
Overview
Background
I am an NHMRC Leadership Fellow with joint apointments at the Institute for Molecular Bioscience (IMB) and School of Pharmacy, UQ. My research interests lie in the fields of peripheral pain mechanisms, target identification and analgesic drug discovery. I investigate the contribution of ion channels to sensory neuronal physiology using highly subtype-selective toxins isolated from venomous animals with the aim to develop novel analgesics with improved efficacy and tolerability.
Availability
- Professor Irina Vetter is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Understanding pain pathways
Pain is a major medical and socio-economic issue affecting one in five Australians. Our research aims to understand the molecular mechanisms behind pain. The current focus of the lab is to use toxins from plants and venomous animals to understand the molecular pharmacology of pain. These toxins are highly selective for ion channels and receptors found in the sensory neurons that detect pain and can potentially be developed into novel analgesics. Our research also investigates the mechanisms contributing to chemotherapy-induced pain, cancer-associated pain, inflammatory and neuropathic pain, and the painful marine toxin disease known as ciguatera. To investigate the neuropharmacology of pain we use a range of techniques including: in vivo pain pathway characterisation, high-content imaging of cultured sensory neurons, high-throughput screening using calcium and membrane potential assays, and traditional pharmacological assays. While all pain has similar symptoms, it is becoming clear that the underlying mechanisms behind pain can vary. Our research has already challenged traditional understanding of pain pathways and sensory neuronal physiology. We work in collaboration with other leading Australian and international researchers to identify novel therapeutic pain pathways and targets. By uncovering these new pain pathways, as well as identifying novel targets on peripheral sensory neurons, we aim to develop more effective pain therapies that treat the underlying cause of the pain, not just the symptoms.
Works
Search Professor Irina Vetter’s works on UQ eSpace
2016
Journal Article
Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia
Bressan, Elisangela, Touska, Filip, Vetter, Irina, Kistner, Katrin, Kichko, Tatjana I., Teixeira, Nathalia B., Picolo, Gisele, Cury, Yara, Lewis, Richard J., Fischer, Michael J. M., Zimmermann, Katharina and Reeh, Peter W. (2016). Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia. Pain, 157 (11), 2504-2516. doi: 10.1097/j.pain.0000000000000669
2016
Journal Article
The snake with the scorpion's sting: novel three-finger toxin sodium channel activators from the venom of the long-glanded blue coral snake (Calliophis bivirgatus)
Yang, Daryl C., Deuis, Jennifer R., Dashevsky, Daniel, Dobson, James, Jackson, Timothy N. W., Brust, Andreas, Xie, Bing, Koludarov, Ivan, Debono, Jordan, Hendrikx, Iwan, Hodgson, Wayne C., Josh, Peter, Nouwens, Amanda, Baillie, Gregory J., Bruxner, Timothy J. C., Alewood, Paul F., Peng Lim, Kelvin Kok, Frank, Nathaniel, Vetter, Irina and Fry, Bryan G. (2016). The snake with the scorpion's sting: novel three-finger toxin sodium channel activators from the venom of the long-glanded blue coral snake (Calliophis bivirgatus). Toxins, 8 (10) A034, 303. doi: 10.3390/toxins8100303
2016
Journal Article
The Walker 256 breast cancer cell-induced bone pain model in rats
Shenoy, Priyank A., Kuo, Andy, Vetter, Irina and Smith, Maree T. (2016). The Walker 256 breast cancer cell-induced bone pain model in rats. Frontiers in Pharmacology, 7 (AUG) 286, 286. doi: 10.3389/fphar.2016.00286
2016
Journal Article
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target
Yin, Kathleen, Deuis, Jennifer R., Lewis, Richard J. and Vetter, Irina (2016). Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. Molecular Pain, 12, 1-13. doi: 10.1177/1744806916665366
2016
Journal Article
Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7
Troeira Henriques, Sonia, Deplazes, Evelyne, Lawrence, Nicole, Cheneval, Olivier, Chaousis, Stephanie, Inserra, Marco, Thongyoo, Panumart, King, Glenn F., Mark, Alan E., Vetter, Irina, Craik, David J. and Schroeder, Christina Ingrid (2016). Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7. The Journal of Biological Chemistry, 291 (33), 17049-17065. doi: 10.1074/jbc.M116.729095
2016
Journal Article
Rapid extraction and identification of maitotoxin and ciguatoxin-like toxins from Caribbean and Pacific Gambierdiscus using a new functional bioassay
Lewis, Richard J., Inserra, Marco, Vetter, Irina, Holland, William C., Hardison, D. Ransom, Tester, Patricia A. and Litaker, R. Wayne (2016). Rapid extraction and identification of maitotoxin and ciguatoxin-like toxins from Caribbean and Pacific Gambierdiscus using a new functional bioassay. PLoS ONE, 11 (7) e0160006, e0160006. doi: 10.1371/journal.pone.0160006
2016
Journal Article
How hot is it Down Under?
Mündel, Toby, Nalivaiko, Eugene, Kent, Stephen, Maloney, Shane K. and Vetter, Irina (2016). How hot is it Down Under?. Temperature, 3 (3), 355-357. doi: 10.1080/23328940.2016.1218991
2016
Journal Article
Release of neuropeptides from a neuro-cutaneous co-culture model: a novel in vitro model for studying sensory effects of ciguatoxins
Le Garrec, Raphaele, L'herondelle, Killian, Le Gall-Ianotto, Christelle, Lebonvallet, Nicolas, Leschiera, Raphael, Buhe, Virginie, Talagas, Matthieu, Vetter, Irina, Lewis, Richard J. and Misery, Laurent (2016). Release of neuropeptides from a neuro-cutaneous co-culture model: a novel in vitro model for studying sensory effects of ciguatoxins. Toxicon, 116, 4-10. doi: 10.1016/j.toxicon.2015.11.004
2016
Journal Article
Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8
Deuis, Jennifer R, Dekan, Zoltan, Inserra, Marco C., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Craik, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Schroeder, Christina I., Henriques, Sónia Troeira and Vetter, Irina (2016). Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8. Journal of Biological Chemistry, 291 (22), 11829-11842. doi: 10.1074/jbc.M116.721662
2016
Journal Article
Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica
Ariki, Nathanial K., Muñoz, Lisa E., Armitage, Elizabeth L., Goodstein, Francesca R., George, Kathryn G, Smith, Vanessa L., Vetter, Irina, Herzig, Volker, King, Glenn F. and Loening, Nikolaus M. (2016). Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica. PLoS One, 11 (5) e0156291, e0156291. doi: 10.1371/journal.pone.0156291
2016
Journal Article
Neuronal cell lines as model dorsal root ganglion neurons: a transcriptomic comparison
Yin, Kathleen, Baillie, Gregory J. and Vetter, Irina (2016). Neuronal cell lines as model dorsal root ganglion neurons: a transcriptomic comparison. Molecular Pain, 12, 1-17. doi: 10.1177/1744806916646111
2016
Journal Article
Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain
Deuis, Jennifer R., Wingerd, Joshua S., Winter, Zoltan, Durek, Thomas, Dekan, Zoltan, Sousa, Silmara R., Zimmermann, Katharina, Hoffmann, Tali, Weidner, Christian, Nassar, Mohammed A., Alewood, Paul F., Lewis, Richard J. and Vetter, Irina (2016). Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain. Toxins, 8 (3) 78, 78. doi: 10.3390/toxins8030078
2016
Journal Article
The thermal probe test: a novel behavioral assay to quantify thermal paw withdrawal thresholds in mice
Deuis, Jennifer R. and Vetter, Irina (2016). The thermal probe test: a novel behavioral assay to quantify thermal paw withdrawal thresholds in mice. Temperature, 3 (2), 199-207. doi: 10.1080/23328940.2016.1157668
2016
Journal Article
Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay
Azimi, Iman, Flanagan, Jack U., Stevenson, Ralph J., Inserra, Marco, Vetter, Irina, Monteith, Gregory R. and Denny, William A. (2016). Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay. Bioorganic and Medicinal Chemistry, 25 (1), 440-449. doi: 10.1016/j.bmc.2016.11.007
2016
Conference Publication
Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models
Schroeder, Christina I., Deuis, Jennifer, Henriques, Sonia Troeria, Dekan, Zoltan, Inserra, Marco, Mobli, Mehdi and Vetter, Irina (2016). Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models. 60th Annual Meeting of the Biophysical Society, Los Angeles, CA, United States, 27 Feb - 2 Mar 2016. CAMBRIDGE: CELL PRESS. doi: 10.1016/j.bpj.2015.11.247
2016
Conference Publication
Study of the involvement of itch mediators in the neuropeptide release induced by Pacific-Ciguatoxin-2 in a co-culture model of sensory neurons and keratinocytes
L'herondelle, K., Philippe, R., Mignen, O., Vetter, I., Lewis, R. J., Misery, L. and Le Garrec, R. (2016). Study of the involvement of itch mediators in the neuropeptide release induced by Pacific-Ciguatoxin-2 in a co-culture model of sensory neurons and keratinocytes. 22nd Meeting of the French-Society-of-Toxinology (SFET), Paris, France, 10-11 December 2014. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.toxicon.2016.01.007
2016
Book Chapter
Ciguatoxin and ciguatera
Lewis, Richard J. and Vetter, Irina (2016). Ciguatoxin and ciguatera. Marine and freshwater toxins. (pp. 71-92) edited by P. Gopalakrishnakone, Vidal Haddad Jr., Aurelia Tubaro, Euikyung Kim and William R. Kem. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-007-6419-4_13
2016
Conference Publication
Miklos Bodanszky Award Lecture Probing the Functional Complexity of Ancient Oxytocin in Health and Disease
Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Vetter, Irina, Busnelli, Marta, Chini, Bice, Arrowsmith, Sarah, Wray, Susan, de Araujo, Aline Dantas, Dutertre, Sebastien, Mobli, Mehdi, Lewis, Richard J., Gruber, Christian W. and Alewood, Paul F. (2016). Miklos Bodanszky Award Lecture Probing the Functional Complexity of Ancient Oxytocin in Health and Disease. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Hoboken, NJ United States: Wiley.
2015
Journal Article
Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2
Bugarcic, Andrea, Vetter, Irina, Chalmers, Silke, Kinna, Genevieve, Collins, Brett M. and Teasdale, Rohan D. (2015). Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2. Cell Biology International, 39 (11), 1299-1306. doi: 10.1002/cbin.10508
2015
Journal Article
Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia
Deuis, Jennifer, Whately, Ella, Brust, Andreas, Inserra, Marco, Asvadi, Naghmeh Hajarol, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2015). Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia. ACS Chemical Neuroscience, 6 (10), 1751-1758. doi: 10.1021/acschemneuro.5b00113
Funding
Current funding
Past funding
Supervision
Availability
- Professor Irina Vetter is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
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Doctor Philosophy
Discovery and characterisation of multi-valent peptides
Principal Advisor
Other advisors: Professor Mehdi Mobli
-
Doctor Philosophy
Understanding the function of sodium channel accessory proteins to develop new treatments for chronic pain
Principal Advisor
Other advisors: Dr Jennifer Deuis, Professor Mehdi Mobli
-
Doctor Philosophy
Understanding pain mechanisms in the path towards target-specific analgesic agent design
Principal Advisor
Other advisors: Dr Ingrid Winkler, Dr Hana Starobova
-
Doctor Philosophy
Characterization of bivalency in disulfide-rich peptides
Principal Advisor
Other advisors: Professor Mehdi Mobli
-
Doctor Philosophy
Investigating ion channel function and pathology using toxins as tools
Principal Advisor
Other advisors: Dr Jennifer Deuis, Dr Angelo Keramidas
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Master Philosophy
Using peptide toxins to understand the nociceptor signallosome
Principal Advisor
Other advisors: Dr Jennifer Deuis
-
Doctor Philosophy
Reducing long-term side-effects of chemotherapy in cancer survivors
Principal Advisor
Other advisors: Dr Ingrid Winkler, Dr Hana Starobova
-
Doctor Philosophy
Structure and function of ion channels in pain pathways: a toxin perspective
Principal Advisor
Other advisors: Dr Jennifer Deuis
-
Doctor Philosophy
Developing Models of Cancer Therapy-Induced Late Effects
Principal Advisor
Other advisors: Dr Hana Starobova
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Master Philosophy
Neuro-immune mechanisms of peripheral neuropathy: a novel target offering new prevention and treatment strategies
Principal Advisor
Other advisors: Dr Hana Starobova
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Doctor Philosophy
Identification and characterisation of new pain-causing toxins from animal venoms
Associate Advisor
Other advisors: Dr Jennifer Deuis, Dr Sam Robinson
-
Doctor Philosophy
Chemotherapy-induced motor neuropathy: towards improved understanding of motor neuron dysfunction during chemotherapy
Associate Advisor
Other advisors: Dr Hana Starobova
-
Doctor Philosophy
Using toxins as tools to understand sodium channel structure and function
Associate Advisor
Other advisors: Dr Jennifer Deuis
-
Doctor Philosophy
Evolutionary shifts in venom function and chemistry within Bees (Hymenoptera: Apiformes)
Associate Advisor
Other advisors: Dr Andrew Walker, Dr Sam Robinson
-
Doctor Philosophy
New Toxin Tools for Dissecting Pain
Associate Advisor
Other advisors: Dr Thomas Durek, Dr Sam Robinson
-
Doctor Philosophy
Characterization of novel family of voltage-gated sodium channel toxins from ant venoms
Associate Advisor
Other advisors: Dr Sam Robinson
-
Doctor Philosophy
Accessing structurally elusive states of sodium channels as novel analgesic targets
Associate Advisor
Other advisors: Dr Thomas Durek, Professor Mehdi Mobli
-
Doctor Philosophy
Using genomics to predict the mechanism-of-action of a chemical entity
Associate Advisor
Other advisors: Associate Professor Sonia Shah
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Doctor Philosophy
Identification and characterisation of new pain-causing toxins from animal venoms
Associate Advisor
Other advisors: Dr Jennifer Deuis, Dr Sam Robinson
-
Doctor Philosophy
Probing ion channel function using venom peptides
Associate Advisor
Other advisors: Dr Angelo Keramidas
Completed supervision
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2023
Doctor Philosophy
Development of peptides as gating modifiers to inhibit the voltage-gated sodium channel subtype 1.7
Principal Advisor
-
2023
Doctor Philosophy
Probing the mechanisms underlying physiological and pathological neuronal excitability
Principal Advisor
Other advisors: Dr Jennifer Deuis
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2022
Doctor Philosophy
Novel heterodimeric ion channel modulators derived from conotoxins and spider toxins
Principal Advisor
-
2022
Master Philosophy
Investigating the role of the novel GABAA receptor variant, ß2(L51M), in the pathophysiology of epilepsy
Principal Advisor
Other advisors: Dr Angelo Keramidas
-
2021
Doctor Philosophy
Development of a high-throughput pipeline for the discovery of NaV1.9 modulators from animal venoms
Principal Advisor
Other advisors: Dr Jennifer Deuis
-
2020
Doctor Philosophy
Engineering an optimized analgesic from the NaV1.7 selective spider venom peptide Pn3a
Principal Advisor
Other advisors: Dr Jennifer Deuis, Professor Mehdi Mobli
-
2020
Doctor Philosophy
Novel therapeutic targets for the treatment of vincristine induced peripheral neuropathy
Principal Advisor
Other advisors: Professor Kate Schroder
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2019
Doctor Philosophy
Elucidating the role of NaV1.6 in peripheral sensory neurons
Principal Advisor
Other advisors: Dr Thomas Durek
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2018
Master Philosophy
Identification of pain genes contributing to ciguatoxin-induced pain using haplotype-based computational genetic mapping in mice
Principal Advisor
-
2018
Doctor Philosophy
Establishment, optimization and characterization of a rat model of breast cancer induced bone pain
Principal Advisor
Other advisors: Emeritus Professor Maree Smith, Dr Andy Kuo
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2016
Doctor Philosophy
A Pharmacological and Transcriptomic approach to exploring Novel Pain Targets
Principal Advisor
Other advisors: Professor Peter Cabot, Dr Fernanda Cardoso
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2023
Doctor Philosophy
Characterisation of venom-derived peptides that target acid-sensing ion channels
Associate Advisor
Other advisors: Professor Mehdi Mobli, Dr Lachlan Rash
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2022
Doctor Philosophy
Evolution and Diversification of the Anguimorphan Lizard Venom System
Associate Advisor
Other advisors: Professor Bryan Fry
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2021
Doctor Philosophy
Structural basis of the function of peptide inhibitors targeting voltage-gated sodium channel
Associate Advisor
Other advisors: Professor Mehdi Mobli
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2021
Doctor Philosophy
Solving painful problems: Developing potent and selective NaV channel inhibitors from animal venom
Associate Advisor
Other advisors: Professor David Craik
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2020
Doctor Philosophy
Characterising venom variation and antivenom effectiveness within the "True" vipers (Viperinae: Viperidae)
Associate Advisor
Other advisors: Professor Bryan Fry
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2020
Doctor Philosophy
Novelty in three-finger toxin evolution
Associate Advisor
Other advisors: Professor Bryan Fry
-
2016
Doctor Philosophy
Using toxins to elucidate the role of voltage-gated sodium channels in pain
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Effects of Australian snake venoms on coagulation: Differential potency, biochemistry, and antivenom efficacy
Associate Advisor
Other advisors: Professor Bryan Fry
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2019
Doctor Philosophy
A Blood Bond: Evolutionary, Pathophysiological and Biodiscovery implications of coagulotoxic snake venoms
Associate Advisor
Other advisors: Professor Bryan Fry
-
2018
Doctor Philosophy
Evolution of the venom system in aculeate hymenoptera
Associate Advisor
Other advisors: Professor Bryan Fry
-
2016
Doctor Philosophy
A philosophical and empirical investigation of the evolution of the toxicoferan reptile venom system
Associate Advisor
Other advisors: Professor Glenn King, Professor Bryan Fry
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2014
Doctor Philosophy
Discovery and Characterisation of Novel Analgesic Neurotoxins, hCav2.2 Channel inhibitors, from Cone Snail and Spider Venoms
Associate Advisor
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2014
Doctor Philosophy
Discovery and characterization of NaV modulatory venom peptides
Associate Advisor
Other advisors: Dr Lachlan Rash
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2013
Doctor Philosophy
Pharmacological characterisation of alpha-conopeptides with therapeutic potential
Associate Advisor
Media
Enquiries
Contact Professor Irina Vetter directly for media enquiries about:
- analgesics
- cancer
- cancer pain
- chemotherapy pain
- chronic pain
- ciguatera
- diabetes
- drug development
- drug discovery
- ion channels
- irritable bowel syndrome
- neuropathic pain
- neuropathy
- neuropharmacology
- toxins
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