Overview
Background
Peter Simpson is a recognised expert in the molecular and pathological characterisation of breast and lung cancers. His research is based at the UQ Centre for Clinical Research (UQCCR), where he is the Head of the Cancer Theme and is a Research Group Leader in Cancer Genomics. He has published >150 articles (>12,000 citations, H-index 52; Scopus, May2025) including in Nature, Nature Medicine, Annals of Oncology and the American Journal of Respiratory and Critical Care Medicine. He co-manages the Brisbane Breast Bank (BBB), a tissue bank created to facilitate clinical breast cancer research, and the Debutant lung cancer Program.
Pete also holds a teaching appointment in UQ, where he is passionate about the science and clinical applications of Pathology. He teaches into the UQ Medical Program (Year 1 and 2), as well as to undergraduates. He has co-authored a chapter ‘Breast Diseases’ in the latest edition (11th) of the internationally acclaimed Medical text book Robbins and Cotran Pathologic Basis of Disease.
Outside UQ, Pete is a Fellow of the Faculty of Science in the Royal College of Pathologists of Australasia (FFSc RCPA), a member of the kConFab Executive (https://www.kconfab.org/), a member of the Lobular Breast Cancer Alliance Scientific Advisory Board (https://lobularbreastcancer.org/), and a member of the International Cancer Genome Consortium (Breast Cancer group).
Pete enjoys supervising students at all levels in their careers and collaborating within multidisciplinary teams spanning clinical (e.g. pathology, oncology) and science teams (e.g. in ‘omics, bioinformatics and machine learning).
Availability
- Associate Professor Peter Simpson is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, University of Liverpool
Research interests
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Broad Research Program
Cancer is a very heterogeneous disease, making morphological classification and management of patients a significant challenge. Despite great advances it remains difficult to predict which patients are at risk of their disease returning (recurrence), spreading (metastasis) or which patients will gain most benefit to specific therapies. There has therefore been a concerted effort to supplement the morphological classification of disease with molecular data that can provide a clearer appreciation for this complexity and better predict tumour behaviour. This ideology has driven significant advancements in the field of molecular pathology research. My research program embraces these advances in technology to help better understand mechanisms of disease development and progression and help improve the molecular aspects of diagnosis and patient management. Themes of research involve 1) invasive lobular carcinoma of the breast, 2) breast cancer diagnosed in young individuals, and 3) lung cancer.
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Invasive Lobular Carcinoma
Invasive Lobular Carcinoma (ILC) is the most commonly diagnosed ‘special’ morphological type of breast cancer, comprising up to 15% of all cases. The most important biological feature of lobular breast cancer is the functional loss of cell adhesion molecule E-cadherin. This is the glue that holds epithelial cells together. Loss of E-cadherin leads to a growth pattern that can be diffuse and highly invasive through the breast tissue. This leads to a number of important clinical challenges with diagnosing and managing this cancer: the cancer can be hard to palpate or detect by mammographic screening and hard to fully excise during surgery; if the cancer spreads it can again be hard to detect. A large component of Peter's research focuses on aspects of this specific cancer subtype, including understanding molecular determinants that predict tumour behaviour and prognosis, and mechanisms of invasion and metastasis.
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Familial Breast Cancer
Family history is a significant risk factor for the development of breast cancer, often leading to early diagnosis of disease. For some families, the genetic component of this risk is well understood and attributed to pathogenic germline variants in moderate-high risk genes (e.g. BRCA1, BRCA2, PALB2, TP53, ATM, CHEK2). For many families the underlying genetic risk is unknown. Further, some individuals develop breast cancer at a young age when they have no family history. We study clinical samples using a variety of molecular profiling techniques, including whole genome sequencing and digital spatial transcriptomics, and we are interested in understanding the germline and somatic molecular mechanism that contribute to the development of disease. This work is a collaboration with several tissue banks: kConFab, the BBB and the Australian Breast Cancer Tissue Bank.
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Lung Cancer Diagnostics
Lung Cancer has the highest mortality of all cancers. Most cases are diagnosed at an advance, inoperable stage and so are associated with a poor prognosis. Endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) sampling is an important procedure to make a tissue diagnosis of disease and to provide specimens for molecular testing. Next generation sequencing is an important component of diagnostic practice and therapeutic decision making for lung cancer patients. Our program of work is focused on optimising molecular testing strategies from different types of cancer samples (tissue, supernatant, cfDNA) to improve the success of testing for patients. This is a collaboration with A/Prof David Fielding (https://about.uq.edu.au/experts/9060) from the Department of Thoracic Medicine (RBWH), plus colleagues from Pathology Queensland, QIMR Berghofer and a network of hospitals around Australia.
Research impacts
Breast cancer is the most diagnosed cancer in women worldwide and consequently is the biggest contributor to morbidity and mortality from cancer.
My work in the field of breast cancer genomics has sought to unravel molecular mechanisms driving the evolution of disease, from early lesions through to treatment resistance and metastatic progression. Our work uses various types of ‘omics applications, including whole genome sequencing and spatial transcriptomics, married with detailed cancer morphology assessment. Gene mutations and mutational signature analysis in the context of sporadic and familial breast cancer has revealed pathogenic germline mutations, different mechanisms of genomic evolution and clonal heterogeneity. The work through the International Cancer Genome Consortium contributed to the development of HRDetect (Nature Medicine) for therapeutic decision making.
My work in lobular breast cancer has an international standing. As a research community, we aim to raise the profile of lobular breast cancer as an important, common and yet understudied type of breast cancer. We have demonstrated this disease is in fact a heterogenous subtype, exhibiting morphological variants and diverse genomic features. We developed LobSig as a potential prognostic tool for lobular breast cancer, which is undergoing further validation. We have a program of work to better understand the biology of disease and identify tissue- and blood-based biomarkers of disease progression.
Lung cancer is the highest mortality rate of all cancers worldwide. The Debutant lung cancer clinical research program was established in 2018 and has sought to optimise and expand lung cancer molecular testing applications. The work has been funded by various sources, including Pathology Queensland, Royal Brisbane & Women’s Hospital Foundation, Cancer Council Qld, Cancer Australia, Australian Genomics and the Medical Research Future Fund (MRFF). The work has demonstrated the clinical utility of very small cytology samples and blood (cfDNA) samples using comprehensive genomic assays. The translation of results from this Program could significantly enhance the number of patients eligible for targeted therapies.
Works
Search Professor Peter Simpson’s works on UQ eSpace
2022
Conference Publication
Breast cancer in Honiara - a retrospective audit
Stacey, A., Simpson, P., McCart-Reed, A. and Cummings, M. (2022). Breast cancer in Honiara - a retrospective audit. 34th International Congress of the International Academy of Pathology, Sydney, NSW Australia, 1-15 October 2022. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/his.14739
2022
Journal Article
Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels
Ramarao-Milne, P, Kondrashova, O, Patch, A-M, Nones, K, Koufariotis, L T, Newell, F, Addala, V, Lakis, V, Holmes, O, Leonard, C, Wood, S, Xu, Q, Mukhopadhyay, P, Naeini, M M, Steinfort, D, Williamson, J P, Bint, M, Pahoff, C, Nguyen, P T, Twaddell, S, Arnold, D, Grainge, C, Basirzadeh, F, Fielding, D, Dalley, A J, Chittoory, H, Simpson, P T, Aoude, L G, Bonazzi, V F ... Waddell, N (2022). Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels. ESMO Open, 7 (4) 100540, 1-11. doi: 10.1016/j.esmoop.2022.100540
2022
Journal Article
Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer
Saunus, Jodi M., De Luca, Xavier M., Northwood, Korinne, Raghavendra, Ashwini, Hasson, Alexander, McCart Reed, Amy E., Lim, Malcolm, Lal, Samir, Vargas, A. Cristina, Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Kalaw, Emarene, Kalita-de Croft, Priyakshi, Gresshoff, Irma, Al-Ejeh, Fares, Gee, Julia M. W., Ormandy, Chris, Khanna, Kum Kum, Beesley, Jonathan, Chenevix-Trench, Georgia, Green, Andrew R., Rakha, Emad A., Ellis, Ian O., Nicolau, Dan V., Simpson, Peter T. and Lakhani, Sunil R. (2022). Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer. npj Breast Cancer, 8 (1) 57, 1-16. doi: 10.1038/s41523-022-00425-x
2022
Journal Article
Whole genome deep sequencing analysis of cell-free DNA in samples with low tumour content
Ganesamoorthy, Devika, Robertson, Alan James, Chen, Wenhan, Hall, Michael B., Cao, Minh Duc, Ferguson, Kaltin, Lakhani, Sunil R., Nones, Katia, Simpson, Peter T. and Coin, Lachlan J. M. (2022). Whole genome deep sequencing analysis of cell-free DNA in samples with low tumour content. BMC Cancer, 22 (1) 85, 85. doi: 10.1186/s12885-021-09160-1
2022
Journal Article
Blood-derived extracellular vesicle-associated miR-3182 detects non-small cell lung cancer patients
Visan, Kekoolani S., Lobb, Richard J., Wen, Shu Wen, Bedo, Justin, Lima, Luize G., Krumeich, Sophie, Palma, Carlos, Ferguson, Kaltin, Green, Ben, Niland, Colleen, Cloonan, Nicole, Simpson, Peter T., McCart Reed, Amy E., Everitt, Sarah J., MacManus, Michael P., Hartel, Gunter, Salomon, Carlos, Lakhani, Sunil R., Fielding, David and Möller, Andreas (2022). Blood-derived extracellular vesicle-associated miR-3182 detects non-small cell lung cancer patients. Cancers, 14 (1) 257, 257. doi: 10.3390/cancers14010257
2022
Book Chapter
Future role of molecular profiling in small breast samples and personalised medicine
Foong, Samuel Y. F., Simpson, Peter T., Cummings, Margaret C. and Lakhani, Sunil R. (2022). Future role of molecular profiling in small breast samples and personalised medicine. A comprehensive guide to core needle biopsies of the breast. (pp. 895-915) edited by Sandra J. Shin, Yunn-Yi Chen and Paula S. Ginter. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-031-05532-4_23
2021
Journal Article
Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers (Nature Communications, (2021), 12, 1, (1078), 10.1038/s41467-020-20496-3)
Coignard, Juliette, Lush, Michael, Beesley, Jonathan, O’Mara, Tracy A., Dennis, Joe, Tyrer, Jonathan P., Barnes, Daniel R., McGuffog, Lesley, Leslie, Goska, Bolla, Manjeet K., Adank, Muriel A., Agata, Simona, Ahearn, Thomas, Aittomäki, Kristiina, Andrulis, Irene L., Anton-Culver, Hoda, Arndt, Volker, Arnold, Norbert, Aronson, Kristan J., Arun, Banu K., Augustinsson, Annelie, Azzollini, Jacopo, Barrowdale, Daniel, Baynes, Caroline, Becher, Heko, Bermisheva, Marina, Bernstein, Leslie, Białkowska, Katarzyna, Blomqvist, Carl ... Antoniou, Antonis C. (2021). Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers (Nature Communications, (2021), 12, 1, (1078), 10.1038/s41467-020-20496-3). Nature Communications, 12 (1) 2986. doi: 10.1038/s41467-021-23162-4
2021
Conference Publication
Implementation of precision oncology for breast cancer care in Brisbane: Q-IMPROvE
McCart Reed, Amy, McCurry, Therese, Simpson, Peter, Inglis, Po-Ling, Ung, Owen, Murugappan, Kowsalya, Waddell, Nic, Snell, Cameron, Woodward, Natasha, Middleton, Kathryn, Walpole, Euan, O'Byrne, Ken, Cuff, Katharine, Andelkovic, Vladimir, Roberts, Kate, Steinke, Karin, Santamaria, Gorane, McCarthy, Nicole, Mar Fan, Helen, Kalinowski, Lauren and Lakhani, Sunil (2021). Implementation of precision oncology for breast cancer care in Brisbane: Q-IMPROvE. Brisbane Cancer Conference , Brisbane, QLD Australia, 25-26 Nov 2021.
2021
Conference Publication
Implementation of precision oncology for breast cancer care in Brisbane: Q-IMPROvE
McCart Reed, Amy, McCurry, Therese, Simpson, Peter, Inglis, Po-ling, Ung, Owen, Murugappan, Kowsalya, Waddell, Nic, Snell, Cameron, Woodward, Natasha, Middleton, Kathryn, Walpole, Euan, O'Byrne, Ken, Cuff, Katharine, Andelkovic, Vlad, Roberts, Kate, Steinke, Karin, Santamaria, Gorane, McCarthy, Nicole, Mar Fan, Helen, Kalinowski, Lauren and Lakhani, Sunil (2021). Implementation of precision oncology for breast cancer care in Brisbane: Q-IMPROvE. Herston Symposium, Brisbane, QLD Australia, September 2021.
2021
Journal Article
Correction: McCart Reed et al. The Genomic Landscape of Lobular Breast Cancer. Cancers 2021, 13, 1950
McCart Reed, Amy E., Foong, Samuel, Kutasovic, Jamie R., Nones, Katia, Waddell, Nicola, Lakhani, Sunil R. and Simpson, Peter T. (2021). Correction: McCart Reed et al. The Genomic Landscape of Lobular Breast Cancer. Cancers 2021, 13, 1950. Cancers, 13 (16) 4010, 4010. doi: 10.3390/cancers13164010
2021
Journal Article
Characterization of immune cell subsets of tumor infiltrating lymphocytes in brain metastases
Croft, Priyakshi Kalita-de, Chittoory, Haarika, Nguyen, Tam H., Saunus, Jodi M., Kim, Woo Gyeong, Reed, Amy E. McCart, Lim, Malcolm, De Luca, Xavier M., Ferguson, Kaltin, Niland, Colleen, Mazzieri, Roberta, Dolcetti, Riccardo, Simpson, Peter T. and Lakhani, Sunil R. (2021). Characterization of immune cell subsets of tumor infiltrating lymphocytes in brain metastases. Biology, 10 (5) 425, 425. doi: 10.3390/biology10050425
2021
Journal Article
The genomic landscape of lobular breast cancer
McCart Reed, Amy E., Foong, Samuel, Kutasovic, Jamie R., Nones, Katia, Waddell, Nicola, Lakhani, Sunil R. and Simpson, Peter T. (2021). The genomic landscape of lobular breast cancer. Cancers, 13 (8) 1950, 1950. doi: 10.3390/cancers13081950
2021
Journal Article
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers
Johnson, Nichola, Maguire, Sarah, Morra, Anna, Kapoor, Pooja Middha, Tomczyk, Katarzyna, Jones, Michael E., Schoemaker, Minouk J., Gilham, Clare, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Ahearn, Thomas U., Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Arndt, Volker, Aronson, Kristan J., Augustinsson, Annelie, Baynes, Caroline, Freeman, Laura E. Beane, Beckmann, Matthias W., Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Boeckx, Bram, Bogdanova, Natalia V., Bojesen, Stig E., Brauch, Hiltrud, Brenner, Hermann ... Fletcher, Olivia (2021). CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers. British Journal of Cancer, 124 (4), 842-854. doi: 10.1038/s41416-020-01185-w
2021
Journal Article
Invasive lobular carcinoma of the breast: the increasing importance of this special subtype
McCart Reed, Amy E., Kalinowski, Lauren, Simpson, Peter T. and Lakhani, Sunil R. (2021). Invasive lobular carcinoma of the breast: the increasing importance of this special subtype. Breast Cancer Research, 23 (1) 6, 6. doi: 10.1186/s13058-020-01384-6
2020
Journal Article
Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer-insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system
Wafai, Razan, Williams, Elizabeth D., de Souza, Emma, Simpson, Peter T., Reed, Amy E. McCart, Kutasovic, Jamie R., Waltham, Mark, Snell, Cameron E., Blick, Tony, Thompson, Erik W. and Hugo, Honor J. (2020). Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer-insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system. Breast Cancer Research, 22 (1) 136, 136. doi: 10.1186/s13058-020-01366-8
2020
Journal Article
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
Rubanova, Yulia, Shi, Ruian, Harrigan, Caitlin F., Li, Roujia, Wintersinger, Jeff, Sahin, Nil, Deshwar, Amit G., Dentro, Stefan C., Leshchiner, Ignaty, Gerstung, Moritz, Jolly, Clemency, Haase, Kerstin, Tarabichi, Maxime, Wintersinger, Jeff, Deshwar, Amit G., Yu, Kaixian, Gonzalez, Santiago, Rubanova, Yulia, Macintyre, Geoff, Adams, David J., Anur, Pavana, Beroukhim, Rameen, Boutros, Paul C., Bowtell, David D., Campbell, Peter J., Cao, Shaolong, Christie, Elizabeth L., Cmero, Marek, Cun, Yupeng ... PCAWG Consortium (2020). Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. Nature Communications, 11 (1) 731, 1-12. doi: 10.1038/s41467-020-14352-7
2020
Journal Article
Divergent mutational processes distinguish hypoxic and normoxic tumours
Bhandari, Vinayak, Li, Constance H., Bristow, Robert G., Boutros, Paul C., Aaltonen, Lauri A., Abascal, Federico, Abeshouse, Adam, Aburatani, Hiroyuki, Adams, David J., Agrawal, Nishant, Ahn, Keun Soo, Ahn, Sung-Min, Aikata, Hiroshi, Akbani, Rehan, Akdemir, Kadir C., Al-Ahmadie, Hikmat, Al-Sedairy, Sultan T., Al-Shahrour, Fatima, Alawi, Malik, Albert, Monique, Aldape, Kenneth, Alexandrov, Ludmil B., Ally, Adrian, Alsop, Kathryn, Alvarez, Eva G., Amary, Fernanda, Amin, Samirkumar B., Aminou, Brice, Ammerpohl, Ole ... PCAWG Consortium (2020). Divergent mutational processes distinguish hypoxic and normoxic tumours. Nature Communications, 11 (1) 737. doi: 10.1038/s41467-019-14052-x
2020
Journal Article
Inferring structural variant cancer cell fraction
Cmero, Marek, Yuan, Ke, Ong, Cheng Soon, Schröder, Jan, Adams, David J., Anur, Pavana, Beroukhim, Rameen, Boutros, Paul C., Bowtell, David D. L., Campbell, Peter J., Cao, Shaolong, Christie, Elizabeth L., Cun, Yupeng, Dawson, Kevin J., Demeulemeester, Jonas, Dentro, Stefan C., Deshwar, Amit G., Donmez, Nilgun, Drews, Ruben M., Eils, Roland, Fan, Yu, Fittall, Matthew W., Garsed, Dale W., Gerstung, Moritz, Getz, Gad, Gonzalez, Santiago, Ha, Gavin, Haase, Kerstin, Imielinski, Marcin ... von Mering, Christian (2020). Inferring structural variant cancer cell fraction. Nature Communications, 11 (1) 730. doi: 10.1038/s41467-020-14351-8
2020
Journal Article
Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1
Kalaw, Emarene, Lim, Malcolm, Kutasovic, Jamie R., Sokolova, Anna, Taege, Lucinda, Johnstone, Kate, Bennett, James, Saunus, Jodi M., Niland, Colleen, Ferguson, Kaltin, Gresshoff, Irma, Bettington, Mark, Pathmanathan, Nirmala, Tse, Gary M., Papadimos, David, Pathmanathan, Rajadurai, Harris, Gavin, Yamaguchi, Rin, Tan, Puay Hoon, Fox, Stephen, O’Toole, Sandra A., Simpson, Peter T., Lakhani, Sunil R. and McCart Reed, Amy E. (2020). Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1. British Journal of Cancer, 123 (11), 1665-1672. doi: 10.1038/s41416-020-01065-3
2020
Journal Article
Phenotypic drift in metastatic progression of breast cancer: a case report with histologically heterogeneous lesions that are clonally related
Kutasovic, Jamie R., McCart Reed, Amy E., Sokolova, Anna, Jayanthan, Janani, Da Silva, Leonard, Simpson, Peter T. and Lakhani, Sunil R. (2020). Phenotypic drift in metastatic progression of breast cancer: a case report with histologically heterogeneous lesions that are clonally related. Clinical Case Reports, 8 (12) ccr3.3257, 2725-2731. doi: 10.1002/ccr3.3257
Funding
Current funding
Supervision
Availability
- Associate Professor Peter Simpson is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Applications of Molecular Genetics in Translational Breast Cancer Research
Associate Advisor
Other advisors: Associate Professor Amy McCart Reed, Professor Sunil Lakhani
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Doctor Philosophy
Developing optimal transport models for spatial and single cell data to understand cancer progression
Associate Advisor
Other advisors: Professor Jessica Mar, Dr Quan Nguyen
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Doctor Philosophy
Circulating biomarkers in invasive lobular breast carcinoma
Associate Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Amy McCart Reed
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Doctor Philosophy
Investigating therapeutic vulnerabilities in breast cancer.
Associate Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Amy McCart Reed
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Doctor Philosophy
Breast cancer metastasis prediction via machine learning and spatial cellular pathology
Associate Advisor
Other advisors: Dr Nan Ye, Dr Quan Nguyen
Completed supervision
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2025
Doctor Philosophy
Studies on the utility of Endobronchial Ultrasound Transbronchial Needle Aspiration (EBUS TBNA) samples in novel investigations of lung cancer genomics, and immune responses
Principal Advisor
Other advisors: Professor Sunil Lakhani
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2021
Doctor Philosophy
Multi-omics: Leveraging omics data integration to identify dysregulated biology in breast cancer
Principal Advisor
Other advisors: Associate Professor Amy McCart Reed, Dr Katia Nones
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2018
Doctor Philosophy
Genomic and transcriptomic biomarkers of prognosis in invasive lobular breast cancer.
Principal Advisor
Other advisors: Associate Professor Amy McCart Reed, Professor Sunil Lakhani
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2016
Doctor Philosophy
Intratumour heterogeneity in the development and progression of breast cancer
Principal Advisor
Other advisors: Associate Professor Amy McCart Reed, Professor Sunil Lakhani
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2016
Doctor Philosophy
Computational analysis of DNA repair pathways in breast cancer
Associate Advisor
Other advisors: Honorary Professor Kum Kum Khanna
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2016
Doctor Philosophy
Identification of new prognostic biomarker for triple negative breast cancer
Associate Advisor
Other advisors: Dr Jodi Saunus, Professor Sunil Lakhani
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2013
Doctor Philosophy
A Search For Novel Cancer Susceptibility Genes
Associate Advisor
Other advisors: Professor Sunil Lakhani, Professor Melissa Brown
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2013
Doctor Philosophy
Clinical-Pathological and Molecular Analysis to Understand Breast Cancer Progression
Associate Advisor
Other advisors: Professor Sunil Lakhani
Media
Enquiries
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