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Associate Professor Amy McCart Reed
Associate Professor

Amy McCart Reed

Email: 
Phone: 
+61 7 334 66030

Overview

Background

Associate Prof Amy McCart Reed holds a PhD in molecular biology from The University of Queensland. She is a Fellow of the Faculty of Science of the Royal College of Pathologists Australasia. Her early postdoctoral work focused on understanding the genetic basis of colorectal cancer using experimental disease models, as part of a Cancer Research UK-funded colorectal cancer program led by Professors Ian Tomlinson and Andrew Silver. After returning to Australia, she was recruited to the Molecular Breast Pathology group at UQ’s Centre for Clinical Research and has undertaken a series of studies investigating the genomic landscape of breast cancer special types. Amy's research program includes studies on Metaplastic breast cancer and Invasive Lobular Carcinoma, two breast cancer special types in need of targetted therapy options. A/Prof McCart Reed is the scientific lead on an MRFF-funded genomics program investigating the potential for the application of Whole Genome Sequencing in the breast cancer care pathway in Australia, 'Q-IMPROvE'. She applies genomics and spatial transcriptomics methodologies to archival clinical samples to understand the differences between tumour types and their potential for treatment. Amy is passionate about clinical research, biobanking and precision oncology. In addition to her breast cancer research portfolio, she is on the steering committee for the Brisbane Breast Bank and the Scientific Advisory Board for Breast Cancer Trials.

Availability

Associate Professor Amy McCart Reed is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Breast Cancer

  • Genomics

  • Biobanking

  • Molecular pathology

  • Precision medicine

Works

Search Professor Amy McCart Reed’s works on UQ eSpace

108 works between 1999 and 2024

1 - 20 of 108 works

2024

Journal Article

TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells

Bong, Alice H. L., Robitaille, Mélanie, Lin, Sichun, McCart-Reed, Amy, Milevskiy, Michael, Angers, Stéphane, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells. Cell Death Discovery, 10 (1) 421, 421. doi: 10.1038/s41420-024-02183-0

TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells

2024

Conference Publication

LobSig4 is a superior and readily implementable ILC-focussed prognostic biomarker set

Kalinowski, Lauren, Kutasovic, Jamie, Srihari, Sriganesh, Feng, Yufan, Lal, Samir, Ferguson, Kaltin, Chittoory, Haarika, Sokolova, Anna, Lim, Malcolm, De Croft, Priyakshi Kalita, Lakhani, Sunil, Simpson, Peter and Reed, Amy McCart (2024). LobSig4 is a superior and readily implementable ILC-focussed prognostic biomarker set. San Antonio Breast Cancer Symposium 2023, San Antonio, TX United States, 5-9 December 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.sabcs23-po3-15-09

LobSig4 is a superior and readily implementable ILC-focussed prognostic biomarker set

2024

Journal Article

B7-H3 expression in breast cancer and brain metastasis

Joshi, Vaibhavi, Beecher, Kate, Lim, Malcolm, Stacey, Andrew, Feng, Yufan, Jat, Parmjit S., Duijf, Pascal H. G., Simpson, Peter T., Lakhani, Sunil R. and McCart Reed, Amy E. (2024). B7-H3 expression in breast cancer and brain metastasis. International Journal of Molecular Sciences, 25 (7) 3976, 1-17. doi: 10.3390/ijms25073976

B7-H3 expression in breast cancer and brain metastasis

2024

Journal Article

<scp>NDRG1</scp> is a prognostic biomarker in breast cancer and breast cancer brain metastasis

Joshi, Vaibhavi, Stacey, Andrew, Feng, Yufan, Kalita‐de Croft, Priyakshi, Duijf, Pascal HG, Simpson, Peter T, Lakhani, Sunil R and McCart Reed, Amy E (2024). NDRG1 is a prognostic biomarker in breast cancer and breast cancer brain metastasis. The Journal of Pathology: Clinical Research, 10 (2) e12364. doi: 10.1002/2056-4538.12364

<scp>NDRG1</scp> is a prognostic biomarker in breast cancer and breast cancer brain metastasis

2024

Journal Article

Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A

Palma, Carlos, Lai, Andrew, Scholz‐Romero, Katherin, Chittoory, Haarika, Van Haeringen, Benjamin, Carrion, Flavio, Handberg, Aase, Lappas, Martha, Lakhani, Sunil R., McCart Reed, Amy E, McIntyre, H. David, Nair, Soumyalekshmi and Salomon, Carlos (2024). Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A. Journal of Extracellular Biology, 3 (1) e135, e135. doi: 10.1002/jex2.135

Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A

2023

Journal Article

The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study

Davidson, Aimee L., Dressel, Uwe, Norris, Sarah, Canson, Daffodil M., Glubb, Dylan M., Fortuno, Cristina, Hollway, Georgina E., Parsons, Michael T., Vidgen, Miranda E., Holmes, Oliver, Koufariotis, Lambros T., Lakis, Vanessa, Leonard, Conrad, Wood, Scott, Xu, Qinying, McCart Reed, Amy E., Pickett, Hilda A., Al-Shinnag, Mohammad K., Austin, Rachel L., Burke, Jo, Cops, Elisa J., Nichols, Cassandra B., Goodwin, Annabel, Harris, Marion T., Higgins, Megan J., Ip, Emilia L., Kiraly-Borri, Catherine, Lau, Chiyan, Mansour, Julia L. ... Ward, Robyn L. (2023). The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study. Genome Medicine, 15 (1) 74, 1-16. doi: 10.1186/s13073-023-01223-1

The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study

2023

Journal Article

Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasis

Lim, Malcolm, Fletcher, Nicholas L., Saunus, Jodi M., McCart Reed, Amy E., Chittoory, Haarika, Simpson, Peter T., Thurecht, Kristofer J. and Lakhani, Sunil R. (2023). Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasis. Molecular Pharmaceutics, 20 (12), 6169-6183. doi: 10.1021/acs.molpharmaceut.3c00558

Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasis

2023

Journal Article

Predicting breast cancer-specific survival in metaplastic breast cancer patients using machine learning algorithms

Feng, Yufan, McGuire, Natasha, Walton, Alexandra, Fox, Stephen, Papa, Antonella, Lakhani, Sunil R. and McCart Reed, Amy E. (2023). Predicting breast cancer-specific survival in metaplastic breast cancer patients using machine learning algorithms. Journal of Pathology Informatics, 14 100329, 100329. doi: 10.1016/j.jpi.2023.100329

Predicting breast cancer-specific survival in metaplastic breast cancer patients using machine learning algorithms

2023

Journal Article

Obesity-associated changes in molecular biology of primary breast cancer

Nguyen, Ha-Linh, Geukens, Tatjana, Maetens, Marion, Aparicio, Samuel, Bassez, Ayse, Borg, Ake, Brock, Jane, Broeks, Annegien, Caldas, Carlos, Cardoso, Fatima, De Schepper, Maxim, Delorenzi, Mauro, Drukker, Caroline A., Glas, Annuska M., Green, Andrew R., Isnaldi, Edoardo, Eyfjörð, Jórunn, Khout, Hazem, Knappskog, Stian, Krishnamurthy, Savitri, Lakhani, Sunil R., Langerod, Anita, Martens, John W. M., McCart Reed, Amy E., Murphy, Leigh, Naulaerts, Stefan, Nik-Zainal, Serena, Nevelsteen, Ines, Neven, Patrick ... Desmedt, Christine (2023). Obesity-associated changes in molecular biology of primary breast cancer. Nature Communications, 14 (1) 4418. doi: 10.1038/s41467-023-39996-z

Obesity-associated changes in molecular biology of primary breast cancer

2023

Journal Article

Obesity-associated changes in molecular biology of primary breast cancer

Nguyen, Ha-Linh, Geukens, Tatjana, Maetens, Marion, Aparicio, Samuel, Bassez, Ayse, Borg, Ake, Brock, Jane, Broeks, Annegien, Caldas, Carlos, Cardoso, Fatima, De Schepper, Maxim, Delorenzi, Mauro, Drukker, Caroline A., Glas, Annuska M., Green, Andrew R., Isnaldi, Edoardo, Eyfjoro, Jorunn, Khout, Hazem, Knappskog, Stian, Krishnamurthy, Savitri, Lakhani, Sunil R., Langerod, Anita, Martens, John W. M., Reed, Amy E. McCart, Murphy, Leigh, Naulaerts, Stefan, Nik-Zainal, Serena, Nevelsteen, Ines, Neven, Patrick ... Desmedt, Christine (2023). Obesity-associated changes in molecular biology of primary breast cancer. Nature Communications, 14 (1) ARTN 4418. doi: 10.1038/s41467-023-39996-z

Obesity-associated changes in molecular biology of primary breast cancer

2023

Journal Article

BRCA1 and BRCA2 carriers with breast, ovarian and prostate cancer demonstrate a different pattern of metastatic disease compared with non-carriers: results from a rapid autopsy programme

Thorne, Heather, Devereux, Lisa, Li, Jason, Alsop, Kathryn, Christie, Liz, van Geelen, Courtney T., Burdett, Nikki, Pishas, Kathleen I, Woodford, Noel, Leditschke, Jodie, Izzath, Mohamed H. M. A., Strachan, Kate, Young, Gregory, Jaravaza, Rufaro D., Madadin, Mohammed S., Archer, Melanie, Glengarry, Joanna, Iles, Linda, Rathnaweera, Ajith, Hampson, Clare, Almazrooei, Khamis, Burke, Michael, Bandara, Pradeep, Ranson, David, Saeedi, Essa, McNally, Orla, Mileshkin, Linda, Hamilton, Anne, Ananda, Sumitra ... Fox, Stephen (2023). BRCA1 and BRCA2 carriers with breast, ovarian and prostate cancer demonstrate a different pattern of metastatic disease compared with non-carriers: results from a rapid autopsy programme. Histopathology, 83 (1), 91-103. doi: 10.1111/his.14906

BRCA1 and BRCA2 carriers with breast, ovarian and prostate cancer demonstrate a different pattern of metastatic disease compared with non-carriers: results from a rapid autopsy programme

2023

Journal Article

Cutting-edge cancer genomics saving lives

McCart Reed, Amy, Boughtwood, Tiffany and Simpson, Peter (2023). Cutting-edge cancer genomics saving lives. MJA Insight.

Cutting-edge cancer genomics saving lives

2023

Journal Article

The Queensland IMplementation of PRecision Oncology in brEast cancer ( Q‐IMPROvE ) pilot study

McCart Reed, Amy E., Hollway, Georgina, The Q‐IMPROvE study group and Lakhani, Sunil (2023). The Queensland IMplementation of PRecision Oncology in brEast cancer ( Q‐IMPROvE ) pilot study. Medical Journal of Australia, 218 (8), 374-375. doi: 10.5694/mja2.51900

The Queensland IMplementation of PRecision Oncology in brEast cancer ( Q‐IMPROvE ) pilot study

2023

Journal Article

Hereditary breast cancer: syndromes, tumour pathology and molecular testing

Sokolova, A, Johnstone, K J, McCart Reed, A E, Simpson, P T and Lakhani, S R (2023). Hereditary breast cancer: syndromes, tumour pathology and molecular testing. Histopathology, 82 (1), 70-82. doi: 10.1111/his.14808

Hereditary breast cancer: syndromes, tumour pathology and molecular testing

2022

Journal Article

NDRG1 in Cancer: A Suppressor, Promoter, or Both?

Joshi, Vaibhavi, Lakhani, Sunil R. and McCart Reed, Amy E. (2022). NDRG1 in Cancer: A Suppressor, Promoter, or Both?. Cancers, 14 (23) 5739, 1-15. doi: 10.3390/cancers14235739

NDRG1 in Cancer: A Suppressor, Promoter, or Both?

2022

Journal Article

Comprehensive histopathologic and genomic analysis of a novel case of lipoblastoma-like tumour of the vulva demonstrating malignant behaviour

Kutasovic, Jamie R., Nones, Katia, Lakis, Vanessa, Koufariotis, Lambros T., Ferguson, Kaltin, McCart Reed, Amy E., Simpson, Peter T., Lakhani, Sunil R., Mar Fan, Helen, Higgins, Megan, Davies, Janene, Payton, Diane and Taege, Lucinda (2022). Comprehensive histopathologic and genomic analysis of a novel case of lipoblastoma-like tumour of the vulva demonstrating malignant behaviour. Human Pathology Reports, 30 300678, 300678. doi: 10.1016/j.hpr.2022.300678

Comprehensive histopathologic and genomic analysis of a novel case of lipoblastoma-like tumour of the vulva demonstrating malignant behaviour

2022

Conference Publication

The Q-IMPROvE (Queensland- IMplementation of PRecision Oncology in brEast cancer) pilot study

McCart Reed, Amy (2022). The Q-IMPROvE (Queensland- IMplementation of PRecision Oncology in brEast cancer) pilot study. Australian Genomics Technology Association, Sunshine Coast, QLD Australia, 30 October - 2 November 2022.

The Q-IMPROvE (Queensland- IMplementation of PRecision Oncology in brEast cancer) pilot study

2022

Conference Publication

Breast cancer in Honiara - a retrospective audit

Stacey, A., Simpson, P., McCart-Reed, A. and Cummings, M. (2022). Breast cancer in Honiara - a retrospective audit. 34th International Congress of the International Academy of Pathology, Sydney, NSW Australia, 1-15 October 2022. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/his.14739

Breast cancer in Honiara - a retrospective audit

2022

Journal Article

Editorial: Molecular mechanisms in breast cancer progression and metastasis

Fedele, Monica and Reed, Amy McCart (2022). Editorial: Molecular mechanisms in breast cancer progression and metastasis. Frontiers in Oncology, 12 991758, 991758. doi: 10.3389/fonc.2022.991758

Editorial: Molecular mechanisms in breast cancer progression and metastasis

2022

Journal Article

Modeling brain metastasis by internal carotid artery injection of cancer cells

Lim, Malcolm, Fletcher, Nicholas, Reed, Amy Mccart, Flint, Melanie, Thurecht, Kristofer, Saunus, Jodi and Lakhani, Sunil R. (2022). Modeling brain metastasis by internal carotid artery injection of cancer cells. Journal of Visualized Experiments, 2022 (186) e64216. doi: 10.3791/64216

Modeling brain metastasis by internal carotid artery injection of cancer cells

Funding

Current funding

  • 2024 - 2028
    Reducing invasive lobular carcinoma mortality by enhanced liquid biopsy monitoring
    NHMRC MRFF Genomics Health Futures Mission
    Open grant
  • 2024 - 2029
    The EARLY study: Evaluating the Specificity and feasibility of the EARLY Test for Ovarian Cancer Detetion
    NHMRC Partnership Projects
    Open grant
  • 2024 - 2026
    Proof of concept studies for a novel immunotherapy for triple negative Breast cancer and companion diagnostic
    United States Congressionally Directed Medical Research Programs - Breast Cancer Research Program
    Open grant
  • 2023 - 2025
    High-resolution investigation of pre- and post-neoadjuvant treatment breast cancers
    National Breast Cancer Foundation Investigator Initiated Research Scheme
    Open grant
  • 2020 - 2025
    Whole Genome Sequencing in high-risk breast cancer patients.
    MRFF Genomics Health Futures Mission, Project Grant administered by AusIndustry
    Open grant

Past funding

  • 2019 - 2022
    Lobular Breast Cancer - can we identify the patients likely to have a poor prognosis?
    NHMRC Project Grant
    Open grant
  • 2014 - 2015
    The Brisbane Breast Bank
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2013 - 2015
    Prospective study of breast cancer progression by content analysis of circulating exosomes in serially collected blood samples
    Royal Brisbane and Women's Hospital
    Open grant

Supervision

Availability

Associate Professor Amy McCart Reed is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Media

Enquiries

Contact Associate Professor Amy McCart Reed directly for media enquiries about:

  • breast cancer
  • DNA
  • genomics
  • lobular breast cancer
  • metaplastic breast cancer
  • personalised medicine
  • precision medicine
  • precision oncology

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