
Overview
Background
Moe Thuzar (MBBS, FRCP UK, FRACP, PhD) is an Endocrinologist at the Princess Alexandra Hospital and a Research Fellow at the University of Queensland Frazer Institute, Faculty of Medicine, University of Queensland, Brisbane. She has a strong research interest in the Neuroendocrine Regulation of Metabolism and Cardiovascular Health in Humans. After completing her specialist training and receiving FRACP (Fellowship of the Royal Australasian College of Physicians) in early 2014, she undertook her PhD study (2014-2018, UQ) investigating the role of adrenal neuroendocrine system in the regulation of human brown adipose tissue and energy metabolism under the primary supervision of Professor Ken Ho. Moe then joined the Endocrine Hypertension Unit of Professor Michael Stowasser, pursuing further research in Cardiovascular Endocrinology, in particular, elucidating the role of the mineralocorticoid system in the regulation of cardiometabolic health and its interplay with other systems in humans, and investigating optimal diagnostic and management strategies for primary aldosteronism.
She has received numerous awards for her work including US Endocrine Society’s Outstanding Abstract Award (2016) and Presidential Awards for Excellence in Cardiovascular Endocrinology Research (2017) and in Adipocyte Biology Research (2017), Early Career Researcher Award from the Australian & New Zealand Obesity Society (2016), Australasian Women in Endocrinology Young Investigator Award (2017), Queensland Health & Medical Research Award (Previously “Premier’s award”, finalist, 2017), Young Investigator Award, International Aldosterone Conference (runner-up, 2019). She is a Principal Investigator (PI) or Chief Investigator (CI) of a number of successful competitive grants, totalling ~4 millions to date, which include Royal Australasian College of Physicians-Australian Diabetes Society Research Establishment Fellowship (2023), MRFF Clinician Researchers Project Grant (CI, 2022-2025), Metro South Research Support Scheme Program Grant (PI, 2021-2023), Diabetes Australia Project Grant (PI, 2019-2021), Metro South Research Support Scheme Early Career Researcher Grant (PI, 2019-2022), High Blood Pressure Research Council of Australia International Travel Grant (2021), Endocrine Society of Australia Postdoctoral Fellowship (2019). She has served as an expert reviewer for Grant review panels including UK Research & Innovation Grants Scheme, NHMRC Project Grants Scheme and for top journals in the field, and held editorial roles for a number of journals including the Frontiers in Endocrinology, Metabolites.
Availability
- Dr Moe Thuzar is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Moe Thuzar’s works on UQ eSpace
Featured
2023
Journal Article
Editorial: Adrenal neuroendocrine system and cardiometabolic health: pathophysiology and clinical implications
Thuzar, Moe, Hannah-Shmouni, Fady and Stowasser, Michael (2023). Editorial: Adrenal neuroendocrine system and cardiometabolic health: pathophysiology and clinical implications. Frontiers in Endocrinology, 14 1295655, 1295655. doi: 10.3389/fendo.2023.1295655
Featured
2022
Journal Article
Adrenal surgery for bilateral primary aldosteronism: an international retrospective cohort study
Williams, Tracy Ann, Gong, Siyuan, Tsurutani, Yuya, Tezuka, Yuta, Thuzar, Moe, Burrello, Jacopo, Wu, Vin-Cent, Yamazaki, Yuto, Mulatero, Paolo, Sasano, Hironobu, Stowasser, Michael, Nishikawa, Tetsuo, Satoh, Fumitoshi and Reincke, Martin (2022). Adrenal surgery for bilateral primary aldosteronism: an international retrospective cohort study. The Lancet Diabetes and Endocrinology, 10 (11), 769-771. doi: 10.1016/s2213-8587(22)00253-4
Featured
2022
Journal Article
The metabolic phenotype of patients with primary aldosteronism: impact of subtype and sex – a multicenter-study of 3566 Caucasian and Asian subjects
Spyroglou, Ariadni, Handgriff, Laura, Müller, Lisa, Schwarzlmüller, Paul, Parasiliti-Caprino, Mirko, Fuss, Carmina Teresa, Remde, Hana, Hirsch, Anna, O’Toole, Samuel Matthew, Thuzar, Moe, Petramala, Luigi, Letizia, Claudio, Deflorenne, Elisa, Amar, Laurence, Vrckovnik, Rok, Kocjan, Tomaz, Zhang, Catherine D, Li, Dingfeng, Singh, Sumitabh, Katabami, Takuyuki, Yoneda, Takashi, Murakami, Masanori, Wada, Norio, Inagaki, Nobuya, Quinkler, Marcus, Ghigo, Ezio, Maccario, Mauro, Stowasser, Michael, Drake, William M ... Beuschlein, Felix (2022). The metabolic phenotype of patients with primary aldosteronism: impact of subtype and sex – a multicenter-study of 3566 Caucasian and Asian subjects. European Journal of Endocrinology, 187 (3), 361-372. doi: 10.1530/eje-22-0040
Featured
2019
Journal Article
Diagnosis of primary aldosteronism by seated saline suppression test - variability between immunoassay and HPLC-MS/MS
Thuzar, Moe, Young, Karen, Ahmed, Ashraf H., Ward, Greg, Wolley, Martin, Guo, Zeng, Gordon, Richard D., McWhinney, Brett C., Ungerer, Jacobus P. and Stowasser, Michael (2019). Diagnosis of primary aldosteronism by seated saline suppression test - variability between immunoassay and HPLC-MS/MS. Journal of Clinical Endocrinology and Metabolism, 105 (3) dgz150, e477-e483. doi: 10.1210/clinem/dgz150
Featured
2019
Journal Article
Mineralocorticoid antagonism enhances brown adipose tissue function in humans: a randomized placebo-controlled cross-over study
Thuzar, Moe, Law, W. Phillip, Dimeski, Goce, Stowasser, Michael and Ho, Ken K. Y. (2019). Mineralocorticoid antagonism enhances brown adipose tissue function in humans: a randomized placebo-controlled cross-over study. Diabetes, Obesity and Metabolism, 21 (3), 509-516. doi: 10.1111/dom.13539
Featured
2018
Journal Article
Glucocorticoids suppress brown adipose tissue function in humans: a double-blind placebo-controlled study
Thuzar, Moe, Law, W. Phillip, Ratnasingam, Jeyakantha, Jang, Christina, Dimeski, Goce and Ho, Ken KY (2018). Glucocorticoids suppress brown adipose tissue function in humans: a double-blind placebo-controlled study. Diabetes, Obesity and Metabolism, 20 (4), 840-848. doi: 10.1111/dom.13157
2025
Journal Article
687 Clinicopathologic Characterization of Sloughing Esophagitis: A Monocentric Retrospective Analysis of 11 Cases
Shoaib, Faryal, Thuzar, Moe, Memon, Mohammad, Kazacheuskaya, Liubou and Arora, Kshitij (2025). 687 Clinicopathologic Characterization of Sloughing Esophagitis: A Monocentric Retrospective Analysis of 11 Cases. Laboratory Investigation, 105 (3) 102918, 102918. doi: 10.1016/j.labinv.2024.102918
2024
Journal Article
The mineralocorticoid system, cardiometabolic health and its interplay with adipose tissue
Thuzar, Moe, Abdul Halim, Muthanna and Stowasser, Michael (2024). The mineralocorticoid system, cardiometabolic health and its interplay with adipose tissue. Journal of Endocrinology, 263 (2) e240119. doi: 10.1530/joe-24-0119
2024
Journal Article
Adrenal vein sampling for primary aldosteronism: recommendations from the Australian and New Zealand Working Group
Yang, Jun, Bell, Damon A., Carroll, Richard, Chiang, Cherie, Cowley, Diane, Croker, Emma, Doery, James C. G., Elston, Marianne, Glendenning, Paul, Hetherington, Julie, Horvath, Andrea R., Lu-Shirzad, Shanshan, Ng, Elisabeth, Mather, Amanda, Perera, Nimalie, Rashid, Muddassir, Sachithanandan, Nirupa, Shen, Jimmy, Stowasser, Michael, Swarbrick, Michael J., Tan, Hong Lin Evelyn, Thuzar, Moe, Young, Simon and Chong, Winston (2024). Adrenal vein sampling for primary aldosteronism: recommendations from the Australian and New Zealand Working Group. Clinical Endocrinology, 102 (1), 31-43. doi: 10.1111/cen.15139
2024
Conference Publication
Optimal Adrenal Vein Sampling Lateralization Criteria For Diagnosis Of Unilateral Primary Aldosteronism Using Aldosterone Concentration Measured By LC-MS/MS Post-ATCH Stimulation
Thuzar, Moe, Zaal, Kassem, Ma, Derrick, Morkos, Michael, McWhinney, Brett, Ungerer, Jacobus and Stowasser, Michael (2024). Optimal Adrenal Vein Sampling Lateralization Criteria For Diagnosis Of Unilateral Primary Aldosteronism Using Aldosterone Concentration Measured By LC-MS/MS Post-ATCH Stimulation. ISH 30th Scientific Meeting, Cartagena, Colombia, 19-22 September 2024. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.hjh.0001063080.94646.5d
2022
Journal Article
High-intensity interval training is safe, feasible and efficacious in nonalcoholic steatohepatitis: a randomized controlled trial
Keating, Shelley E., Croci, Ilaria, Wallen, Matthew P., Cox, Emily R., Thuzar, Moe, Pham, Uyen, Mielke, Gregore I., Coombes, Jeff S., Macdonald, Graeme A. and Hickman, Ingrid J. (2022). High-intensity interval training is safe, feasible and efficacious in nonalcoholic steatohepatitis: a randomized controlled trial. Digestive Diseases and Sciences, 68 (5), 1-17. doi: 10.1007/s10620-022-07779-z
2022
Journal Article
Outcomes of a co-located approach for metabolic health care for people with schizophrenia
Siskind, Dan, Yen, Wesley, Thuzar, Moe, Russell, Anthony, Warren, Nicola, Kisely, Steve, Kar Ray, Manaan and Motamarri, Balaji (2022). Outcomes of a co-located approach for metabolic health care for people with schizophrenia. Australasian Psychiatry, 30 (4), 103985622210807-522. doi: 10.1177/10398562221080742
2021
Journal Article
Obesity, metabolic syndrome, and inflammation: an update for anaesthetists caring for patients with obesity
Eley, Victoria A., Thuzar, Moe, Navarro, Séverine, Dodd, Benjamin R. and van Zundert, André A. (2021). Obesity, metabolic syndrome, and inflammation: an update for anaesthetists caring for patients with obesity. Anaesthesia Critical Care and Pain Medicine, 40 (6) 100947, 100947. doi: 10.1016/j.accpm.2021.100947
2021
Journal Article
The mineralocorticoid receptor-an emerging player in metabolic syndrome?
Thuzar, Moe and Stowasser, Michael (2021). The mineralocorticoid receptor-an emerging player in metabolic syndrome?. Journal of Human Hypertension, 35 (2), 117-123. doi: 10.1038/s41371-020-00467-3
2020
Journal Article
Biochemical, histopathological and genetic characterization of posture responsive and unresponsive APAs
Guo, Zeng, Nanba, Kazutaka, Udager, Aaron, McWhinney, Brett C., Ungerer, Jacobus P. J., Wolley, Martin, Thuzar, Moe, Gordon, Richard D., Rainey, William E. and Stowasser, Michael (2020). Biochemical, histopathological and genetic characterization of posture responsive and unresponsive APAs. Journal of Clinical Endocrinology and Metabolism, 105 (9), e3224-e3235. doi: 10.1210/clinem/dgaa367
2020
Conference Publication
Relationship between the hypothalmic-pituitary-adrenocortical axis activity and the characteristics of aldosterone-producing adenomas
Thuzar, Moe, Lo, Yu-Chin, Guo, Zeng, Inder, Warrick J. and Stowasser, Michael (2020). Relationship between the hypothalmic-pituitary-adrenocortical axis activity and the characteristics of aldosterone-producing adenomas. 22nd European Congress of Endocrinology, Online, 5 - 9 September 2020. Bristol, United Kingdom: Bioscientifica. doi: 10.1530/endoabs.70.aep47
2020
Journal Article
Controversies and advances in adrenal venous sampling in the diagnostic workup of primary aldosteronism
Wolley, Martin, Thuzar, Moe and Stowasser, Michael (2020). Controversies and advances in adrenal venous sampling in the diagnostic workup of primary aldosteronism. Best Practice & Research Clinical Endocrinology & Metabolism, 34 (3) 101400, 101400. doi: 10.1016/j.beem.2020.101400
2019
Conference Publication
Defining the optimal cut-off plasma aldosterone level measured by immunoassay for the diagnosis of primary aldosteronism using seated salines suppression test
Thuzar, M., Young, K., Ahmed, A., Wolley, M., Guo, Z., Ward, G., McWhinney, B., Ungerer, J. and Stowasser, M. (2019). Defining the optimal cut-off plasma aldosterone level measured by immunoassay for the diagnosis of primary aldosteronism using seated salines suppression test. 29th European Meeting of Hypertension and Cardiovascular Protection of the European-Society-of-Hypertension (ESH), Milan, Italy, 21-24 June 2019. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.hjh.0000570272.55373.54
2018
Conference Publication
Effect of mineralocorticoid blockade on human brown fat-a randomised placebo-controlled cross-over study
Thuzar, Moe, Law, W. Phillip, Dimeski, Goce, Stowasser, Michael and Ho, Ken K. Y. (2018). Effect of mineralocorticoid blockade on human brown fat-a randomised placebo-controlled cross-over study. Joint Annual Scientific Meetings of Endocrine-Society-of-Australia (ESA) and Society-for-Reproductive-Biology (SRB), Perth Australia, Aug 27-30, 2017. HOBOKEN: WILEY.
2018
Other Outputs
Regulation and metabolic significance of brown adipose tissue in humans
Thuzar, Moe (2018). Regulation and metabolic significance of brown adipose tissue in humans. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2018.397
Funding
Past funding
Supervision
Availability
- Dr Moe Thuzar is:
- Available for supervision
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Available projects
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Defining the Novel Effects of Mineralocorticoid Receptor Antagonism on Metabolism in Humans
This project involves a randomised clinical trial designed to investigate the potential novel metabolic benefits of Mineralocorticoid receptor (MR) antagonism and to elucidate the mechanistic changes underlying the metabolic benefits conferred by MR antagonism in humans.
MRs are hormone receptors present in high abundance on fat cells of obese subjects. Metabolic syndrome is commonly found with mineralocorticoid hormone excess (primary hyperaldosteronism) and in the general population, mineralocorticoid level is predictive of obesity and metabolic diseases. There is strong evidence in animals that blocking MRs (MR antagonism) protects against obesity and metabolic complications. It is not known if similar mechanisms operate in humans.
This project will help define the novel therapeutic potential of MR antagonists for management of obesity and metabolic diseases in overweight/obese humans. The results may also offer unique physiological insights into the underlying mechanisms modulating metabolic health for future research and development.
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Mineralocorticoid Receptor Antagonist To Counteract Cardiometabolic Adverse Effects of Steroids/Glucocorticoids
Metabolic syndrome and cardiovascular diseases are common side effects of steroids/glucocorticoids such as prednisolone, widely used for inflammatory diseases; there is no specific agent to counteract these adverse effects. There is evidence that these side effects are likely mediated by closely-related hormone receptors called mineralocorticoid receptors (MRs), present in fat and cardiac tissues and immune cells. We have previously discovered in healthy humans that MR antagonists exert opposing effects to those of glucocorticoids on adipose tissue metabolism.
This project will examine if blocking the MRs by spironolactone can counteract metabolic and cardiac side effects without compromising beneficial antiinflammatory effects in people requiring prednisolone.
Supervision history
Current supervision
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Doctor Philosophy
Defining The Role Of Mineralocorticoid Receptor In Cardiometabolic Health & Inflammation & Optimising The Diagnostic Approach For Aldosterone-producing Adenoma
Associate Advisor
Other advisors: Professor Michael Stowasser
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Doctor Philosophy
Defining The Role Of Mineralocorticoid Receptor In Cardiometabolic Health & Inflammation & Optimising The Diagnostic Approach For Aldosterone-producing Adenoma
Associate Advisor
Other advisors: Professor Michael Stowasser
Media
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