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2020

Journal Article

Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning

Bridgford, Jessica L., Lee, Su Min, Lee, Christine M. M., Guglielmelli, Paola, Rumi, Elisa, Pietra, Daniela, Wilcox, Stephen, Chhabra, Yash, Rubin, Alan F., Cazzola, Mario, Vannucchi, Alessandro M., Brooks, Andrew J., Call, Matthew Edwin and Call, Melissa Joy (2020). Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning. Blood, 135 (4), 287-292. doi: 10.1182/blood.2019002561

Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning

2019

Journal Article

Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7Rα cause receptor hypersensitivity

Campos, Livia Weijenborg, Zenatti, Priscila Pini, Pissinato, Leonardo Granato, Rodrigues, Gisele Olinto Libanio, Artico, Leonardo Luís, Guimarães, Thais Rafael, Archangelo, Leticia Fröhlich, Martínez, Leandro, Brooks, Andrew J. and Yunes, Jose Andres (2019). Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7Rα cause receptor hypersensitivity. Blood, 133 (11), 1259-1263. doi: 10.1182/blood-2018-09-872945

Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7Rα cause receptor hypersensitivity

2018

Journal Article

A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

Chhabra, Y., Wong, H. Y., Nikolajsen, L. F., Steinocher, H., Papadopulos, A., Tunny, K. A., Meunier, F. A., Smith, A. G., Kragelund, B. B., Brooks, A. J. and Waters, M. J. (2018). A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation. Oncogene, 37 (4), 489-501. doi: 10.1038/onc.2017.352

A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation

2014

Journal Article

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

Brooks, Andrew J., Dai, Wei, O’Mara, Megan L., Abankwa, Daniel, Chhabra, Yash, Pelekanos, Rebecca A., Gardon, Olivier, Tunny, Kathryn A., Blucher, Kristopher M., Morton, Craig J., Parker, Michael W., Sierecki, Emma, Gambin, Yann, Gomez, Guillermo A., Alexandrov, Kirill, Wilson, Ian A., Doxastakis, Manolis, Mark, Alan E. and Waters, Michael J. (2014). Mechanism of activation of protein kinase JAK2 by the growth hormone receptor. Science, 344 (6185) 1249783, 1249783.1-1249783.12. doi: 10.1126/science.1249783

Mechanism of activation of protein kinase JAK2 by the growth hormone receptor

2010

Journal Article

The growth hormone receptor: mechanism of activation and clinical implications

Brooks, Andrew J. and Waters, Michael J. (2010). The growth hormone receptor: mechanism of activation and clinical implications. Nature Reviews Endocrinology, 6 (9), 515-525. doi: 10.1038/nrendo.2010.123

The growth hormone receptor: mechanism of activation and clinical implications

2008

Journal Article

An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway

Rowlinson, Scott W., Yoshizato, Hideo, Barclay, Johanna L., Brooks, Andrew J., Behncken, Stuart N., Kerr, Linda M., Millard, Kirstin, Palethorpe, Kathryn, Nielsen, Katherine, Clyde-Smith, Jodie, Hancock, John F. and Waters, Michael J. (2008). An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway. Nature Cell Biology, 10 (6), 740-747. doi: 10.1038/ncb1737

An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway

2024

Journal Article

Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival

Dang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival. Clinical and Translational Immunology, 13 (12) e70018, 1-18. doi: 10.1002/cti2.70018

Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival

2024

Journal Article

The roles of Growth Hormone dependent JAK-STAT5 and Lyn kinase signalling in determining lifespan and cancer incidence

Chhabra, Yash, Bielefeldt-Ohmann, Helle, Brooks, Tania Louise, Brooks, Andrew James and Waters, Michael J (2024). The roles of Growth Hormone dependent JAK-STAT5 and Lyn kinase signalling in determining lifespan and cancer incidence. Endocrinology, 165 (11) ARTN bqae136. doi: 10.1210/endocr/bqae136

The roles of Growth Hormone dependent JAK-STAT5 and Lyn kinase signalling in determining lifespan and cancer incidence

2024

Journal Article

A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy

Rossi, Gustavo R., Sun, Jane, Lin, Cheng‐Yu, Wong, Joshua K.M., Alim, Louisa, Lam, Pui Yeng, Khosrotehrani, Kiarash, Wolvetang, Ernst, Cheetham, Seth W., Derrick, Emily B., Amoako, Akwasi, Lehner, Christoph, Brooks, Andrew J., Beavis, Paul A. and Souza‐Fonseca‐Guimaraes, Fernando (2024). A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy. Immunology & Cell Biology, 102 (10), 1-11. doi: 10.1111/imcb.12820

A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy

2024

Journal Article

The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation

Fernandez-Rojo, Manuel A., Pearen, Michael A., Burgess, Anita G., Ikonomopoulou, Maria P., Hoang-Le, Diem, Genz, Berit, Saggiomo, Silvia L., Nawaratna, Sujeevi S. K., Poli, Maura, Reissmann, Regina, Gobert, Geoffrey N., Deutsch, Urban, Engelhardt, Britta, Brooks, Andrew J., Jones, Alun, Arosio, Paolo and Ramm, Grant A. (2024). The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation. Science Signaling, 17 (830) eade4335, 1-16. doi: 10.1126/scisignal.ade4335

The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation

2024

Journal Article

Seasonal differences in amounts of oviposition habitat and egg-laying by caddisflies in rivers with regulated versus unregulated flows

Wahjudi, Handoko, Bovill, William D., Brooks, Andrew J. and Downes, Barbara J. (2024). Seasonal differences in amounts of oviposition habitat and egg-laying by caddisflies in rivers with regulated versus unregulated flows. Freshwater Biology, 69 (5), 645-659. doi: 10.1111/fwb.14236

Seasonal differences in amounts of oviposition habitat and egg-laying by caddisflies in rivers with regulated versus unregulated flows

2024

Journal Article

Do magnesium and chloride ameliorate high sodium bicarbonate concentrations? A comparison between laboratory and mesocosm toxicity experiments

Kefford, Ben J., Brooks, Andrew J., Shenton, Mark D., Hills, Kasey, Nichols, Susan J., Bray, Jonathan P. and Hyne, Ross V. (2024). Do magnesium and chloride ameliorate high sodium bicarbonate concentrations? A comparison between laboratory and mesocosm toxicity experiments. Science of the Total Environment, 912 169003, 1-13. doi: 10.1016/j.scitotenv.2023.169003

Do magnesium and chloride ameliorate high sodium bicarbonate concentrations? A comparison between laboratory and mesocosm toxicity experiments

2024

Journal Article

Location, location, location: Protein kinase nanoclustering for optimised signalling output

Gormal, Rachel S., Martinez-Marmol, Ramon, Brooks, Andrew J. and Meunier, Frédéric A. (2024). Location, location, location: Protein kinase nanoclustering for optimised signalling output. eLife, 13 ARTN e93902, 1-21. doi: 10.7554/elife.93902

Location, location, location: Protein kinase nanoclustering for optimised signalling output

2023

Journal Article

Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J. and Nicholson, Sandra E. (2023). Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications, 14 (1) 7951, 7951. doi: 10.1038/s41467-023-42706-4

Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

2023

Journal Article

Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation

Chhabra, Yash, Seiffert, Pernille, Gormal, Rachel S., Vullings, Manon, Lee, Christine Mei Mei, Wallis, Tristan P., Dehkhoda, Farhad, Indrakumar, Sowmya, Jacobsen, Nina L., Lindorff-Larsen, Kresten, Durisic, Nela, Waters, Michael J., Meunier, Frederic A., Kragelund, Birthe B. and Brooks, Andrew J. (2023). Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation. Cell Reports, 42 (5) 112490, 112490. doi: 10.1016/j.celrep.2023.112490

Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation

2022

Journal Article

Germline missense variants in SH2B3 underpin platelet count variation and inherited MPN

Butler, Liesl, Lee, Christine, Magor, Graham William, Morris, Rhiannon, Tallack, Michael, Lam, Charlene, Ivey, Adam, Lin, Jane, Deng, Zihao, Grigg, Andrew, Mason, Jane, Perchard, Malaika, Weston, Helen, Cummings, Nik, Brooks, Andrew, Babon, Jeffrey J, Murphy, Andrew J, Salmon, Jessica M and Perkins, Andrew Charles (2022). Germline missense variants in SH2B3 underpin platelet count variation and inherited MPN. Blood, 140 (S1), 1093-1094. doi: 10.1182/blood-2022-159416

Germline missense variants in SH2B3 underpin platelet count variation and inherited MPN

2021

Journal Article

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J. and Nicholson, Sandra E. (2021). Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications, 12 (1) 7032, 7032. doi: 10.1038/s41467-021-26983-5

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

2021

Journal Article

GHR signalling: Receptor activation and degradation mechanisms

Chhabra, Yash, Lee, Christine M. M., Mueller, Alexandra Franziska and Brooks, Andrew J. (2021). GHR signalling: Receptor activation and degradation mechanisms. Molecular and Cellular Endocrinology, 520 111075, 1-11. doi: 10.1016/j.mce.2020.111075

GHR signalling: Receptor activation and degradation mechanisms

2020

Journal Article

Reply to Letter to the Editors: Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy Allowing Liver Regeneration and Survival by Induction of H2‐Bl/HLA‐G

Brooks, Andrew J., Ishikawa, Mayumi, Fernández‐Rojo, Manuel A., Vivian, Julian P., Rossjohn, Jamie and Waters, Michael J. (2020). Reply to Letter to the Editors: Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy Allowing Liver Regeneration and Survival by Induction of H2‐Bl/HLA‐G. Hepatology, 73 (3) hep.31531, 1239-1239. doi: 10.1002/hep.31531

Reply to Letter to the Editors: Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy Allowing Liver Regeneration and Survival by Induction of H2‐Bl/HLA‐G

2020

Journal Article

JAK-STAT signalling pathway in cancer

Brooks, Andrew J. and Putoczki, Tracy (2020). JAK-STAT signalling pathway in cancer. Cancers, 12 (7) 1971, 1971-3. doi: 10.3390/cancers12071971

JAK-STAT signalling pathway in cancer