Overview
Background
Associate Prof Amy McCart Reed holds a PhD in molecular biology from The University of Queensland. She is a Fellow of the Faculty of Science of the Royal College of Pathologists Australasia. Her early postdoctoral work focused on understanding the genetic basis of colorectal cancer using experimental disease models, as part of a Cancer Research UK-funded colorectal cancer program led by Professors Ian Tomlinson and Andrew Silver. After returning to Australia, she was recruited to the Molecular Breast Pathology group at UQ’s Centre for Clinical Research and has undertaken a series of studies investigating the genomic landscape of breast cancer special types. Amy's research program includes studies on Metaplastic breast cancer and Invasive Lobular Carcinoma, two breast cancer special types in need of targetted therapy options. A/Prof McCart Reed is the scientific lead on an MRFF-funded genomics program investigating the potential for the application of Whole Genome Sequencing in the breast cancer care pathway in Australia, 'Q-IMPROvE'. She applies genomics and spatial transcriptomics methodologies to archival clinical samples to understand the differences between tumour types and their potential for treatment. Amy is passionate about clinical research, biobanking and precision oncology. In addition to her breast cancer research portfolio, she is on the steering committee for the Brisbane Breast Bank and the Scientific Advisory Board for Breast Cancer Trials.
Availability
- Associate Professor Amy McCart Reed is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Breast Cancer
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Genomics
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Biobanking
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Molecular pathology
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Precision medicine
Works
Search Professor Amy McCart Reed’s works on UQ eSpace
2024
Journal Article
TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells
Bong, Alice H. L., Robitaille, Mélanie, Lin, Sichun, McCart-Reed, Amy, Milevskiy, Michael, Angers, Stéphane, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells. Cell Death Discovery, 10 (1) 421, 421. doi: 10.1038/s41420-024-02183-0
2024
Conference Publication
LobSig4 is a superior and readily implementable ILC-focussed prognostic biomarker set
Kalinowski, Lauren, Kutasovic, Jamie, Srihari, Sriganesh, Feng, Yufan, Lal, Samir, Ferguson, Kaltin, Chittoory, Haarika, Sokolova, Anna, Lim, Malcolm, De Croft, Priyakshi Kalita, Lakhani, Sunil, Simpson, Peter and Reed, Amy McCart (2024). LobSig4 is a superior and readily implementable ILC-focussed prognostic biomarker set. San Antonio Breast Cancer Symposium 2023, San Antonio, TX United States, 5-9 December 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.sabcs23-po3-15-09
2024
Journal Article
B7-H3 expression in breast cancer and brain metastasis
Joshi, Vaibhavi, Beecher, Kate, Lim, Malcolm, Stacey, Andrew, Feng, Yufan, Jat, Parmjit S., Duijf, Pascal H. G., Simpson, Peter T., Lakhani, Sunil R. and McCart Reed, Amy E. (2024). B7-H3 expression in breast cancer and brain metastasis. International Journal of Molecular Sciences, 25 (7) 3976, 1-17. doi: 10.3390/ijms25073976
2024
Journal Article
<scp>NDRG1</scp> is a prognostic biomarker in breast cancer and breast cancer brain metastasis
Joshi, Vaibhavi, Stacey, Andrew, Feng, Yufan, Kalita‐de Croft, Priyakshi, Duijf, Pascal HG, Simpson, Peter T, Lakhani, Sunil R and McCart Reed, Amy E (2024). NDRG1 is a prognostic biomarker in breast cancer and breast cancer brain metastasis. The Journal of Pathology: Clinical Research, 10 (2) e12364. doi: 10.1002/2056-4538.12364
2024
Journal Article
Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A
Palma, Carlos, Lai, Andrew, Scholz‐Romero, Katherin, Chittoory, Haarika, Van Haeringen, Benjamin, Carrion, Flavio, Handberg, Aase, Lappas, Martha, Lakhani, Sunil R., McCart Reed, Amy E, McIntyre, H. David, Nair, Soumyalekshmi and Salomon, Carlos (2024). Differential response of placental cells to high D‐glucose and its impact on extracellular vesicle biogenesis and trafficking via small GTPase Ras‐related protein RAB‐7A. Journal of Extracellular Biology, 3 (1) e135, e135. doi: 10.1002/jex2.135
2023
Journal Article
The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study
Davidson, Aimee L., Dressel, Uwe, Norris, Sarah, Canson, Daffodil M., Glubb, Dylan M., Fortuno, Cristina, Hollway, Georgina E., Parsons, Michael T., Vidgen, Miranda E., Holmes, Oliver, Koufariotis, Lambros T., Lakis, Vanessa, Leonard, Conrad, Wood, Scott, Xu, Qinying, McCart Reed, Amy E., Pickett, Hilda A., Al-Shinnag, Mohammad K., Austin, Rachel L., Burke, Jo, Cops, Elisa J., Nichols, Cassandra B., Goodwin, Annabel, Harris, Marion T., Higgins, Megan J., Ip, Emilia L., Kiraly-Borri, Catherine, Lau, Chiyan, Mansour, Julia L. ... Ward, Robyn L. (2023). The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study. Genome Medicine, 15 (1) 74, 1-16. doi: 10.1186/s13073-023-01223-1
2023
Journal Article
Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasis
Lim, Malcolm, Fletcher, Nicholas L., Saunus, Jodi M., McCart Reed, Amy E., Chittoory, Haarika, Simpson, Peter T., Thurecht, Kristofer J. and Lakhani, Sunil R. (2023). Targeted hyperbranched nanoparticles for delivery of doxorubicin in breast cancer brain metastasis. Molecular Pharmaceutics, 20 (12), 6169-6183. doi: 10.1021/acs.molpharmaceut.3c00558
2023
Journal Article
Predicting breast cancer-specific survival in metaplastic breast cancer patients using machine learning algorithms
Feng, Yufan, McGuire, Natasha, Walton, Alexandra, Fox, Stephen, Papa, Antonella, Lakhani, Sunil R. and McCart Reed, Amy E. (2023). Predicting breast cancer-specific survival in metaplastic breast cancer patients using machine learning algorithms. Journal of Pathology Informatics, 14 100329, 100329. doi: 10.1016/j.jpi.2023.100329
2023
Journal Article
Obesity-associated changes in molecular biology of primary breast cancer
Nguyen, Ha-Linh, Geukens, Tatjana, Maetens, Marion, Aparicio, Samuel, Bassez, Ayse, Borg, Ake, Brock, Jane, Broeks, Annegien, Caldas, Carlos, Cardoso, Fatima, De Schepper, Maxim, Delorenzi, Mauro, Drukker, Caroline A., Glas, Annuska M., Green, Andrew R., Isnaldi, Edoardo, Eyfjörð, Jórunn, Khout, Hazem, Knappskog, Stian, Krishnamurthy, Savitri, Lakhani, Sunil R., Langerod, Anita, Martens, John W. M., McCart Reed, Amy E., Murphy, Leigh, Naulaerts, Stefan, Nik-Zainal, Serena, Nevelsteen, Ines, Neven, Patrick ... Desmedt, Christine (2023). Obesity-associated changes in molecular biology of primary breast cancer. Nature Communications, 14 (1) 4418. doi: 10.1038/s41467-023-39996-z
2023
Journal Article
Obesity-associated changes in molecular biology of primary breast cancer
Nguyen, Ha-Linh, Geukens, Tatjana, Maetens, Marion, Aparicio, Samuel, Bassez, Ayse, Borg, Ake, Brock, Jane, Broeks, Annegien, Caldas, Carlos, Cardoso, Fatima, De Schepper, Maxim, Delorenzi, Mauro, Drukker, Caroline A., Glas, Annuska M., Green, Andrew R., Isnaldi, Edoardo, Eyfjoro, Jorunn, Khout, Hazem, Knappskog, Stian, Krishnamurthy, Savitri, Lakhani, Sunil R., Langerod, Anita, Martens, John W. M., Reed, Amy E. McCart, Murphy, Leigh, Naulaerts, Stefan, Nik-Zainal, Serena, Nevelsteen, Ines, Neven, Patrick ... Desmedt, Christine (2023). Obesity-associated changes in molecular biology of primary breast cancer. Nature Communications, 14 (1) ARTN 4418. doi: 10.1038/s41467-023-39996-z
2023
Journal Article
BRCA1 and BRCA2 carriers with breast, ovarian and prostate cancer demonstrate a different pattern of metastatic disease compared with non-carriers: results from a rapid autopsy programme
Thorne, Heather, Devereux, Lisa, Li, Jason, Alsop, Kathryn, Christie, Liz, van Geelen, Courtney T., Burdett, Nikki, Pishas, Kathleen I, Woodford, Noel, Leditschke, Jodie, Izzath, Mohamed H. M. A., Strachan, Kate, Young, Gregory, Jaravaza, Rufaro D., Madadin, Mohammed S., Archer, Melanie, Glengarry, Joanna, Iles, Linda, Rathnaweera, Ajith, Hampson, Clare, Almazrooei, Khamis, Burke, Michael, Bandara, Pradeep, Ranson, David, Saeedi, Essa, McNally, Orla, Mileshkin, Linda, Hamilton, Anne, Ananda, Sumitra ... Fox, Stephen (2023). BRCA1 and BRCA2 carriers with breast, ovarian and prostate cancer demonstrate a different pattern of metastatic disease compared with non-carriers: results from a rapid autopsy programme. Histopathology, 83 (1), 91-103. doi: 10.1111/his.14906
2023
Journal Article
Cutting-edge cancer genomics saving lives
McCart Reed, Amy, Boughtwood, Tiffany and Simpson, Peter (2023). Cutting-edge cancer genomics saving lives. MJA Insight.
2023
Journal Article
The Queensland IMplementation of PRecision Oncology in brEast cancer ( Q‐IMPROvE ) pilot study
McCart Reed, Amy E., Hollway, Georgina, The Q‐IMPROvE study group and Lakhani, Sunil (2023). The Queensland IMplementation of PRecision Oncology in brEast cancer ( Q‐IMPROvE ) pilot study. Medical Journal of Australia, 218 (8), 374-375. doi: 10.5694/mja2.51900
2023
Journal Article
Hereditary breast cancer: syndromes, tumour pathology and molecular testing
Sokolova, A, Johnstone, K J, McCart Reed, A E, Simpson, P T and Lakhani, S R (2023). Hereditary breast cancer: syndromes, tumour pathology and molecular testing. Histopathology, 82 (1), 70-82. doi: 10.1111/his.14808
2022
Journal Article
NDRG1 in Cancer: A Suppressor, Promoter, or Both?
Joshi, Vaibhavi, Lakhani, Sunil R. and McCart Reed, Amy E. (2022). NDRG1 in Cancer: A Suppressor, Promoter, or Both?. Cancers, 14 (23) 5739, 1-15. doi: 10.3390/cancers14235739
2022
Journal Article
Comprehensive histopathologic and genomic analysis of a novel case of lipoblastoma-like tumour of the vulva demonstrating malignant behaviour
Kutasovic, Jamie R., Nones, Katia, Lakis, Vanessa, Koufariotis, Lambros T., Ferguson, Kaltin, McCart Reed, Amy E., Simpson, Peter T., Lakhani, Sunil R., Mar Fan, Helen, Higgins, Megan, Davies, Janene, Payton, Diane and Taege, Lucinda (2022). Comprehensive histopathologic and genomic analysis of a novel case of lipoblastoma-like tumour of the vulva demonstrating malignant behaviour. Human Pathology Reports, 30 300678, 300678. doi: 10.1016/j.hpr.2022.300678
2022
Conference Publication
The Q-IMPROvE (Queensland- IMplementation of PRecision Oncology in brEast cancer) pilot study
McCart Reed, Amy (2022). The Q-IMPROvE (Queensland- IMplementation of PRecision Oncology in brEast cancer) pilot study. Australian Genomics Technology Association, Sunshine Coast, QLD Australia, 30 October - 2 November 2022.
2022
Conference Publication
Breast cancer in Honiara - a retrospective audit
Stacey, A., Simpson, P., McCart-Reed, A. and Cummings, M. (2022). Breast cancer in Honiara - a retrospective audit. 34th International Congress of the International Academy of Pathology, Sydney, NSW Australia, 1-15 October 2022. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/his.14739
2022
Journal Article
Editorial: Molecular mechanisms in breast cancer progression and metastasis
Fedele, Monica and Reed, Amy McCart (2022). Editorial: Molecular mechanisms in breast cancer progression and metastasis. Frontiers in Oncology, 12 991758, 991758. doi: 10.3389/fonc.2022.991758
2022
Journal Article
Modeling brain metastasis by internal carotid artery injection of cancer cells
Lim, Malcolm, Fletcher, Nicholas, Reed, Amy Mccart, Flint, Melanie, Thurecht, Kristofer, Saunus, Jodi and Lakhani, Sunil R. (2022). Modeling brain metastasis by internal carotid artery injection of cancer cells. Journal of Visualized Experiments, 2022 (186) e64216. doi: 10.3791/64216
Funding
Current funding
Past funding
Supervision
Availability
- Associate Professor Amy McCart Reed is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Investigating therapeutic vulnerabilities in breast cancer.
Principal Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
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Doctor Philosophy
Circulating biomarkers in invasive lobular breast carcinoma
Principal Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
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Master Philosophy
Applications of Molecular Genetics in Translational Breast Cancer Research
Associate Advisor
Other advisors: Associate Professor Peter Simpson, Professor Sunil Lakhani
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Master Philosophy
Application of molecular genetics in Translational Breast Cancer Research
Associate Advisor
Other advisors: Associate Professor Peter Simpson, Professor Sunil Lakhani
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Master Philosophy
E-cadherin, ROS1 and synthetic lethality in ILC
Associate Advisor
Other advisors: Professor Sunil Lakhani
Completed supervision
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2024
Doctor Philosophy
Identifying and characterising targetable proteins in breast cancer brain metastasis
Principal Advisor
Other advisors: Professor Sunil Lakhani
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2021
Doctor Philosophy
Detailed Characterisation of Metaplastic Breast Carcinoma
Principal Advisor
Other advisors: Dr Jodi Saunus, Professor Sunil Lakhani
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2021
Doctor Philosophy
Multi-omics: Leveraging omics data integration to identify dysregulated biology in breast cancer
Associate Advisor
Other advisors: Dr Katia Nones, Associate Professor Peter Simpson
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2019
Doctor Philosophy
Identifying novel potential prognostic biomarkers in breast cancer
Associate Advisor
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2018
Doctor Philosophy
Genomic and transcriptomic biomarkers of prognosis in invasive lobular breast cancer.
Associate Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
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2016
Doctor Philosophy
Intratumour heterogeneity in the development and progression of breast cancer
Associate Advisor
Other advisors: Professor Sunil Lakhani, Associate Professor Peter Simpson
Media
Enquiries
Contact Associate Professor Amy McCart Reed directly for media enquiries about:
- breast cancer
- DNA
- genomics
- lobular breast cancer
- metaplastic breast cancer
- personalised medicine
- precision medicine
- precision oncology
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