
Overview
Background
I am an NHMRC Leadership Fellow with joint apointments at the Institute for Molecular Bioscience (IMB) and School of Pharmacy, UQ. My research interests lie in the fields of peripheral pain mechanisms, target identification and analgesic drug discovery. I investigate the contribution of ion channels to sensory neuronal physiology using highly subtype-selective toxins isolated from venomous animals with the aim to develop novel analgesics with improved efficacy and tolerability.
Availability
- Professor Irina Vetter is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Understanding pain pathways
Pain is a major medical and socio-economic issue affecting one in five Australians. Our research aims to understand the molecular mechanisms behind pain. The current focus of the lab is to use toxins from plants and venomous animals to understand the molecular pharmacology of pain. These toxins are highly selective for ion channels and receptors found in the sensory neurons that detect pain and can potentially be developed into novel analgesics. Our research also investigates the mechanisms contributing to chemotherapy-induced pain, cancer-associated pain, inflammatory and neuropathic pain, and the painful marine toxin disease known as ciguatera. To investigate the neuropharmacology of pain we use a range of techniques including: in vivo pain pathway characterisation, high-content imaging of cultured sensory neurons, high-throughput screening using calcium and membrane potential assays, and traditional pharmacological assays. While all pain has similar symptoms, it is becoming clear that the underlying mechanisms behind pain can vary. Our research has already challenged traditional understanding of pain pathways and sensory neuronal physiology. We work in collaboration with other leading Australian and international researchers to identify novel therapeutic pain pathways and targets. By uncovering these new pain pathways, as well as identifying novel targets on peripheral sensory neurons, we aim to develop more effective pain therapies that treat the underlying cause of the pain, not just the symptoms.
Works
Search Professor Irina Vetter’s works on UQ eSpace
2015
Journal Article
Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus
Himaya S.W.A., Jin, Ai-Hua, Dutertre, Sebastien, Giacomotto, Jean, Mohialdeen, Hoshyar, Vetter, Irina, Alewood, Paul F. and Lewis, Richard J. (2015). Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus. Journal of Proteome Research, 14 (10), 4372-4381. doi: 10.1021/acs.jproteome.5b00630
2015
Journal Article
(-)-Pentylsedinine, a new alkaloid from the leaves of lobelia tupa with agonist activity at nicotinic acetylcholine receptor
Paz, Cristian, Becerra, Jose, Silva, Mario, Burgos, Viviana, Heydenreich, Matthias, Schmidt, Bernd, Thu Tran and Vetter, Irina (2015). (-)-Pentylsedinine, a new alkaloid from the leaves of lobelia tupa with agonist activity at nicotinic acetylcholine receptor. Natural Product Communications, 10 (8), 1355-1357. doi: 10.1177/1934578x1501000810
2015
Journal Article
Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens
Cardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178
2015
Journal Article
δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails
Jin, Ai-Hua, Israel, Mathilde R., Inserra, Marco, Smith, Jennifer J., Lewis, Richard J., Alewood, Paul F., Vetter, Irina and Dutertre, Sebastien (2015). δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proceedings of the Royal Society B: Biological Sciences, 282 (1811) 20150817, 1-8. doi: 10.1098/rspb.2015.0817
2015
Journal Article
Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach
Klint, Julie K., Smith, Jennifer J., Vetter, Irina, Rupasinghe, Darshani B., Er, Sing Yan, Senff, Sebastian, Herzig, Volker, Mobli, Mehdi, Lewis, Richard J., Bosmans, Frank and King, Glenn F. (2015). Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach. British Journal of Pharmacology, 172 (10), 2445-2458. doi: 10.1111/bph.13081
2015
Journal Article
Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives
Gleeson, Ellen C., Graham, Janease E., Spiller, Sandro, Vetter, Irina, Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2015). Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives. Marine Drugs, 13 (4), 2030-2045. doi: 10.3390/md13042030
2015
Journal Article
α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors
Mueller, Alexander, Starobova, Hana, Inserra, Marco C., Jin, Ai-Hua, Deuis, Jennifer R., Dutertre, Sebastien, Lewis, Richard J., Alewood, Paul F., Daly, Norelle L. and Vetter, Irina (2015). α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochemical Pharmacology, 94 (2), 155-163. doi: 10.1016/j.bcp.2015.01.011
2015
Journal Article
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Coll, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Muñoz-Planillo, Raúl, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stütz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Núñez, Gabriel, Latz, Eicke, Kästner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A. and O'Neill, Luke A. J. (2015). A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 21 (3), 248-257. doi: 10.1038/nm.3806
2015
Journal Article
Therapeutic opportunities for targeting cold pain pathways
Yin, Kathleen, Zimmermann, Katharina, Vetter, Irina and Lewis, Richard J. (2015). Therapeutic opportunities for targeting cold pain pathways. Biochemical Pharmacology, 93 (2), 125-140. doi: 10.1016/j.bcp.2014.09.024
2015
Book Chapter
Venoms-based drug discovery: bioassays, electrophysiology, high-throughput screens and target identification
Vetter, Irina, Hodgson, Wayne C., Adams, David J. and McIntyre, Peter (2015). Venoms-based drug discovery: bioassays, electrophysiology, high-throughput screens and target identification. Venoms to drugs: venom as a source for the development of human therapeutics. (pp. 97-128) edited by Glenn F. King. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876-00097
2015
Book Chapter
Research methods
Fry, B. G., Undheim, E. A. B., Jackson, T. N. W., Georgieva, D., Vetter, I., Calvete, J. J., Schieb, H., Cribb, B. W., Yang, D. C., Daly, N. L., Manchadi, M. L. Roy, Gutierrez, J. M., Roelants, K., Lomonte, B., Nicholson, G. M., Dziemborowicz, S., Lavergne, V., Ragnarsson, L., Rash, L. D., Mobli, M., Hodgson, W. C., Casewell, N. R., Nouwens, A., Wagstaff, S. C., Ali, S. A., Whitehead, D. L., Herzig, V., Monagle, P., Kurniawan, N. D. ... Sunagar, K. (2015). Research methods. Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. (pp. 153-214) New York, NY, United States: Oxford University Press.
2015
Journal Article
Vergiftung durch Tropenfisch: Ciguatera-Epidemie in Deutschland
Zimmermann, Katharina, Eisenblätte, Anneka, Vetter, Irina, Ebbecke, Martin, Friedemann, Miriam and Desel, Herbert (2015). Vergiftung durch Tropenfisch: Ciguatera-Epidemie in Deutschland. Deutsche Medizinische Wochenschrift, 140 (2), 125-130. doi: 10.1055/s-0040-100439
2015
Conference Publication
Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker
Rahnama, S., Lachlan, R., Cardoso, F. C., Smith, J., Deuis, J., Vetter, I., King, G. F. and Mobli, M. (2015). Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker. The 40th Lorne Conference on Protein Structure and Function, Lorne VIC, Australia, 8-12 February 2015.
2015
Journal Article
Feeling hot, feeling cold: TRP channels - a great story unfolds
Vetter, Irina, Kym, Philip R. and Szallasi, Arpad (2015). Feeling hot, feeling cold: TRP channels - a great story unfolds. Temperature, 2 (2), 150-151. doi: 10.1080/23328940.2015.1047721
2015
Book Chapter
Seeing the woods for the trees: understanding venom evolution as a guide for biodiscovery
Fry, Bryan G., Koludarov, Ivan, Jackson, Timothy N. W., Holford, Mandë, Terrat, Yves, Casewell, Nicholas R., Undheim, Eivind A. B., Vetter, Irina, Ali, Syed A., Low, Dolyce H. W. and Sunagar, Kartik (2015). Seeing the woods for the trees: understanding venom evolution as a guide for biodiscovery. Venoms to drugs: venom as a source for the development of human therapeutics. (pp. 1-36) edited by Glenn F. King. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876-00001
2015
Journal Article
Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom
Jin, Ai-Hua, Vetter, Irina, Himaya, Siddhihalu W. A., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2015). Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom. Proteomics, 15 (23-24), 4030-4040. doi: 10.1002/pmic.201500220
2015
Book Chapter
Does nature do ion channel drug discovery better than us?
Lewis, Richard J., Vetter, Irina, Cardoso, Fernanda C., Inserra, Marco and King, Glenn (2015). Does nature do ion channel drug discovery better than us?. Ion channel drug discovery. (pp. 297-313) edited by Brian Cox and Martin Gosling. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849735087-00297
2015
Journal Article
α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors
Wan, Jingjing, Huang, Johnny X., Vetter, Irina, Mobli, Mehdi, Lawson, Joshua, Tae, Han-Shen, Abraham, Nikita, Paul, Blessy, Cooper, Matthew A., Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2015). α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. Journal of the American Chemical Society, 137 (9), 3209-3212. doi: 10.1021/jacs.5b00244
2014
Journal Article
Design, synthesis and biological evaluation of two opioid agonist and Cav2.2 blocker multitarget ligands
Mollica, Adriano, Costante, Roberto, Novellino, Ettore, Stefanucci, Azzurra, Pieretti, Stefano, Zador, Ferenc, Samavati, Reza, Borsodi, Anna, Benyhe, Sandor, Vetter, Irina and Lewis, Richard J. (2014). Design, synthesis and biological evaluation of two opioid agonist and Cav2.2 blocker multitarget ligands. Chemical Biology and Drug Design, 86 (2), 156-162. doi: 10.1111/cbdd.12479
2014
Journal Article
Ciguatera fish poisoning: a first epidemic in Germany highlights an increasing risk for European countries
Mattei, Cesar, Vetter, Irina, Eisenblatter, Anneka, Krock, Bernd, Ebbecke, Martin, Desel, Herbert and Zimmermann, Katharina (2014). Ciguatera fish poisoning: a first epidemic in Germany highlights an increasing risk for European countries. Toxicon, 91 (2), 76-83. doi: 10.1016/j.toxicon.2014.10.016
Funding
Current funding
Past funding
Supervision
Availability
- Professor Irina Vetter is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Discovery and characterisation of multi-valent peptides
Principal Advisor
Other advisors: Professor Mehdi Mobli
-
Doctor Philosophy
Understanding the function of sodium channel accessory proteins to develop new treatments for chronic pain
Principal Advisor
Other advisors: Dr Jennifer Deuis, Professor Mehdi Mobli
-
Doctor Philosophy
Understanding pain mechanisms in the path towards target-specific analgesic agent design
Principal Advisor
Other advisors: Dr Ingrid Winkler, Dr Hana Starobova
-
Doctor Philosophy
Characterization of bivalency in disulfide-rich peptides
Principal Advisor
Other advisors: Professor Mehdi Mobli
-
Doctor Philosophy
Investigating ion channel function and pathology using toxins as tools
Principal Advisor
Other advisors: Dr Jennifer Deuis, Dr Angelo Keramidas
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Master Philosophy
Using peptide toxins to understand the nociceptor signallosome
Principal Advisor
Other advisors: Dr Jennifer Deuis
-
Doctor Philosophy
Reducing long-term side-effects of chemotherapy in cancer survivors
Principal Advisor
Other advisors: Dr Ingrid Winkler, Dr Hana Starobova
-
Doctor Philosophy
Structure and function of ion channels in pain pathways: a toxin perspective
Principal Advisor
Other advisors: Dr Jennifer Deuis
-
Doctor Philosophy
Developing Models of Cancer Therapy-Induced Late Effects
Principal Advisor
Other advisors: Dr Hana Starobova
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Master Philosophy
Neuro-immune mechanisms of peripheral neuropathy: a novel target offering new prevention and treatment strategies
Principal Advisor
Other advisors: Dr Hana Starobova
-
Doctor Philosophy
Identification and characterisation of new pain-causing toxins from animal venoms
Associate Advisor
Other advisors: Dr Jennifer Deuis, Dr Sam Robinson
-
Doctor Philosophy
Chemotherapy-induced motor neuropathy: towards improved understanding of motor neuron dysfunction during chemotherapy
Associate Advisor
Other advisors: Dr Hana Starobova
-
Doctor Philosophy
Using toxins as tools to understand sodium channel structure and function
Associate Advisor
Other advisors: Dr Jennifer Deuis
-
Doctor Philosophy
Evolutionary shifts in venom function and chemistry within Bees (Hymenoptera: Apiformes)
Associate Advisor
Other advisors: Dr Andrew Walker, Dr Sam Robinson
-
Doctor Philosophy
New Toxin Tools for Dissecting Pain
Associate Advisor
Other advisors: Dr Thomas Durek, Dr Sam Robinson
-
Doctor Philosophy
Characterization of novel family of voltage-gated sodium channel toxins from ant venoms
Associate Advisor
Other advisors: Dr Sam Robinson
-
Doctor Philosophy
Accessing structurally elusive states of sodium channels as novel analgesic targets
Associate Advisor
Other advisors: Dr Thomas Durek, Professor Mehdi Mobli
-
Doctor Philosophy
Using genomics to predict the mechanism-of-action of a chemical entity
Associate Advisor
Other advisors: Associate Professor Sonia Shah
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Doctor Philosophy
Identification and characterisation of new pain-causing toxins from animal venoms
Associate Advisor
Other advisors: Dr Jennifer Deuis, Dr Sam Robinson
-
Doctor Philosophy
Probing ion channel function using venom peptides
Associate Advisor
Other advisors: Dr Angelo Keramidas
Completed supervision
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2023
Doctor Philosophy
Development of peptides as gating modifiers to inhibit the voltage-gated sodium channel subtype 1.7
Principal Advisor
-
2023
Doctor Philosophy
Probing the mechanisms underlying physiological and pathological neuronal excitability
Principal Advisor
Other advisors: Dr Jennifer Deuis
-
2022
Doctor Philosophy
Novel heterodimeric ion channel modulators derived from conotoxins and spider toxins
Principal Advisor
-
2022
Master Philosophy
Investigating the role of the novel GABAA receptor variant, ß2(L51M), in the pathophysiology of epilepsy
Principal Advisor
Other advisors: Dr Angelo Keramidas
-
2021
Doctor Philosophy
Development of a high-throughput pipeline for the discovery of NaV1.9 modulators from animal venoms
Principal Advisor
Other advisors: Dr Jennifer Deuis
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2020
Doctor Philosophy
Novel therapeutic targets for the treatment of vincristine induced peripheral neuropathy
Principal Advisor
Other advisors: Professor Kate Schroder
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2020
Doctor Philosophy
Engineering an optimized analgesic from the NaV1.7 selective spider venom peptide Pn3a
Principal Advisor
Other advisors: Dr Jennifer Deuis, Professor Mehdi Mobli
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2019
Doctor Philosophy
Elucidating the role of NaV1.6 in peripheral sensory neurons
Principal Advisor
Other advisors: Dr Thomas Durek
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2018
Master Philosophy
Identification of pain genes contributing to ciguatoxin-induced pain using haplotype-based computational genetic mapping in mice
Principal Advisor
-
2018
Doctor Philosophy
Establishment, optimization and characterization of a rat model of breast cancer induced bone pain
Principal Advisor
Other advisors: Emeritus Professor Maree Smith, Dr Andy Kuo
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2016
Doctor Philosophy
A Pharmacological and Transcriptomic approach to exploring Novel Pain Targets
Principal Advisor
Other advisors: Professor Peter Cabot, Dr Fernanda Cardoso
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2023
Doctor Philosophy
Characterisation of venom-derived peptides that target acid-sensing ion channels
Associate Advisor
Other advisors: Professor Mehdi Mobli, Dr Lachlan Rash
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2022
Doctor Philosophy
Evolution and Diversification of the Anguimorphan Lizard Venom System
Associate Advisor
Other advisors: Professor Bryan Fry
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2021
Doctor Philosophy
Structural basis of the function of peptide inhibitors targeting voltage-gated sodium channel
Associate Advisor
Other advisors: Professor Mehdi Mobli
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2021
Doctor Philosophy
Solving painful problems: Developing potent and selective NaV channel inhibitors from animal venom
Associate Advisor
Other advisors: Professor David Craik
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2020
Doctor Philosophy
Characterising venom variation and antivenom effectiveness within the "True" vipers (Viperinae: Viperidae)
Associate Advisor
Other advisors: Professor Bryan Fry
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2020
Doctor Philosophy
Effects of Australian snake venoms on coagulation: Differential potency, biochemistry, and antivenom efficacy
Associate Advisor
Other advisors: Professor Bryan Fry
-
2016
Doctor Philosophy
Using toxins to elucidate the role of voltage-gated sodium channels in pain
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Novelty in three-finger toxin evolution
Associate Advisor
Other advisors: Professor Bryan Fry
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2019
Doctor Philosophy
A Blood Bond: Evolutionary, Pathophysiological and Biodiscovery implications of coagulotoxic snake venoms
Associate Advisor
Other advisors: Professor Bryan Fry
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2018
Doctor Philosophy
Evolution of the venom system in aculeate hymenoptera
Associate Advisor
Other advisors: Professor Bryan Fry
-
2016
Doctor Philosophy
A philosophical and empirical investigation of the evolution of the toxicoferan reptile venom system
Associate Advisor
Other advisors: Professor Glenn King, Professor Bryan Fry
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2014
Doctor Philosophy
Discovery and Characterisation of Novel Analgesic Neurotoxins, hCav2.2 Channel inhibitors, from Cone Snail and Spider Venoms
Associate Advisor
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2014
Doctor Philosophy
Discovery and characterization of NaV modulatory venom peptides
Associate Advisor
Other advisors: Dr Lachlan Rash
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2013
Doctor Philosophy
Pharmacological characterisation of alpha-conopeptides with therapeutic potential
Associate Advisor
Media
Enquiries
Contact Professor Irina Vetter directly for media enquiries about:
- analgesics
- cancer
- cancer pain
- chemotherapy pain
- chronic pain
- ciguatera
- diabetes
- drug development
- drug discovery
- ion channels
- irritable bowel syndrome
- neuropathic pain
- neuropathy
- neuropharmacology
- toxins
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