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Dr Lachlan De Hayr
Dr

Lachlan De Hayr

Email: 

Overview

Background

I am a molecular biologist and postdoctoral research fellow in Prof. Alexander Khromykh's laboratory. I specialise in non-coding RNA response to viral infections, virus genomics, RNA structure, and viral neuropathogenesis.

I began my journey with a Bachelor of Science in Molecular Biology, graduating in 2012. I then completed a master’s degree where I conducted research under Prof. Keith Chappell in viral protein structure (2015). I then pursued my PhD (2016-2020) at UQ's School of Biology under Prof. Sassan Asgari, where I studied the role of miRNAs in Aedes aegypti biology and viral infection as well as the use of small RNAs to induce gene expression in insects.

From 2020 to 2023 I worked as a postdoctoral researcher in Prof. Robert Harvey’s laboratory at the University of the Sunshine Coast. I conducted research into the genomics and molecular function of congenital neurodevelopmental disorders where our multi discipline team through the Centre for Research Excellence Neurocognitive Disorder identified and characterised new genes linked to developmental disorders.

Since 2023, I have been a postdoctoral researcher in Prof. Alexander Khromykh's RNA Virology lab. Here, I have contributed to work focusing on the role of flavivirus sfRNA in interferon signalling inhibition, as well as using single-cell sequencing and human brain organoids to study the pathogenesis of encephalitic flaviviruses. I have also been working on mosquito single-cell projects and insect-specific viruses for their role in preventing the transmission of pathogenic flaviviruses with Dr. Andrii Slonchak. In late 2024 as a Chief investigator, my team was awarded an NHMRC ideas grant for $1.4mil over four years to study a new class of small RNAs called tRNA-half, for their role in flavivirus infection and their potential use for therapeutics.

Availability

Dr Lachlan De Hayr is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Biochemistry and Molecular Biology, The University of Queensland
  • Masters (Coursework) of Molecular Biology, The University of Queensland
  • Doctor of Philosophy of Molecular Biology, The University of Queensland

Research interests

  • non-coding RNA responses during viral infection

    Investigating the role of non-coding RNAs during flavivirus infection. Using cutting edge RNA sequencing methods and human organoid models to investigate the involvement of host derived miRNAs, tiRNAs and other non-coding RNAs in viral infection.

  • Neuropathology of flavivirus infections

    Using human Brain organoid models to study the effects of neurotropic flavivirus infection. Analysis of gene expression and development using cutting single cell RNA sequencing and spatial transcriptomics.

  • Mosquitoes as vectors of flavivirus infection

    Investigating the mosquito's response to viral infections, targeting non-coding RNA pathways. Also investigating the effects of host switching on viral evolution and structure.

Works

Search Professor Lachlan De Hayr’s works on UQ eSpace

9 works between 2019 and 2025

1 - 9 of 9 works

2025

Journal Article

Biallelic SLC13A1 loss-of-function variants result in impaired sulfate transport and skeletal phenotypes including short stature, scoliosis, and skeletal dysplasia

Tise, Christina G., Ashton, Katie, de Hayr, Lachlan, Lee, Kun-Di, Patkar, Omkar L., Krzesinski, Emma, Bassetti, Jennifer A., Carter, Erin M., Raggio, Cathleen, Zankl, Andreas, Khanshour, Anas M., Atala, Kristhen N., Rios, Jonathan J., Wise, Carol A., Zhu, Ying, Zhang, Futao, Roscioli, Tony, Buckley, Michael, Harvey, Robert J. and Dawson, Paul A. (2025). Biallelic SLC13A1 loss-of-function variants result in impaired sulfate transport and skeletal phenotypes including short stature, scoliosis, and skeletal dysplasia. Genetics in Medicine Open, 3 101958, 101958. doi: 10.1016/j.gimo.2024.101958

Biallelic SLC13A1 loss-of-function variants result in impaired sulfate transport and skeletal phenotypes including short stature, scoliosis, and skeletal dysplasia

2024

Journal Article

Biallelic variants in GTF3C3 result in an autosomal recessive disorder with intellectual disability

De Hayr, Lachlan, Blok, Laura E.R., Dias, Kerith-Rae, Long, Jingyi, Begemann, Anaïs, Moir, Robyn D., Willis, Ian M., Mocera, Martina, Siegel, Gabriele, Steindl, Katharina, Evans, Carey-Anne, Zhu, Ying, Zhang, Futao, Field, Michael, Ma, Alan, Adès, Lesley, Josephi-Taylor, Sarah, Pfundt, Rolph, Zaki, Maha S., Tomoum, Hoda, Gregor, Anne, Laube, Julia, Reis, André, Maddirevula, Sateesh, Hashem, Mais O., Zweier, Markus, Alkuraya, Fowzan S., Maroofian, Reza, Buckley, Michael F. ... Harvey, Robert J. (2024). Biallelic variants in GTF3C3 result in an autosomal recessive disorder with intellectual disability. Genetics in Medicine, 27 (1) 101253, 101253. doi: 10.1016/j.gim.2024.101253

Biallelic variants in GTF3C3 result in an autosomal recessive disorder with intellectual disability

2024

Journal Article

The flavivirus Non-Structural Protein 5 (NS5): structure, functions, and targeting for development of vaccines and therapeutics

Goh, Jarvis Z. H., De Hayr, Lachlan, Khromykh, Alexander A. and Slonchak, Andrii (2024). The flavivirus Non-Structural Protein 5 (NS5): structure, functions, and targeting for development of vaccines and therapeutics. Vaccines, 12 (8) 865, 865. doi: 10.3390/vaccines12080865

The flavivirus Non-Structural Protein 5 (NS5): structure, functions, and targeting for development of vaccines and therapeutics

2023

Journal Article

Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife

Takano, Kotaro, de Hayr, Lachlan, Carver, Scott, Harvey, Robert J. and Mounsey, Kate E. (2023). Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife. International Journal for Parasitology: Drugs and Drug Resistance, 21, 97-113. doi: 10.1016/j.ijpddr.2023.02.004

Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife

2022

Journal Article

De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations

Dias, Kerith-Rae, Carlston, Colleen M., Blok, Laura E. R., De Hayr, Lachlan, Nawaz, Urwah, Evans, Carey-Anne, Bayrak-Toydemir, Pinar, Htun, Stephanie, Zhu, Ying, Ma, Alan, Lynch, Sally Ann, Moorwood, Catherine, Stals, Karen, Ellard, Sian, Bainbridge, Matthew N., Friedman, Jennifer, Pappas, John G., Rabin, Rachel, Nowak, Catherine B., Douglas, Jessica, Wilson, Theodore E., Guillen Sacoto, Maria J., Mullegama, Sureni V., Palculict, Timothy Blake, Kirk, Edwin P., Pinner, Jason R., Edwards, Matthew, Montanari, Francesca, Graziano, Claudio ... Roscioli, Tony (2022). De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations. Genetics in Medicine, 24 (9), 1952-1966. doi: 10.1016/j.gim.2022.06.001

De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations

2022

Journal Article

Loss, gain and altered function of GlyR α2 subunit mutations in neurodevelopmental disorders

Chen, Xiumin, Wilson, Katie A., Schaefer, Natascha, De Hayr, Lachlan, Windsor, Mark, Scalais, Emmanuel, van Rijckevorsel, Germaine, Stouffs, Katrien, Villmann, Carmen, O’Mara, Megan L., Lynch, Joseph W. and Harvey, Robert J. (2022). Loss, gain and altered function of GlyR α2 subunit mutations in neurodevelopmental disorders. Frontiers in Molecular Neuroscience, 15 886729. doi: 10.3389/fnmol.2022.886729

Loss, gain and altered function of GlyR α2 subunit mutations in neurodevelopmental disorders

2020

Other Outputs

Investigating the role of non-coding RNAs in Aedes aegypti biology

De Hayr, Lachlan (2020). Investigating the role of non-coding RNAs in Aedes aegypti biology. PhD Thesis, School of Biological Sciences , The University of Queensland. doi: 10.14264/uql.2020.702

Investigating the role of non-coding RNAs in Aedes aegypti biology

2020

Journal Article

RNA activation in insects: the targeted activation of endogenous and exogenous genes

De Hayr, Lachlan, Asad, Sultan, Hussain, Mazhar and Asgari, Sassan (2020). RNA activation in insects: the targeted activation of endogenous and exogenous genes. Insect Biochemistry and Molecular Biology, 119 103325, 103325. doi: 10.1016/j.ibmb.2020.103325

RNA activation in insects: the targeted activation of endogenous and exogenous genes

2019

Journal Article

Density-dependent enhanced replication of a densovirus in Wolbachia-infected Aedes cells is associated with production of piRNAs and higher virus-derived siRNAs

Parry, Rhys, Bishop, Cameron, De Hayr, Lachlan and Asgari, Sassan (2019). Density-dependent enhanced replication of a densovirus in Wolbachia-infected Aedes cells is associated with production of piRNAs and higher virus-derived siRNAs. Virology, 528, 89-100. doi: 10.1016/j.virol.2018.12.006

Density-dependent enhanced replication of a densovirus in Wolbachia-infected Aedes cells is associated with production of piRNAs and higher virus-derived siRNAs

Funding

Current funding

  • 2025 - 2028
    Lost in translation: why flaviviruses induce cleavage of tRNAs
    NHMRC IDEAS Grants
    Open grant

Supervision

Availability

Dr Lachlan De Hayr is:
Available for supervision

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Media

Enquiries

Contact Dr Lachlan De Hayr directly for media enquiries about:

  • non-coding RNA
  • vector biology
  • virology

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