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2023 Journal Article Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticusBayaraa, Tenuun, Lonhienne, Thierry, Sutiono, Samuel, Melse, Okke, Brück, Thomas B., Marcellin, Esteban, Bernhardt, Paul V., Boden, Mikael, Harmer, Jeffrey R., Sieber, Volker, Guddat, Luke W. and Schenk, Gerhard (2023). Structural and functional insight into the mechanism of the Fe‐S cluster‐dependent dehydratase from Paralcaligenes ureilyticus. Chemistry: A European Journal, 29 (9) e202203140, 1-13. doi: 10.1002/chem.202203140 |
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2022 Journal Article Facet-specific active surface regulation of BixMOy (M=Mo, V, W) nanosheets for boosted photocatalytic CO2 reductionZhang, Yanzhao, Zhi, Xing, Harmer, Jeffrey R., Xu, Haolan, Davey, Kenneth, Ran, Jingrun and Qiao, Shi-Zhang (2022). Facet-specific active surface regulation of BixMOy (M=Mo, V, W) nanosheets for boosted photocatalytic CO2 reduction. Angewandte Chemie - International Edition, 61 (50) e202212355, 1-8. doi: 10.1002/anie.202212355 |
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2022 Journal Article Catalytic electrochemistry of the bacterial Molybdoenzyme YcbXKalimuthu, Palraj, Harmer, Jeffrey R., Baldauf, Milena, Hassan, Ahmed H., Kruse, Tobias and Bernhardt, Paul V. (2022). Catalytic electrochemistry of the bacterial Molybdoenzyme YcbX. Biochimica et Biophysica Acta - Bioenergetics, 1863 (7) 148579, 148579. doi: 10.1016/j.bbabio.2022.148579 |
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2022 Journal Article Short-range ENDOR distance measurements between Gd(iii) and trifluoromethyl labels in proteinsJudd, Martyna, Abdelkader, Elwy H., Qi, Mian, Harmer, Jeffrey R., Huber, Thomas, Godt, Adelheid, Savitsky, Anton, Otting, Gottfried and Cox, Nicholas (2022). Short-range ENDOR distance measurements between Gd(iii) and trifluoromethyl labels in proteins. Physical Chemistry Chemical Physics, 24 (41), 25214-25226. doi: 10.1039/d2cp02889a |
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2022 Journal Article Locking the ultrasound-induced active conformation of metalloenzymes in metal–organic frameworksLiang, Jieying, Bin Zulkifli, Muhammad Yazid, Yong, Joel, Du, Zeping, Ao, Zhimin, Rawal, Aditya, Scott, Jason A., Harmer, Jeffrey R., Wang, Joseph and Liang, Kang (2022). Locking the ultrasound-induced active conformation of metalloenzymes in metal–organic frameworks. Journal of the American Chemical Society, 144 (39), 17865-17875. doi: 10.1021/jacs.2c06471 |
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2022 Journal Article Dihydroxy‐acid dehydratases from pathogenic bacteria: emerging drug targets to combat antibiotic resistanceBayaraa, Tenuun, Gaete, Jose, Sutiono, Samuel, Kurz, Julia, Lonhienne, Thierry, Harmer, Jeffrey R., Bernhardt, Paul V., Sieber, Volker, Guddat, Luke and Schenk, Gerhard (2022). Dihydroxy‐acid dehydratases from pathogenic bacteria: emerging drug targets to combat antibiotic resistance. Chemistry: A European Journal, 28 (44) e202200927, 1-14. doi: 10.1002/chem.202200927 |
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2022 Journal Article Enzyme electrode biosensors for N-hydroxylated prodrugs incorporating the mitochondrial amidoxime reducing componentZapiter, Joan, Harmer, Jeffrey R., Struwe, Michel, Scheidig, Axel, Clement, Bernd and Bernhardt, Paul V. (2022). Enzyme electrode biosensors for N-hydroxylated prodrugs incorporating the mitochondrial amidoxime reducing component. Analytical Chemistry, 94 (25), 9208-9215. doi: 10.1021/acs.analchem.2c02232 |
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2022 Journal Article The cytochrome P450 OxyA from the kistamicin biosynthesis cyclization cascade is highly sensitive to oxidative damageGreule, Anja, Izoré, Thierry, Machell, Daniel, Hansen, Mathias H., Schoppet, Melanie, De Voss, James J., Charkoudian, Louise K., Schittenhelm, Ralf B., Harmer, Jeffrey R. and Cryle, Max J. (2022). The cytochrome P450 OxyA from the kistamicin biosynthesis cyclization cascade is highly sensitive to oxidative damage. Frontiers in Chemistry, 10 868240, 868240. doi: 10.3389/fchem.2022.868240 |
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2022 Journal Article Electrochemically driven catalysis of the bacterial molybdenum enzyme YiiMKalimuthu, Palraj, Harmer, Jeffrey R., Baldauf, Milena, Hassan, Ahmed H., Kruse, Tobias and Bernhardt, Paul V. (2022). Electrochemically driven catalysis of the bacterial molybdenum enzyme YiiM. Biochimica et Biophysica Acta - Bioenergetics, 1863 (3) 148523, 148523. doi: 10.1016/j.bbabio.2021.148523 |
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2022 Journal Article Mechanochemically synthesised flexible electrodes based on bimetallic metal–organic framework glasses for the oxygen evolution reactionLin, Rijia, Li, Xuemei, Krajnc, Andraž, Li, Zhiheng, Li, Mengran, Wang, Wupeng, Zhuang, Linzhou, Smart, Simon, Zhu, Zhonghua, Appadoo, Dominique, Harmer, Jeffrey R., Wang, Zhiliang, Buzanich, Ana Guilherme, Beyer, Sebastian, Wang, Lianzhou, Mali, Gregor, Bennett, Thomas D., Chen, Vicki and Hou, Jingwei (2022). Mechanochemically synthesised flexible electrodes based on bimetallic metal–organic framework glasses for the oxygen evolution reaction. Angewandte Chemie, 134 (4) e202112880, 21-7. doi: 10.1002/ange.202112880 |
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2022 Journal Article An altered heme environment in an engineered cytochrome P450 enzyme enables the switch from monooxygenase to peroxygenase activityPodgorski, Matthew N., Harbort, Joshua S., Lee, Joel H. Z., Nguyen, Giang T.H., Bruning, John B., Donald, William A., Bernhardt, Paul V., Harmer, Jeffrey R. and Bell, Stephen G. (2022). An altered heme environment in an engineered cytochrome P450 enzyme enables the switch from monooxygenase to peroxygenase activity. ACS Catalysis, 12 (3), 1614-1625. doi: 10.1021/acscatal.1c05877 |
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2021 Journal Article Mechanochemically synthesised flexible electrodes based on bimetallic metal–organic framework glasses for the oxygen evolution reactionLin, Rijia, Li, Xuemei, Krajnc, Andraž, Li, Zhiheng, Li, Mengran, Wang, Wupeng, Zhuang, Linzhou, Smart, Simon, Zhu, Zhonghua, Appadoo, Dominique, Harmer, Jeffrey R., Wang, Zhiliang, Buzanich, Ana Guilherme, Beyer, Sebastian, Wang, Lianzhou, Mali, Gregor, Bennett, Thomas D., Chen, Vicki and Hou, Jingwei (2021). Mechanochemically synthesised flexible electrodes based on bimetallic metal–organic framework glasses for the oxygen evolution reaction. Angewandte Chemie International Edition, 61 (4) e202112880, e202112880. doi: 10.1002/anie.202112880 |
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2021 Journal Article TOAC spin-labeled peptides tailored for DNP-NMR studies in lipid membrane environmentsZhu, Shiying, Kachooei, Ehsan, Harmer, Jeffrey R., Brown, Louise J., Separovic, Frances and Sani, Marc-Antoine (2021). TOAC spin-labeled peptides tailored for DNP-NMR studies in lipid membrane environments. Biophysical Journal, 120 (20), 4501-4511. doi: 10.1016/j.bpj.2021.08.040 |
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2021 Journal Article Mapping the pathway to organocopper(II) complexes relevant to atom transfer radical polymerizationGonzálvez, Miguel A., Harmer, Jeffrey R. and Bernhardt, Paul V. (2021). Mapping the pathway to organocopper(II) complexes relevant to atom transfer radical polymerization. Inorganic Chemistry, 60 (14) acs.inorgchem.1c01309, 10648-10655. doi: 10.1021/acs.inorgchem.1c01309 |
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2021 Journal Article A trap-door mechanism for zinc acquisition by Streptococcus pneumoniae AdcALuo, Zhenyao, Morey, Jacqueline R., Deplazes, Evelyne, Motygullina, Alina, Tan, Aimee, Ganio, Katherine, Neville, Stephanie L., Eleftheriadis, Nikolaos, Isselstein, Michael, Pederick, Victoria G., Paton, James C., Cordes, Thorben, Harmer, Jeffrey R., Kobe, Bostjan and McDevitt, Christopher A. (2021). A trap-door mechanism for zinc acquisition by Streptococcus pneumoniae AdcA. mBio, 12 (1) e01958-20, 1-14. doi: 10.1128/mBio.01958-20 |
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2021 Journal Article Understanding the mechanistic requirements for efficient and stereoselective alkene epoxidation by a cytochrome P450 enzymeColeman, Tom, Kirk, Alicia M., Chao, Rebecca R., Podgorski, Matthew N., Harbort, Joshua S., Churchman, Luke R., Bruning, John B., Bernhardt, Paul V., Harmer, Jeffrey R., Krenske, Elizabeth H., De Voss, James J. and Bell, Stephen G. (2021). Understanding the mechanistic requirements for efficient and stereoselective alkene epoxidation by a cytochrome P450 enzyme. ACS Catalysis, 11 (4), 1995-2010. doi: 10.1021/acscatal.0c04872 |
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2021 Journal Article Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymesStruwe, Michel A., Kalimuthu, Palraj, Luo, Zhenyao, Zhong, Qifeng, Ellis, Daniel, Yang, Jing, Khadanand, K.C., Harmer, Jeffrey R., Kirk, Martin L., McEwan, Alastair G., Clement, Bernd, Bernhardt, Paul V., Kobe, Bostjan and Kappler, Ulrike (2021). Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymes. Journal of Biological Chemistry, 296 100672, 1-16. doi: 10.1016/j.jbc.2021.100672 |
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2020 Journal Article Cross-linking, DEER-spectroscopy and molecular dynamics confirm the inward facing state of P-glycoprotein in a lipid membraneCarey Hulyer, Alex R., Briggs, Deborah A., O'Mara, Megan L., Kerr, Ian D., Harmer, Jeffrey R. and Callaghan, Richard (2020). Cross-linking, DEER-spectroscopy and molecular dynamics confirm the inward facing state of P-glycoprotein in a lipid membrane. Journal of Structural Biology, 211 (1) 107513, 1-14. doi: 10.1016/j.jsb.2020.107513 |
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2020 Journal Article Amyloid β chaperone — lipocalin-type prostaglandin D synthase acts as a peroxidase in the presence of hemePhillips, Margaret, Kannaian, Bhuvaneswari, Yang, Justin Ng Tze, Kather, Ralf, Mu Yuguang, , Harmer, Jeffrey R. and Pervushin, Konstantin (2020). Amyloid β chaperone — lipocalin-type prostaglandin D synthase acts as a peroxidase in the presence of heme. Biochemical Journal, 477 (7), 1227-1240. doi: 10.1042/BCJ20190536 |
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2020 Journal Article Biophysical techniques for distinguishing ligand binding modes in cytochrome P450 monooxygenasesPodgorski, Matthew N., Harbort, Joshua S., Coleman, Tom, Stok, Jeanette E., Yorke, Jake A., Wong, Luet-Lok, Bruning, John B., Bernhardt, Paul V., De Voss, James J., Harmer, Jeffrey R. and Bell, Stephen G. (2020). Biophysical techniques for distinguishing ligand binding modes in cytochrome P450 monooxygenases. Biochemistry, 59 (9) acs.biochem.0c00027, 1038-1050. doi: 10.1021/acs.biochem.0c00027 |
