
Overview
Background
I am an NHMRC Leadership Fellow with joint apointments at the Institute for Molecular Bioscience (IMB) and School of Pharmacy, UQ. My research interests lie in the fields of peripheral pain mechanisms, target identification and analgesic drug discovery. I investigate the contribution of ion channels to sensory neuronal physiology using highly subtype-selective toxins isolated from venomous animals with the aim to develop novel analgesics with improved efficacy and tolerability.
Availability
- Professor Irina Vetter is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Understanding pain pathways
Pain is a major medical and socio-economic issue affecting one in five Australians. Our research aims to understand the molecular mechanisms behind pain. The current focus of the lab is to use toxins from plants and venomous animals to understand the molecular pharmacology of pain. These toxins are highly selective for ion channels and receptors found in the sensory neurons that detect pain and can potentially be developed into novel analgesics. Our research also investigates the mechanisms contributing to chemotherapy-induced pain, cancer-associated pain, inflammatory and neuropathic pain, and the painful marine toxin disease known as ciguatera. To investigate the neuropharmacology of pain we use a range of techniques including: in vivo pain pathway characterisation, high-content imaging of cultured sensory neurons, high-throughput screening using calcium and membrane potential assays, and traditional pharmacological assays. While all pain has similar symptoms, it is becoming clear that the underlying mechanisms behind pain can vary. Our research has already challenged traditional understanding of pain pathways and sensory neuronal physiology. We work in collaboration with other leading Australian and international researchers to identify novel therapeutic pain pathways and targets. By uncovering these new pain pathways, as well as identifying novel targets on peripheral sensory neurons, we aim to develop more effective pain therapies that treat the underlying cause of the pain, not just the symptoms.
Works
Search Professor Irina Vetter’s works on UQ eSpace
2017
Journal Article
Optimization and in vivo profiling of a refined rat model of Walker 256 breast cancer cell-induced bone pain using behavioral, radiological, histological, immunohistochemical and pharmacological methods
Shenoy, Priyank, Kuo, Andy, Vetter, Irina and Smith, Maree T. (2017). Optimization and in vivo profiling of a refined rat model of Walker 256 breast cancer cell-induced bone pain using behavioral, radiological, histological, immunohistochemical and pharmacological methods. Frontiers in Pharmacology, 8 (JUL) 442, 442. doi: 10.3389/fphar.2017.00442
2017
Journal Article
Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities
Dekan, Zoltan, Headey, Stephen J., Scanlon, Martin, Baldo, Brian A., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Deuis, Jennifer R., Vetter, Irina, Elliott, Alysha G., Amado, Maite, Cooper, Matthew A., Alewood, Dianne and Alewood, Paul F. (2017). Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities. Angewandte Chemie, 56 (29), 8495-8499. doi: 10.1002/anie.201703360
2017
Journal Article
Pathophysiology of chemotherapy-induced peripheral neuropathy
Starobova, Hana and Vetter, Irina (2017). Pathophysiology of chemotherapy-induced peripheral neuropathy. Frontiers in Molecular Neuroscience, 10 174. doi: 10.3389/fnmol.2017.00174
2017
Journal Article
Corrigendum: Pharmacological characterisation of the highly Na v 1.7 selective spider venom peptide Pn3a (Scientific Reports (2017) 7 (40883)
Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Corrigendum: Pharmacological characterisation of the highly Na v 1.7 selective spider venom peptide Pn3a (Scientific Reports (2017) 7 (40883). Scientific Reports, 7 (1) 46816, 46816. doi: 10.1038/srep46816
2017
Journal Article
Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus
Cardoso, Fernanda Caldas, Dekan, Zoltan, Smith, Jennifer J., Deuis, Jennifer R., Vetter, Irina, Herzig, Volker, Alewood, Paul F., King, Glenn F and Lewis, Richard J. (2017). Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology, 174 (15), 2528-2544. doi: 10.1111/bph.13865
2017
Journal Article
The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes (vol 27, pg 1184, 2017)
Casewell, Nicholas R., Visser, Jeroen C., Baumann, Kate, Dobson, James, Han, Han, Kuruppu, Sanjaya, Morgan, Michael, Romilio, Anthony, Weisbecker, Vera, Mardon, Karine, Ali, Syed A., Debono, Jordan, Koludarov, Ivan, Que, Ivo, Bird, Gregory C., Cooke, Gavan M., Nouwens, Amanda, Hodgson, Wayne C., Wagstaff, Simon C., Cheney, Karen L., Vetter, Irina, van der Weerd, Louise, Richardson, Michael K. and Fry, Bryan G. (2017). The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes (vol 27, pg 1184, 2017). Current Biology, 27 (10), 1549-1550. doi: 10.1016/j.cub.2017.05.009
2017
Journal Article
The pharmacology of voltage-gated sodium channel activators
Deuis, Jennifer R., Mueller, Alexander, Israel, Mathilde R. and Vetter, Irina (2017). The pharmacology of voltage-gated sodium channel activators. Neuropharmacology, 127, 87-108. doi: 10.1016/j.neuropharm.2017.04.014
2017
Journal Article
Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors
Windley, Monique J., Vetter, Irina, Lewis, Richard J. and Nicholson, Graham M. (2017). Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors. Neuropharmacology, 127, 224-242. doi: 10.1016/j.neuropharm.2017.04.008
2017
Journal Article
Sodium Channels and Venom Peptide Pharmacology
Israel, Mathilde R., Tay, Bryan, Deuis, Jennifer R. and Vetter, Irina (2017). Sodium Channels and Venom Peptide Pharmacology. Advances in Pharmacology, 79, 67-116. doi: 10.1016/bs.apha.2017.01.004
2017
Journal Article
Pharmacological screening technologies for venom peptide discovery
Prashanth, Jutty Rajan, Hasaballah, Nojod and Vetter, Irina (2017). Pharmacological screening technologies for venom peptide discovery. Neuropharmacology, 127, 4-19. doi: 10.1016/j.neuropharm.2017.03.038
2017
Journal Article
The evolution of fangs, venom, and mimicry systems in blenny fishes
Casewell, Nicholas R., Visser, Jeroen C., Baumann, Kate, Dobson, James, Han, Han, Kuruppu, Sanjaya, Morgan, Michael, Romilio, Anthony, Weisbecker, Vera, Ali, Syed A., Debono, Jordan, Koludarov, Ivan, Que, Ivo, Bird, Gregory C., Cooke, Gavan M., Nouwens, Amanda, Hodgson, Wayne C., Wagstaff, Simon C., Cheney, Karen L., Vetter, Irina, van der Weerd, Louise, Richardson, Michael K. and Fry, Bryan G. (2017). The evolution of fangs, venom, and mimicry systems in blenny fishes. Current Biology, 27 (8), 1184-1191. doi: 10.1016/j.cub.2017.02.067
2017
Journal Article
The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant
Rahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina and Mobli, Mehdi (2017). The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant. PLoS One, 12 (3) e0173551, e0173551. doi: 10.1371/journal.pone.0173551
2017
Journal Article
Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1
Inserra, Marco C., Isreal, Mathilde, Caldwell, Ashlee, Castro, Joel, Deuis, Jennifer R., Harrington, Andrea M., Keramidas, Angelo, Garcia-Caraballo, Sonia, Maddern, Jessica, Erickson, Andelain, Grundy, Luke, Rychkov, Grigori Y., Zimmerman, Katharina, Lewis, Richard J., Brierley, Stuart M. and Vetter, Irina (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7 (1) 42810, 42810. doi: 10.1038/srep42810
2017
Journal Article
Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses
Wan, Jingjing, Mobli, Mehdi, Brust, Andreas, Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Castro, Joel, Vetter, Irina, Huang, Johnny X., Nilsson, Mathias, Brierley, Stuart M., Cooper, Matthew A., Lewis, Richard J. and Alewood, Paul F. (2017). Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70 (2), 162-171. doi: 10.1071/CH16407
2017
Journal Article
Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a
Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a. Scientific Reports, 7 (1) 40883, 40883. doi: 10.1038/srep40883
2017
Journal Article
The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states
Barry, Guy, Briggs, James A., Hwang, Do Won, Nayler, Sam P., Fortuna, Patrick R. J., Jonkhout, Nicky, Dachet, Fabien, Maag, Jesper L. V., Mestdagh, Pieter, Singh, Erin M., Avesson, Lotta, Kaczorowski, Dominik C., Ozturk, Ezgi, Jones, Nigel C., Vetter, Irina, Arriola-Martinez, Luis, Hu, Jianfei, Franco, Gloria R., Warn, Victoria M., Gong, Andrew, Dinger, Marcel E., Rigo, Frank, Lipovich, Leonard, Morris, Margaret J., O'Brien, Terence J., Lee, Dong Soo, Loeb, Jeffrey A., Blackshaw, Seth, Mattick, John S. and Wolvetang, Ernst J. (2017). The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states. Scientific Reports, 7 (1) 40127, 40127. doi: 10.1038/srep40127
2017
Book Chapter
Ciguatoxin detection methods and high-throughput assays
Inserra, Marco, Lavrukhina, Yelena, Jones, Alun, Lewis, Richard J. and Vetter, Irina (2017). Ciguatoxin detection methods and high-throughput assays. Analysis of food toxins and toxicants. (pp. 469-487) edited by Yiu-Chung Wong and Richard J. Lewis. Oxford, United Kingdom: Wiley Blackwell. doi: 10.1002/9781118992685.ch15
2016
Journal Article
Role of NLRP3 inflammasome in a model of acute burn-induced pain
Deuis, Jennifer R., Yin, Kathleen, Cooper, Matthew A., Schroder, Kate and Vetter, Irina (2016). Role of NLRP3 inflammasome in a model of acute burn-induced pain. Burns, 43 (2), 304-309. doi: 10.1016/j.burns.2016.09.001
2016
Journal Article
NaV1.7 as a pain target – from gene to pharmacology
Vetter, Irina, Deuis, Jennifer, Mueller, Alexander, Israel, Mathilde R., Hana Starobova, Zhang, Alan, Rash, Lachlan D. and Mobli, Mehdi (2016). NaV1.7 as a pain target – from gene to pharmacology. Pharmacology and Therapeutics, 172, 73-100. doi: 10.1016/j.pharmthera.2016.11.015
2016
Journal Article
New insight in cold pain: role of ion channels, modulation, and clinical perspectives
Lolignier, Stéphane, Gkika, Dimitra, Andersson, David, Leipold, Enrico, Vetter, Irina, Viana, Felix, Noel, Jacques and Busserolles, Jérôme (2016). New insight in cold pain: role of ion channels, modulation, and clinical perspectives. The Journal of Neuroscience, 36 (45), 11435-11439. doi: 10.1523/JNEUROSCI.2327-16.2016
Funding
Current funding
Past funding
Supervision
Availability
- Professor Irina Vetter is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Discovery and characterisation of multi-valent peptides
Principal Advisor
Other advisors: Professor Mehdi Mobli
-
Doctor Philosophy
Understanding the function of sodium channel accessory proteins to develop new treatments for chronic pain
Principal Advisor
Other advisors: Dr Jennifer Deuis, Professor Mehdi Mobli
-
Doctor Philosophy
Understanding pain mechanisms in the path towards target-specific analgesic agent design
Principal Advisor
Other advisors: Dr Ingrid Winkler, Dr Hana Starobova
-
Doctor Philosophy
Characterization of bivalency in disulfide-rich peptides
Principal Advisor
Other advisors: Professor Mehdi Mobli
-
Doctor Philosophy
Investigating ion channel function and pathology using toxins as tools
Principal Advisor
Other advisors: Dr Jennifer Deuis, Dr Angelo Keramidas
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Master Philosophy
Using peptide toxins to understand the nociceptor signallosome
Principal Advisor
Other advisors: Dr Jennifer Deuis
-
Doctor Philosophy
Reducing long-term side-effects of chemotherapy in cancer survivors
Principal Advisor
Other advisors: Dr Ingrid Winkler, Dr Hana Starobova
-
Doctor Philosophy
Structure and function of ion channels in pain pathways: a toxin perspective
Principal Advisor
Other advisors: Dr Jennifer Deuis
-
Doctor Philosophy
Developing Models of Cancer Therapy-Induced Late Effects
Principal Advisor
Other advisors: Dr Hana Starobova
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Master Philosophy
Neuro-immune mechanisms of peripheral neuropathy: a novel target offering new prevention and treatment strategies
Principal Advisor
Other advisors: Dr Hana Starobova
-
Doctor Philosophy
Identification and characterisation of new pain-causing toxins from animal venoms
Associate Advisor
Other advisors: Dr Jennifer Deuis, Dr Sam Robinson
-
Doctor Philosophy
Chemotherapy-induced motor neuropathy: towards improved understanding of motor neuron dysfunction during chemotherapy
Associate Advisor
Other advisors: Dr Hana Starobova
-
Doctor Philosophy
Using toxins as tools to understand sodium channel structure and function
Associate Advisor
Other advisors: Dr Jennifer Deuis
-
Doctor Philosophy
Evolutionary shifts in venom function and chemistry within Bees (Hymenoptera: Apiformes)
Associate Advisor
Other advisors: Dr Andrew Walker, Dr Sam Robinson
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Doctor Philosophy
New Toxin Tools for Dissecting Pain
Associate Advisor
Other advisors: Dr Thomas Durek, Dr Sam Robinson
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Doctor Philosophy
Characterization of novel family of voltage-gated sodium channel toxins from ant venoms
Associate Advisor
Other advisors: Dr Sam Robinson
-
Doctor Philosophy
Accessing structurally elusive states of sodium channels as novel analgesic targets
Associate Advisor
Other advisors: Dr Thomas Durek, Professor Mehdi Mobli
-
Doctor Philosophy
Using genomics to predict the mechanism-of-action of a chemical entity
Associate Advisor
Other advisors: Associate Professor Sonia Shah
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Doctor Philosophy
Identification and characterisation of new pain-causing toxins from animal venoms
Associate Advisor
Other advisors: Dr Jennifer Deuis, Dr Sam Robinson
-
Doctor Philosophy
Probing ion channel function using venom peptides
Associate Advisor
Other advisors: Dr Angelo Keramidas
Completed supervision
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2023
Doctor Philosophy
Development of peptides as gating modifiers to inhibit the voltage-gated sodium channel subtype 1.7
Principal Advisor
-
2023
Doctor Philosophy
Probing the mechanisms underlying physiological and pathological neuronal excitability
Principal Advisor
Other advisors: Dr Jennifer Deuis
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2022
Doctor Philosophy
Novel heterodimeric ion channel modulators derived from conotoxins and spider toxins
Principal Advisor
-
2022
Master Philosophy
Investigating the role of the novel GABAA receptor variant, ß2(L51M), in the pathophysiology of epilepsy
Principal Advisor
Other advisors: Dr Angelo Keramidas
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2021
Doctor Philosophy
Development of a high-throughput pipeline for the discovery of NaV1.9 modulators from animal venoms
Principal Advisor
Other advisors: Dr Jennifer Deuis
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2020
Doctor Philosophy
Novel therapeutic targets for the treatment of vincristine induced peripheral neuropathy
Principal Advisor
Other advisors: Professor Kate Schroder
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2020
Doctor Philosophy
Engineering an optimized analgesic from the NaV1.7 selective spider venom peptide Pn3a
Principal Advisor
Other advisors: Dr Jennifer Deuis, Professor Mehdi Mobli
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2019
Doctor Philosophy
Elucidating the role of NaV1.6 in peripheral sensory neurons
Principal Advisor
Other advisors: Dr Thomas Durek
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2018
Master Philosophy
Identification of pain genes contributing to ciguatoxin-induced pain using haplotype-based computational genetic mapping in mice
Principal Advisor
-
2018
Doctor Philosophy
Establishment, optimization and characterization of a rat model of breast cancer induced bone pain
Principal Advisor
Other advisors: Emeritus Professor Maree Smith, Dr Andy Kuo
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2016
Doctor Philosophy
A Pharmacological and Transcriptomic approach to exploring Novel Pain Targets
Principal Advisor
Other advisors: Professor Peter Cabot, Dr Fernanda Cardoso
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2023
Doctor Philosophy
Characterisation of venom-derived peptides that target acid-sensing ion channels
Associate Advisor
Other advisors: Professor Mehdi Mobli, Dr Lachlan Rash
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2022
Doctor Philosophy
Evolution and Diversification of the Anguimorphan Lizard Venom System
Associate Advisor
Other advisors: Professor Bryan Fry
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2021
Doctor Philosophy
Structural basis of the function of peptide inhibitors targeting voltage-gated sodium channel
Associate Advisor
Other advisors: Professor Mehdi Mobli
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2021
Doctor Philosophy
Solving painful problems: Developing potent and selective NaV channel inhibitors from animal venom
Associate Advisor
Other advisors: Professor David Craik
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2020
Doctor Philosophy
Characterising venom variation and antivenom effectiveness within the "True" vipers (Viperinae: Viperidae)
Associate Advisor
Other advisors: Professor Bryan Fry
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2020
Doctor Philosophy
Effects of Australian snake venoms on coagulation: Differential potency, biochemistry, and antivenom efficacy
Associate Advisor
Other advisors: Professor Bryan Fry
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2016
Doctor Philosophy
Using toxins to elucidate the role of voltage-gated sodium channels in pain
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Novelty in three-finger toxin evolution
Associate Advisor
Other advisors: Professor Bryan Fry
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2019
Doctor Philosophy
A Blood Bond: Evolutionary, Pathophysiological and Biodiscovery implications of coagulotoxic snake venoms
Associate Advisor
Other advisors: Professor Bryan Fry
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2018
Doctor Philosophy
Evolution of the venom system in aculeate hymenoptera
Associate Advisor
Other advisors: Professor Bryan Fry
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2016
Doctor Philosophy
A philosophical and empirical investigation of the evolution of the toxicoferan reptile venom system
Associate Advisor
Other advisors: Professor Glenn King, Professor Bryan Fry
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2014
Doctor Philosophy
Discovery and Characterisation of Novel Analgesic Neurotoxins, hCav2.2 Channel inhibitors, from Cone Snail and Spider Venoms
Associate Advisor
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2014
Doctor Philosophy
Discovery and characterization of NaV modulatory venom peptides
Associate Advisor
Other advisors: Dr Lachlan Rash
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2013
Doctor Philosophy
Pharmacological characterisation of alpha-conopeptides with therapeutic potential
Associate Advisor
Media
Enquiries
Contact Professor Irina Vetter directly for media enquiries about:
- analgesics
- cancer
- cancer pain
- chemotherapy pain
- chronic pain
- ciguatera
- diabetes
- drug development
- drug discovery
- ion channels
- irritable bowel syndrome
- neuropathic pain
- neuropathy
- neuropharmacology
- toxins
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