery: a meta-research study on factors affecting surgical research collaborations with Africa. Systematic Reviews, 13 (1) 89, 1-17. doi: 10.1186/s13643-024-02474-8
2024
Journal Article
A novel speckle‐tracking echocardiography parameter assessing left ventricular afterload
Sato, Kei, Wildi, Karin, Chan, Jonathan, Palmieri, Chiara, Obonyo, Nchafatso G., Heinsar, Silver, Liu, Keibun, Livingstone, Samantha, Sato, Noriko, Ainola, Carmen, Abbate, Gabriella, Bouquet, Mahé, Wilson, Emily, Passmore, Margaret, Hyslop, Kieran, Platts, David G., Suen, Jacky, Bassi, Gianluigi Li and Fraser, John F. (2024). A novel speckle‐tracking echocardiography parameter assessing left ventricular afterload. European Journal of Clinical Investigation, 54 (2) e14106, 1-12. doi: 10.1111/eci.14106
2024
Journal Article
Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): A Phase II Randomised Controlled trial: Trial Protocol
Olupot-Olupot, Peter, Aloroker, Florence, Mpoya, Ayub, Mnjalla, Hellen, Paasi, George, Nakuya, Margaret, Houston, Kirsty, Obonyo, Nchafatso, Hamaluba, Mainga, Evans, Jennifer A, Dewez, Manuel, Atti, Salifou, Guindo, Ousmane, Ouattara, San Maurice, Chara, Abdullahi, Sainna, Hadiza Alhaji, Amos, Omokore Oluseyi, Ogundipe, Oluwakemi, Sunyoto, Temmy, Coldiron, Matthew, LANGENDORF, Celine, SCHERRER, Marie-Francoise, PETRUCCI, Roberta, Connon, Roisin, George, Elizabeth C., Gibb, Diana M. and Maitland, Kathryn (2024). Gastroenteritis Rehydration Of children with Severe Acute Malnutrition (GASTROSAM): A Phase II Randomised Controlled trial: Trial Protocol. Wellcome Open Research, 6 160, 1-18. doi: 10.12688/wellcomeopenres.16885.2
2023
Journal Article
Resuscitation-associated endotheliopathy (RAsE): a conceptual framework based on a systematic review and meta-analysis
Obonyo, Nchafatso G., Sela, Declan P., Raman, Sainath, Rachakonda, Reema, Schneider, Bailey, Hoe, Louise E. See, Fanning, Jonathon P., Bassi, Gianluigi Li, Maitland, Kathryn, Suen, Jacky Y. and Fraser, John F. (2023). Resuscitation-associated endotheliopathy (RAsE): a conceptual framework based on a systematic review and meta-analysis. Systematic Reviews, 12 (1) 221, 1-17. doi: 10.1186/s13643-023-02385-0
Supervision
Availability
- Dr Nchafatso Obonyo is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Pre-clinical models of cardiac critical illness
Resuscitation-associated endotheliopathy in shock states
https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-023-02385-0
Media
Enquiries
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